Abstract：
:Although both cytokines and chemokines have been implicated in the pathogenesis of clinical and histological EAE, their interactions in vivo have not yet been clearly established. To address this issue, we evaluated expression of chemokines and receptors in the CNS of wild-type control and cytokine deficient mice at the peak of EAE induced with MOG-35-55 peptide in CFA. Our results demonstrate that: 1) expression of most chemokines/receptors was drastically inhibited in TNF-alpha deficient mice, and was reflective of delayed onset and reduced severity of EAE; 2) distinct patterns of chemokine expression occurred in various other cytokine knockout mice that did not significantly affect expression of clinical EAE; 3) there was a strong association between expression of MIP-1alpha, MIP-2 and MCP-1 in CNS and overall severity of EAE in wild-type and cytokine knockout mice; and 4) among CNS infiltrating cells at the peak of EAE, macrophages and CD8+ T cells were the primary cellular source of most of the chemokines. Of note, we present evidence that TNF-alpha may be involved in regulating RANTES and MIP-1alpha, and that IL-4 may be involved in regulating MCP-1. Our results not only identify the cellular source of chemokines in CNS, but also implicate MIP-1alpha, MIP-2, and MCP-1 in controlling CNS inflammation and severity of EAE.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Matejuk A,Dwyer J,Ito A,Bruender Z,Vandenbark AA,Offner Hdoi
10.1002/jnr.10156keywords:
subject
Has Abstractpub_date
2002-03-01 00:00:00pages
680-8issue
5eissn
0360-4012issn
1097-4547pii
10.1002/jnr.10156journal_volume
67pub_type
杂志文章abstract：:Neuronal cell differentiation alterations induced by mutant presenilin 2 (PS2) were investigated in transgenic mice expressing wild-type or mutant-type PS2. Progressive increases in differentiation and marker protein expression were found in neuronal cells expressing wild-type PS2, whereas these processes were much pe...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.20655
更新日期：2005-11-15 00:00:00
abstract：:Cisplatin is a highly effective chemotherapeutic agent but with significant ototoxic side effects. Apoptosis is an important mechanism of cochlear hair cell loss following exposure to an ototoxic level of cisplatin. The present study investigated the effects of the cannabinoid receptor 2 (CB2) ligand JWH-015 on cispla...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.21168
更新日期：2007-03-01 00:00:00
abstract：:The presence of the apolipoprotein E (apoE) allele epsilon4 is a major risk factor for the development of Alzheimer's disease (AD); however, the molecular mechanism underlying the acceleration of AD development in individuals with epsilon4 remains to be determined. To investigate the isoform-specific effects of apoE o...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/(SICI)1097-4547(19981001)54:1<58::AID-JNR7
更新日期：1998-10-01 00:00:00
abstract：:Heat shock protein 60 (HSP60) and HSP10 are mitochondrial chaperonin proteins and are responsible for the folding of newly imported proteins and 13 polypeptides encoded by mitochondrial DNA. The expressions of HSP60 and HSP10 are regulated simultaneously because these genes are localized head to head on chromosome, se...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.21236
更新日期：2007-05-01 00:00:00
abstract：:The discharge behavior of neurons depends on a variable expression and sorting pattern of voltage-dependent potassium (Kv) channels that changes during development. The rodent retina represents a neuronal network whose main functions develop after birth. To obtain information about neuronal maturation we analyzed the ...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.21105
更新日期：2007-01-01 00:00:00
abstract：:Histology, immunohistochemistry, and Western blotting were used to characterize the changes in morphology, distribution pattern, and marker protein expression of striatal interneurons in the transition zone of striatal injury induced by 3-NP. The 3-NP treatment in rats yielded movement, motor coordination, and cogniti...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.22591
更新日期：2011-05-01 00:00:00
abstract：:Soluble oligomeric aggregates of the amyloid-beta (A beta) peptide are believed to be the most neurotoxic A beta species affecting the brain in Alzheimer disease (AD), a terminal neurodegenerative disorder involving severe cognitive decline underscored by initial synaptic dysfunction and later extensive neuronal death...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.22445
更新日期：2010-10-01 00:00:00
abstract：:Fibroblast growth factor 2 (FGF2) exhibits pleiotropic functions during embryogenesis. In neural development, both pro- and antineurogenic activities of FGF2 have been described in the differentiation of neuronal progenitors into postmitotic neurons. We used cultured neural stem cells (NSCs) derived from rat embryonic...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.20627
