Abstract:
:Several neurological diseases involve focal injury of specific brain structures. Poisons of the electron transport chain complexes (ETCC) can also produce selective injury of brain structures when given systemically and have been implicated in the development of neurological disease. Why ETCC poisons damage particular brain regions is unclear. Calculations of the relative ETCC expression level to glucose utilization rate (GUR) ratio from published observations here reveal that a low ETCC/GUR ratio predisposes a brain structure to injury by a poison of that complex. While GUR can rise with increased neuronal activity, ETCC expression is fixed in the short term. A high ETCC/GUR therefore represents surplus ETCC capacity, allowing for increased ATP generation with short-term increases in demand. A low ETCC/GUR indicates the opposite and will lead to energy failure when the specific ETCC is poisoned. These observations may explain why cyanide, a specific ETCC (IV) inhibitor, can produce selective injury of white matter, which has the lowest ETCC (IV)/GUR found in the brain. They are also consistent with the selective damage of the striatum produced by poisons such as rotenone, a form of injury implicated in Parkinson's disease. The striatum has a low ETCC (I)/GUR ratio, whereas rotenone is a selective ETCC (I) inhibitor.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Fern Rdoi
10.1002/jnr.10553keywords:
subject
Has Abstractpub_date
2003-03-15 00:00:00pages
759-62issue
6eissn
0360-4012issn
1097-4547journal_volume
71pub_type
杂志文章,评审abstract::Cerebrospinal fluid was collected from the lateral ventricles and cisternal space from beagle dogs under light pentobarbital anesthesia. Homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA), and 3-methoxy-4-hydroxyphenylglyco-sulfate (MOPEG-SO4) levels in the liquor taken from these two regions were evaluated,...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490010513
更新日期:1975-01-01 00:00:00
abstract::Cultures of chicken day 8 embryo retinal cells, essentially free of contaminating non-neuronal elements, were used to examine the neurotoxicity of various excitatory amino acid transmitter receptor agonists. At 7 days in vitro, N-methyl-D-aspartate (NMDA), following 24 hr exposure to 0.1-1.0 mM, destroyed 60-70% of th...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490270210
更新日期:1990-10-01 00:00:00
abstract::Because there is a strong correlation between tuberous sclerosis and autism, we used a tuberous sclerosis model (Eker rat) to test the hypothesis that these animals would have an altered regional cerebral O2 consumption that might be associated with autism. We also examined whether the altered cerebral O2 consumption ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21378
更新日期:2007-08-15 00:00:00
abstract::The turmeric derivative curcumin protects against cerebral ischemic injury. We previously demonstrated that curcumin activates peroxisome proliferator-activated receptor-γ (PPARγ), a ligand-activated transcription factor involved in both neuroprotective and anti-inflammatory signaling pathways. This study tested wheth...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.23438
更新日期:2014-11-01 00:00:00
abstract::Stroke is not only a leading cause of mortality and morbidity worldwide it also disproportionally affects women. There are currently over 500,000 more women stroke survivors in the US than men, and elderly women bear the brunt of stroke-related disability. Stroke has dropped to the fifth leading cause of death in men,...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.23962
更新日期:2017-01-02 00:00:00
abstract::We have studied the interaction between several growth factors to promote parasympathetic neuronal survival. Neither insulin nor insulin-like growth factor-I (IGF-I) had any effect on the survival of embryonic day 8 chick ciliary neurons in culture. Similarly, the protein kinase C activator phorbol dibutyrate (PdBu) h...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490280112
更新日期:1991-01-01 00:00:00
abstract::Alcohol-related events have been proposed to be under neurochemical control. For example, the concentration of methionine enkephalin (Met-enkephalin) in brain has been inversely correlated with ethanol consumption in alcohol-preferring and alcohol-nonpreferring mice. The concentrations of Met-enkephalin are controlled...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:
更新日期:1997-05-01 00:00:00
abstract::In order to identify the relative number of benzodiazepine (BZ) receptors in Purkinje and granule cells, the Purkinje cell degeneration (pcd) mutant mouse was used at different ages. In these mice, Purkinje cells have degenerated almost completely by 45-50 days of age. Granule cell loss occurs only later, and is most ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490090308
