Abstract:
:Migraine is a common neurological disorder with significantly higher incidence and prevalence in women than men. The presentation of the disease in women is modulated by changes in sex hormones from adolescence to pregnancy and menopause. Yet, the effect of sex influences has often been neglected in both basic and clinical and in clinical management of the disease. In this review, evidence from epidemiological, clinical, animal, and neuroimaging studies on the significance of the sex-related influences in migraine is presented, and the unmet needs in each area are discussed. © 2016 Wiley Periodicals, Inc.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Pavlovic JM,Akcali D,Bolay H,Bernstein C,Maleki Ndoi
10.1002/jnr.23903subject
Has Abstractpub_date
2017-01-02 00:00:00pages
587-593issue
1-2eissn
0360-4012issn
1097-4547journal_volume
95pub_type
杂志文章,评审abstract::Substance P (SP) acts as an immunoregulator by binding to specific functional cell surface receptors on a subpopulation of human T-helper lymphocytes. Receptors with similar properties have also been characterized on the human IM-9 B-lymphoblast cell line. Four distinct proteins of molecular weight (MW) 33,000, 58,000...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490180127
更新日期:1987-01-01 00:00:00
abstract::Heme oxygenase-1 (HO1) catalyzes oxidation of the heme molecule in concert with NADPH-cytochrome P450 reductase following the specific cleavage of heme into carbon monoxide, iron, and biliverdin, which is rapidly metabolized to bilirubin. HO1 is a stress-inducible protein that protects cells against oxidative injury, ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10514
更新日期:2003-02-15 00:00:00
abstract::The recent recognition that the p75 neurotrophin receptor, p75((NTR)), can induce apoptotic signals has contributed to the perception that it acts primarily as a death receptor. Although the molecular mechanisms of p75(NTR) signaling remain to be fully characterized, many of the currently identified pathways activated...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/1097-4547(20000801)61:3<237::AID-JNR1>3.0.
更新日期:2000-08-01 00:00:00
abstract::Male gerbils (Meriones unguiculatus) were bred and reared either grouped under enriched environmental conditions or isolated under impoverished environmental conditions. The objective of the present study was to examine the influence of social environment on structural and functional ontogeny of the medial prefrontal ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19980415)52:2<201::AID-JNR
更新日期:1998-04-15 00:00:00
abstract::Spinal cord injury (SCI) triggers chronic intraspinal inflammation consisting of activated resident and infiltrating immune cells (especially microglia/macrophages). The environmental factors contributing to this protracted inflammation are not well understood; however, myelin lipid debris is a hallmark of SCI. Myelin...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.24114
更新日期:2018-06-01 00:00:00
abstract::Neuronal development and differentiation is modulated by activity-dependent mechanisms that stimulate endogenous neurogenesis and differentiation to promote adaptive survival of the organism. Studies on bird odor imprinting have shown how sensory stimuli or environmental influences can affect neonatal behavior, presum...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.23966
更新日期:2017-05-01 00:00:00
abstract::Intrinsic mechanisms that guide damaged axons to regenerate following spinal cord injury remain poorly understood. Manipulation of posttranslational modifications of key proteins in mature neurons could reinvigorate growth machinery after injury. One such modification is acetylation, a reversible process controlled by...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.23573
更新日期:2015-08-01 00:00:00
abstract::Cultured astrocytes from neonatal rat cerebral hemispheres are depolarized by the excitatory neurotransmitter glutamate. In this study we have used selective agonists of different neuronal glutamate receptor subtypes, namely, the N-methyl-D-aspartate (NMDA), kainate, and quisqualate type, to characterize pharmacologic...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490220307
更新日期:1989-03-01 00:00:00
abstract::We studied the effects of oxygen-derived free radicals on the ultrastructure of brain cortical slices and the release of fatty acids from phospholipids of crude synaptosomes. Xanthine oxidase, hypoxanthine, and ADP-Fe3+, a free-radical-generating system, caused swelling of cellular processes and mitochondria. The oxyg...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490120408