更新日期：2005-10-15 00:00:00
abstract：:Systemic osmotic homeostasis is regulated mainly by neuroendocrine system of arginine-vasopressin (AVP) in mammalians. In the present study, we demonstrated that the immunoreactivity of tissue plasminogen activator (tPA) was observed specifically at neurosecretory granules of AVP-positive magnocellular terminals and t...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.22370
更新日期：2010-07-01 00:00:00
abstract：:Human T-cell lymphotropic virus type I (HTLV-I) may infect up to 10% of peripheral blood T cells in patients with HTLV-I myelopathy. To examine the impact of HTLV-I infection on the abilities of T cells to present and respond to peptide antigen, we HTLV-I infected and subcloned a myelin basic protein peptide 84-102 (M...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/(SICI)1097-4547(19960915)45:6<786::AID-JNR
更新日期：1996-09-15 00:00:00
abstract：:A study was conducted on the adsorption of 14C-ATP to a surface film of a hydrophobic protein derived from synaptic membranes isolated from bovine cerebellum. The adsorption of ATP to the protein film followed a rate law based on diffusion and an energy barrier to adsorption, the rate law being generally applicable to...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490020109
更新日期：1976-01-01 00:00:00
abstract：:With the use of an antiserum directed against the human smooth muscle-associated protein 8 (SMAP8) fragment SMAP8(98-138), Western blot and immunohistochemical studies revealed SMAP8 expression in the rat brain. A band with a molecular size of about 45 kDa was detected in tissues from the rat hypothalamus and a weaker...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.21315
更新日期：2007-06-01 00:00:00
abstract：:The distribution of both tyrosine hydroxylase (TH) antigen and messenger RNA was investigated in the ventral mesencephalon from human brain using a 35S-labeled human TH cDNA probe and a polyclonal TH antibody. A hybridization signal was detected not only in the perikaryon but also in the neurites, most probably dendri...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490250415
更新日期：1990-04-01 00:00:00
abstract：:Pinealocytes of various mammalian species contain abundant synaptic-like microvesicles (SLMVs) which are considered the endocrine equivalent of neuronal synaptic vesicles. Although the pinealocytes may thus be a suitable cellular model for experimental in vitro studies of SLMVs, nothing is known about the presence of ...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/(sici)1097-4547(19970301)47:5<509::aid-jnr
更新日期：1997-03-01 00:00:00
abstract：:Oligodendrocytes generate and maintain myelin, which is essential for axonal function and protection of the mammalian central nervous system. To advance our molecular understanding of differentiation by these cells, we screened libraries of pharmacologically active compounds and identified inducers of differentiation ...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.22434
更新日期：2010-09-01 00:00:00
abstract：:The BM89 antigen, first identified in porcine brain by means of a monoclonal antibody, is a neuron-specific molecule widely distributed in the mammalian central and peripheral nervous system (Merkouri and Matsas: Neuroscience 50:53-68, 1992). Here we describe the purification of BM89 antigen from porcine and mouse bra...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：
更新日期：1997-06-15 00:00:00
abstract：:P0-glycoprotein, the major integral membrane protein of peripheral nerve myelin, is thought to mediate myelination and membrane interactions via its extracellular domain (P0-ED). Molecular modeling of P0-ED has suggested which of its amino acid side-chains may be involved in heterophilic and homophilic adhesions. We p...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/(SICI)1097-4547(19961115)46:4<502::AID-JNR
更新日期：1996-11-15 00:00:00
abstract：:Double immunofluorescence studies using antibodies against NF-L and peripherin revealed three distinct subpopulations of neurons in rat dorsal root ganglia (DRG). In the adult rat, 46% of the DRG neurons were small and peripherin-positive (NF-L-negative), and 48% were large and NF-L-positive (peripherin-negative). Abo...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490300111
更新日期：1991-09-01 00:00:00
abstract：:Physiological responses to acute stress proceed with the activation of the hypothalamus-pituitary-adrenal gland (HPA) system. Many brain regions are known to modulate the HPA axis activation in stress responses, but the detailed neural circuits and signaling system in the upstream of the HPA axis have to be explored f...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.22119