更新日期:1983-01-01 00:00:00
abstract::Astrocyte activation is an important feature in many disorders of the central nervous system, including chronic pain conditions. Activation of astrocytes is characterized by a change in morphology, including hypertrophy and increased size of processes, proliferation, and an increased production of proinflammatory medi...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.23144
更新日期:2013-02-01 00:00:00
abstract::Time-to-contact (TTC) perception refers to the ability of an observer to estimate the remaining time before an object reaches a point in the environment, and is of crucial importance in daily life. Noninvasive correlational approaches have identified several brain areas sensitive to TTC information. Here we report the...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.24740
更新日期:2021-02-01 00:00:00
abstract::Peroxides are generated continuously in cells that consume oxygen. Among the different peroxides, hydrogen peroxide is the molecule that is formed in highest quantities. In addition, organic hydroperoxides are synthesized as products of cellular metabolism. Generation and disposal of peroxides is a very important proc...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.20280
更新日期:2005-01-01 00:00:00
abstract::Previous studies have demonstrated variability in the phenotype of rat C6 glioma cells. In the present study, we compared morphology, growth rate, and beta-adrenergic regulation of gene expression in early (P39-47) and late (P55-90) passage C6 cells. Morphological changes were observed in five independently derived, l...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490330213
更新日期:1992-10-01 00:00:00
abstract::Gap junctions (GJs) are widely distributed in brains across the animal kingdom. To visualize the GJ- coupled networks of two major mechanosensory neurons in the ganglia of medicinal leeches, we injected these cells with the GJ-permeable tracer Neurobiotin. When diffusion time was limited to only 30 min, tracer couplin...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.24599
更新日期:2020-06-01 00:00:00
abstract::The purpose of this study was to determine how oligodendrocytes die following Fas receptor activation. An immortalized human oligodendrocyte hybrid line (MO3.13) was challenged with Fas ligand (FasL), and cell death was assessed by flow cytometry and DNA gel electrophoresis. Caspase activation was determined by either...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10285
更新日期:2002-07-15 00:00:00
abstract::Netrin-1 regulates axon extension during embryonic development and is expressed by neurons and myelinating oligodendrocytes in the adult CNS. To investigate the potential role of netrin-1 after spinal cord injury, we examined the expression of netrin-1 and netrin receptors after sagittal myelotomy in adult rats. This ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21070
更新日期:2006-12-01 00:00:00
abstract::Pharmacological characterization of the action of the novel non-N-methyl-D-aspartate (non-NMDA) antagonist AMOA (2-amino-3-[3-(carboxymethoxy)-5-methylisoxazol-4-yl]propionate) on glutamate receptors was investigated in Xenopus oocytes injected with mouse brain mRNA. AMOA (150 microM) produced a nearly parallel shift ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490330305
更新日期:1992-11-01 00:00:00
abstract::Ex vivo gene therapy is emerging as a promising approach for the treatment of neurodegenerative diseases and central nervous system (CNS) trauma. We have shown previously that human adult astrocytes can be expanded in vitro and can express various therapeutic transgenes (Ridet et al. [1999] Hum. Gene Ther. 10:271-280;...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10617
更新日期:2003-06-15 00:00:00
abstract::Progressive "dying back" neurodegenerative diseases are debilitating due to loss of connectivity after nerve terminal and axonal withdrawal, which impairs peripheral nerve function and leads ultimately to neuronal cell death. The mutant mouse (Wallerian degeneration slow; Wld(s)) provides an accessible model system to...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20016
更新日期:2004-04-01 00:00:00
abstract::The purpose of this study was to determine if calpain-induced proteolysis was associated with retinal degeneration or dysfunction in the rat acute ocular hypertensive model. Acute glaucoma was produced by elevation of IOP to 120 mm Hg for 1 hr. Retinal degeneration was evaluated by H&E staining and apoptosis was deter...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20827
