Platelet-derived growth factor and regulation of Schwann cell proliferation in vivo.

abstract：:The role of the NT-3 has been implicated in the survival of progenitor oligodendrocytes in culture. The object of this study was to investigate the expression of the TrkC receptor and its responsiveness in glial cells. We report the expression of two TrkC receptor isoforms in rat primary oligodendrocyte cultures, a gl...

journal_title：Journal of neuroscience research

authors： Kumar S,de Vellis J

更新日期：1996-06-01 00:00:00

abstract：:Using subtype-specific Ca-channel blockers, we have characterised the voltage-sensitive Ca2+ currents as well as neurotransmitter release from cultured mouse cerebellar granule cells. The whole cell version of the patch clamp technique was adapted to monitor the isolated Ca-channel currents. The currents were activate...

journal_title：Journal of neuroscience research

authors： Varming T,Christopherson P,Schousboe A,Drejer J

更新日期：1997-04-01 00:00:00

abstract：:We report a study of the characterization of voltage-activated potassium (K+) currents in retinal ON bipolar cells in zebrafish. At single-channels levels, the open probability of the K+ channels increased when the membrane potential was increased. The maximal open proportion was 0.76+/-0.05 under our testing conditio...

journal_title：Journal of neuroscience research

authors： Yu CJ,Li L

更新日期：2005-11-01 00:00:00

abstract：:Rapsyn is a key molecule involved in the formation of postsynaptic specializations at the neuromuscular junction, in its absence there are both pre- and post-synaptic deficits including failure to cluster acetylcholine receptors. Recently we have documented increases in both nerve-muscle branching and numbers of moton...

journal_title：Journal of neuroscience research

authors： Bartlett SE,Banks GB,Reynolds AJ,Waters MJ,Hendry IA,Noakes PG

更新日期：2001-06-15 00:00:00

abstract：:A frontal pole cDNA library from monkey (Macaca mulatta) brain was screened to identify mRNAs that are expressed more in frontal pole as compared to primary visual cortex. Three cDNA clones, whose greater expression was confirmed by Northern blot analysis, were identified as cytochrome oxidase (COX) subunits I, II, an...

journal_title：Journal of neuroscience research

authors： Chandrasekaran K,Stoll J,Giordano T,Atack JR,Matocha MF,Brady DR,Rapoport SI

更新日期：1992-07-01 00:00:00

abstract：:A study was conducted on the adsorption of 14C-ATP to a surface film of a hydrophobic protein derived from synaptic membranes isolated from bovine cerebellum. The adsorption of ATP to the protein film followed a rate law based on diffusion and an energy barrier to adsorption, the rate law being generally applicable to...

journal_title：Journal of neuroscience research

authors： Hoss W,Abood LG

更新日期：1976-01-01 00:00:00

abstract：:The effects of bilateral lesions of the ventral noradrenergic bundle (VNA) were studied in male rats. In contrast to data reported by others, hyperphagia and obesity were not observed following VNA lesions. Indeed, except for a depression during the first three postoperative days, food intake (FI) of the VNA lesioned ...

journal_title：Journal of neuroscience research

authors： Bellinger LL,Bernardis LL,Goldman JK

更新日期：1976-01-01 00:00:00

abstract：:Neuroadaptations in the nucleus accumbens (NAc) are associated with the development of drug addiction. Plasticity in synaptic strength and intrinsic excitability of NAc medium spiny neurons (MSNs) play critical roles in addiction induced by different classes of abused drugs. However, it is unknown whether morphine exp...

journal_title：Journal of neuroscience research

authors： Wu X,Shi M,Wei C,Yang M,Liu Y,Liu Z,Zhang X,Ren W

更新日期：2012-06-01 00:00:00

abstract：:Antiglycolipid IgM antibodies are known to induce formation of "wide spaced" or "expanded" myelin, a distinctive form of dysmyelination characterized by a repeat period approximately two or three times normal, which is seen also in diseases, including multiple sclerosis. To determine whether an antibody directed again...

journal_title：Journal of neuroscience research

authors： Rosenbluth J,Schiff R

更新日期：2009-03-01 00:00:00

abstract：:In the striatum, dopamine (DA) exerts a major modulatory influence on voltage- and ligand-gated currents. Previously we have shown that DA modulates glutamatergic neurotransmission and that the direction of this modulation depends on, among other factors, the glutamate and DA receptor subtypes activated. These effects...

journal_title：Journal of neuroscience research

authors： Liu JC,DeFazio RA,Espinosa-Jeffrey A,Cepeda C,de Vellis J,Levine MS

更新日期：2004-05-01 00:00:00

abstract：:The molecular pathways underlying the neuroprotective effects of preconditioning are promising, potentially drugable targets to promote cell survival. However, these pathways are complex and are not yet fully understood. In this study we have established a paradigm of hypoxic preconditioning based on a chick embryo mo...

