Addition of tetrodotoxin alters the morphology of thalamocortical axons in organotypic cocultures.

abstract：:In a military setting, traumatic brain injury (TBI) is frequently caused by blast waves that can trigger a series of neuronal biochemical changes. Although many animal models have been used to study the effects of primary blast waves, elucidating the mechanisms of damage in a whole-animal model is extremely complex. I...

journal_title：Journal of neuroscience research

authors： Zander NE,Piehler T,Boggs ME,Banton R,Benjamin R

更新日期：2015-09-01 00:00:00

abstract：:Although both cytokines and chemokines have been implicated in the pathogenesis of clinical and histological EAE, their interactions in vivo have not yet been clearly established. To address this issue, we evaluated expression of chemokines and receptors in the CNS of wild-type control and cytokine deficient mice at t...

journal_title：Journal of neuroscience research

authors： Matejuk A,Dwyer J,Ito A,Bruender Z,Vandenbark AA,Offner H

更新日期：2002-03-01 00:00:00

abstract：:Myelin-associated glycoprotein (MAG) is expressed on the innermost myelin membrane wrap, directly apposed to the axon surface. Although it is not required for myelination, MAG enhances long-term axon-myelin stability, helps to structure nodes of Ranvier, and regulates the axon cytoskeleton. In addition to its role in ...

journal_title：Journal of neuroscience research

authors： Schnaar RL,Lopez PH

更新日期：2009-11-15 00:00:00

abstract：:Neuron-glia interactions at paranodal junctions play important roles in action potential propagation. Among their many functions, they contribute to the passive electrical properties of myelinated nerve fibers and actively regulate the polarized distribution of ion channels along axons. Despite their importance, relat...

journal_title：Journal of neuroscience research

authors： Ogawa Y,Rasband MN

更新日期：2009-11-15 00:00:00

abstract：:Spinocerebellar ataxia type 17 (SCA17) is a type of autosomal dominant cerebellar ataxia (ADCA) characterized by variable manifestations, including cerebellar ataxia, dementia, and psychiatric symptoms. Since the identification of a CAG repeat expansion in the TATA-box binding protein (TBP) gene in a patient with atax...

journal_title：Journal of neuroscience research

authors： Cui Y,Yang S,Li XJ,Li S

更新日期：2017-08-01 00:00:00

abstract：:Primary fibroblasts initiated from skin biopsies of Wistar rats were transfected with a plasmid that encodes the human growth hormone and the neomycin resistance genes. Cell clones selected for G418 resistance and expressing high levels of human growth hormone were propagated in vitro and subsequently transplanted int...

journal_title：Journal of neuroscience research

authors： Doering LC,Chang PL

更新日期：1991-07-01 00:00:00

abstract：:The demyelinative potential of the cytokines interleukin-1 alpha (IL-1 alpha), interferon-gamma (IFN-gamma), and tumor necrosis factor-alpha (TNF-alpha) has been investigated in myelinating aggregate brain cell cultures. Treatment of myelinated cultures with these cytokines resulted in a reduction in myelin basic prot...

journal_title：Journal of neuroscience research

authors： Loughlin AJ,Honegger P,Woodroofe MN,Comte V,Matthieu JM,Cuzner ML

更新日期：1994-04-01 00:00:00

abstract：:We report a study of the characterization of voltage-activated potassium (K+) currents in retinal ON bipolar cells in zebrafish. At single-channels levels, the open probability of the K+ channels increased when the membrane potential was increased. The maximal open proportion was 0.76+/-0.05 under our testing conditio...

journal_title：Journal of neuroscience research

authors： Yu CJ,Li L

更新日期：2005-11-01 00:00:00

abstract：:Accumulating evidence points to roles for oxidative stress, amyloid beta (Aβ), and mitochondrial dysfunction in the pathogenesis of Alzheimer's disease (AD). In neurons, the base excision repair pathway is the predominant DNA repair (BER) pathway for repairing oxidized base lesions. Apurinic/apyrimidinic endonuclease ...

journal_title：Journal of neuroscience research

authors： Kaur N,Dhiman M,Perez-Polo JR,Mantha AK

更新日期：2015-06-01 00:00:00

abstract：:Clusterin (apolipoprotein J) is a highly conserved, multifunctional, vertebrate glycoprotein. Several isoforms of clusterin have been described including the predominant secreted isoform (sCLU) and several nuclear isoforms (nCLU) associated with cell death. sCLU has been shown to bind a variety of partly unfolded, str...

journal_title：Journal of neuroscience research

authors： Carreras I,Garrett-Young R,Ullman MD,Eisenhauer PB,Fine RE,Wells JM,Conn KJ

更新日期：2005-02-15 00:00:00

abstract：:Although gangliosides have been reported to enhance recovery from 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced lesions of the substantia nigra, evidence as to whether the administered gangliosides actually reach this or any other site of lesion in the central nervous system (CNS) at which they putativel...

