Release of polyunsaturated fatty acids from phospholipids and alteration of brain membrane integrity by oxygen-derived free radicals.

abstract：:The transfer of the adenovirus 5 E1A gene into brain cells from rat embryos led to the establishment of phenotypically untransformed clonal glial cell lines. Some lines displayed properties of oligodendrocyte-astrocyte progenitors. Their differentiation involved several steps that were dependent on culture conditions ...

journal_title：Journal of neuroscience research

authors： Evrard C,Galiana E,Rouget P

更新日期：1988-09-01 00:00:00

abstract：:This study tested the hypothesis that sensitivity to the Ca(2+) -induced loss of mitochondrial membrane potential (ΔΨ(m)) and the sensitivity of the loss of ΔΨ to mitochondrial permeability transition pore (PTP) inhibitors are different for neurons and astrocytes. Primary cultures of rat cortical neurons and astrocyte...

journal_title：Journal of neuroscience research

authors： Kahraman S,Bambrick LL,Fiskum G

更新日期：2011-12-01 00:00:00

abstract：:The influence of a concentrated extract of soluble substances from the sciatic nerve upon the acetylcholine receptor (AChR) content in the soleus muscle of adult rats was examined by in vivo infusions. Internal and membrane-inserted AChR were quantitated by the specific binding of 125I-alpha-bungarotoxin (a-BuTX). Int...

journal_title：Journal of neuroscience research

authors： Sayers ST,Yeoh HC,McLane JA,Held IR

更新日期：1986-01-01 00:00:00

abstract：:Pathogenesis of Parkinson's disease and related catecholaminergic neurological disorders is closely associated with changes in the levels of tyrosine hydroxylase (TH). Therefore, investigation of the regulation of the TH gene system should assist in understanding the pathomechanisms involved in these neurological diso...

journal_title：Journal of neuroscience research

authors： Choi EY,Yang JW,Park MS,Sun W,Kim H,Kim SU,Lee MA

更新日期：2012-10-01 00:00:00

abstract：:Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system with an autoimmune attack on the components of the myelin sheath and axons. The etiology of the disease remains largely unknown, but it is commonly acknowledged that the development of MS probably results from the interacti...

journal_title：Journal of neuroscience research

authors： Cheng Y,Sun L,Xie Z,Fan X,Cao Q,Han J,Zhu J,Jin T

更新日期：2017-10-01 00:00:00

abstract：:T cell receptor (TCR) transgenic mice have been used extensively to study T cell development in vivo. Such studies have demonstrated high levels of expression of the TCR transgenes. Although a number of human T cell receptors appear to play a role in the development of autoimmune diseases, in vitro studies have proven...

journal_title：Journal of neuroscience research

authors： Baker AM,Wang Y,Richert JR

更新日期：1996-08-15 00:00:00

abstract：:Cathepsin D-like activity in homogenates of five brain areas of 3-month-old and 24-month-old Fischer 344 rats was measured. With hemoglobin as substrate at pH 3.2, more than 90% of the activity was inhibited by pepstatin. In each area studied, activity was more than twice as high in the old rat brain: 140-160% higher ...

journal_title：Journal of neuroscience research

authors： Kenessey A,Banay-Schwartz M,DeGuzman T,Lajtha A

更新日期：1989-08-01 00:00:00

abstract：:Topoisomerase IIβ (top IIβ) is a nuclear enzyme with an essential role in neural development. The regulation of top IIβ gene expression during neural differentiation is poorly understood. Functional analysis of top IIβ gene structure displayed a GC box sequence in its transcription promoter, which binds the nuclear tr...

journal_title：Journal of neuroscience research

authors： Guo H,Cao C,Chi X,Zhao J,Liu X,Zhou N,Han S,Yan Y,Wang Y,Xu Y,Yan Y,Cui H,Sun H

更新日期：2014-10-01 00:00:00

abstract：:Cyclooxygenase-2 (COX-2), a key enzyme in prostanoid biosynthesis, may represent an important therapeutic target in Alzheimer's disease (AD). In the present study, we explored the regulation of COX-2 in the hippocampal formation in sporadic AD. Using semiquantitative immunocytochemical techniques, we found that in AD ...

journal_title：Journal of neuroscience research

authors： Ho L,Pieroni C,Winger D,Purohit DP,Aisen PS,Pasinetti GM

更新日期：1999-08-01 00:00:00

abstract：:HEPES inhibited the taurine uptake in glial cells. A different kind of inhibition was observed when HEPES was present in the culture medium or in the incubation medium used for the taurine-uptake measurement. As an example of a possible interference of HEPES in pharmacological experiments, we have studied the effect o...

