Differential expression of cytochrome oxidase (COX) genes in different regions of monkey brain.

abstract：:Music has a long history of healing or mitigating physical and mental illness in the clinical setting. We aimed to test changes in behavioral cognition and serum proteomics in rats undergoing music intervention (MI). The Morris water maze (MWM) was used to evaluate spatial learning and memory in rats. Serum protein ex...

journal_title：Journal of neuroscience research

authors： Xiong X,Han L,Liu S,Miao J,Luo M,Xue M,Wang X,Ni L,Yang J,Huang C

更新日期：2018-10-01 00:00:00

abstract：:Ca(2+) influx through L-type Ca(2+) channels regulates several different cellular processes in developing Purkinje neurons, including activation of transcription factors and expression of cellular proteins. In the current studies, we examined the age dependence of these actions of Ca(2+) during the early developmental...

journal_title：Journal of neuroscience research

authors： Gruol DL,Quina LA,Netzeband JG,Nguyen D,Gullette CE

更新日期：2006-06-01 00:00:00

abstract：:The ED1 monoclonal antibody recognizes an antigen in lysosomal membranes of phagocytes. The expression of this antigen in cells increases during phagocytic activity. Here we describe the expression of ED1-immunoreactivity during the various stages of both acute (monophasic) and chronic relapsing experimental autoimmun...

journal_title：Journal of neuroscience research

authors： Bauer J,Sminia T,Wouterlood FG,Dijkstra CD

更新日期：1994-07-01 00:00:00

abstract：:Uptake of 2-deoxy-D-glucose (2-DG) has been studied in synaptosomes from the Long-Evans rat. Although there are some differences, the results are generally similar to those reported for Sprague--Dawley rats. Both D-glucose and 2-DG are taken up by the same carrier, since D-glucose was found to inhibit uptake of 2-DG. ...

journal_title：Journal of neuroscience research

authors： Wheeler DD,Hollingsworth RG

更新日期：1979-01-01 00:00:00

abstract：:Heme oxygenase-1 (HO1) catalyzes oxidation of the heme molecule in concert with NADPH-cytochrome P450 reductase following the specific cleavage of heme into carbon monoxide, iron, and biliverdin, which is rapidly metabolized to bilirubin. HO1 is a stress-inducible protein that protects cells against oxidative injury, ...

journal_title：Journal of neuroscience research

authors： Kitamura Y,Ishida Y,Takata K,Mizutani H,Kakimura J,Inden M,Nakata J,Taniguchi T,Tsukahara T,Akaike A,Shimohama S

更新日期：2003-02-15 00:00:00

abstract：:Microglia activated by neural injuries produce proinflammatory mediators, but activated microglia also appear in developing neural tissue to phagocytose cell debris resulting from programmed cell death without inducing tissue damage. Thus, factors associated with the developing CNS may modulate microglial activities. ...

journal_title：Journal of neuroscience research

authors： Tzeng SF,Huang HY,Lee TI,Jwo JK

更新日期：2005-09-01 00:00:00

abstract：:Zinc is an endogenous N-methyl-D-aspartate (NMDA) receptor blocker. It is possible that zinc-mediated modification of hippocampal CA1 long-term potentiation (LTP) is linked to the expression of NMDA receptor subunits, which varies with postnatal development. In the present study, the effect of ZnCl(2) and CaEDTA, a me...

journal_title：Journal of neuroscience research

authors： Takeda A,Itagaki K,Ando M,Oku N

更新日期：2012-03-01 00:00:00

abstract：:Previous studies have demonstrated variability in the phenotype of rat C6 glioma cells. In the present study, we compared morphology, growth rate, and beta-adrenergic regulation of gene expression in early (P39-47) and late (P55-90) passage C6 cells. Morphological changes were observed in five independently derived, l...

journal_title：Journal of neuroscience research

authors： Gubits RM,Yu H,Casey G,Munell F,Vitek MP

更新日期：1992-10-01 00:00:00

abstract：:We have recently demonstrated that brain plastic events significantly modify synaptic protein synthesis measured by the incorporation of [(35)S]methionine in brain synaptosomal proteins. Notably, in rats learning a two-way active avoidance task, the local synthesis of two synaptic proteins was selectively enhanced. Be...

journal_title：Journal of neuroscience research

authors： Ferrara E,Cefaliello C,Eyman M,De Stefano R,Giuditta A,Crispino M

更新日期：2009-07-01 00:00:00

abstract：:The normal innervation of structures in mouse foot pads was investigated with immunohistochemistry and confocal microscopy. Nerves were visualized by incubating Zamboni fixed, thick, frozen sections with antibodies to protein gene product 9.5 (PGP 9.5), vasoactive intestinal peptide, substance P, calcitonin gene-relat...

