Abstract：
:Uptake of 2-deoxy-D-glucose (2-DG) has been studied in synaptosomes from the Long-Evans rat. Although there are some differences, the results are generally similar to those reported for Sprague--Dawley rats. Both D-glucose and 2-DG are taken up by the same carrier, since D-glucose was found to inhibit uptake of 2-DG. Uptake is highly dependent on a source of metabolic energy, since incubation at 0 degrees C completely eliminated uptake, while 10(-3) M 2,4-dinitrophenol (DNP) inhibited uptake by 76.5%. Uptake has also been measured as a function of both 2-DG and sodium concentration and the data fitted to a model. Sodium is found to inhibit uptake. A model assuming noncompetitive inhibition by sodium gives best fit to the data. Thus both Kt and apparent Vm are dependent on the sodium concentration. Although these effects are small, Kt increases with [Na], while apparent Vm declines.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Wheeler DD,Hollingsworth RGdoi
10.1002/jnr.490040207subject
Has Abstractpub_date
1979-01-01 00:00:00pages
133-45issue
2eissn
0360-4012issn
1097-4547journal_volume
4pub_type
杂志文章abstract：:The olfactory ensheathing cell (OEC) is a unique glial cell able to support neurite outgrowth in the CNS throughout life. The OEC has been described as having both Schwann cell-like and astrocyte-like characteristics. The purpose of this study was to compare gap junctional communication and connexin (Cx) expression in...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.1182
更新日期：2001-09-15 00:00:00
abstract：:Insulin-like growth factor II (IGF-II) plays significant roles in the growth and development of mammals through the regulation of mitogenesis and cell survival. Previously, IGF-II mRNA transcripts within the CNS were detected in the choroid plexus and leptomeninges (DeChiara et al., 1991). The objective of this study ...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/(SICI)1097-4547(19971215)50:6<958::AID-JNR
更新日期：1997-12-15 00:00:00
abstract：:PC12 cells can differentiate into neuron-like cells after treatment with either nerve growth factor (NGF) or transduction with a retrovirus which expresses the K-ras oncogene. The concomitant treatment of NGF plus ras differentiates PC12 cells further than either agent alone with respect to neurite outgrowth, acetylch...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490420306
更新日期：1995-10-15 00:00:00
abstract：:The transfer of the adenovirus 5 E1A gene into brain cells from rat embryos led to the establishment of phenotypically untransformed clonal glial cell lines. Some lines displayed properties of oligodendrocyte-astrocyte progenitors. Their differentiation involved several steps that were dependent on culture conditions ...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490210112
更新日期：1988-09-01 00:00:00
abstract：:Currently, presymtomatic hematopoietic stem and progenitor cell transplantation (HSPCT) is the only therapeutic modality that alleviates Krabbe's disease (KD)-induced central nervous system damage. However, all HSPCT-treated patients exhibit severe deterioration in peripheral nervous system function characterized by m...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.23847
更新日期：2016-11-01 00:00:00
abstract：:Mannitol, which is a cell-impermeable and nontoxic polyalcohol, has been shown to be a useful tool for reversible opening of the blood-brain barrier (BBB). Despite successful clinical trials, the molecular mechanism of the mannitol-induced changes in cerebral endothelial cells (CECs) are poorly understood. For our exp...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.20521
更新日期：2005-06-15 00:00:00
abstract：:Despite the large number of growth factors shown to affect dopaminergic cell survival and differentiation in vitro, presently little is known about the role these growth factors play during normal in vivo development of dopaminergic neurons. To address this issue, glia and neurons of both the mesencephalic home region...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/(SICI)1097-4547(19980815)53:4<405::AID-JNR
更新日期：1998-08-15 00:00:00
abstract：:In the present study, following previous experience with electrolytic lesion of the rat brain, and subsequent reduction of reactive gliosis with 7 beta-hydroxycholesterol derivatives (Bochelen et al.: Neuroscience 51:827-834, 1992), we have performed a hemisection of the spinal cord in adult rats and investigated the ...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490410110
更新日期：1995-05-01 00:00:00