journal_title：Journal of neuroscience research

authors： Saulino MF,Schengrund CL

更新日期：1994-02-15 00:00:00

abstract：:Tungstate treatment increases the phosphorylation of glycogen synthase kinase-3beta (GSK3beta) at serine 9, which triggers its inactivation both in cultured neural cells and in vivo. GSK3 phosphorylation is dependent on the activation of extracellular signal-regulated kinases 1/2 (ERK1/2) induced by tungstate. As a co...

journal_title：Journal of neuroscience research

authors： Gómez-Ramos A,Domínguez J,Zafra D,Corominola H,Gomis R,Guinovart JJ,Avila J

更新日期：2006-02-01 00:00:00

abstract：:The galactolipids galactocerebroside and sulfatide have been implicated in oligodendrocyte (OL) development and myelin formation. Much of the early evidence for myelin galactolipid function has been derived from antibody and chemical perturbation of OLs in vitro. To determine the role of these lipids in vivo, we previ...

journal_title：Journal of neuroscience research

authors： Shroff SM,Pomicter AD,Chow WN,Fox MA,Colello RJ,Henderson SC,Dupree JL

更新日期：2009-11-15 00:00:00

abstract：:Two clones encoding human glial fibrillary acidic protein (GFAP) were isolated from a human astrocytoma cDNA library. The clones pHGFAP1 and pHGFAP2 were selected by the combined use of differential colony hybridization and hybridization-selection technique with polyclonal anti GFAP antiserum. The longer one, pHGFAP1,...

journal_title：Journal of neuroscience research

authors： Rataboul P,Faucon Biguet N,Vernier P,De Vitry F,Boularand S,Privat A,Mallet J

更新日期：1988-01-01 00:00:00

abstract：:Synaptic circuitry in the upper dorsal horn, disorganized due to transganglionic degenerative atrophy (evoked by blockade of retrograde axoplasmic transport in the related peripheral nerve), begins to be reestablished by a process of regenerative synaptoneogenesis as soon as retrograde transport is resumed. Central ax...

journal_title：Journal of neuroscience research

authors： Knyihár-Csillik E,Kreutzberg GW,Csillik B

更新日期：1989-01-01 00:00:00

abstract：:In order to study the voltage-dependent ion channels in microglia, and their possible modulation by pro-inflammatory substances like lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma) we employed the patch-clamp technique on purified rat microglial cell subcultures grown for 1 - 5 days in control condition or a...

journal_title：Journal of neuroscience research

authors： Visentin S,Agresti C,Patrizio M,Levi G

更新日期：1995-11-01 00:00:00

abstract：:This study examined the growth of basal plate explants from 40-hr chick embryos containing the trigeminal motor nucleus in the presence of target muscle-conditioned medium (MCM) from day-4, day-10, and day-18 embryos. We had previously found that MCM derived from the 4-day target tissue enhanced neurite outgrowth from...

journal_title：Journal of neuroscience research

authors： Heaton MB

更新日期：1988-01-01 00:00:00

abstract：:Brain slices obtained from young rats were incubated with different radioactive precursors, in the presence and absence of L-cycloserine (an inhibitor of the synthesis of sphingosine) in order to explore the possibility that transport of proteolipids--and specifically of the major myelin proteolipid PLP--to the myelin...

journal_title：Journal of neuroscience research

authors： Pasquini JM,Guarna MM,Besio-Moreno MA,Iturregui MT,Oteiza PI,Soto EF

更新日期：1989-03-01 00:00:00

abstract：:Polychlorinated biphenyls (PCBs) cause a wide spectrum of toxic effects in the brain through undefined mechanisms. Exposure to the PCB mixture Aroclor-1254 (A1254) increases the repressor element-1 silencing transcription factor (REST) expression, leading to neuronal death. This study sought to understand the sequence...

journal_title：Journal of neuroscience research

authors： Formisano L,Guida N,Laudati G,Boscia F,Esposito A,Secondo A,Di Renzo G,Canzoniero LM

更新日期：2015-01-01 00:00:00

abstract：:Bovine cerebrum, including the corpus callosum, and a human oligodendroglioma were investigated by an immunohistochemical technique to determine the distribution of 2':3'-cyclic nucleotide 3'-phosphodiesterase (CNP). Also, three human oligodendrogliomas (ODG) were characterized by an immunoblot procedure to identify a...

journal_title：Journal of neuroscience research

authors： Sheedlo HJ,Yaghmai F,Wolfe L 3rd,Sprinkle TJ

更新日期：1985-01-01 00:00:00

abstract：:The non-receptor protein tyrosine kinase Fyn, which is a member of the Src family of kinases, has been shown to be essential for normal myelination and has been suggested to play a role in oligodendrocyte development. However, oligodendrocyte development has not been studied directly in cells lacking Fyn. Additionally...

