Nerve growth factors in chick tissues.

abstract：:To examine the role of platelet-derived growth factor (PDGF) in the in vivo regulation of Schwann cell proliferation, steady-state levels of mRNAs encoding PDGF A and B chains, and PDGF alpha and beta receptors were measured in immature and adult rat sciatic nerves and in cultured rat Schwann cells. PDGF B chain and P...

journal_title：Journal of neuroscience research

authors： Hardy M,Reddy UR,Pleasure D

更新日期：1992-02-01 00:00:00

abstract：:The occurrence of type-1 plasminogen activator inhibitor (PAI-1) in human cerebrospinal fluid (CSF) has not previously been reported. As a member of the serpin superfamily of serine protease inhibitors and an acute phase response component, PAI-1 has powerful potential roles in nervous system homeostasis. We have dete...

journal_title：Journal of neuroscience research

authors： Rao JS,Chen M,Festoff BW

更新日期：1993-02-15 00:00:00

abstract：:There is growing evidence on the existence of endogenous ouabain-like factors that modulate Na+, K(+)-ATPase activity. In this laboratory, two soluble subfractions (peaks I and II) were previously separated from rat cerebral cortex, which had opposite effects on Na+, K(+)-ATPase activity. Peak I stimulated and peak II...

journal_title：Journal of neuroscience research

authors： Antonelli M,Casillas T,Rodríguez de Lores Arnaiz G

更新日期：1991-03-01 00:00:00

abstract：:A rodent model of Parkinson's disease, the 1-methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine treated mouse, was used to determine whether striatal dopamine levels recover following grafting adrenal medulla into the striatum. Four types of grafts were performed: 1) adult mouse adrenal medulla, 2) adult adrenal me...

journal_title：Journal of neuroscience research

authors： Bohn MC,Kanuicki M

更新日期：1990-03-01 00:00:00

abstract：:The inherited deficiency of galactosylceramide beta-galactosidase (E.C. 3.2.1.46: galactocerebrosidase) activity results in globoid cell leukodystrophy in humans (Krabbe disease) and in mice (twitcher mutant). To determine whether Krabbe patients' cells complement twitcher cells to produce, in hybrid combination, grea...

journal_title：Journal of neuroscience research

authors： Skiba MC,Lyerla TA,Konola JT,Raghavan S

更新日期：1990-12-01 00:00:00

abstract：:Most previous studies on spinal cord injury (SCI) have used rodent models. Direct extrapolation of the results obtained in rodents to clinical cases is difficult, however, because of neurofunctional and anatomic differences between rodents and primates. In the present study, the development of histopathologic changes ...

journal_title：Journal of neuroscience research

authors： Iwanami A,Yamane J,Katoh H,Nakamura M,Momoshima S,Ishii H,Tanioka Y,Tamaoki N,Nomura T,Toyama Y,Okano H

更新日期：2005-04-15 00:00:00

abstract：:The Oct-2 transcription factor has a predominantly inhibitory effect on gene expression in neuronal cell lines. This factor and its corresponding mRNA have previously been shown to be elevated in adult rat dorsal root ganglion (DRG) neurons chronically exposed to nerve growth factor (NGF). Here we show that the Oct-2 ...

journal_title：Journal of neuroscience research

authors： Kendall G,Brar-Rai A,Ensor E,Winter J,Wood JN,Latchman DS

更新日期：1995-02-01 00:00:00

abstract：:We describe here the presence of ubiquitin and its conjugation system in the rat retina. Retinal homogenates and supernatants conjugate [125I]human ubiquitin with either endogenous or exogenous proteins. The conjugating activity is relatively stable over time, requires ATP, and has a pH optimum of approximately 8. The...

journal_title：Journal of neuroscience research

authors： Naash M,Izbicka E,Anderson RE

更新日期：1991-10-01 00:00:00

abstract：:Ferritin is the major iron storage protein and accounts for the majority of the iron in the brain. Thus, ferritin is a key component in protecting the brain from iron induced oxidative damage. The high lipid content, high rate of oxidative metabolism, and high iron content combine to make the brain the organ most susc...

journal_title：Journal of neuroscience research

authors： Connor JR,Boeshore KL,Benkovic SA,Menzies SL

更新日期：1994-03-01 00:00:00

abstract：:In this study, the responses of nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) and neuronal nitric oxide synthase (nNOS) activities were quantitatively analyzed at different times in both ipsilateral and contralateral sides of trigeminal nuclei, after unilateral trigeminal muscle nerve transection, i...

