Co-activation of insulin-like growth factor-I receptors and protein kinase C results in parasympathetic neuronal survival.

abstract：:Axotomy is a powerful stimulus of axon growth and plastic changes. We investigated the potential role of BDNF/trkB signaling in the sprouting of dopaminergic nigral axons in response to axotomy of the medial forebrain bundle. Tyrosine hydroxylase immunohistochemistry revealed the existence of sprouting mechanisms in t...

journal_title：Journal of neuroscience research

authors： García Navia JT,Burguillos MA,Ramón-Cueto A,Machado A,Cano J,Venero JL

更新日期：2008-07-01 00:00:00

abstract：:Previous studies have shown that treating rat cortical neurons in primary culture with apolipoprotein E (apoE) peptide increased cytoplasmic Ca2+ by 2 mechanisms: 1) an influx of extracellular Ca2+ resulting from the activation of a cell surface Ca2+ channel; and 2) release of Ca2+ from internal Ca2+ stores via a G-pr...

journal_title：Journal of neuroscience research

authors： Wang X,Luebbe P,Gruenstein E,Zemlan F

更新日期：1998-03-01 00:00:00

abstract：:Fetal low brain oxygenation may be an outcome of maternal complications during pregnancy and is associated with increased risk of cerebral palsy and periventricular leukomalacia in newborns. One treatment used for prevention of fetal brain damage is maternal treatment with MgSO(4). Although this treatment is indicated...

journal_title：Journal of neuroscience research

authors： Golan H,Kashtuzki I,Hallak M,Sorokin Y,Huleihel M

更新日期：2004-11-01 00:00:00

abstract：:The five major antioxidant enzymes, glutathione, and in vivo or in vitro stimulated (Fe(++)-ascorbate) peroxidation were similar in old and young Rana perezi frogs. Long-term (2.5 months) treatment with aminotriazole strongly decreased cerebral catalase (CAT) activity and increased in vivo but not in vitro peroxidatio...

journal_title：Journal of neuroscience research

authors： Barja de Quiroga G,Pérez-Campo R,López-Torres M

更新日期：1990-07-01 00:00:00

abstract：:Human P0 is the main myelin glycoprotein of the peripheral nervous system. It can bind six different glycans, all linked to Asn(93) , the unique glycosylation site. Other myelin glycoproteins, also with a single glycosylation site (PMP22 at Asn(36) , MOG at Asn(31) ), bind only one glycan. The MAG has 10 glycosylation...

journal_title：Journal of neuroscience research

authors： Sedzik J,Jastrzebski JP,Grandis M

更新日期：2015-01-01 00:00:00

abstract：:Zinc concentration and (65)Zn uptake in the brain of rats fed zinc-deficient diet for 12 weeks were examined, based on a previous finding of the impairment of learning behavior by the zinc deprivation. Zinc concentrations in the brain, except for the hippocampal formation, did not decrease significantly in zinc-defici...

journal_title：Journal of neuroscience research

authors： Takeda A,Minami A,Takefuta S,Tochigi M,Oku N

更新日期：2001-03-01 00:00:00

abstract：:We investigated by (13)C nuclear magnetic resonance (NMR) the mechanisms underlying Li(+) effects on glutamatergic and GABAergic neurotransmission systems in the adult rat brain and in primary cultures of cortical neurons and astrocytes during the metabolism of (1-(13)C) glucose or (2-(13)C) acetate. Adult male rats r...

journal_title：Journal of neuroscience research

authors： Fonseca CP,Sierra A,Geraldes CF,Cerdán S,Castro MM

更新日期：2009-03-01 00:00:00

abstract：:To identify and characterize the lineage potential of rat neural retina progenitor cells (NRPCs) in vitro and engrafted into rats with retinal degeneration, NRPCs were isolated from neural retinas of embryonic day 17 Long Evans rats and cultured in serum-free or serum-containing media with fibroblast growth factor 2 a...

journal_title：Journal of neuroscience research

authors： Yang P,Seiler MJ,Aramant RB,Whittemore SR

更新日期：2002-08-15 00:00:00

abstract：:In the embryonic and postnatal rat retina a cell surface antigen that is detected by monoclonal antibody JONES is distributed in a dorsoventral gradient. Biochemical analysis has determined that the antigen is a modified ganglioside, 9-O-acetyl GD3. In the present study, the distributions of 9-O-acetyl GD3 and its pos...

journal_title：Journal of neuroscience research

authors： Sparrow JR,Barnstable CJ

更新日期：1988-10-01 00:00:00

abstract：:Most previous studies on spinal cord injury (SCI) have used rodent models. Direct extrapolation of the results obtained in rodents to clinical cases is difficult, however, because of neurofunctional and anatomic differences between rodents and primates. In the present study, the development of histopathologic changes ...

