NID67, a small putative membrane protein, is preferentially induced by NGF in PC12 pheochromocytoma cells.

abstract：:Numerical synaptic density and synaptic vesicle density in rat frontal cortex were examined by electron microscopy as a function of age. The density of axospinous synapses, a major population of synapses, was found to peak at age 1 month, and to gradually decrease with aging. The synaptic vesicle density in axospinous...

journal_title：Journal of neuroscience research

authors： Nakamura H,Kobayashi S,Ohashi Y,Ando S

更新日期：1999-05-01 00:00:00

abstract：:The thrombospondin (TSP) family of extracellular matrix glycoproteins are widely expressed in the developing and adult central nervous system although their function remains poorly defined. We have used cell culture techniques to analyse the expression and function of TSPs in glial cells derived from myelinated region...

journal_title：Journal of neuroscience research

authors： Scott-Drew S,ffrench-Constant C

更新日期：1997-10-15 00:00:00

abstract：:Light microscopic anterograde tracing studies indicate that neurons in the central nucleus of the amygdala (CNA) project to a region of the dorsal pontine tegmentum ventral to the superior cerebellar peduncle which contains noradrenergic dendrites of the nucleus locus coeruleus (LC). However, it has not been establish...

journal_title：Journal of neuroscience research

authors： Van Bockstaele EJ,Chan J,Pickel VM

更新日期：1996-08-01 00:00:00

abstract：:Toll-like receptors (TLRs) play a key role in controlling innate immune responses to a wide variety of pathogen-associated molecules as well as endogenous signals. In addition, TLR expression within nonimmune cells has been recognized as as modulator of cell behavior. In this study we have addressed the question of wh...

journal_title：Journal of neuroscience research

authors： Bsibsi M,Nomden A,van Noort JM,Baron W

更新日期：2012-02-01 00:00:00

abstract：:Dopamine has been implicated as a potential mediating factor in a variety of neurodegenerative disorders. Dopamine can be oxidized to form a reactive dopamine quinone that can covalently modify cellular macromolecules including protein and DNA. This oxidation can be enhanced through various enzymes including tyrosinas...

journal_title：Journal of neuroscience research

authors： Xu Y,Stokes AH,Roskoski R Jr,Vrana KE

更新日期：1998-12-01 00:00:00

abstract：:The N-methyl-D-aspartate receptor (NMDAR) is a major neurotransmitter receptor in the central nervous system (CNS), with functional roles in learning, memory, and sensation. Several mechanisms potentiate NMDARs, and NMDAR hyperexcitability plays pathophysiological roles in many conditions, such as neurodegenerative di...

journal_title：Journal of neuroscience research

authors： Mattar PA,Holmes KD,Dekaban GA

更新日期：2003-12-01 00:00:00

abstract：:The development of cells of the oligodendroglial lineage, from immature progenitor to myelinating cells, occurs largely in a neuronal environment, yet little is known about specific interactions between these 2 cell types. We have tested the effects of medium conditioned by cultures of rat cerebral cortical neurons (C...

journal_title：Journal of neuroscience research

authors： Hardy R,Reynolds R

更新日期：1993-04-01 00:00:00

abstract：:The growth cone, the motile tip of developing neuronal processes, is considered responsible for the exact guidance of axons and synaptogenesis. High activity of tyrosine kinases in growth cones may contribute to the functions of growth cones. Our previous work revealed that vinculin is one of the endogenous substrates...

journal_title：Journal of neuroscience research

authors： Igarashi M,Komiya Y

更新日期：1991-09-01 00:00:00

abstract：:Nerve growth factor (NGF) is a protein essential for the survival and normal function of sympathetic neurons. Two-site immunoassays have been developed over the past decade in several laboratories and used to estimate its endogenous concentrations in a variety of effector tissues. However, levels appear restricted to ...

journal_title：Journal of neuroscience research

authors： Zettler C,Bridges DC,Zhou XF,Rush RA

更新日期：1996-12-01 00:00:00

abstract：:In order to better characterize the presynaptic GABA receptors regulating glutamate release in the cerebellum [Levi and Gallo, 1981], a number of GABA agonists and GABA transport inhibitors were tested for their ability to potentiate the depolarization-induced release of the glutamate analog D-[3H]aspartate from super...

journal_title：Journal of neuroscience research

authors： Aloisi F,Gallo V,Levi G

更新日期：1983-01-01 00:00:00

abstract：:The chronic constriction injury (CCI) of the sciatic nerve is a nerve injury-based model of neuropathic pain (NP). Comorbidities of NP such as depression, anxiety, and cognitive deficits are associated with a functional reorganization of the medial prefrontal cortex (mPFC). Here, we have employed an adapted model of C...