更新日期:1984-01-01 00:00:00
abstract::Extracellular matrix molecules take part in functional isolation and stabilization of neuronal compartments but form a vivid interface between neuronal elements at the same time. Previous studies have shown that the accumulation of extracellular matrix, especially its typical phenotypic form, termed perineuronal nets,...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22493
更新日期:2010-11-15 00:00:00
abstract::Nicotinates, pantothenates, riboflavin, vitamins B6 and B12' free (acetyl) and total (free and bound) choline, biopterin, thiamin, biotin, methylated and nonmethylated folates in frontal, temporal, precentral, postcentral, and occipital cortex, thalamus, cerebellum, pons, basal ganglia, and substantia nigra were estim...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490110409
更新日期:1984-01-01 00:00:00
abstract::Changes in dopamine (DA) D(1), D(2), D(3), and D(4) receptors and serotonin 5-HT(1A) and 5-HT(2A) receptors in rat forebrain regions were autoradiographically quantified after continuous infusion of JL 13 [(5-(4-methylpiperazin-1-yl)-8-chloro-pyrido[2,3-b][1,5]benzoxazepine fumarate] for 28 days with osmotic minipumps...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20972
更新日期:2006-08-15 00:00:00
abstract::Bioassays of factors promoting nerve growth in embryonic ganglia are described. Chick embryo extract evokes fiber outgrowth in both sympathetic and ciliary ganglia explanted into a collagen gel. The response is not suppressed by antibodies directed against mouse nerve growth factor (NGF). Chick embryo extract also sup...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490080206
更新日期:1982-01-01 00:00:00
abstract::The inherited deficiency of galactosylceramide beta-galactosidase (E.C. 3.2.1.46: galactocerebrosidase) activity results in globoid cell leukodystrophy in humans (Krabbe disease) and in mice (twitcher mutant). To determine whether Krabbe patients' cells complement twitcher cells to produce, in hybrid combination, grea...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490270406
更新日期:1990-12-01 00:00:00
abstract::Brain-derived neurotrophic factor (BDNF) acutely modulates the efficacy of central glutamatergic synapses via activation of the receptor tyrosine kinase TrkB. On a longer time scale, recent evidence suggests an additional role of TrkB signaling in the formation of excitatory synaptic connections. Here, we have overexp...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10007
更新日期:2001-11-01 00:00:00
abstract::Studies using Aplysia californica have demonstrated that transcription after nerve injury occurs during a rapid, transient first phase and a delayed, prolonged second phase. Although the second phase is especially important for regeneration, the mRNAs produced during this phase have not been identified. We characteriz...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20645
更新日期:2005-11-15 00:00:00
abstract::Antibody-producing hybridoma cells specifically bind to microgram quantities of antigen molecules adsorbed onto the surface of plastic microtiter plates. The binding of hybridoma cells to nonantigen is optimally below 5%, similar binding of non-antibody-producing cells is 4-7%, compared to the binding of the hybridoma...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490150312
更新日期:1986-01-01 00:00:00
abstract::Preterm birth and associated brain injury are the primary cause of cerebral palsy and developmental disabilities and are among the most serious global health issues that modern society faces. Current therapy for infants suffering from premature brain injury is still mainly supportive, and there are no effective treatm...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.24548
更新日期:2020-05-01 00:00:00
abstract::We recently reported that a new monoclonal antibody, 4F2, which labels oligodendroglial lineage cells, recognizes a DEAD-box RNA helicase Ddx54 and that Ddx54 binds to myelin basic protein (MBP) in brain and cultured oligodendrocytes. To elucidate the biological function of Ddx54, we generated a recombinant adenovirus...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.23162
更新日期:2013-03-01 00:00:00