journal_title：Journal of neuroscience research

authors： Iwanami A,Yamane J,Katoh H,Nakamura M,Momoshima S,Ishii H,Tanioka Y,Tamaoki N,Nomura T,Toyama Y,Okano H

更新日期：2005-04-15 00:00:00

abstract：:Neuropathic pain is a debilitating chronic pain and represents a major clinical challenge. The molecular and cellular mechanisms underlying its development and maintenance are not fully understood but involve abnormal excitability in the dorsal horn of the spinal cord. A growing body of evidence has shown that this ab...

journal_title：Journal of neuroscience research

authors： Tsuda M

更新日期：2017-06-01 00:00:00

abstract：:P-glycoprotein (P-gp), a drug efflux pump, is known to alter the bioavailability of antiretroviral drugs at several sites, including the brain. We have previously shown that human immunodeficiency virus-1 (HIV-1) glycoprotein 120 (gp120) induces proinflammatory cytokine secretion and decreases P-gp functional expressi...

journal_title：Journal of neuroscience research

authors： Ashraf T,Ronaldson PT,Persidsky Y,Bendayan R

更新日期：2011-11-01 00:00:00

abstract：:High levels of the proto-oncogene product, pp60c-src, have been found in developing and adult neural tissues as well as in certain fully mature cells of the hematopoietic lineage, e.g., platelets and myelomonocytes. Adrenal medullary chromaffin cells exhibit characteristics of both types of cells, i.e., they are deriv...

journal_title：Journal of neuroscience research

authors： Oddie KM,Litz JS,Balserak JC,Payne DM,Creutz CE,Parsons SJ

更新日期：1989-09-01 00:00:00

abstract：:Fractionation of muscle microsomes rich in sarcoplasmic reticulum (SR) by isopicnic centrifugation yielded three types of membranes. Heavy (HM), intermediate (IM), and light membranes (LM), with isopicnic points of 38, 33, and 25% w/w sucrose, were rich in terminal cisternae/triads, longitudinal SR, and T-tubules, res...

journal_title：Journal of neuroscience research

authors： Campoy FJ,Cabezas-Herrera J,Vidal CJ

更新日期：1992-12-01 00:00:00

abstract：:PC12 cells can differentiate into neuron-like cells after treatment with either nerve growth factor (NGF) or transduction with a retrovirus which expresses the K-ras oncogene. The concomitant treatment of NGF plus ras differentiates PC12 cells further than either agent alone with respect to neurite outgrowth, acetylch...

journal_title：Journal of neuroscience research

authors： Tao-Cheng JH,Dosemeci A,Bressler JP,Brightman MW,Simpson DL

更新日期：1995-10-15 00:00:00

abstract：:Myelin-associated glycoprotein (MAG) is expressed on the innermost myelin membrane wrap, directly apposed to the axon surface. Although it is not required for myelination, MAG enhances long-term axon-myelin stability, helps to structure nodes of Ranvier, and regulates the axon cytoskeleton. In addition to its role in ...

journal_title：Journal of neuroscience research

authors： Schnaar RL,Lopez PH

更新日期：2009-11-15 00:00:00

abstract：:Neuron-glia interactions at paranodal junctions play important roles in action potential propagation. Among their many functions, they contribute to the passive electrical properties of myelinated nerve fibers and actively regulate the polarized distribution of ion channels along axons. Despite their importance, relat...

journal_title：Journal of neuroscience research

authors： Ogawa Y,Rasband MN

更新日期：2009-11-15 00:00:00

abstract：:Cisplatin is a highly effective chemotherapeutic agent but with significant ototoxic side effects. Apoptosis is an important mechanism of cochlear hair cell loss following exposure to an ototoxic level of cisplatin. The present study investigated the effects of the cannabinoid receptor 2 (CB2) ligand JWH-015 on cispla...

journal_title：Journal of neuroscience research

authors： Jeong HJ,Kim SJ,Moon PD,Kim NH,Kim JS,Park RK,Kim MS,Park BR,Jeong S,Um JY,Kim HM,Hong SH

更新日期：2007-03-01 00:00:00

abstract：:An elevated expression of c-fos nuclear protooncogene (immediate early gene) has been shown repeatedly to correlate with long-term neuronal responses. This paper reviews recent data suggesting that neuronal plasticity, including learning and memory formation, may involve c-fos expression as well. On the basis of biolo...

journal_title：Journal of neuroscience research

authors： Kaczmarek L

更新日期：1993-03-01 00:00:00

abstract：:In a number of pathological states of the brain, the activation of the inducible nitric oxide synthase (iNOS) plays a major role. Interleukin (IL)-1beta is believed to be an essential factor in the induction of iNOS. However, little is known about the cascade of events culminating in iNOS expression in vivo. To identi...

