Time-to-contact perception in the brain.

abstract：:Rapsyn is a protein that interacts with the cytoplasmic face of the nicotinic acetylcholine receptors (AChR) to cluster them within postsynaptic membrane of muscle. Here we show that intracellular AChRs are also affected by rapsyn. When rapsyn was co-transfected with AChR into QT-6 fibroblasts, (125)I-alpha-bungarotox...

journal_title：Journal of neuroscience research

authors： Han H,Yang SH,Phillips WD

更新日期：2000-04-15 00:00:00

abstract：:Both the adenosine analogue 2-chloro-adenosine (2-CA) and the reducing sugar deoxy-D-ribose (dRib) induce apoptosis of astroglial cells in rat brain primary cultures (Abbracchio et al.: Biochem Biophys Res Commun 213:908-915, 1995). The present study was undertaken to elucidate by both morphological and cytofluorimetr...

journal_title：Journal of neuroscience research

authors： Ceruti S,Barbieri D,Veronese E,Cattabeni F,Cossarizza A,Giammarioli AM,Malorni W,Franceschi C,Abbracchio MP

更新日期：1997-02-15 00:00:00

abstract：:The remarkable quantities of myelin membrane produced by oligodendrocytes has led us to examine the mechanisms involved in the sorting and transport of proteins and lipids during myelinogenesis. Noting that it has been proposed that proteins destined for the apical surface of polarized epithelial cells co-cluster with...

journal_title：Journal of neuroscience research

authors： Kim T,Fiedler K,Madison DL,Krueger WH,Pfeiffer SE

更新日期：1995-10-15 00:00:00

abstract：:An experimental model based on kainic acid (KA) injections replicates many phenomenological features of human temporal lobe epilepsy, the most common type of epilepsy in adults. Taurine, 2-aminoethanesulfonic acid, present in high concentrations in many invertebrate and vertebrate systems, is believed to serve several...

journal_title：Journal of neuroscience research

authors： Junyent F,Utrera J,Romero R,Pallàs M,Camins A,Duque D,Auladell C

更新日期：2009-05-01 00:00:00

abstract：:Corticosterone (CORT), one of the glucocorticoids, causes neuronal damage in the hippocampus, but the mechanism(s) of action underlying its effects remains unknown. Brain-derived neurotrophic factor (BDNF) is a neurotrophic factor that belongs to the neurotrophin family, affects the survival and/or differentiation of ...

journal_title：Journal of neuroscience research

authors： Nitta A,Ohmiya M,Sometani A,Itoh M,Nomoto H,Furukawa Y,Furukawa S

更新日期：1999-07-15 00:00:00

abstract：:Fractionation of muscle microsomes rich in sarcoplasmic reticulum (SR) by isopicnic centrifugation yielded three types of membranes. Heavy (HM), intermediate (IM), and light membranes (LM), with isopicnic points of 38, 33, and 25% w/w sucrose, were rich in terminal cisternae/triads, longitudinal SR, and T-tubules, res...

journal_title：Journal of neuroscience research

authors： Campoy FJ,Cabezas-Herrera J,Vidal CJ

更新日期：1992-12-01 00:00:00

abstract：:In order to quantify the changes that occur in the cholinergic central nervous system with aging, we have compared acetylcholine (Ach) formation in brain cortex slice preparations from 2-year-old aged CBF-1 mouse brains and compared the findings with those in 2-4-month-old young adult mouse brain slices. Incorporation...

journal_title：Journal of neuroscience research

authors： Saito M,Kindel G,Karczmar AG,Rosenberg A

更新日期：1986-01-01 00:00:00

abstract：:We have previously shown in rat primary cultured mesencephalic cells that cyanide induces a high level of oxidative stress and necrotic death. To evaluate the mechanism of the cytotoxicity, the effects of cyanide on intracellular glutathione (GSH) pools and inducible nitric oxide synthase (iNOS)-mediated reactive nitr...

journal_title：Journal of neuroscience research

authors： Prabhakaran K,Li L,Borowitz JL,Isom GE

更新日期：2006-10-01 00:00:00

abstract：:Brain zinc homeostasis is strictly controlled under healthy conditions, indicating the importance of zinc for physiological function in the brain. A part of zinc in the brain exists in the synaptic vesicles, is released from a subclass of glutamatergic neurons (i.e., zincergic neurons), and serves as a signal factor (...

journal_title：Journal of neuroscience research

authors： Takeda A,Fujii H,Minamino T,Tamano H

更新日期：2014-07-01 00:00:00

abstract：:Regulatory factor X4 variant 3 (RFX4_v3) is a recently identified transcription factor specifically expressed in the brain. Gene disruption in mice demonstrated that interruption of a single allele (heterozygous, +/-) prevented formation of the subcommissural organ (SCO), resulting in congenital hydrocephalus, whereas...