journal_title：Journal of neuroscience research

authors： Giusti S,Fiszer de Plazas S

更新日期：2012-02-01 00:00:00

abstract：:The close homologue of L1 (CHL1) is a member of the L1 family of cell recognition molecules. The protein is expressed by a variety of nerve cell types and subpopulations of glial cells in vivo and promotes elongation of neurites and survival of nerve cells in vitro. Here we demonstrate that glial cells up-regulate exp...

journal_title：Journal of neuroscience research

authors： Rolf B,Lang D,Hillenbrand R,Richter M,Schachner M,Bartsch U

更新日期：2003-03-15 00:00:00

abstract：:To determine whether one or more opioid receptor types might be preferentially involved in gliogenesis, primary mixed glial cultures derived from mouse cerebra were continuously treated with varying concentrations of opioid agonists selective for mu (mu), i.e., DAGO ([D-Ala2, MePhe4, Gly(ol)5]enkephalin), delta (delta...

journal_title：Journal of neuroscience research

authors： Stiene-Martin A,Hauser KF

更新日期：1991-08-01 00:00:00

abstract：:Multiple neurodegenerative disorders are associated with altered mitochondrial bioenergetics. Although mitochondrial O(2) consumption is frequently measured in isolated mitochondria, isolated synaptic nerve terminals (synaptosomes), or cultured cells, the absence of mature brain circuitry is a remaining limitation. He...

journal_title：Journal of neuroscience research

authors： Schuh RA,Clerc P,Hwang H,Mehrabian Z,Bittman K,Chen H,Polster BM

更新日期：2011-12-01 00:00:00

abstract：:The alpha subtype of the estrogen receptor (ERalpha) is present in nociceptive and parasympathetic regions of the adult rat spinal cord. The pattern of ERalpha expression in the rat spinal cord during development, however, is unknown. We used a polyclonal antibody (ER-21) to examine the expression of ERalpha in male r...

journal_title：Journal of neuroscience research

authors： Burke KA,Schroeder DM,Abel RA,Richardson SC,Bigsby RM,Nephew KP

更新日期：2000-08-01 00:00:00

abstract：:Forty-seven rats were cannulated permanently in either the globus pallidus or neostriatum and subsequently injected with carbachol, scopolamine, or carbachol plus scopolamine. The injection of carbachol (1 mug) into the globus pallidus produced transient hyperkinetic phasic dyskinesias (84%) followed in some cases by ...

journal_title：Journal of neuroscience research

authors： Springer P,Dill RE

更新日期：1975-01-01 00:00:00

abstract：:The G protein-coupled muscarinic acetylcholine receptor (mAChR) isoforms have been identified in neural stem/progenitor (or precursor) cells. In previous studies, activation of these receptors induced elevations in intracellular Ca(2+) signals and mitogen-activated protein (MAP) kinase activity that led to enhanced DN...

journal_title：Journal of neuroscience research

authors： Zhao WQ,Alkon DL,Ma W

更新日期：2003-05-01 00:00:00

abstract：:Taurine, 2-aminoethanesulfonic acid, is present at high concentrations in many invertebrate and vertebrate systems and has several biological functions. In addition, it has been related to a neuroprotective role against several diseases such as epilepsy. In the present work, we treated mice with taurine and examined i...

journal_title：Journal of neuroscience research

authors： Junyent F,Romero R,de Lemos L,Utrera J,Camins A,Pallàs M,Auladell C

更新日期：2010-01-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a late-onset progressive neurodegenerative disease affecting motor neurons. About 2% of patients with the disease are associated with mutations in the gene encoding Cu/Zn superoxide dismutase (SOD1). The purpose of this study is to assess the effect of rosemary extract and its ma...

journal_title：Journal of neuroscience research

authors： Shimojo Y,Kosaka K,Noda Y,Shimizu T,Shirasawa T

更新日期：2010-03-01 00:00:00

abstract：:During late postnatal development, mice with the autosomal recessive wobbler mutation (wr/wr) develop motoneuron degeneration associated with astrogliosis in the spinal cord. In vitro, primary wobbler astrocytes are also affected, exhibiting abnormal cell-cell contacts. To characterize further the wobbler disease, we ...

