Rab7 may be a novel therapeutic target for neurologic diseases as a key regulator in autophagy.

abstract：:Anorexia nervosa (AN) is a severe and complex psychiatric disorder characterized by intense fear about weight gain and finalized to food-related control behaviors. Growing interest has been demonstrated about neurobiological processes subtend to AN physiopathology. The present review aimed to collect neurostructural a...

journal_title：Journal of neuroscience research

authors： Alfano V,Mele G,Cotugno A,Longarzo M

更新日期：2020-11-01 00:00:00

abstract：:The use of progesterone following brain injury has a controversial history. On one hand, some lab-based models have showed progesterone as being neuroprotective, but on the other, clinical trials have showed quite the opposite. One of many complaints that arose from this discrepancy was the lack of a diverse pool of a...

journal_title：Journal of neuroscience research

authors： Blackshear K,Giessner S,Hayden JP,Duncan KA

更新日期：2018-04-01 00:00:00

abstract：:Protein kinase C (PKC) and its potential role in myelin gene expression were investigated in primary cultured rat oligodendrocytes. The major myelin genes were expressed in a developmentally coordinated manner in cultured oligodendrocytes. PKC activity in these cells was similarly regulated with differential expressio...

journal_title：Journal of neuroscience research

authors： Asotra K,Macklin WB

更新日期：1993-04-01 00:00:00

abstract：:The aim of the present study was to prepare cultures enriched in type-2 astrocytes (AS) and to analyze some of the properties of these cells over relatively long culture periods. Cultures enriched in type-2 AS were obtained by subculturing, at low cell density and in the presence of fetal calf serum, a cell population...

journal_title：Journal of neuroscience research

authors： Aloisi F,Agresti C,Levi G

更新日期：1988-10-01 00:00:00

abstract：:The effects of hyposmotic conditions on taurine uptake and release were studied in mice cultured cerebellar granule cells. The effect of DIDS (4,4'-diisothiocyanatostilbene-2,2'-disulfonate) and of the divalent cations Mg++ and Mn++ on the hyposmolarity-induced changes in these parameters was investigated. Mg++ (20 mM...

journal_title：Journal of neuroscience research

authors： Schousboe A,Sánchez Olea R,Morán J,Pasantes-Morales H

更新日期：1991-12-01 00:00:00

abstract：:NG2 chondroitin sulfate proteoglycan is a surface marker of oligodendroglial progenitor cells (OPCs) in various species. In contrast to well-studied rat OPCs, however, we found that purified mouse NG2 surface positive cells (NG2(+) cells) require additional activation of cyclic AMP (cAMP) signaling for survival in a m...

journal_title：Journal of neuroscience research

authors： Horiuchi M,Lindsten T,Pleasure D,Itoh T

更新日期：2010-04-01 00:00:00

abstract：:Living organotypic cocultures of rat thalamic and cortical explants were used to examine the effects of blocking action potential activity on the morphological development of axons in the mammalian neocortex. Studies in vivo have suggested that blocking sodium channel-dependent activity influences the growth character...

journal_title：Journal of neuroscience research

authors： Wilkemeyer MF,Angelides KJ

更新日期：1996-03-15 00:00:00

abstract：:A series of major and minor ganglioside species were isolated from a single human adult brain and analyzed for their lipophilic composition. Hematosides, GM3 and GD3, each showing double bands on thin-layer chromatograms, were separated into the upper band and lower band fractions to be analyzed for the heterogeneity ...

journal_title：Journal of neuroscience research

authors： Ando S,Yu RK

更新日期：1984-01-01 00:00:00

abstract：:This study examined the growth of basal plate explants from 40-hr chick embryos containing the trigeminal motor nucleus in the presence of target muscle-conditioned medium (MCM) from day-4, day-10, and day-18 embryos. We had previously found that MCM derived from the 4-day target tissue enhanced neurite outgrowth from...

journal_title：Journal of neuroscience research

authors： Heaton MB

更新日期：1988-01-01 00:00:00

abstract：:Preterm birth results in significant cognitive and motor disabilities, but recent evidence suggests that there is variable recovery over time. One possibility that may explain this variable recovery entails variable neurogenic responses in the subventricular zone (SVZ) following the period of chronic hypoxia experienc...

journal_title：Journal of neuroscience research

authors： Li Q,Michaud M,Stewart W,Schwartz M,Madri JA

更新日期：2008-05-01 00:00:00

abstract：:The GTP binding proteins Rhes and AGS1/Dexras1 define a subfamily of the Ras superfamily and have been shown to affect signaling by G-protein-coupled receptors. We tested the effects of both proteins at an early stage of signaling by dopamine receptors, activation of adenylyl cyclase. Rhes decreased dopamine D1 recept...