abstract：:The multifactorial nature of traumatic brain injury (TBI), especially the complex secondary tissue injury involving intertwined networks of molecular pathways that mediate cellular behavior, has confounded attempts to elucidate the pathology underlying the progression of TBI. Here, systems biology strategies are explo...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.23503
更新日期：2015-02-01 00:00:00
abstract：:We investigated by (13)C nuclear magnetic resonance (NMR) the mechanisms underlying Li(+) effects on glutamatergic and GABAergic neurotransmission systems in the adult rat brain and in primary cultures of cortical neurons and astrocytes during the metabolism of (1-(13)C) glucose or (2-(13)C) acetate. Adult male rats r...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.21900
更新日期：2009-03-01 00:00:00
abstract：:The function of the prion protein is unknown despite suggestions it binds copper. Radioactive copper (Cu(67)) was used to demonstrate that histidine-dependent uptake of copper by cerebellar cells in culture is related to the level of PrP(c) expression. Copper is released by neurones at the synapse. Veratridine-induced...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：
更新日期：1999-12-01 00:00:00
abstract：:The relationship between brain myelination and nutritional insufficiency in suckling rats whose dams had a restricted dietary intake was studied. The undernourished pups were characterized by body weight and brain weight that were 40-70% and 82-88% that of controls throughout the suckling period. Myelin concentrations...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490190311
更新日期：1988-03-01 00:00:00
abstract：:We have shown previously that in oligodendrocytes, the transcription factor cyclic AMP response element binding protein (CREB) is maximally expressed immediately prior to the most rapid period of myelination in rat brain. We have begun to investigate the role of this protein during myelination by downregulating CREB s...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/(SICI)1097-4547(19961001)46:1<98::AID-JNR1
更新日期：1996-10-01 00:00:00
abstract：:Although protein kinase Cdk5-p35 is important in many aspects of the development and function of the central nervous system, relatively little is known about its regulation. In the present study, we examined the relationship between the association of this kinase with membranes and its activity in perinatal and adult ...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.21438
更新日期：2007-11-01 00:00:00
abstract：:A sensitive and convenient method of endopeptidase assay using as substrate globin modified with pyridoxal-5-phosphate was used for determination of acid proteinases in bovine hypothalamus separated by isoelectric focusing. The soluble protein fraction of hypothalamus upon elution from Sephadex gave five peaks of prot...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490040505
更新日期：1979-01-01 00:00:00
abstract：:An aminopeptidase purified to homogeneity from cytosol of rat brain cleaved dynorphins having 5-17 residues and selected proenkephalins at the Tyr-Gly bond only to release Tyr and the desTyr fragments. The enzyme protein consisted of a single polypeptide chain of Mr 103,000 and was inhibited by puromycin, bestatin, an...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490110311
更新日期：1984-01-01 00:00:00
abstract：:Neuronal cell differentiation alterations induced by mutant presenilin 2 (PS2) were investigated in transgenic mice expressing wild-type or mutant-type PS2. Progressive increases in differentiation and marker protein expression were found in neuronal cells expressing wild-type PS2, whereas these processes were much pe...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.20655
更新日期：2005-11-15 00:00:00
abstract：:Glial cell line-derived neurotrophic factor (GDNF) has been shown to be a preferentially selective neurotrophic factor for dopamine (DA) neurons. In the present study, we have examined the distribution of GDNF mRNA expression in several major DA-containing cell body and terminal areas and the regulation of GDNF mRNA e...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/(SICI)1097-4547(19980901)53:5<593::AID-JNR
更新日期：1998-09-01 00:00:00
abstract：:Although serotonin regulates synthesis of the neurotrophic factor S-100 beta by astrocytes, its ability to affect nerve growth factor (NGF) synthesis has never been examined. We report here that there is a correlation between the effect of serotonin on cyclic adenosine monophosphate (cAMP) content and on NGF content i...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.1074
更新日期：2001-05-01 00:00:00