journal_title：Journal of neuroscience research

authors： Sperber BR,McMorris FA

更新日期：2001-02-15 00:00:00

abstract：:In order to identify the relative number of benzodiazepine (BZ) receptors in Purkinje and granule cells, the Purkinje cell degeneration (pcd) mutant mouse was used at different ages. In these mice, Purkinje cells have degenerated almost completely by 45-50 days of age. Granule cell loss occurs only later, and is most ...

journal_title：Journal of neuroscience research

authors： Vaccarino FM,Ghetti B,Wade SE,Rea MA,Aprison MH

更新日期：1983-01-01 00:00:00

abstract：:The expression of many myelin-specific molecules in Schwann cells is profoundly decreased following denervation. This study examines the early reexpression of myelin protein genes associated with reinnervation. Following sciatic nerve crush, the distal, regenerated nerve was divided into appropriate (2.5 or 5 mm) cons...

journal_title：Journal of neuroscience research

authors： Mitchell LS,Griffiths IR,Morrison S,Barrie JA,Kirkham D,McPhilemy K

更新日期：1990-10-01 00:00:00

abstract：:Leptin is a potent AMP kinase (AMPK) inhibitor that induces neuroprotection, neurogenesis, and angiogenesis when administered immediately after stroke. To dissociate these effects, we explored the effects of delayed administration of leptin, at 10 days after stroke onset, on neurogenesis and angiogenesis after stroke....

journal_title：Journal of neuroscience research

authors： Avraham Y,Dayan M,Lassri V,Vorobiev L,Davidi N,Chernoguz D,Berry E,Leker RR

更新日期：2013-02-01 00:00:00

abstract：:Pharmacological characterization of the action of the novel non-N-methyl-D-aspartate (non-NMDA) antagonist AMOA (2-amino-3-[3-(carboxymethoxy)-5-methylisoxazol-4-yl]propionate) on glutamate receptors was investigated in Xenopus oocytes injected with mouse brain mRNA. AMOA (150 microM) produced a nearly parallel shift ...

journal_title：Journal of neuroscience research

authors： Wahl P,Nielsen B,Krogsgaard-Larsen P,Hansen JJ,Schousboe A,Miledi R

更新日期：1992-11-01 00:00:00

abstract：:In this study, we examined the neuroprotective effect of standardized Bacopa monniera extract (BME: BESEB CDRI-08) against the D-galactose (D-gal)-induced brain aging in rats. Experimental groups were subjected to contextual-associative learning task. We found that the administration of BME in the D-gal-treated group ...

journal_title：Journal of neuroscience research

authors： Prisila Dulcy C,Singh HK,Preethi J,Rajan KE

更新日期：2012-10-01 00:00:00

abstract：:The pathogenic processing of the amyloid precursor protein (APP) into beta-amyloid peptides, which give rise to beta-amyloid plaques in the brains of Alzheimer's disease patients, requires the enzymatic activity of the beta-site APP-cleaving enzyme 1 (BACE1). We report the cloning and sequence of a 1.5-kb DNA fragment...

journal_title：Journal of neuroscience research

authors： Lange-Dohna C,Zeitschel U,Gaunitz F,Perez-Polo JR,Bigl V,Rossner S

更新日期：2003-07-01 00:00:00

abstract：:Taurine, 2-aminoethanesulfonic acid, is present at high concentrations in many invertebrate and vertebrate systems and has several biological functions. In addition, it has been related to a neuroprotective role against several diseases such as epilepsy. In the present work, we treated mice with taurine and examined i...

journal_title：Journal of neuroscience research

authors： Junyent F,Romero R,de Lemos L,Utrera J,Camins A,Pallàs M,Auladell C

更新日期：2010-01-01 00:00:00

abstract：:Efficient functioning of maintenance and repair processes seem to be crucial for both survival and physical quality of life. This is accomplished by a complex network of the so-called longevity assurance processes, under control of several genes termed vitagenes. These include members of the heat shock protein system,...

journal_title：Journal of neuroscience research

authors： Calabrese V,Ravagna A,Colombrita C,Scapagnini G,Guagliano E,Calvani M,Butterfield DA,Giuffrida Stella AM

更新日期：2005-02-15 00:00:00

abstract：:Tau microtubule-associated proteins are believed to play a role in regulation of the growth of neuronal processes. In order to study the function of tau protein in vivo, we examined the inhibition of tau expression in PC12 cells by exposing the cells to tau antisense oligodeoxynucleotides. A specific retraction of neu...

journal_title：Journal of neuroscience research

authors： Hanemaaijer R,Ginzburg I

更新日期：1991-09-01 00:00:00