journal_title：Journal of neuroscience research

authors： Zhang D,Zeldin DC,Blackshear PJ

更新日期：2007-12-01 00:00:00

abstract：:Apolipoprotein E (ApoE) is the major brain lipoprotein and plays an important role in lipid transport. ApoE-deficient mice whose apoE gene has been knocked out have distinct cognitive and neurochemical deficits, and their recovery from brain injury is impaired. In the present study we examined the possibility that the...

journal_title：Journal of neuroscience research

authors： Lomnitski L,Oron L,Sklan D,Michaelson DM

更新日期：1999-11-15 00:00:00

abstract：:Cortical or total brain cultures of microglia are commonly used as a model to study the inflammatory processes in Parkinson's disease. Here we characterize microglia cultures from rat ventral midbrain and evaluate their response to zymosan A. We used specific markers of microglia and evaluated the morphology, the phag...

journal_title：Journal of neuroscience research

authors： Cristóvão AC,Saavedra A,Fonseca CP,Campos F,Duarte EP,Baltazar G

更新日期：2010-02-15 00:00:00

abstract：:Several neuronal and non-neuronal cell lines express a Ca(2+)-dependent mechanism of transmitter release that can be demonstrated after loading the cells with acetylcholine during culture. In contrast, a particular cell line, the neuroblastoma N18TG-2, was found to be deficient for release. We transfected N18TG-2 cell...

journal_title：Journal of neuroscience research

authors： Falk-Vairant J,Meunier FM,Lesbats B,Corrèges P,Eder-Colli L,Salem N,Synguelakis M,Dunant Y,Israël M

更新日期：1996-08-01 00:00:00

abstract：:Immunocytochemical studies indicated that Purkinje cells cultured from chick embryonic cerebellum (embryonic day 8) strongly express a glutamate transporter EAAT2 cloned from human brain (GLT-1 in rat brain). At both 7 days and 14 days in culture, Purkinje neurons accumulated 1 microM [3H]L-glutamate via a potent "hig...

journal_title：Journal of neuroscience research

authors： Meaney JA,Balcar VJ,Rothstein JD,Jeffrey PL

更新日期：1998-12-01 00:00:00

abstract：:Fatty acid amide hydrolase (FAAH) is a membrane-bound enzyme activity that degrades neuromodulatory fatty acid amides, including oleamide and anandamide. A single 2.5-kb FAAH mRNA is distributed throughout the rat CNS and accumulates progressively between embryonic day 14 and postnatal day 10, remains high until postn...

journal_title：Journal of neuroscience research

authors： Thomas EA,Cravatt BF,Danielson PE,Gilula NB,Sutcliffe JG

更新日期：1997-12-15 00:00:00

abstract：:The effects of the nematocyst venom of the sea anemone Bunodosoma cangicum on depolarization-activated currents were studies in opener crayfish muscle fibers and in cultured bovine chromaffin cells. The venom selectively and reversibly blocked the Ca(2+)-dependent K+ current (IK(Ca)) present in crayfish muscle in a do...

journal_title：Journal of neuroscience research

authors： Araque A,Urbano FJ,Cerveñansky C,Gandía L,Buño W

更新日期：1995-11-01 00:00:00

abstract：:Recent studies suggest that heterotypic cell-cell interactions influence gliogenesis in the developing rat central nervous system. CNS neuron-derived factors have been hypothesized to exist, and several have been identified and partially characterized which affect the number of oligodendrocytes in vitro. In order to s...

journal_title：Journal of neuroscience research

authors： Bottenstein JE,Hunter SF,Seidel M

更新日期：1988-07-01 00:00:00

abstract：:Microarray analyses demonstrated that a variety of genes was affected by treatment of cerebellar granule cell neurons with the neurotrophic factor pigment epithelium-derived factor (PEDF). The genes for neurotrophins, glial cell-derived neurotrophic factor (GDNF), and their receptors were regulated differentially in i...

journal_title：Journal of neuroscience research

authors： Yabe T,Herbert JT,Takanohashi A,Schwartz JP

更新日期：2004-09-01 00:00:00

abstract：:We investigated the role of kainate (KA) receptor activation and desensitization in inducing the increase in the intracellular free Ca(2+) concentration ([Ca(2+)](i)) in individual cultured rat hippocampal neurons. The rat hippocampal neurons in the cultures were shown to express kainate receptor subunits, KA2 and Glu...

journal_title：Journal of neuroscience research

authors： Silva AP,Malva JO,Ambrósio AF,Salgado AJ,Carvalho AP,Carvalho CM

更新日期：2001-09-01 00:00:00

abstract：:The cell line PC12, derived from a rat pheochromocytoma, has served as a model for studies on the mechanism of action of nerve growth factor, as well as for the exploration of neuronal differentiation in general. When treated with nanomolar concentrations of nerve growth factor, these neoplastic chromaffin-like cells ...

journal_title：Journal of neuroscience research

authors： Simpson DL,Dickens G,Doll S,Koizumi S,Tocco M,Okuda O,Oshima M,Rudkin BB,Brightman M,Guroff G

