Abstract:
:Oligodendrocyte-specific protein (OSP/claudin-11) is a major component of CNS myelin and has been recently added to the claudin family of tight junction proteins. In this study, the developmental expression of OSP/claudin-11 was determined using in situ hybridization, immunohistochemistry (IH), and Western blot analysis. OSP/claudin-11 mRNA was expressed in a bimodal fashion. During prenatal development, OSP/claudin-11 mRNA was abundant in developing meninges, in areas adjacent to cartilage, and in mesoderm. In postnatal animals, OSP/claudin-11 was expressed primarily in developing oligodendrocytes and to a lesser extent, in testes. Double-labeled IH using O2-A progenitor cells revealed that OSP/claudin-11 expression occurs from the early progenitor stage and continues in mature oligodendrocytes. Electron microscopic IH localized OSP/claudin-11 to laminar myelin in the adult CNS. Western blot analysis of OSP/claudin-11 in developing brain revealed the expression of two separate transcripts that were developmentally regulated. These data demonstrate that OSP/claudin-11 expression is highly regulated during development and, therefore, may play an important role in growth and differentiation of oligodendrocytes and other cells outside the CNS.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Bronstein JM,Chen K,Tiwari-Woodruff S,Kornblum HIdoi
10.1002/(SICI)1097-4547(20000501)60:3<284::AID-JNRkeywords:
subject
Has Abstractpub_date
2000-05-01 00:00:00pages
284-90issue
3eissn
0360-4012issn
1097-4547pii
10.1002/(SICI)1097-4547(20000501)60:3<284::AID-JNRjournal_volume
60pub_type
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