journal_title：Journal of neuroscience research

authors： Harrison LM,He Y

更新日期：2011-06-01 00:00:00

abstract：:Mitochondrial dysfunction has been implicated in cell death in many neurodegenerative diseases. Diminished activity of the alpha-ketoglutarate dehydrogenase complex (KGDHC), a key and arguably rate-limiting enzyme of the Krebs cycle, occurs in these disorders and may underlie decreased brain metabolism. The present st...

journal_title：Journal of neuroscience research

authors： Huang HM,Ou HC,Xu H,Chen HL,Fowler C,Gibson GE

更新日期：2003-10-15 00:00:00

abstract：:Tungstate treatment increases the phosphorylation of glycogen synthase kinase-3beta (GSK3beta) at serine 9, which triggers its inactivation both in cultured neural cells and in vivo. GSK3 phosphorylation is dependent on the activation of extracellular signal-regulated kinases 1/2 (ERK1/2) induced by tungstate. As a co...

journal_title：Journal of neuroscience research

authors： Gómez-Ramos A,Domínguez J,Zafra D,Corominola H,Gomis R,Guinovart JJ,Avila J

更新日期：2006-02-01 00:00:00

abstract：:Relationships among different intensities of electroshock treatment (EST), EEG-recordable primary after discharge (PAD), and beta-adrenergic binding in various brain regions were investigated in adult rats. Different intensities of EST (1-2, 6-8, 20-30 mamp) were applied through ear-clip electrodes for 7 consecutive d...

journal_title：Journal of neuroscience research

authors： Perumal AS,Barkai AI

更新日期：1982-01-01 00:00:00

abstract：:An experimental model based on kainic acid (KA) injections replicates many phenomenological features of human temporal lobe epilepsy, the most common type of epilepsy in adults. Taurine, 2-aminoethanesulfonic acid, present in high concentrations in many invertebrate and vertebrate systems, is believed to serve several...

journal_title：Journal of neuroscience research

authors： Junyent F,Utrera J,Romero R,Pallàs M,Camins A,Duque D,Auladell C

更新日期：2009-05-01 00:00:00

abstract：:Sildenafil, given shortly before 3,4-methylenedioxymethamphetamine (MDMA), affords protection against 5-hydroxytryptamine (5-HT) depletions caused by this amphetamine derivative by an acute preconditioning-like mechanism. Because acute and delayed preconditionings do not share the same mechanisms, we investigated whet...

journal_title：Journal of neuroscience research

authors： Puerta E,Barros-Miñones L,Hervias I,Gomez-Rodriguez V,Orejana L,Pizarro N,de la Torre R,Jordán J,Aguirre N

更新日期：2012-02-01 00:00:00

abstract：:The neurotrophin receptor p75 (p75NTR) is expressed by both neurons and glia. Nerve injury triggers up-regulation of p75NTR in Schwann cells (SC) but not in central glia. In contrast to neuronal p75NTR, which mediates negative signals from myelin-associated proteins resulting in neurite collapse, glial p75NTR may play...

journal_title：Journal of neuroscience research

authors： Zhou XF,Li HY

更新日期：2007-06-01 00:00:00

abstract：:Brain cathepsin D, purified by affinity chromatography on Sepharose pepstatin columns, was incubated with synthetic peptides corresponding to the susceptible regions of the myelin basic protein encompassing the two Phe-Phe bonds. One peptide, Leu-Gly-Arg-Phe-Phe-Gly-Gly, was cleaved by cathepsin D at the Phe-Phe bond ...

journal_title：Journal of neuroscience research

authors： Marks N,Benuck M,Hashim G

更新日期：1980-01-01 00:00:00

abstract：:We previously demonstrated that a synthetic retinoic acid receptor agonist, Am80, attenuated intracerebral hemorrhage (ICH)-induced neuropathological changes and neurological dysfunction. Because inflammatory events are among the prominent features of ICH pathology that are affected by Am80, this study investigated th...

journal_title：Journal of neuroscience research

authors： Matsushita H,Hijioka M,Ishibashi H,Anan J,Kurauchi Y,Hisatsune A,Seki T,Shudo K,Katsuki H

更新日期：2014-08-01 00:00:00

abstract：:Target ablation by olfactory bulbectomy synchronizes the degenerative cell death of olfactory receptor neurons (ORNs), infiltration of macrophages, and proliferation of progenitor cells, leading to neurogenesis, ORN replacement, and regeneration of the sensory epithelium. Although macrophages participate in the degene...