更新日期：2009-10-01 00:00:00
abstract：:Netrin-1 regulates axon extension during embryonic development and is expressed by neurons and myelinating oligodendrocytes in the adult CNS. To investigate the potential role of netrin-1 after spinal cord injury, we examined the expression of netrin-1 and netrin receptors after sagittal myelotomy in adult rats. This ...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.21070
更新日期：2006-12-01 00:00:00
abstract：:Cell transplantation offers a potential new treatment for stroke. Animal studies using models that produce ischemic damage in both the striatum and the frontal cortex have shown beneficial effects when hNT cells (postmitotic immature neurons) were transplanted into the ischemic striatum. In this study, we investigated...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.20800
更新日期：2006-05-01 00:00:00
abstract：:Microglia, the resident macrophages of the central nervous system, are the primary cells to respond to injury in the brain, both in inflammation, e.g., in multiple sclerosis, and trauma. Chemokines are potential mediators of microglial cell recruitment to sites of injury; thus, the ability of microglia to migrate in r...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/(SICI)1097-4547(19990101)55:1<17::AID-JNR3
更新日期：1999-01-01 00:00:00
abstract：:Pyruvate dehydrogenase complex (PDH) is a brain mitochondrial matrix enzyme. PDH impairment after stroke is particularly devastating given PDH's critical role in the link between anaerobic and aerobic metabolism. This study evaluates the restoration of oxidative metabolism and energy regulation with a therapeutic comb...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.23740
更新日期：2016-08-01 00:00:00
abstract：:Recent studies have revealed a significant decrease in white matter volume, including loss of myelin, with age but minimal decrease in gray matter volume (Guttmann et al., [1998] Neurology 50:972-978). Myelin is necessary for the rapid conduction of impulses along axons. Myelinated nerve includes various domains, the ...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.10386
更新日期：2002-11-01 00:00:00
abstract：:As it displays progressive hair-cell loss and degeneration of spiral ganglion neurons (SGNs) characterized by early-onset progressive hearing loss (ePHL), DBA/2J is an inbred mouse strain widely used in hearing research. Mouse nerve growth factor (mNGF), as a common exogenous nerve growth factor (NGF), has been studie...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.24056
更新日期：2017-10-01 00:00:00
abstract：:The cell line PC12, derived from a rat pheochromocytoma, has served as a model for studies on the mechanism of action of nerve growth factor, as well as for the exploration of neuronal differentiation in general. When treated with nanomolar concentrations of nerve growth factor, these neoplastic chromaffin-like cells ...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490280405
更新日期：1991-04-01 00:00:00
abstract：:Manganese (Mn) is an essential metal and plays an important role in the brain. To evaluate Mn uptake into the brain during development and aging, 54Mn concentrations in the brain of rats aged from 5 days to 95 weeks were measured after injection of 54MnCl2. 54Mn concentration in the brain of 5-day-old rats was the hig...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/(SICI)1097-4547(19990401)56:1<93::AID-JNR1
更新日期：1999-04-01 00:00:00
abstract：:In contrast to mammals, teleost fish are able to regrow severed long-range projection axons in the central nervous system (CNS), leading to recovery of function. The optic projection in teleost fish is used to study neuron-intrinsic and environmental molecular factors that determine successful axon regrowth and naviga...
journal_title：Journal of neuroscience research
pub_type： 杂志文章,评审
doi：10.1002/jnr.21121
更新日期：2007-09-01 00:00:00
abstract：:The brainstem nucleus of the solitary tract (NTS) is the key integrating relay in the central processing of sensory information from the thoracic and from most subdiaphragmatic viscera. Modulation of neuronal excitability and synaptic activity in the NTS by nicotinic agents can have potent effects on vital physiologic...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.23436
更新日期：2014-11-01 00:00:00
abstract：:Sexual differentiation of the brain occurs early in life as a result of sex-typical hormone action and sex chromosome effects. Immunocompetent cells are being recognized as underappreciated regulators of sex differences in brain and behavioral development, including microglia, astrocytes, and possibly other less well ...
journal_title：Journal of neuroscience research
pub_type： 杂志文章,评审
doi：10.1002/jnr.23821
更新日期：2017-01-02 00:00:00
