Plasminogen activator inhibitor 1, the primary regulator of fibrinolysis, in normal human cerebrospinal fluid.

abstract：:Zinc ion elevation contributes to acute excitotoxic brain injury and correlates with the severity of dementia in chronic neurodegenerative diseases. Downstream control of zinc-triggered signals is believed to be an efficient countermeasure. In the current study, we examined whether the flavonoid luteolin (Lu) could pr...

journal_title：Journal of neuroscience research

authors： Zhou F,Qu L,Lv K,Chen H,Liu J,Liu X,Li Y,Sun X

更新日期：2011-11-01 00:00:00

abstract：:Soluble oligomeric aggregates of the amyloid-beta (A beta) peptide are believed to be the most neurotoxic A beta species affecting the brain in Alzheimer disease (AD), a terminal neurodegenerative disorder involving severe cognitive decline underscored by initial synaptic dysfunction and later extensive neuronal death...

journal_title：Journal of neuroscience research

authors： Dineley KT,Kayed R,Neugebauer V,Fu Y,Zhang W,Reese LC,Taglialatela G

更新日期：2010-10-01 00:00:00

abstract：:F5 was identified originally as an interleukin-2-regulated gene in L2 cells, a murine helper T-lymphocyte clone. In adult mouse, F5 mRNA was expressed at a modest level in lymphoid tissues, at a high level in mature neurons in the nervous system, but not in other tissues. Although the F5 sequence is highly conserved o...

journal_title：Journal of neuroscience research

authors： Arai M,Cohen JA

更新日期：1993-10-15 00:00:00

abstract：:Here we assess the potential functional role of increased aquaporin 9 (APQ9) in astrocytes. Increased AQP9 expression was achieved in primary astrocyte cultures by transfection of a plasmid-containing green fluorescent protein fused to either wild-type or mutated human AQP9. Increased AQP9 expression and phosphorylati...

journal_title：Journal of neuroscience research

authors： Hirt L,Price M,Mastour N,Brunet JF,Barrière G,Friscourt F,Badaut J

更新日期：2018-02-01 00:00:00

abstract：:Mitochondrial dysfunction has been implicated in cell death in many neurodegenerative diseases. Diminished activity of the alpha-ketoglutarate dehydrogenase complex (KGDHC), a key and arguably rate-limiting enzyme of the Krebs cycle, occurs in these disorders and may underlie decreased brain metabolism. The present st...

journal_title：Journal of neuroscience research

authors： Huang HM,Ou HC,Xu H,Chen HL,Fowler C,Gibson GE

更新日期：2003-10-15 00:00:00

abstract：:The postmortem stability of brain RNA was measured in rat and human samples for up to 48 hr. Whole rat brains, cooled at a rate approximating that of human brains awaiting autopsy, were collected at intervals from 0 to 48 hr after death and frozen. These samples were compared with freshly obtained, unfrozen rat brains...

journal_title：Journal of neuroscience research

authors： Johnson SA,Morgan DG,Finch CE

更新日期：1986-01-01 00:00:00

abstract：:Astrocyte activation is an important feature in many disorders of the central nervous system, including chronic pain conditions. Activation of astrocytes is characterized by a change in morphology, including hypertrophy and increased size of processes, proliferation, and an increased production of proinflammatory medi...

journal_title：Journal of neuroscience research

authors： Norsted Gregory E,Delaney A,Abdelmoaty S,Bas DB,Codeluppi S,Wigerblad G,Svensson CI

更新日期：2013-02-01 00:00:00

abstract：:The cell line PC12, derived from a rat pheochromocytoma, has served as a model for studies on the mechanism of action of nerve growth factor, as well as for the exploration of neuronal differentiation in general. When treated with nanomolar concentrations of nerve growth factor, these neoplastic chromaffin-like cells ...

journal_title：Journal of neuroscience research

authors： Simpson DL,Dickens G,Doll S,Koizumi S,Tocco M,Okuda O,Oshima M,Rudkin BB,Brightman M,Guroff G

更新日期：1991-04-01 00:00:00

abstract：:Gamma-Aminobutyric acid (GABA), the principal inhibitory neurotransmitter of CNS, has been consistently implicated in the pathophysiology of schizophrenia. GABA is synthesized from glutamate by the enzyme glutamic acid decarboxylase (GAD). Two isoforms of GAD have been identified and have been named GAD65 and GAD67 ba...

journal_title：Journal of neuroscience research

authors： Dracheva S,Elhakem SL,McGurk SR,Davis KL,Haroutunian V

更新日期：2004-05-15 00:00:00

abstract：:The activity levels of pyruvate dehydrogenase, enzymes of the citric acid cycle, aspartate and alanine aminotransferases, and NADP+-isocitrate dehydrogenase were determined in the cerebral cortex, cerebellum, brain stem, corpus striatum, hippocampus, and midbrain regions of normal rats and rats injected with acute and...