更新日期:2006-05-15 00:00:00
abstract::The Oct-2 transcription factor has a predominantly inhibitory effect on gene expression in neuronal cell lines. This factor and its corresponding mRNA have previously been shown to be elevated in adult rat dorsal root ganglion (DRG) neurons chronically exposed to nerve growth factor (NGF). Here we show that the Oct-2 ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490400205
更新日期:1995-02-01 00:00:00
abstract::Apolipoprotein E (ApoE) is the major brain lipoprotein and plays an important role in lipid transport. ApoE-deficient mice whose apoE gene has been knocked out have distinct cognitive and neurochemical deficits, and their recovery from brain injury is impaired. In the present study we examined the possibility that the...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:
更新日期:1999-11-15 00:00:00
abstract::Fourteen-day gestation fetal cerebral cortex homografts were transplanted into the thoracic (T6) spinal cord between the left dorsal column and dorsal horn of adult host rats. The transplants were soaked in 2.0 micrograms/ml of the lectin Phaseolus vulgaris leucoagglutinin (PHAL) prior to implantation. Transplanted ho...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490170410
更新日期:1987-01-01 00:00:00
abstract::Destruction of the ventromedial hypothalamic nuclei (VMN) in the weanling rat without injury to the median eminence results in a series of somatic, endocrine, and metabolic changes that are characterized by normal food and water intake but decreased linear growth, normal body weight but increased carcass fat and reduc...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490020202
更新日期:1976-01-01 00:00:00
abstract::Catecholamine-producing cell types are generated from specified neuronal lineages during vertebrate development. The catecholaminergic phenotype is also expressed transiently in some cell types in non-catecholaminergic tissues, including the sensory ganglia, enteric ganglia, and ventral portions of the neural tube dur...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20229
更新日期:2004-10-01 00:00:00
abstract::CADASIL is a cerebrovascular disease caused by mutations in the NOTCH3 gene. Most mutations result in a gain or loss of cysteine residue in one of the 34 epidermal growth factor-like repeats in the extracellular domain of the Notch3 protein, thus sparing the number of cysteine residues. To date, more than 130 differen...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21935
更新日期:2009-04-01 00:00:00
abstract::The effects of KCl-treatment on the survival and proliferation of NE-4C self-renewing neural progenitor cells were investigated during early phases of in vitro induced neurogenesis. NE-4C cells, derived from the anterior brain vesicles of embryonic mouse (E9), divided continuously under non-inducing conditions, but ac...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10155
更新日期:2002-03-01 00:00:00
abstract::Deletion of the tumor suppressor gene p53 has been shown to improve the outcome in experimental models of focal cerebral ischemia and kainate-induced seizures. To evaluate the potential role of p53 in traumatic brain injury, genetically modified mice lacking a functional p53 gene (p53(-/-), n = 9) and their wild-type ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22491
更新日期:2010-11-15 00:00:00
abstract::The effects of bilateral lesions of the ventral noradrenergic bundle (VNA) were studied in male rats. In contrast to data reported by others, hyperphagia and obesity were not observed following VNA lesions. Indeed, except for a depression during the first three postoperative days, food intake (FI) of the VNA lesioned ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490020305
更新日期:1976-01-01 00:00:00
abstract::It was previously reported that a monoclonal antibody to beta-amyloid precursor protein (mab22C11; Boehringer Mannheim, Indianapolis, IN) labels an intermediate filament-associated protein (beta APP-IFAP) in cultured human skin fibroblasts (Dooley et al.: J Neurosci Res 33:60-67, 1992). The time course of its expressi...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490380605
更新日期:1994-08-15 00:00:00
abstract::In order to better characterize the presynaptic GABA receptors regulating glutamate release in the cerebellum [Levi and Gallo, 1981], a number of GABA agonists and GABA transport inhibitors were tested for their ability to potentiate the depolarization-induced release of the glutamate analog D-[3H]aspartate from super...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490100204
更新日期:1983-01-01 00:00:00