journal_title：Journal of neuroscience research

authors： Aït-Ikhlef A,Hantaz-Ambroise D,Henderson CE,Rieger F

更新日期：2000-01-01 00:00:00

abstract：:Previous studies have shown that the mechanical wounding of 3-week-old cultured rat astrocytes results in cell proliferation and hypertrophy resembling astrocyte responses to a brain injury in vivo. We now report the effects of basic fibroblast growth factor (bFGF) and an anti-bFGF antibody on astrocyte morphology, pr...

journal_title：Journal of neuroscience research

authors： Hou YJ,Yu AC,Garcia JM,Aotaki-Keen A,Lee YL,Eng LF,Hjelmeland LJ,Menon VK

更新日期：1995-02-15 00:00:00

abstract：:We have recently reported a potent mitogenic stimulation of oligodendroglial (OL) progenitors by the protein kinase C (PKC) activating phorbol ester, i.e., phorbol 12-myristate 13-acetate (PMA) (Bhat NR, J Neurosci Res 22:20-27, 1989). The present study deals with PMA-induced protein phosphorylation reactions in cultu...

journal_title：Journal of neuroscience research

authors： Bhat NR

更新日期：1991-10-01 00:00:00

abstract：:The effects of the environmental contaminants methylmercury (MeHg) and inorganic mercury (HgCl(2)) on cell viability, intracellular calcium concentration ([Ca(2+)](i)), and reactive oxygen species (ROS) generation were studied in rat cerebellar granule neuron cultures using fluorescent methods. MeHg exhibited an LC(50...

journal_title：Journal of neuroscience research

authors： Gassó S,Cristòfol RM,Selema G,Rosa R,Rodríguez-Farré E,Sanfeliu C

更新日期：2001-10-01 00:00:00

abstract：:Niemann-Pick C (NPC) disease is an autosomal recessive lipidosis characterized by lysosomal accumulations of unesterified cholesterol. Cultured NPC cells exhibit a defect in the intracellular trafficking of LDL-derived cholesterol that leads to lysosomal accumulations of unesterified cholesterol. We found in a prelimi...

journal_title：Journal of neuroscience research

authors： Goodrum JF,Pentchev PG

更新日期：1997-08-01 00:00:00

abstract：:The incubation of murine thymocytes for 24 hr in the presence of cholinergic agonists induces selective proliferation of PNA- cells as measured by thymidine incorporation. The response of PNA- cells is mediated by the activation of nicotinic receptors. This conclusion is suggested by the inability of the muscarinic ag...

journal_title：Journal of neuroscience research

authors： Rossi A,Tria MA,Baschieri S,Doria G,Frasca D

更新日期：1989-11-01 00:00:00

abstract：:The high circulating levels of leptin in neonatal rodents do not seem to be regulating energy balance at this age, but rather may play an important role for brain development. We tested the hypothesis that high neonatal leptin levels modify hippocampal function and production of synaptic proteins with possible long-te...

journal_title：Journal of neuroscience research

authors： Walker CD,Long H,Williams S,Richard D

更新日期：2007-03-01 00:00:00

abstract：:We suggest that a dysregulation of energy metabolism in the brain of genetic absence epilepsy rats from Strasbourg (GAERS) could create a specific cerebral environment that would favor the expression of spike-and-wave discharges (SWD) in the thalamocortical loop, largely dependent on glutamatergic and gamma-aminobutyr...

journal_title：Journal of neuroscience research

authors： Dufour F,Nalecz KA,Nalecz MJ,Nehlig A

更新日期：2001-12-01 00:00:00

abstract：:Data from a study in which 12 chronic mental patients and 12 control subject were given D-[3-14C] glucose intravenously in our arterio-venous technique for determining cerebral metabolism in vivo were reexamined. Previously unpublished whole-blood lactate determinations in these experiments indicated a cerebral produc...

journal_title：Journal of neuroscience research

authors： Sacks W,Schechter DC,Sacks S

更新日期：1981-01-01 00:00:00

abstract：:The osteoinductive capacity of biological noncellular material has been widely recognized. Studies using bone morphogenetic proteins and acellular bone matrix demonstrate that host mesenchymal cells can be readily transformed into osteoprogenitor cells. The current study sought to determine whether another biological ...

journal_title：Journal of neuroscience research

authors： Carpenter EM,Llamas C,Buck BE,Malinin TI

更新日期：2015-03-01 00:00:00

abstract：:Sympathetic noradrenergic nerve fibers, stained with antiserum for tyrosine hydroxylase (TH), richly innervate the splenic white pulp. These fibers distribute with the vascular and trabecular systems, and associate mainly with the central artery and its branches, the periarteriolar lymphatic sheath (PALS), the margina...

journal_title：Journal of neuroscience research

authors： Felten DL,Ackerman KD,Wiegand SJ,Felten SY

更新日期：1987-01-01 00:00:00