Adult CST-null mice maintain an increased number of oligodendrocytes.

abstract：:The present experiments tested the hypothesis that one of the critical mechanisms underlying genetically defined aggressiveness involves brain serotonin 5-HT1A receptors. 5-HT1A receptor density, the receptor mRNA expression in brain structures, and functional correlates for 5-HT1A receptors identified as 8-OH-DPAT-in...

journal_title：Journal of neuroscience research

authors： Popova NK,Naumenko VS,Plyusnina IZ,Kulikov AV

更新日期：2005-04-15 00:00:00

abstract：:Using a solution-hybridization assay and specific oligonucleotidic probes, we have studied IGF-I and insulin receptor mRNAs in the rat central nervous system during development. The expression of mRNAs was maximal at embryonic day 15 and 20 for IGF-I receptors, and at embryonic day 20 and the day of birth for insulin ...

journal_title：Journal of neuroscience research

authors： Baron-Van Evercooren A,Olichon-Berthe C,Kowalski A,Visciano G,Van Obberghen E

更新日期：1991-02-01 00:00:00

abstract：:Traumatic brain injuries (TBIs) pose a massive burden of disease and continue to be a leading cause of morbidity and mortality throughout the world. A major obstacle in developing effective treatments is the lack of comprehensive understanding of the underlying mechanisms that mediate tissue damage and recovery after ...

journal_title：Journal of neuroscience research

authors： Bogoslovsky T,Bernstock JD,Bull G,Gouty S,Cox BM,Hallenbeck JM,Maric D

更新日期：2018-04-01 00:00:00

abstract：:The 14-3-3 proteins exist predominantly in the brain and may play regulatory roles in cellular processes of growth, differentiation, survival, and apoptosis. The biological functions, however, of the various 14-3-3 isoforms (beta, epsilon, eta, gamma, and zeta) in the brain remain unclear. We have reported previously ...

journal_title：Journal of neuroscience research

authors： Chen XQ,Liu S,Qin LY,Wang CR,Fung YW,Yu AC

更新日期：2005-01-01 00:00:00

abstract：:NOD-like receptors (NLRs) are critical cytoplasmic pattern-recognition receptors (PRRs) that play an important role in the host innate immune response and immunity homeostasis. There is a growing body of evidence that NLRs are involved in a wide range of inflammatory diseases, including cancer, metabolic diseases, and...

journal_title：Journal of neuroscience research

authors： Kong X,Yuan Z,Cheng J

更新日期：2017-08-01 00:00:00

abstract：:Glycolysis was blocked in the hippocampus of the otherwise unaffected rabbit by perfusion of a previously implanted thin dialysis tube with a medium containing 0.1 mM iodoacetate. The perfusate from the dialysis tube was analyzed for free amino acids with liquid chromatographic separation of ortophthaldialdehyde deriv...

journal_title：Journal of neuroscience research

authors： Sandberg M,Nyström B,Hamberger A

更新日期：1985-01-01 00:00:00

abstract：:Although protein kinase Cdk5-p35 is important in many aspects of the development and function of the central nervous system, relatively little is known about its regulation. In the present study, we examined the relationship between the association of this kinase with membranes and its activity in perinatal and adult ...

journal_title：Journal of neuroscience research

authors： Sato K,Zhu YS,Saito T,Yotsumoto K,Asada A,Hasegawa M,Hisanaga S

更新日期：2007-11-01 00:00:00

abstract：:Ca(2+) and synaptotagmin (a Ca(2+)-binding protein that regulates axolemmal fusion of synaptic vesicles) play essential roles in the repair of axolemmal damage in invertebrate giant axons. We now report that neurites of a rat pheochromocytoma (PC12) cell line transected and maintained in a serum medium form a dye barr...

journal_title：Journal of neuroscience research

authors： Detrait ER,Yoo S,Eddleman CS,Fukuda M,Bittner GD,Fishman HM

更新日期：2000-11-15 00:00:00

abstract：:The demyelinative potential of the cytokines interleukin-1 alpha (IL-1 alpha), interferon-gamma (IFN-gamma), and tumor necrosis factor-alpha (TNF-alpha) has been investigated in myelinating aggregate brain cell cultures. Treatment of myelinated cultures with these cytokines resulted in a reduction in myelin basic prot...

journal_title：Journal of neuroscience research

authors： Loughlin AJ,Honegger P,Woodroofe MN,Comte V,Matthieu JM,Cuzner ML

更新日期：1994-04-01 00:00:00

abstract：:The p53 tumor suppressor gene, which is considered the guardian of the genome, encodes a phosphoprotein, which is a sequence-specific transcriptional activator or repressor of target genes. The role of p53 in developmental processes has not been studied extensively, although its expression appears to undergo temporal ...