journal_title：Journal of neuroscience research

authors： Navarro X,Verdú E,Wendelscafer-Crabb G,Kennedy WR

更新日期：1995-05-01 00:00:00

abstract：:New neurons are continuously generated throughout life in the subgranular zone in the dentate gyrus of the mammalian hippocampus and in the subventricular zone of the lateral ventricles. With the aid of new methodologies, significant progress has been made in the characterization of endogenous stem cells (ependymal ce...

journal_title：Journal of neuroscience research

authors： Qin Y,Zhang W,Yang P

更新日期：2015-03-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha) coactivates a number of transcription factors critical for mitochondrial biogenesis. Previously, we found that the expression of PGC-1alpha is governed by neuronal activity, but the signaling mechanism is poorly understood. The present st...

journal_title：Journal of neuroscience research

authors： Liang HL,Dhar SS,Wong-Riley MT

更新日期：2010-02-15 00:00:00

abstract：:Progressive "dying back" neurodegenerative diseases are debilitating due to loss of connectivity after nerve terminal and axonal withdrawal, which impairs peripheral nerve function and leads ultimately to neuronal cell death. The mutant mouse (Wallerian degeneration slow; Wld(s)) provides an accessible model system to...

journal_title：Journal of neuroscience research

authors： Parson SH,Ribchester RR,Davie N,Gandhi NP,Malik RQ,Gillingwater TH,Thomson D

更新日期：2004-04-01 00:00:00

abstract：:Chronic alcohol consumption has adverse effects on the central nervous system, affecting some hippocampal and hypothalamic functions. In this study we tempted to demonstrate that some of these modifications could involve impairment of neurotrophic factors. Three experimental groups of male Sprague Dawley rats were stu...

journal_title：Journal of neuroscience research

authors： Tapia-Arancibia L,Rage F,Givalois L,Dingeon P,Arancibia S,Beaugé F

更新日期：2001-01-15 00:00:00

abstract：:Alpha2-adrenergic receptors control norepinephrine (NE) release and tumor necrosis factor-alpha (TNF) production from neurons. TNF regulates NE release, depending on alpha2-adrenergic receptor functioning. The relationship between TNF production in the brain and alpha2-adrenergic receptor activation could have profoun...

journal_title：Journal of neuroscience research

authors： Reynolds JL,Ignatowski TA,Spengler RN

更新日期：2005-03-15 00:00:00

abstract：:Calcium-activated neutral proteinase (CANP) activity was determined in cytosolic and membranous subcellular fractions of transformed Schwann cells (tSc). The muM and mM Ca(2+)-sensitive (mu- and mCANP) forms of CANP were separated by DEAE and phenyl Sepharose column chromatography, the latter step enabling removal of ...

journal_title：Journal of neuroscience research

authors： Banik NL,DeVries GH,Neuberger T,Russell T,Chakrabarti AK,Hogan EL

更新日期：1991-07-01 00:00:00

abstract：:Elk is a member of the eph family of receptor-like tyrosine kinases. Although its function is unknown, elk is postulated to play a role in nervous system development. Using Northern analysis, we examined the developmental regulation of RNAs encoding elk, and several ligands for the eph family of RTKs, the LERKs. Expre...

journal_title：Journal of neuroscience research

authors： Carpenter MK,Shilling H,VandenBos T,Beckmann MP,Cerretti DP,Kott JN,Westrum LE,Davison BL,Fletcher FA

更新日期：1995-10-01 00:00:00

abstract：:Adenosine signalling has an important role in cochlear protection from oxidative stress. In most tissues, intracellular adenosine kinase (ADK) is the primary route of adenosine metabolism and the key regulator of intracellular and extracellular adenosine levels. The present study provides the first evidence for ADK di...

journal_title：Journal of neuroscience research

authors： Vlajkovic SM,Guo CX,Dharmawardana N,Wong AC,Boison D,Housley GD,Thorne PR

更新日期：2010-09-01 00:00:00

abstract：:Sildenafil, given shortly before 3,4-methylenedioxymethamphetamine (MDMA), affords protection against 5-hydroxytryptamine (5-HT) depletions caused by this amphetamine derivative by an acute preconditioning-like mechanism. Because acute and delayed preconditionings do not share the same mechanisms, we investigated whet...

journal_title：Journal of neuroscience research

authors： Puerta E,Barros-Miñones L,Hervias I,Gomez-Rodriguez V,Orejana L,Pizarro N,de la Torre R,Jordán J,Aguirre N

更新日期：2012-02-01 00:00:00

abstract：:Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that form a subfamily within the steroid hormone receptor group. Recent work has shown that one member of this group, PPARgamma, plays a central role in adipocyte differentiation. As oligodendrocytes are major lipid-producin...