journal_title：Journal of neuroscience research

authors： Ratnakumari L,Subbalakshmi GY,Murthy CR

更新日期：1985-01-01 00:00:00

abstract：:In this study, we examined the neuroprotective effect of standardized Bacopa monniera extract (BME: BESEB CDRI-08) against the D-galactose (D-gal)-induced brain aging in rats. Experimental groups were subjected to contextual-associative learning task. We found that the administration of BME in the D-gal-treated group ...

journal_title：Journal of neuroscience research

authors： Prisila Dulcy C,Singh HK,Preethi J,Rajan KE

更新日期：2012-10-01 00:00:00

abstract：:In an effort to identify genes involved in neuronal differentiation, we have used representational difference analysis (RDA) to clone cDNAs that are preferentially induced by nerve growth factor (NGF) vs. epidermal growth factor (EGF) in PC12 pheochromocytoma cells. We now report the cloning of a previously unknown pr...

journal_title：Journal of neuroscience research

authors： Vician L,Silver AL,Farias-Eisner R,Herschman HR

更新日期：2001-04-15 00:00:00

abstract：:Most previous studies on spinal cord injury (SCI) have used rodent models. Direct extrapolation of the results obtained in rodents to clinical cases is difficult, however, because of neurofunctional and anatomic differences between rodents and primates. In the present study, the development of histopathologic changes ...

journal_title：Journal of neuroscience research

authors： Iwanami A,Yamane J,Katoh H,Nakamura M,Momoshima S,Ishii H,Tanioka Y,Tamaoki N,Nomura T,Toyama Y,Okano H

更新日期：2005-04-15 00:00:00

abstract：:The neural cell adhesion molecule (NCAM) plays a key role in neural development, regeneration, and synaptic plasticity. The crystal structure of a fragment of NCAM comprising the three N-terminal immunoglobulin (Ig)-like modules indicates that the first and second Ig modules bind to each other, thereby presumably medi...

journal_title：Journal of neuroscience research

authors： Køhler LB,Soroka V,Korshunova I,Berezin V,Bock E

更新日期：2010-08-01 00:00:00

abstract：:Little is known about the structural neural substrates that may contribute to sex differences in risk-taking propensity (RTP). A close association between risk-seeking behavior and the emotional-regulation network led us to hypothesize that the sex differences in RTP would be associated with sex differences in brain m...

journal_title：Journal of neuroscience research

authors： Bajaj S,Killgore WDS

更新日期：2020-02-01 00:00:00

abstract：:As it displays progressive hair-cell loss and degeneration of spiral ganglion neurons (SGNs) characterized by early-onset progressive hearing loss (ePHL), DBA/2J is an inbred mouse strain widely used in hearing research. Mouse nerve growth factor (mNGF), as a common exogenous nerve growth factor (NGF), has been studie...

journal_title：Journal of neuroscience research

authors： Wang Q,Zhao H,Zheng T,Wang W,Zhang X,Wang A,Li B,Wang Y,Zheng Q

更新日期：2017-10-01 00:00:00

abstract：:Neuronal pathology of the brain with Alzheimer's disease (AD) is characterized by numerous depositions of amyloid-beta peptides (Abeta). Abeta binding to the 75-kDa neurotrophin receptor (p75NTR) causes neuronal cell death. Here we report that Abeta causes cell death in neuronal hybrid cells transfected with p75NTR, b...

journal_title：Journal of neuroscience research

authors： Tsukamoto E,Hashimoto Y,Kanekura K,Niikura T,Aiso S,Nishimoto I

更新日期：2003-09-01 00:00:00

abstract：:Metabotropic glutamate receptors (mGluRs) and calcium receptors (CaR) are closely related G protein-coupled receptors (GPCRs). The similar structural and functional properties of mGluRs and CaRs include conserved amino acid residues involved in glutamate binding in mGluRs and Ca2+ binding in the CaR. Furthermore, rece...

journal_title：Journal of neuroscience research

authors： Francesconi A,Duvoisin RM

更新日期：2004-02-15 00:00:00

abstract：:In contrast to mammals, teleost fish are able to regrow severed long-range projection axons in the central nervous system (CNS), leading to recovery of function. The optic projection in teleost fish is used to study neuron-intrinsic and environmental molecular factors that determine successful axon regrowth and naviga...

journal_title：Journal of neuroscience research

authors： Becker CG,Becker T

更新日期：2007-09-01 00:00:00

abstract：:Ca(2+) and synaptotagmin (a Ca(2+)-binding protein that regulates axolemmal fusion of synaptic vesicles) play essential roles in the repair of axolemmal damage in invertebrate giant axons. We now report that neurites of a rat pheochromocytoma (PC12) cell line transected and maintained in a serum medium form a dye barr...