journal_title：Journal of neuroscience research

authors： Poulaki V,Benekou A,Bozas E,Bolaris S,Stylianopoulou F

更新日期：1999-05-15 00:00:00

abstract：:The Rho GTPases are important regulators of neurite outgrowth and pathfinding. We have recently reported that a Rho-family guanine nucleotide exchange factor, GEFT, modulates dendrite spine morphology and basal neurite outgrowth in primary hippocampal neurons and Neuro2A cells, respectively. Here we demonstrate that G...

journal_title：Journal of neuroscience research

authors： Bryan BA,Cai Y,Liu M

更新日期：2006-05-15 00:00:00

abstract：:Histology, immunohistochemistry, and Western blotting were used to characterize the changes in morphology, distribution pattern, and marker protein expression of striatal interneurons in the transition zone of striatal injury induced by 3-NP. The 3-NP treatment in rats yielded movement, motor coordination, and cogniti...

journal_title：Journal of neuroscience research

authors： Mu S,OuYang L,Liu B,Zhu Y,Li K,Zhan M,Liu Z,Jia Y,Lei W,Reiner A

更新日期：2011-05-01 00:00:00

abstract：:Ionotropic glutamate receptors, N-methyl-d-aspartate receptors (NMDARs) and alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors (AMPARs), are densely distributed in the mammalian brain and actively regulate a variety of cellular activities. Expression and function of these receptors are also under a tig...

journal_title：Journal of neuroscience research

authors： Wang JQ,Liu X,Zhang G,Parelkar NK,Arora A,Haines M,Fibuch EE,Mao L

更新日期：2006-12-01 00:00:00

abstract：:The role of the transcription factor AP-1 in regulating D2 receptor transcriptional activity was investigated in D2 receptor expressing neuroblastoma cells, NB41A3, and in non-D2 receptor expressing CHO cells. Deletion of a region containing the putative AP-1 binding site resulted in a significant reduction in the act...

journal_title：Journal of neuroscience research

authors： Wang J,Miller JC,Friedhoff AJ

更新日期：1997-10-01 00:00:00

abstract：:The growth cone, the motile tip of developing neuronal processes, is considered responsible for the exact guidance of axons and synaptogenesis. High activity of tyrosine kinases in growth cones may contribute to the functions of growth cones. Our previous work revealed that vinculin is one of the endogenous substrates...

journal_title：Journal of neuroscience research

authors： Igarashi M,Komiya Y

更新日期：1991-09-01 00:00:00

abstract：:Dissociated neurons from the neural tube containing the trigeminal motor nucleus from early chick embryos were cultured on laminin or collagen-polyornithine substrates, with and without nerve growth factor (NGF). Control cultures were grown in similar conditions with cytochrome-C. It was found that neuronal survival w...

journal_title：Journal of neuroscience research

authors： Heaton MB

更新日期：1989-04-01 00:00:00

abstract：:The aim of the present study was to prepare cultures enriched in type-2 astrocytes (AS) and to analyze some of the properties of these cells over relatively long culture periods. Cultures enriched in type-2 AS were obtained by subculturing, at low cell density and in the presence of fetal calf serum, a cell population...

journal_title：Journal of neuroscience research

authors： Aloisi F,Agresti C,Levi G

更新日期：1988-10-01 00:00:00

abstract：:The possibility that neuron-astrocyte communication may be responsible for glutamate (Glu)-stimulated cGMP formation even in relatively homogeneous primary cultures of mouse cerebellar granule cells (7 days in vitro) was investigated. Pharmacological analysis using selective excitatory amino acid (EAA) receptor antago...

journal_title：Journal of neuroscience research

authors： Malcolm C,Grieve A,Ritchie L,Schousboe A,Griffiths R

更新日期：1996-07-15 00:00:00

abstract：:Despite consistent observations of sex differences in depression and related emotional disorders, we do not yet know how these sex differences modulate the effects of genetic polymorphisms implicated in risk for these disorders. This Mini-Review focuses on genetic polymorphisms of the serotonergic system to illustrate...

journal_title：Journal of neuroscience research

authors： Perry LM,Goldstein-Piekarski AN,Williams LM

更新日期：2017-01-02 00:00:00

abstract：:Mice heterozygously deficient in the major myelin component P0 are an established model of an inherited neuropathy and show signs of myelin degeneration in motor nerves. Unlike the case in patients, the sensory nerves are only mildly affected in the mouse mutants and do not show features indicative of myelin degenerat...