journal_title：Journal of neuroscience research

authors： Getchell TV,Subhedar NK,Shah DS,Hackley G,Partin JV,Sen G,Getchell ML

更新日期：2002-12-15 00:00:00

abstract：:The role of the plasmin-generating system, a serum component, in the development of dissociated embryonic chick spinal cord cells in culture was studied. Studies were performed in a defined system where the cells were maintained in a serum-free medium. Under these conditions the cells produce plasminogen activator. It...

journal_title：Journal of neuroscience research

authors： Kalderon N

更新日期：1982-01-01 00:00:00

abstract：:Rapsyn is a protein that interacts with the cytoplasmic face of the nicotinic acetylcholine receptors (AChR) to cluster them within postsynaptic membrane of muscle. Here we show that intracellular AChRs are also affected by rapsyn. When rapsyn was co-transfected with AChR into QT-6 fibroblasts, (125)I-alpha-bungarotox...

journal_title：Journal of neuroscience research

authors： Han H,Yang SH,Phillips WD

更新日期：2000-04-15 00:00:00

abstract：:Microtubule-associated protein (MAP)1B-heterozygous (MAP1B+/-) mice are deficient in the expression of MAP1B in the hippocampus, cerebellum, and olfactory cortex. Although MAP1B+/- mice showed half the normal levels of MAP1B protein, they had no measurable amounts of phosphorylated MAP1B. High-frequency theta burst st...

journal_title：Journal of neuroscience research

authors： Zervas M,Opitz T,Edelmann W,Wainer B,Kucherlapati R,Stanton PK

更新日期：2005-10-01 00:00:00

abstract：:Peroxides are generated continuously in cells that consume oxygen. Among the different peroxides, hydrogen peroxide is the molecule that is formed in highest quantities. In addition, organic hydroperoxides are synthesized as products of cellular metabolism. Generation and disposal of peroxides is a very important proc...

journal_title：Journal of neuroscience research

authors： Dringen R,Pawlowski PG,Hirrlinger J

更新日期：2005-01-01 00:00:00

abstract：:In order to better characterize the presynaptic GABA receptors regulating glutamate release in the cerebellum [Levi and Gallo, 1981], a number of GABA agonists and GABA transport inhibitors were tested for their ability to potentiate the depolarization-induced release of the glutamate analog D-[3H]aspartate from super...

journal_title：Journal of neuroscience research

authors： Aloisi F,Gallo V,Levi G

更新日期：1983-01-01 00:00:00

abstract：:Ex vivo gene therapy is emerging as a promising approach for the treatment of neurodegenerative diseases and central nervous system (CNS) trauma. We have shown previously that human adult astrocytes can be expanded in vitro and can express various therapeutic transgenes (Ridet et al. [1999] Hum. Gene Ther. 10:271-280;...

journal_title：Journal of neuroscience research

authors： Ridet JL,Sarkis C,Serguera C,Zennou V,Charneau P,Mallet J

更新日期：2003-06-15 00:00:00

abstract：:α-Synuclein (α-syn) is the major component of pathological inclusions characteristic of several neurodegenerative disorders, such as Parkinson's disease. The major posttranslational modification of α-syn is phosphorylation at S129, and previous studies estimate that approximately 90% of α-syn in proteinaceous, patholo...

journal_title：Journal of neuroscience research

authors： Waxman EA,Giasson BI

更新日期：2011-02-01 00:00:00

abstract：:Neural stem cells (NSCs) have great potential as a therapeutic tool for the repair of a number of CNS disorders. NSCs can either be isolated from embryonic and adult brain tissue or be induced from both mouse and human ES cells. These cells proliferate in vitro through many passages without losing their multipotential...

journal_title：Journal of neuroscience research

authors： Cao Q,Benton RL,Whittemore SR

更新日期：2002-06-01 00:00:00

abstract：:The subcellular targeting of mRNAs encoding myelin proteins to the oligodendrocyte processes is an accepted fact in myelin formation. How these messengers are kept silent during their movement to the subcellular domain where they are turned on remains a mystery. This review focuses on aspects of mRNA targeting and spe...

journal_title：Journal of neuroscience research

authors： Boccaccio GL

更新日期：2000-11-15 00:00:00

abstract：:Our previous work indicated that in E14 embryonic rat spinal cord cultures ciliary neuronotrophic factor (CNTF) exerted (1) a survival-promoting effect on motor neurons and on a large population of unidentified neurons, and (2) a regulatory role on the expression of ChAT and low affinity NGF receptor (LNGFR) in a popu...

journal_title：Journal of neuroscience research

authors： Magal E,Burnham P,Varon S

更新日期：1991-11-01 00:00:00