journal_title：Journal of neuroscience research

authors： Detrait ER,Yoo S,Eddleman CS,Fukuda M,Bittner GD,Fishman HM

更新日期：2000-11-15 00:00:00

abstract：:Chloride efflux is known to be involved in the progression of apoptosis in various cell types. We have recently shown that the volume-sensitive outwardly rectifying (VSOR) anion channel serves as the pathway for apoptotic chloride efflux in some cells. In the present study, we tested the neuroprotective effects of dru...

journal_title：Journal of neuroscience research

authors： Inoue H,Ohtaki H,Nakamachi T,Shioda S,Okada Y

更新日期：2007-05-15 00:00:00

abstract：:This study tested the hypothesis that sensitivity to the Ca(2+) -induced loss of mitochondrial membrane potential (ΔΨ(m)) and the sensitivity of the loss of ΔΨ to mitochondrial permeability transition pore (PTP) inhibitors are different for neurons and astrocytes. Primary cultures of rat cortical neurons and astrocyte...

journal_title：Journal of neuroscience research

authors： Kahraman S,Bambrick LL,Fiskum G

更新日期：2011-12-01 00:00:00

abstract：:Interleukin-1beta has been demonstrated in neurons of the rat hypothalamus, including cells of the magnocellular neurosecretory system and tuberoinfundibular system (Lechan et al., [1990] Brain Res. 514:135-140). Despite its potential importance to regulation of neuroendocrine function, however, neither the specific c...

journal_title：Journal of neuroscience research

authors： Watt JA,Hobbs NK

更新日期：2000-05-15 00:00:00

abstract：:The pathogenic processing of the amyloid precursor protein (APP) into beta-amyloid peptides, which give rise to beta-amyloid plaques in the brains of Alzheimer's disease patients, requires the enzymatic activity of the beta-site APP-cleaving enzyme 1 (BACE1). We report the cloning and sequence of a 1.5-kb DNA fragment...

journal_title：Journal of neuroscience research

authors： Lange-Dohna C,Zeitschel U,Gaunitz F,Perez-Polo JR,Bigl V,Rossner S

更新日期：2003-07-01 00:00:00

abstract：:By using two different approaches, ubiquitin C-terminal hydrolase 1 (UCHL1) was identified as a potential cerebrospinal fluid (CSF) biomarker of neuronal loss in aneurysmal subarachnoid hemorrhage (ASAH) and presumably other CNS damage and disease states. Appropriate antibodies and a sensitive ELISA were generated, an...

journal_title：Journal of neuroscience research

authors： Lewis SB,Wolper R,Chi YY,Miralia L,Wang Y,Yang C,Shaw G

更新日期：2010-05-15 00:00:00

abstract：:Destruction of the ventromedial hypothalamic nuclei (VMN) in the weanling rat without injury to the median eminence results in a series of somatic, endocrine, and metabolic changes that are characterized by normal food and water intake but decreased linear growth, normal body weight but increased carcass fat and reduc...

journal_title：Journal of neuroscience research

authors： Bernardis LL,Goldman JK

更新日期：1976-01-01 00:00:00

abstract：:Diabetes and obesity are characterized by hyperlipidemia and represent risk factors for premature neurological disorders. Diabetic/obese animals have impaired adult neurogenesis. We hypothesize that lipotoxicity leading to neurogenesis impairment plays a role in the development of neurological complications. If so, no...

journal_title：Journal of neuroscience research

authors： Mansouri S,Ortsäter H,Pintor Gallego O,Darsalia V,Sjöholm A,Patrone C

更新日期：2012-04-01 00:00:00

abstract：:The cytokines ciliary neurotrophic factor (CNTF) and leukemia inhibitory factor (LIF) signal through a receptor complex formed between two transmembrane proteins, gp130 and LIFRbeta. In addition, CNTF also uses a ligand-binding component which is anchored to the cell membrane. In the case of cardiotrophin-1 (CT-1), LI...

journal_title：Journal of neuroscience research

authors： Arce V,Garces A,de Bovis B,Filippi P,Henderson C,Pettmann B,deLapeyrière O

更新日期：1999-01-01 00:00:00

abstract：:Individuals who regularly shift their sleep timing, like night and/or shift-workers suffer from circadian desynchrony and are at risk of developing cardiometabolic diseases and cancer. Also, shift-work is are suggested to be a risk factor for the development of mood disorders such as the burn out syndrome, anxiety, an...

journal_title：Journal of neuroscience research

authors： Guerrero-Vargas NN,Zárate-Mozo C,Guzmán-Ruiz MA,Cárdenas-Rivera A,Escobar C

更新日期：2021-02-01 00:00:00

abstract：:We used intracellular recording to investigate the functional interaction between protein kinase C (PKC) and protein kinase A (PKA) signal transduction cascades in the control of transmitter release in the neuromuscular synapses from adult rats. Our results indicate that: 1) PKA and PKC are independently involved in a...

journal_title：Journal of neuroscience research

authors： Santafé MM,Garcia N,Lanuza MA,Tomàs M,Tomàs J

更新日期：2009-02-15 00:00:00