journal_title：Journal of neuroscience research

authors： Medeiros P,de Freitas RL,Boccella S,Iannotta M,Belardo C,Mazzitelli M,Romano R,De Gregorio D,Coimbra NC,Palazzo E,Maione S

更新日期：2020-02-01 00:00:00

abstract：:The use of progesterone following brain injury has a controversial history. On one hand, some lab-based models have showed progesterone as being neuroprotective, but on the other, clinical trials have showed quite the opposite. One of many complaints that arose from this discrepancy was the lack of a diverse pool of a...

journal_title：Journal of neuroscience research

authors： Blackshear K,Giessner S,Hayden JP,Duncan KA

更新日期：2018-04-01 00:00:00

abstract：:This paper describes a novel technique to identify and study neurons that express specific mRNAs. The method is called Live FISH because it is like fluorescent in situ hybridization (FISH) but can be applied to living tissues. In Live FISH, molecular beacons, which fluoresce only in the presence of the complementary m...

journal_title：Journal of neuroscience research

authors： Simon B,Sandhu M,Myhr KL

更新日期：2010-01-01 00:00:00

abstract：:Trophic factors, such as the neurotrophins, CNTF, and GDNF, represent unique families of proteins that are essential for the development of the vertebrate nervous system. Surprisingly, there is little evidence to date that these proteins exist in Drosophila melanogaster and Caenorhabditis elegans, even though other po...

journal_title：Journal of neuroscience research

authors： Chao MV

更新日期：2000-02-01 00:00:00

abstract：:Lithium, the most prevalent treatment for manic-depressive illness, might have a neuroprotective effect after brain injury. In culture, lithium can exert neurotoxic effects associated with reduction in polyamine synthesis but neuroprotective effects as cultured neurons mature. Cumulative evidence suggests that lithium...

journal_title：Journal of neuroscience research

authors： Gilad GM,Gilad VH

更新日期：2007-02-15 00:00:00

abstract：:Systemic osmotic homeostasis is regulated mainly by neuroendocrine system of arginine-vasopressin (AVP) in mammalians. In the present study, we demonstrated that the immunoreactivity of tissue plasminogen activator (tPA) was observed specifically at neurosecretory granules of AVP-positive magnocellular terminals and t...

journal_title：Journal of neuroscience research

authors： Imamura Y,Morita S,Nakatani Y,Okada K,Ueshima S,Matsuo O,Miyata S

更新日期：2010-07-01 00:00:00

abstract：:Using subtype-specific Ca-channel blockers, we have characterised the voltage-sensitive Ca2+ currents as well as neurotransmitter release from cultured mouse cerebellar granule cells. The whole cell version of the patch clamp technique was adapted to monitor the isolated Ca-channel currents. The currents were activate...

journal_title：Journal of neuroscience research

authors： Varming T,Christopherson P,Schousboe A,Drejer J

更新日期：1997-04-01 00:00:00

abstract：:In the striatum, dopamine (DA) exerts a major modulatory influence on voltage- and ligand-gated currents. Previously we have shown that DA modulates glutamatergic neurotransmission and that the direction of this modulation depends on, among other factors, the glutamate and DA receptor subtypes activated. These effects...

journal_title：Journal of neuroscience research

authors： Liu JC,DeFazio RA,Espinosa-Jeffrey A,Cepeda C,de Vellis J,Levine MS

更新日期：2004-05-01 00:00:00

abstract：:There is supporting evidence of alcohol negative effects on the brain: neuroimaging and psychophysiological studies finding anatomical and functional connectivity (FC) changes associated with the dependence process. Thus, the aim of this work was to evaluate brain FC and network characteristics of alcohol-dependent in...

journal_title：Journal of neuroscience research

authors： Sion A,Bruña Fernández R,Martínez Maldonado A,Domínguez Centeno I,Torrado-Carvajal A,Rubio G,Pereda E,Jurado-Barba R

更新日期：2020-10-01 00:00:00

abstract：:Traumatic brain injury (TBI) is the major cause of physical disability and emotional vulnerability. Treatment of TBI is lacking due to its multimechanistic etiology, including derailed mitochondrial and cellular energy metabolism. Previous studies from our laboratory show that an endogenous nitric oxide (NO) metabolit...

journal_title：Journal of neuroscience research

authors： Khan M,Shunmugavel A,Dhammu TS,Khan H,Singh I,Singh AK

更新日期：2018-12-01 00:00:00

abstract：:Glial and glia-derived cells express a variety of receptors for neurotransmitters and hormones, the majority of which evoke both Ca(2+) release from intracellular stores and Ca(2+) entry across the plasma membrane. We investigated the links between histamine H(1) receptor activation, Ca(2+) release from intracellular ...