abstract：:Glial cell line-derived neurotrophic factor (GDNF) acts as a potent survival factor for many neuronal populations, including spinal motoneurons, indicating the therapeutic promise of GDNF for neurological disorders. Injury to spinal cord (SCI) triggers processes destructive to ascending sensory and descending motor co...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.10303
更新日期：2002-08-01 00:00:00
abstract：:Human T-cell lymphotropic virus type I (HTLV-I) may infect up to 10% of peripheral blood T cells in patients with HTLV-I myelopathy. To examine the impact of HTLV-I infection on the abilities of T cells to present and respond to peptide antigen, we HTLV-I infected and subcloned a myelin basic protein peptide 84-102 (M...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/(SICI)1097-4547(19960915)45:6<786::AID-JNR
更新日期：1996-09-15 00:00:00
abstract：:Mononuclear cell infiltration into the CNS and induction of inflammatory cytokines and iNOS in diseases like multiple sclerosis (MS) and experimental allergic encephalomyelitis (EAE) have been implicated in subsequent disease pathogenesis and progression. We report that Lovastatin treatment blocks the clinical disease...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.1207
更新日期：2001-10-15 00:00:00
abstract：:Within the parenchyma of the CNS, the endothelium of all vessels is surrounded by a layer of cells, pericytes in capillaries and periendothelial or intima smooth muscle cells in other vessels. The origin of these cell types, their relationship, and their role are unclear. However, it has been recently shown that genet...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：
更新日期：1999-11-01 00:00:00
abstract：:Peroxides are generated continuously in cells that consume oxygen. Among the different peroxides, hydrogen peroxide is the molecule that is formed in highest quantities. In addition, organic hydroperoxides are synthesized as products of cellular metabolism. Generation and disposal of peroxides is a very important proc...
journal_title：Journal of neuroscience research
pub_type： 杂志文章,评审
doi：10.1002/jnr.20280
更新日期：2005-01-01 00:00:00
abstract：:Parkinson's disease (PD) is the most common movement disorder associated with the elderly which, other than symptomatic therapies, has no effective treatment or preventive measures. Sirtuins and their pharmacological activators/inhibitors have been associated with a range of neuroprotective effects, and a large body o...
journal_title：Journal of neuroscience research
pub_type： 杂志文章,评审
doi：10.1002/jnr.23806
更新日期：2017-04-01 00:00:00
abstract：:Target ablation by olfactory bulbectomy synchronizes the degenerative cell death of olfactory receptor neurons (ORNs), infiltration of macrophages, and proliferation of progenitor cells, leading to neurogenesis, ORN replacement, and regeneration of the sensory epithelium. Although macrophages participate in the degene...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.10432
更新日期：2002-12-15 00:00:00
abstract：:Several neurological diseases involve focal injury of specific brain structures. Poisons of the electron transport chain complexes (ETCC) can also produce selective injury of brain structures when given systemically and have been implicated in the development of neurological disease. Why ETCC poisons damage particular...
journal_title：Journal of neuroscience research
pub_type： 杂志文章,评审
doi：10.1002/jnr.10553
更新日期：2003-03-15 00:00:00
abstract：:The transplantation of dopaminergic (DA) progenitors derived from pluripotent stem cells improves the behavior of Parkinson's disease model animals. However, the survival of DA progenitors is low, and the final yield of DA neurons is only approximately 0.3%-2% the number of transplanted cells. Zonisamide (ZNS) increas...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.24668
更新日期：2020-08-01 00:00:00
abstract：:Neural expression of constitutive hsc70 mRNA and hyperthermia-inducible hsp70 mRNA is examined using radioactive and non-radioactive in situ hybridization procedures. A strong induction of hsp70 mRNA was noted in cell populations in cerebellar layers and in the brainstem which demonstrated expression of mRNA encoding ...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490410506
更新日期：1995-08-01 00:00:00
abstract：:Astrocytes are the predominant cell type in the vicinity of glutamatergic synapses, where they monitor and maintain low levels of glutamate. Synaptic homeostasis of glutamate involves its removal from the synaptic cleft via high-affinity glutamate transporters, glutamate transporter-1 (GLT-1)/excitatory amino acid tra...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.10236
更新日期：2002-06-01 00:00:00