journal_title：Journal of neuroscience research

authors： Samsam M,Frei R,Marziniak M,Martini R,Sommer C

更新日期：2002-01-15 00:00:00

abstract：:The potassium-induced stimulation of oxygen consumption in brain slices has a threshold value of 15-20 mM potassium, and it reaches its maximum at 35-50 mM. Although this phenomenon now has been known for almost 50 years, its physiological role remains undetermined. One reason for this may be that the high concentrati...

journal_title：Journal of neuroscience research

authors： Hertz L,Kjeldsen CS

更新日期：1985-01-01 00:00:00

abstract：:After hemisection of the spinal cord in rats, alterations in amino acid incorporation into protein have been observed in brain and spinal cord. Proteins mediating these changes have been studied in the present experiment. Male, Long-Evans hooded rats were given either a laminectomy and dura incision (sham) at spinal s...

journal_title：Journal of neuroscience research

authors： Wells MR

更新日期：1980-01-01 00:00:00

abstract：:The mutant hypogonadal (hpg) mouse lacks a functioning gene for the neurohormone gonadotropin releasing hormone (GnRH). Previous studies from our laboratory had indicated that the initiation and maintenance of reproductive function in these mice could be brought about by the implantation of normal fetal grafts into ad...

journal_title：Journal of neuroscience research

authors： Silverman RC,Gibson MJ,Silverman AJ

更新日期：1992-01-01 00:00:00

abstract：:Neuronal degeneration has been shown to be involved in various neurological disorders. Growth/trophic factors and their receptors are known to be important for the regeneration and survival of neurons. We report here the molecular cloning of a receptor-like protein tyrosine kinase, bsk, (for brain specific kinase). Bs...

journal_title：Journal of neuroscience research

authors： Zhou R,Copeland TD,Kromer LF,Schulz NT

更新日期：1994-01-01 00:00:00

abstract：:Studies using Aplysia californica have demonstrated that transcription after nerve injury occurs during a rapid, transient first phase and a delayed, prolonged second phase. Although the second phase is especially important for regeneration, the mRNAs produced during this phase have not been identified. We characteriz...

journal_title：Journal of neuroscience research

authors： Colby GP,Sung YJ,Ambron RT

更新日期：2005-11-15 00:00:00

abstract：:Neural stem cells can be propagated in culture as neurospheres, yielding neurons and glial cells upon differentiation. Although the neurosphere model is widely used, the functional properties of the neurosphere-derived neurons have been only partially characterized, and it is unclear whether repeated passaging alters ...

journal_title：Journal of neuroscience research

authors： Pagani F,Lauro C,Fucile S,Catalano M,Limatola C,Eusebi F,Grassi F

更新日期：2006-06-01 00:00:00

abstract：:Calcium/calmodulin-dependent serine kinase (CASK), a causative gene in X-linked mental retardation, carries out multiple functions in neurons, including vesicle trafficking of ion channels, synapse formation, and gene transcription. From a yeast two-hybrid screen, Krüppel-like zinc finger protein B cell lymphoma/COUP-...

journal_title：Journal of neuroscience research

authors： Kuo TY,Hong CJ,Chien HL,Hsueh YP

更新日期：2010-08-15 00:00:00

abstract：:The inner ear of humans and experimental animals demonstrate an abundance of glucocorticoid receptors (GR). Glucocorticoids (GC) are widely used to treat different hearing disorders; yet the mechanisms of GC action on the inner ear are unknown. We demonstrate how GR can directly modulate hearing sensitivity in respons...

journal_title：Journal of neuroscience research

authors： Tahera Y,Meltser I,Johansson P,Bian Z,Stierna P,Hansson AC,Canlon B

更新日期：2006-05-01 00:00:00

abstract：:Physiological responses to acute stress proceed with the activation of the hypothalamus-pituitary-adrenal gland (HPA) system. Many brain regions are known to modulate the HPA axis activation in stress responses, but the detailed neural circuits and signaling system in the upstream of the HPA axis have to be explored f...

journal_title：Journal of neuroscience research

authors： Kim KS,Han PL

更新日期：2009-10-01 00:00:00

abstract：:The development of cells of the oligodendroglial lineage, from immature progenitor to myelinating cells, occurs largely in a neuronal environment, yet little is known about specific interactions between these 2 cell types. We have tested the effects of medium conditioned by cultures of rat cerebral cortical neurons (C...

journal_title：Journal of neuroscience research

authors： Hardy R,Reynolds R

更新日期：1993-04-01 00:00:00