journal_title：Journal of neuroscience research

authors： Barajas M,Andrade A,Hernandez-Hernandez O,Felix R,Arias-Montaño JA

更新日期：2008-11-15 00:00:00

abstract：:Time-to-contact (TTC) perception refers to the ability of an observer to estimate the remaining time before an object reaches a point in the environment, and is of crucial importance in daily life. Noninvasive correlational approaches have identified several brain areas sensitive to TTC information. Here we report the...

journal_title：Journal of neuroscience research

authors： Baurès R,Fourteau M,Thébault S,Gazard C,Pasquio L,Meneghini G,Perrin J,Rosito M,Durand JB,Roux FE

更新日期：2021-02-01 00:00:00

abstract：:Although the thalamus is not considered primarily as a limbic structure, abundant evidence indicates the essential role of the thalamus as a modulator of limbic functions indirectly through the amygdala. The amygdala is a central component of the limbic system and serves an essential role in modulating the core proces...

journal_title：Journal of neuroscience research

authors： Kamali A,Riascos RF,Pillai JJ,Sair HI,Patel R,Nelson FM,Lincoln JA,Tandon N,Mirbagheri S,Rabiei P,Keser Z,Hasan KM

更新日期：2018-07-01 00:00:00

abstract：:Encephalitogenic T cells from Lewis rats use a restricted T cell receptor (TCR) gene combination, Vbeta8.2 and Valpha2. The oral administration of myelin basic protein (MBP) to Lewis rats prior to encephalitogenic challenge results in a marked inhibition of clinical neurologic signs of encephalitis, reduced central ne...

journal_title：Journal of neuroscience research

authors： Goldman-Brezinski S,Brezinski K,Zhang XM,Gienapp I,Cox K,Heber-Katz E,Whitacre C

更新日期：1998-01-01 00:00:00

abstract：:The use of trimethadione (TMO) as a protector in hyperbaric oxygen toxicity in the conscious rat has been examined in detail. The oxidation-reduction state of pyridine nucleotides was measured simultaneously with the EEG activity from the surface of the brain cortex. From the data obtained, a few parameters were calcu...

journal_title：Journal of neuroscience research

authors： Mayevsky A

更新日期：1975-01-01 00:00:00

abstract：:Double immunofluorescence studies using antibodies against NF-L and peripherin revealed three distinct subpopulations of neurons in rat dorsal root ganglia (DRG). In the adult rat, 46% of the DRG neurons were small and peripherin-positive (NF-L-negative), and 48% were large and NF-L-positive (peripherin-negative). Abo...

journal_title：Journal of neuroscience research

authors： Goldstein ME,House SB,Gainer H

更新日期：1991-09-01 00:00:00

abstract：:Fibroblast growth factors (FGFs) are known to act on glial cells in vitro. At the present time, their involvement in the remyelinating process of the adult central nervous system (CNS) is still unknown. In the present study, using immunohistochemistry (IHC), we investigated the evolution in time and space of acidic FG...

journal_title：Journal of neuroscience research

authors： Tourbah A,Baron-Van Evercooren A,Oliver L,Raulais D,Jeanny JC,Gumpel M

更新日期：1992-09-01 00:00:00

abstract：:A new subdivision with distinctive morphological and functional attributes has been identified at the caudomedial margin of the neostriatum and surrounding the rostrolateral border of the globus pallidus in the brains of the rat, cat, monkey, and human. The subdivision is termed marginal division (MrD) based on its lo...

journal_title：Journal of neuroscience research

authors： Shu SY,Bao X,Li S,Niu D,Xu Z,Li Y

更新日期：1999-10-15 00:00:00

abstract：:We previously demonstrated that a synthetic retinoic acid receptor agonist, Am80, attenuated intracerebral hemorrhage (ICH)-induced neuropathological changes and neurological dysfunction. Because inflammatory events are among the prominent features of ICH pathology that are affected by Am80, this study investigated th...

journal_title：Journal of neuroscience research

authors： Matsushita H,Hijioka M,Ishibashi H,Anan J,Kurauchi Y,Hisatsune A,Seki T,Shudo K,Katsuki H

更新日期：2014-08-01 00:00:00

abstract：:We have previously shown in rat primary cultured mesencephalic cells that cyanide induces a high level of oxidative stress and necrotic death. To evaluate the mechanism of the cytotoxicity, the effects of cyanide on intracellular glutathione (GSH) pools and inducible nitric oxide synthase (iNOS)-mediated reactive nitr...

journal_title：Journal of neuroscience research

authors： Prabhakaran K,Li L,Borowitz JL,Isom GE

更新日期：2006-10-01 00:00:00