abstract::Protein kinase C (PKC) and its potential role in myelin gene expression were investigated in primary cultured rat oligodendrocytes. The major myelin genes were expressed in a developmentally coordinated manner in cultured oligodendrocytes. PKC activity in these cells was similarly regulated with differential expressio...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490340509
更新日期:1993-04-01 00:00:00
abstract::Previously we reported the amplification of the peripheral myelin protein 22 (PMP22) gene in cell lines of human osteogenic and glioma tumors. PMP22 normally is expressed at high levels in Schwann cells of the peripheral nervous system and is suggested to function as a structural protein of the myelin sheath. One of t...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:
更新日期:1999-12-01 00:00:00
abstract::Experimental autoimmune encephalomyelitis (EAE) is an inflammatory demyelinating disease with similarities to multiple sclerosis that requires the activation of auto reactive T cells that infiltrate the central nervous system. In previous studies we have shown that intraperitoneal administration of synaptosomal antige...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22048
更新日期:2009-08-01 00:00:00
abstract::Microarray analyses demonstrated that a variety of genes was affected by treatment of cerebellar granule cell neurons with the neurotrophic factor pigment epithelium-derived factor (PEDF). The genes for neurotrophins, glial cell-derived neurotrophic factor (GDNF), and their receptors were regulated differentially in i...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20196
更新日期:2004-09-01 00:00:00
abstract::The effects of KCl-treatment on the survival and proliferation of NE-4C self-renewing neural progenitor cells were investigated during early phases of in vitro induced neurogenesis. NE-4C cells, derived from the anterior brain vesicles of embryonic mouse (E9), divided continuously under non-inducing conditions, but ac...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10155
更新日期:2002-03-01 00:00:00
abstract::In this study we used as glial cell models, early and late passage C-6 glial cells, 2B clone, and advanced passages of glial cells derived from aged mouse cerebral hemispheres (MACH) to examine responsiveness to opioids. We have previously reported that early passage C-6 glial cells, 2B clone, are bipotential and can ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490360509
更新日期:1993-12-01 00:00:00
abstract::L-deprenyl protects neurons in a number of in vivo and in vitro models and it has been postulated that it ameliorates some neurodegenerative disorders. Superoxide dismutase (SOD) is one of the enzymes responsible for the inactivation of oxygen free radicals, and one of the mechanisms of the effect of L-deprenyl is tho...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19980715)53:2<235::AID-JNR
更新日期:1998-07-15 00:00:00
abstract::It was previously reported that a monoclonal antibody to beta-amyloid precursor protein (mab22C11; Boehringer Mannheim, Indianapolis, IN) labels an intermediate filament-associated protein (beta APP-IFAP) in cultured human skin fibroblasts (Dooley et al.: J Neurosci Res 33:60-67, 1992). The time course of its expressi...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490380605
更新日期:1994-08-15 00:00:00
abstract::The remarkable quantities of myelin membrane produced by oligodendrocytes has led us to examine the mechanisms involved in the sorting and transport of proteins and lipids during myelinogenesis. Noting that it has been proposed that proteins destined for the apical surface of polarized epithelial cells co-cluster with...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490420316
更新日期:1995-10-15 00:00:00
abstract::Human T-cell lymphotropic virus type I (HTLV-I) may infect up to 10% of peripheral blood T cells in patients with HTLV-I myelopathy. To examine the impact of HTLV-I infection on the abilities of T cells to present and respond to peptide antigen, we HTLV-I infected and subcloned a myelin basic protein peptide 84-102 (M...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19960915)45:6<786::AID-JNR
更新日期:1996-09-15 00:00:00
abstract::Long-duration exposure to weightlessness results in bone demineralization, muscle atrophy, cardiovascular deconditioning, altered sensory-motor control, and central nervous system reorganizations. Exercise countermeasures and body loading methods so far employed have failed to prevent these changes. A human mission to...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/1097-4547(20001015)62:2<169::AID-JNR2>3.0.
更新日期:2000-10-15 00:00:00