journal_title：Journal of neuroscience research

authors： Varathan V,Shigenaga Y,Takemura M

更新日期：2001-11-01 00:00:00

abstract：:The interaction of bovine white matter proteolipid apoproteins with sodium dodecyl sulfate (SDS) was studied. Equilibrium dialysis binding measurements show that the apoprotein binds approximately 1.5 gm SDS per gram protein at high ionic strength (gamma/2 = 0.17). At low ionic strength (gamma/2 = 0.01) the protein bi...

journal_title：Journal of neuroscience research

authors： Sakura JD

更新日期：1981-01-01 00:00:00

abstract：:In the rat brain, a heteromeric association between adenosine A(1) and purinergic P2Y(1) receptors has been demonstrated. It is suggested that this association plays an important role in the control of purine-mediated responses during pathophysiological conditions. Recently, we have demonstrated that these receptors c...

journal_title：Journal of neuroscience research

authors： Tonazzini I,Trincavelli ML,Montali M,Martini C

更新日期：2008-10-01 00:00:00

abstract：:Astrocytes are the predominant cell type in the vicinity of glutamatergic synapses, where they monitor and maintain low levels of glutamate. Synaptic homeostasis of glutamate involves its removal from the synaptic cleft via high-affinity glutamate transporters, glutamate transporter-1 (GLT-1)/excitatory amino acid tra...

journal_title：Journal of neuroscience research

authors： Sandhu JK,Sikorska M,Walker PR

更新日期：2002-06-01 00:00:00

abstract：:Muscarinic cholinergic receptors of the M5 subtype are expressed by dopamine-containing neurons of the ventral tegmentum. These M5 receptors modulate the activity of midbrain dopaminergic neurons, which play an important role in mediating reinforcing properties of abused psychostimulants like cocaine. The potential ro...

journal_title：Journal of neuroscience research

authors： Fink-Jensen A,Fedorova I,Wörtwein G,Woldbye DP,Rasmussen T,Thomsen M,Bolwig TG,Knitowski KM,McKinzie DL,Yamada M,Wess J,Basile A

更新日期：2003-10-01 00:00:00

abstract：:Accumulating evidence points to roles for oxidative stress, amyloid beta (Aβ), and mitochondrial dysfunction in the pathogenesis of Alzheimer's disease (AD). In neurons, the base excision repair pathway is the predominant DNA repair (BER) pathway for repairing oxidized base lesions. Apurinic/apyrimidinic endonuclease ...

journal_title：Journal of neuroscience research

authors： Kaur N,Dhiman M,Perez-Polo JR,Mantha AK

更新日期：2015-06-01 00:00:00

abstract：:A frontal pole cDNA library from monkey (Macaca mulatta) brain was screened to identify mRNAs that are expressed more in frontal pole as compared to primary visual cortex. Three cDNA clones, whose greater expression was confirmed by Northern blot analysis, were identified as cytochrome oxidase (COX) subunits I, II, an...

journal_title：Journal of neuroscience research

authors： Chandrasekaran K,Stoll J,Giordano T,Atack JR,Matocha MF,Brady DR,Rapoport SI

更新日期：1992-07-01 00:00:00

abstract：:Glycolysis was blocked in the hippocampus of the otherwise unaffected rabbit by perfusion of a previously implanted thin dialysis tube with a medium containing 0.1 mM iodoacetate. The perfusate from the dialysis tube was analyzed for free amino acids with liquid chromatographic separation of ortophthaldialdehyde deriv...

journal_title：Journal of neuroscience research

authors： Sandberg M,Nyström B,Hamberger A

更新日期：1985-01-01 00:00:00

abstract：:Cannabinoids bind to two G-protein-coupled receptors, CB1 and CB2, expressed by neurons and cells of the immune system, respectively. Glioma cells (astrocyte-derived brain tumor cells) express cannabinoid receptors, and numerous in vitro and in vivo studies performed in rodents have concluded that apoptosis could be i...

journal_title：Journal of neuroscience research

authors： Widmer M,Hanemann CO,Zajicek J

更新日期：2008-11-01 00:00:00

abstract：:Huntington's disease (HD) is a progressive neurodegenerative disorder caused by an expanded CAG repeat within the huntingtin (HTT) gene. The Q140 and HdhQ150 knock-in HD mouse models were generated such that HdhQ150 mice have an expanded CAG repeat inserted into the mouse Htt gene, whereas in the Q140s, mouse exon 1 H...

journal_title：Journal of neuroscience research

authors： Franich NR,Hickey MA,Zhu C,Osborne GF,Ali N,Chu T,Bove NH,Lemesre V,Lerner RP,Zeitlin SO,Howland D,Neueder A,Landles C,Bates GP,Chesselet MF

更新日期：2019-12-01 00:00:00

abstract：:Autonomic neuropathy in several neurodegenerative disorders results from disturbance in physiological functions of different cell types in the central and peripheral nervous systems. For a clearer understanding of the etiology and pathogenesis of the autonomic disorders it is necessary to create animal models in which...