journal_title：Journal of neuroscience research

authors： Granneman J,Skoff R,Yang X

更新日期：1998-03-01 00:00:00

abstract：:Calcium/calmodulin-dependent serine kinase (CASK), a causative gene in X-linked mental retardation, carries out multiple functions in neurons, including vesicle trafficking of ion channels, synapse formation, and gene transcription. From a yeast two-hybrid screen, Krüppel-like zinc finger protein B cell lymphoma/COUP-...

journal_title：Journal of neuroscience research

authors： Kuo TY,Hong CJ,Chien HL,Hsueh YP

更新日期：2010-08-15 00:00:00

abstract：:One premise regarding the mechanism of injury-evoked neuroregeneration is that injured cells induce the release of neurotrophic factors to trigger neurogenesis. Extracellular purine nucleotides exert multiple neurotrophic actions in the central nervous system mediated via activation of purinergic receptors. However, w...

journal_title：Journal of neuroscience research

authors： Kanekar S,Jia C,Hegg CC

更新日期：2009-05-01 00:00:00

abstract：:Cognitive decline in Parkinson's disease (PD) is a common sequela of the disorder that has a large impact on patient well-being. Its physiological etiology, however, remains elusive. Our study used graph theory analysis to investigate the large-scale topological patterns of the extrastriatal dopamine D2 receptor netwo...

journal_title：Journal of neuroscience research

authors： Mihaescu AS,Kim J,Masellis M,Graff-Guerrero A,Cho SS,Christopher L,Valli M,Díez-Cirarda M,Koshimori Y,Strafella AP

更新日期：2020-12-03 00:00:00

abstract：:Metabolic abnormalities found in epileptogenic tissue provide considerable evidence of brain hypometabolism, while major risk factors for acquired epilepsy all share brain hypometabolism as one common outcome, suggesting that a breakdown of brain energy homeostasis may actually precede epileptogenesis. However, a caus...

journal_title：Journal of neuroscience research

authors： Samokhina E,Popova I,Malkov A,Ivanov AI,Papadia D,Osypov A,Molchanov M,Paskevich S,Fisahn A,Zilberter M,Zilberter Y

更新日期：2017-11-01 00:00:00

abstract：:We studied the effects of electrical stimulation of the inferior alveolar nerve (IAN) on cardiovascular responses in cats. There was statistical correlation between cardiovascular response and prestimulus mean arterial blood pressure (MABP) and heart rate (HR). A trigeminal depressor response (TDR) was induced when th...

journal_title：Journal of neuroscience research

authors： Ohshita N,Nakajo N,Takemura M

更新日期：2004-06-15 00:00:00

abstract：:Studies have shown that individuals with both a history of traumatic brain injury and inheritance of apolipoprotein E-4 (ApoE4) allele are associated with a poor neurologic outcome and an increased risk for Alzheimer's disease. We assessed the hypothesis that thrombin released during brain injury causes an increase in...

journal_title：Journal of neuroscience research

authors： Mhatre M,Hensley K,Nguyen A,Grammas P

更新日期：2006-08-01 00:00:00

abstract：:The expression of different muscarinic receptor subtypes was analyzed in immature Schwann cells obtained from sciatic nerve of 2-day neonatal rats. By using RT-PCR analysis, we demonstrated the presence of M1, M2, M3, and M4 receptor subtypes in cultured Schwann cells, with M2 displaying the highest expression levels....

journal_title：Journal of neuroscience research

authors： Loreti S,Vilaró MT,Visentin S,Rees H,Levey AI,Tata AM

更新日期：2006-07-01 00:00:00

abstract：:Nerve growth factor (NGF) is a homodimer that binds to two distinct receptor types, TrkA and p75, to support survival and differentiation of neurons. The high-affinity binding on the cell surface is believed to involve a heteroreceptor complex, but its exact nature is unclear. We developed a heterodimer (heteromutein)...

journal_title：Journal of neuroscience research

authors： Mehta HM,Woo SB,Neet KE

更新日期：2012-12-01 00:00:00

abstract：:To further our understanding of the functions of the major myelin proteins, myelin basic protein (MBP) and proteolipid protein (PLP), and other myelin proteins, such as 2'3'-cyclic nucleotide 3'-phosphodiesterase (CNP) and myelin-associated glycoprotein (MAG), bovine brain myelin was extracted with Triton X-100, and p...

journal_title：Journal of neuroscience research

authors： Arvanitis DN,Yang W,Boggs JM

更新日期：2002-10-01 00:00:00

abstract：:Myelin gene expression in normal oligodendrocytes (OLG) depends on developmentally regulated protein kinase C (PKC) enzyme activity (Asotra and Macklin: J Neurosci Res 34:571-588, 1993). We studied the developmental expression of the Ca(++)-dependent PKC-alpha, -beta 1, -beta II and -gamma isozymes, and the Ca(++)-ind...

journal_title：Journal of neuroscience research

authors： Asotra K,Macklin WB

更新日期：1994-10-15 00:00:00