journal_title：Journal of neuroscience research

authors： Hartlage-Rübsamen M,Lemke R,Schliebs R

更新日期：1999-08-01 00:00:00

abstract：:A frontal pole cDNA library from monkey (Macaca mulatta) brain was screened to identify mRNAs that are expressed more in frontal pole as compared to primary visual cortex. Three cDNA clones, whose greater expression was confirmed by Northern blot analysis, were identified as cytochrome oxidase (COX) subunits I, II, an...

journal_title：Journal of neuroscience research

authors： Chandrasekaran K,Stoll J,Giordano T,Atack JR,Matocha MF,Brady DR,Rapoport SI

更新日期：1992-07-01 00:00:00

abstract：:Remyelination of the central nervous system in multiple sclerosis patients is often incomplete. Remyelination depends on normal oligodendrogenesis and the differentiation of oligodendrocyte precursor cells (OPC) into mature oligodendrocytes (OL). Inhibitor of DNA binding (ID), a transcription factor, is thought to inh...

journal_title：Journal of neuroscience research

authors： Chen XS,Zhang YH,Cai QY,Yao ZX

更新日期：2012-05-01 00:00:00

abstract：:A study was conducted on the adsorption of 14C-ATP to a surface film of a hydrophobic protein derived from synaptic membranes isolated from bovine cerebellum. The adsorption of ATP to the protein film followed a rate law based on diffusion and an energy barrier to adsorption, the rate law being generally applicable to...

journal_title：Journal of neuroscience research

authors： Hoss W,Abood LG

更新日期：1976-01-01 00:00:00

abstract：:Fast oscillations at approximately 200 Hz, termed ripples, occur in the hippocampus and cortex of several species, including humans, and are thought to play a role in physiological (e.g., sensory information processing or memory consolidation) and pathological (e.g., seizures) processes. Blocking gamma-aminobutyric ac...

journal_title：Journal of neuroscience research

authors： D'Antuono M,de Guzman P,Kano T,Avoli M

更新日期：2005-04-01 00:00:00

abstract：:In order to study the voltage-dependent ion channels in microglia, and their possible modulation by pro-inflammatory substances like lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma) we employed the patch-clamp technique on purified rat microglial cell subcultures grown for 1 - 5 days in control condition or a...

journal_title：Journal of neuroscience research

authors： Visentin S,Agresti C,Patrizio M,Levi G

更新日期：1995-11-01 00:00:00

abstract：:Gamma-Aminobutyric acid (GABA) is the principal inhibitory neurotransmitter in the brain. A deficiency of GABAergic inhibition mediated via the GABAA receptor complex has for a long time been suspected to be a central factor in epileptogenesis. Status epilepticus is a condition of sustained and prolonged excitation of...

journal_title：Journal of neuroscience research

authors： Karle J,Woldbye DP,Elster L,Diemer NH,Bolwig TG,Olsen RW,Nielsen M

更新日期：1998-12-15 00:00:00

abstract：:Cytomegalovirus (CMV) is a major cause of congenital brain disease, and its neuropathogenesis may be related to viral infection of rapidly dividing, susceptible neural precursor cells (NPCs). In the present study, we evaluated the susceptibility of human fetal brain-derived NPCs (nestin(+), A2B5(+), CD133(+)) to infec...

journal_title：Journal of neuroscience research

authors： Cheeran MC,Hu S,Ni HT,Sheng W,Palmquist JM,Peterson PK,Lokensgard JR

更新日期：2005-12-15 00:00:00

abstract：:We studied the postischemic alterations of second messenger and receptor systems focusing on the strionigral pathway in order to clarify the mechanism of the delayed neuronal changes in remote areas of the rat brain after transient focal ischemia. Chronological changes of [3H]forskolin and [3H]SCH 23390 binding sites ...

journal_title：Journal of neuroscience research

authors： Nagasawa H,Araki T,Kogure K

更新日期：1992-11-01 00:00:00

abstract：:Several neurological diseases involve focal injury of specific brain structures. Poisons of the electron transport chain complexes (ETCC) can also produce selective injury of brain structures when given systemically and have been implicated in the development of neurological disease. Why ETCC poisons damage particular...

journal_title：Journal of neuroscience research

authors： Fern R

更新日期：2003-03-15 00:00:00

abstract：:Toll-like receptors (TLRs) play an essential role in initiating intracellular type I interferon (IFN)-mediated innate immunity against viral infections. We examined whether human neuronal cells (primary human neurons, NT2-N and CHP-212 cells) express TLRs and mount type I IFN-mediated innate immunity against herpes si...

journal_title：Journal of neuroscience research

authors： Zhou Y,Ye L,Wan Q,Zhou L,Wang X,Li J,Hu S,Zhou D,Ho W

更新日期：2009-10-01 00:00:00