journal_title：Journal of neuroscience research

authors： Sawada H,Nishii K,Suzuki T,Hasegawa K,Hata T,Nagatsu I,Kreitman RJ,Pastan I,Nagatsu T,Kobayashi K

更新日期：1998-01-15 00:00:00

abstract：:Axotomy of peripheral nerves in neonatal rats induces motoneuron death that can be delayed but not arrested by the application of several neurotrophic factors (NFs) or adenoviral vectors carrying genes for NFs. We tested whether an adenoviral vector carrying the gene for glial cell-line-derived neurotrophic factor (Ad...

journal_title：Journal of neuroscience research

authors： Baumgartner BJ,Shine HD

更新日期：1998-12-15 00:00:00

abstract：:Oligodendrocyte-specific protein (OSP/claudin-11) is a major component of CNS myelin and has been recently added to the claudin family of tight junction proteins. In this study, the developmental expression of OSP/claudin-11 was determined using in situ hybridization, immunohistochemistry (IH), and Western blot analys...

journal_title：Journal of neuroscience research

authors： Bronstein JM,Chen K,Tiwari-Woodruff S,Kornblum HI

更新日期：2000-05-01 00:00:00

abstract：:This essay discusses the directional movements of metazoan tissue cells generally, with special emphasis on neurons, in an attempt to show that the directional movements of all share fundamental similarities. ...

journal_title：Journal of neuroscience research

authors： Trinkaus JP

更新日期：1985-01-01 00:00:00

abstract：:The mammalian genome contains both constitutively expressed and heat-shock-inducible members of the hsp70 gene family. Riboprobes derived from members of these two classes of heat shock genes were utilized in Northern blot studies to analyze brain mRNA isolated from control rabbits and rats and from animals subjected ...

journal_title：Journal of neuroscience research

authors： Brown IR,Rush SJ

更新日期：1990-01-01 00:00:00

abstract：:Thirty-day readmission rates has been increasingly used by clinicians, hospital administrators, and policy makers as a metric for the quality of care. However, the 30-day readmission rates may be affected by other factors intrinsic to the patient and may not be a good measure of the quality of care provided by the hos...

journal_title：Journal of neuroscience research

authors： Ng I,Du R

更新日期：2020-01-01 00:00:00

abstract：:This study aimed at determining, based on independent predictors of taste intensity and emotional response, whether individual personality traits could affect prediction models of overall liking and preference rank toward basic taste solutions. Sixty-seven participants rated taste intensities (TI) of four basic-taste ...

journal_title：Journal of neuroscience research

authors： Samant SS,Seo HS

更新日期：2019-03-01 00:00:00

abstract：:We have determined the localization of Cav1.2 (L-Type) Ca2+ channels in the cells and nerve fibers in molars of normal or injured rats. We observed high levels of immunostaining of L-type Ca2+ channels in odontoblast cell bodies and their processes, in fibroblast cell bodies and in Schwann cells. Many Cav1.2-containin...

journal_title：Journal of neuroscience research

authors： Westenbroek RE,Anderson NL,Byers MR

更新日期：2004-02-01 00:00:00

abstract：:With the use of an antiserum directed against the human smooth muscle-associated protein 8 (SMAP8) fragment SMAP8(98-138), Western blot and immunohistochemical studies revealed SMAP8 expression in the rat brain. A band with a molecular size of about 45 kDa was detected in tissues from the rat hypothalamus and a weaker...

journal_title：Journal of neuroscience research

authors： Brailoiu GC,Dun SL,Mizuo K,Brailoiu E,Yang J,Chang JK,Dun NJ

更新日期：2007-06-01 00:00:00

abstract：:The expression of many myelin-specific molecules in Schwann cells is profoundly decreased following denervation. This study examines the early reexpression of myelin protein genes associated with reinnervation. Following sciatic nerve crush, the distal, regenerated nerve was divided into appropriate (2.5 or 5 mm) cons...

journal_title：Journal of neuroscience research

authors： Mitchell LS,Griffiths IR,Morrison S,Barrie JA,Kirkham D,McPhilemy K

更新日期：1990-10-01 00:00:00

abstract：:Mononuclear cell infiltration into the CNS and induction of inflammatory cytokines and iNOS in diseases like multiple sclerosis (MS) and experimental allergic encephalomyelitis (EAE) have been implicated in subsequent disease pathogenesis and progression. We report that Lovastatin treatment blocks the clinical disease...

journal_title：Journal of neuroscience research

authors： Stanislaus R,Singh AK,Singh I

更新日期：2001-10-15 00:00:00