journal_title：Journal of neuroscience research

authors： Lleu PL,Rebel G

更新日期：1989-05-01 00:00:00

abstract：:Hyperglycemia and acidosis are the key factors in diabetic complications. It has been shown that acute or chronic diabetes alters serotonin levels in brain. However, the mechanism of hyperglycemia- or acidosis-induced changes in serotonin levels remains poorly understood. Because Ca2+-dependent protein kinases play a ...

journal_title：Journal of neuroscience research

authors： Ramakrishnan R,Prabhakaran K,Jayakumar AR,Gunasekaran P,Sheeladevi R,Suthanthirarajan N

更新日期：2005-05-15 00:00:00

abstract：:The effects of the nematocyst venom of the sea anemone Bunodosoma cangicum on depolarization-activated currents were studies in opener crayfish muscle fibers and in cultured bovine chromaffin cells. The venom selectively and reversibly blocked the Ca(2+)-dependent K+ current (IK(Ca)) present in crayfish muscle in a do...

journal_title：Journal of neuroscience research

authors： Araque A,Urbano FJ,Cerveñansky C,Gandía L,Buño W

更新日期：1995-11-01 00:00:00

abstract：:Increased serum level of homocysteine, a sulfur-containing amino acid, is considered a risk factor in vascular disorders and in dementias. The effect of homocysteine and metabolically related compounds on brain production of kynurenic acid (KYNA), an endogenous antagonist of glutamate ionotropic receptors, was studied...

journal_title：Journal of neuroscience research

authors： Luchowska E,Luchowski P,Paczek R,Ziembowicz A,Kocki T,Turski WA,Wielosz M,Lazarewicz J,Urbanska EM

更新日期：2005-02-01 00:00:00

abstract：:Metabolism of amyloid-beta peptide (A beta) is closely associated with the pathology and etiology of Alzheimer's disease (AD). Neprilysin is the only rate-limiting catabolic peptidase proven by means of reverse genetics to participate in A beta metabolism in vivo. The aim of the present study is to assess whether poss...

journal_title：Journal of neuroscience research

authors： Iwata N,Takaki Y,Fukami S,Tsubuki S,Saido TC

更新日期：2002-11-01 00:00:00

abstract：:The interaction of bovine white matter proteolipid apoproteins with sodium dodecyl sulfate (SDS) was studied. Equilibrium dialysis binding measurements show that the apoprotein binds approximately 1.5 gm SDS per gram protein at high ionic strength (gamma/2 = 0.17). At low ionic strength (gamma/2 = 0.01) the protein bi...

journal_title：Journal of neuroscience research

authors： Sakura JD

更新日期：1981-01-01 00:00:00

abstract：:Organotypic slices are used frequently in studies of central nervous system development and function because they provide excellent experimental access with significant preservation of cellular context and relationships. Within a slice, however, a variety of factors may cause individual classes of neurons to respond d...

journal_title：Journal of neuroscience research

authors： Niblock MM,Brunso-Bechtold JK,Riddle DR

更新日期：2001-09-01 00:00:00

abstract：:Synaptic vesicles were isolated from adult bovine cortical gray matter by differential centrifugation and membrane filtration of a hypoosmotically lysed crude mitochondrial fraction. Vesicle preparations were analyzed for purity by electron microscopy and enzyme assays. Polyacrylamide gel electrophoresis of SDS-solubi...

journal_title：Journal of neuroscience research

authors： Richter-Landsberg C,Neuhoff V,Waehneldt TV

更新日期：1977-01-01 00:00:00

abstract：:Unilateral eye removal results in an increased delivery of blood-borne glucose, norepinephrine, choline, and tyrosine, but not of proline, to the denervated optic lobes. Administration of reserpine to chicks increases penetrance of norepinephrine into the brain but not of tyrosine, choline, or proline. Selective alter...

journal_title：Journal of neuroscience research

authors： Walker JB,Walker JP,Bondy SC,Purdy J

更新日期：1975-01-01 00:00:00

abstract：:Ephrins and Eph receptors are a family of molecules that have been implicated in axonal pathfinding. A unique feature of B-class ephrins and Eph receptors is their ability to transmit bidirectional signals in both ephrin- and Eph receptor-expressing cells upon cell-cell contact. These signals can lead to cytoskeletal ...

journal_title：Journal of neuroscience research

authors： Liebl DJ,Morris CJ,Henkemeyer M,Parada LF

更新日期：2003-01-01 00:00:00

abstract：:An inflammatory response involving activated microglia in neuritic beta-amyloid plaques is found in Alzheimer's disease (AD) brain. Because HDL lipoproteins have been shown to carry the beta-amyloid peptide (Abeta) in plasma and CSF, we have investigated the influence of plasma high-density lipoprotein (HDL) and lipid...