更新日期：1991-04-01 00:00:00

abstract：:Cultured rat mesencephalic neurons were used to assess the effects of gamma-aminobutyric acid (GABA) transport blockers on toxicity caused by malonate, a reversible, competitive inhibitor of succinate dehydrogenase. Previous studies utilizing an ex vivo chick retinal preparation have shown that GABA release and cell s...

journal_title：Journal of neuroscience research

authors： Stokes AH,Bernard LP,Nicklas WJ,Zeevalk GD

更新日期：2001-04-01 00:00:00

abstract：:Lipoic acid plays a crucial role as antioxidant and metabolic component of enzymes involved in glucose metabolism of different cell types. Choline alphoscerate (α-glyceryl-phosphoryl-choline [αGPC]) is a semisynthetic derivative of phosphatidylcholines representing, among acetilcholine precursors, a cholinergic drug. ...

journal_title：Journal of neuroscience research

authors： Grasso S,Bramanti V,Tomassoni D,Bronzi D,Malfa G,Traini E,Napoli M,Renis M,Amenta F,Avola R

更新日期：2014-01-01 00:00:00

abstract：:The effects of bilateral lesions of the ventral noradrenergic bundle (VNA) were studied in male rats. In contrast to data reported by others, hyperphagia and obesity were not observed following VNA lesions. Indeed, except for a depression during the first three postoperative days, food intake (FI) of the VNA lesioned ...

journal_title：Journal of neuroscience research

authors： Bellinger LL,Bernardis LL,Goldman JK

更新日期：1976-01-01 00:00:00

abstract：:One premise regarding the mechanism of injury-evoked neuroregeneration is that injured cells induce the release of neurotrophic factors to trigger neurogenesis. Extracellular purine nucleotides exert multiple neurotrophic actions in the central nervous system mediated via activation of purinergic receptors. However, w...

journal_title：Journal of neuroscience research

authors： Kanekar S,Jia C,Hegg CC

更新日期：2009-05-01 00:00:00

abstract：:In the present study, following previous experience with electrolytic lesion of the rat brain, and subsequent reduction of reactive gliosis with 7 beta-hydroxycholesterol derivatives (Bochelen et al.: Neuroscience 51:827-834, 1992), we have performed a hemisection of the spinal cord in adult rats and investigated the ...

journal_title：Journal of neuroscience research

authors： Giménez y Ribotta M,Rajaofetra N,Morin-Richaud C,Alonso G,Bochelen D,Sandillon F,Legrand A,Mersel M,Privat A

更新日期：1995-05-01 00:00:00

abstract：:In rodents, oligodendrocytes and myelinating Schwann cells express connexin32 (Cx32) and Cx29, which have different localizations in the two cell types. We show here that, in contrast to Cx32, Cx29 does not form gap junction plaques or functional gap junctions in transfected cells. Furthermore, when expressed together...

journal_title：Journal of neuroscience research

authors： Ahn M,Lee J,Gustafsson A,Enriquez A,Lancaster E,Sul JY,Haydon PG,Paul DL,Huang Y,Abrams CK,Scherer SS

更新日期：2008-04-01 00:00:00

abstract：:DBA/2J mice are one of several animal strains used for experimental models of both intraocular hypertension and glaucoma. This study investigates the relationship between endoplasmic reticulum (ER) stress and optic nerve degeneration in DBA/2J mice. Intraocular pressure (IOP) was measured in DBA/2J mice between the ag...

journal_title：Journal of neuroscience research

authors： Ojino K,Shimazawa M,Izawa H,Nakano Y,Tsuruma K,Hara H

更新日期：2015-11-01 00:00:00

abstract：:Mitotic activity persists in various regions of the adult mammal CNS. While evidences of neurogenesis appeared, many studies focused on the features of the adult stem cells from germinative areas such as the subventricular zone of the lateral ventricles, the dentate gyrus of the hippocampus, the cortex, the fourth ven...

journal_title：Journal of neuroscience research

authors： Picard-Riera N,Nait-Oumesmar B,Baron-Van Evercooren A

更新日期：2004-04-15 00:00:00

abstract：:Glial and glia-derived cells express a variety of receptors for neurotransmitters and hormones, the majority of which evoke both Ca(2+) release from intracellular stores and Ca(2+) entry across the plasma membrane. We investigated the links between histamine H(1) receptor activation, Ca(2+) release from intracellular ...

journal_title：Journal of neuroscience research

authors： Barajas M,Andrade A,Hernandez-Hernandez O,Felix R,Arias-Montaño JA

更新日期：2008-11-15 00:00:00

abstract：:Neurotrophic factors regulate the developmental survival and differentiation of specific neuronal populations. Brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) are members of the nerve growth factor (NGF) protein family, also known as the neurotrophins. Insights into the different roles of neurotroph...

journal_title：Journal of neuroscience research

authors： Escandón E,Burton LE,Szönyi E,Nikolics K

更新日期：1993-04-15 00:00:00