journal_title：Journal of neuroscience research

authors： Cole GM,Beech W,Frautschy SA,Sigel J,Glasgow C,Ard MD

更新日期：1999-08-15 00:00:00

abstract：:Epilepsy is one of the leading causes of chronic neurological morbidity worldwide. Acquired epilepsy may result from a number of conditions, such as brain injury, anoxia, tumors, stroke, neurotoxicity, and prolonged seizures. Sex differences have been observed in many seizure types; however, some sex-specific seizure ...

journal_title：Journal of neuroscience research

authors： Samba Reddy D

更新日期：2017-01-02 00:00:00

abstract：:The midbrain central gray (periaqueductal gray; PAG) mediates defensive behaviors and is implicated in the rewarding effects of opiate drugs. Projections from the PAG to the ventral tegmental area (VTA) suggest that this region might also regulate behaviors involving motivation and cognition. However, studies have not...

journal_title：Journal of neuroscience research

authors： Omelchenko N,Sesack SR

更新日期：2010-04-01 00:00:00

abstract：:Lead is putatively regarded as an environmental neurotoxicant. Long-term low-level lead exposure causes cognitive deficits, but the mechanism remains to be elucidated. In the present study, the excitatory effects of low-level lead exposure on action potential (AP) firing of pyramidal neurons in CA1 region of rat hippo...

journal_title：Journal of neuroscience research

authors： Yan D,Xiao C,Ma FL,Wang L,Luo YY,Liu J,Wang HL,Chen JT,Ruan DY

更新日期：2008-12-01 00:00:00

abstract：:A high density of opioid receptor-like 1 (ORL1) receptor (also referred to as NOP receptor) is found in limbic areas and in regions containing monoamines, which are implicated in emotional activity and physiopathology of depression and anxiety. We aimed at defining precisely the localization of ORL1 receptors in dorsa...

journal_title：Journal of neuroscience research

authors： Le Maître E,Vilpoux C,Costentin J,Leroux-Nicollet I

更新日期：2005-08-15 00:00:00

abstract：:Studies have shown that individuals with both a history of traumatic brain injury and inheritance of apolipoprotein E-4 (ApoE4) allele are associated with a poor neurologic outcome and an increased risk for Alzheimer's disease. We assessed the hypothesis that thrombin released during brain injury causes an increase in...

journal_title：Journal of neuroscience research

authors： Mhatre M,Hensley K,Nguyen A,Grammas P

更新日期：2006-08-01 00:00:00

abstract：:Heat shock proteins (HSPs) are stress-responsive proteins that serve as important molecules contributing to cellular "protein triage." We and others have reported an increase of selected HSPs in multiple sclerosis (MS) lesions. However, the exact expression pattern of HSP family genes in MS is not known. The aim of ou...

journal_title：Journal of neuroscience research

authors： Mycko MP,Brosnan CF,Raine CS,Fendler W,Selmaj KW

更新日期：2012-10-01 00:00:00

abstract：:The periglomerular cells (PG) of the olfactory bulb (OB) are involved in the primary processing and the refinement of sensory information from the olfactory epithelium. The neurochemical composition of these neurons has been studied in depth in many species, and over the last decades such studies have focused mainly o...

journal_title：Journal of neuroscience research

authors： Baltanás FC,Curto GG,Gómez C,Díaz D,Murias AR,Crespo C,Erdelyi F,Szabó G,Alonso JR,Weruaga E

更新日期：2011-01-01 00:00:00

abstract：:In previous studies, we have shown that a traumatic lesion to the hippocampus of adult mice induces the transitory expression of TNF alpha and IL-1 alpha by neurons of different brain areas and also by glial cells at the site of injury. The aim of the present study was to establish whether the expression of TNF alpha ...

journal_title：Journal of neuroscience research

authors： Tchélingérian JL,Le Saux F,Jacque C

更新日期：1996-01-01 00:00:00

abstract：:The effects of cations on the spontaneous and potassium-stimulated taurine release from mouse cerebral cortex slices were assessed with an emphasis on the as yet unestablished calcium dependence of the stimulated release. Spontaneous and stimulated GABA release was analyzed for comparison. A depolarizing concentration...

journal_title：Journal of neuroscience research

authors： Oja SS,Kontro P

更新日期：1987-01-01 00:00:00

abstract：:Myelin-associated glycoprotein (MAG) is a potent inhibitor of axonal regeneration and also, depending on the age and type of neuron, can promote axonal growth. In addition, MAG influences stability of both myelin and the axon in the intact, mature nervous system. The identity of the neuron/axonal MAG-binding receptor ...

journal_title：Journal of neuroscience research

authors： De Bellard ME,Filbin MT

更新日期：1999-04-15 00:00:00