Diffusible factor(s) from adult rat sciatic nerve increases cell number and neurite outgrowth of cultured embryonic ventral mesencephalic tyrosine hydroxylase-positive neurons.

abstract：:The effects of phorbol 12-tetradecanoyl-13-acetate (TPA) and dibutyryl cAMP on the glutamate transport present in chick Bergmann glial cell (BGC) cultures were examined. TPA produced a significant decrease in [3H]-D-aspartate uptake, while dibutyryl cAMP treatment elicited a slight reduction in the transport. This eff...

journal_title：Journal of neuroscience research

authors： González MI,Ortega A

更新日期：1997-11-15 00:00:00

abstract：:Time-to-contact (TTC) perception refers to the ability of an observer to estimate the remaining time before an object reaches a point in the environment, and is of crucial importance in daily life. Noninvasive correlational approaches have identified several brain areas sensitive to TTC information. Here we report the...

journal_title：Journal of neuroscience research

authors： Baurès R,Fourteau M,Thébault S,Gazard C,Pasquio L,Meneghini G,Perrin J,Rosito M,Durand JB,Roux FE

更新日期：2021-02-01 00:00:00

abstract：:A rodent model of Parkinson's disease, the 1-methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine treated mouse, was used to determine whether striatal dopamine levels recover following grafting adrenal medulla into the striatum. Four types of grafts were performed: 1) adult mouse adrenal medulla, 2) adult adrenal me...

journal_title：Journal of neuroscience research

authors： Bohn MC,Kanuicki M

更新日期：1990-03-01 00:00:00

abstract：:The contribution of glucose carbon to the biosynthesis of cholesterol and phospholipids in distinct brain regions was studied quantitatively in the adult male rat. Rates of flow of glucose carbon into the lipids in vivo were calculated from two measurements: the curve representing the decrease in plasma 14C-glucose wi...

journal_title：Journal of neuroscience research

authors： Barkai AI

更新日期：1981-01-01 00:00:00

abstract：:The use of progesterone following brain injury has a controversial history. On one hand, some lab-based models have showed progesterone as being neuroprotective, but on the other, clinical trials have showed quite the opposite. One of many complaints that arose from this discrepancy was the lack of a diverse pool of a...

journal_title：Journal of neuroscience research

authors： Blackshear K,Giessner S,Hayden JP,Duncan KA

更新日期：2018-04-01 00:00:00

abstract：:We used the Plp1-overexpressing transgenic mouse model to investigate whether progressive demyelination of axons results in adaptive changes involving mitochondria within the axons. These models have myelinated axons from birth but gradually lose myelin and develop axonal loss associated with progressive neurological ...

journal_title：Journal of neuroscience research

authors： Hogan V,White K,Edgar J,McGill A,Karim S,McLaughlin M,Griffiths I,Turnbull D,Nichols P

更新日期：2009-02-01 00:00:00

abstract：:Zinc concentration and (65)Zn uptake in the brain of rats fed zinc-deficient diet for 12 weeks were examined, based on a previous finding of the impairment of learning behavior by the zinc deprivation. Zinc concentrations in the brain, except for the hippocampal formation, did not decrease significantly in zinc-defici...

journal_title：Journal of neuroscience research

authors： Takeda A,Minami A,Takefuta S,Tochigi M,Oku N

更新日期：2001-03-01 00:00:00

abstract：:Molecular cloning has introduced an unexpected, large diversity of neurotransmitter hetero- oligomeric receptors. Extensive research on the molecular structure of the γ-aminobutyric acid receptor (GABAR) has been of great significance for understanding how the nervous system works in both vertebrates and invertebrates...

journal_title：Journal of neuroscience research

authors： Jiménez-Vázquez EN,Díaz-Velásquez CE,Uribe RM,Arias JM,García U

更新日期：2016-02-01 00:00:00

abstract：:The transfer of the adenovirus 5 E1A gene into brain cells from rat embryos led to the establishment of phenotypically untransformed clonal glial cell lines. Some lines displayed properties of oligodendrocyte-astrocyte progenitors. Their differentiation involved several steps that were dependent on culture conditions ...

journal_title：Journal of neuroscience research

authors： Evrard C,Galiana E,Rouget P

更新日期：1988-09-01 00:00:00

abstract：:Antibody-producing hybridoma cells specifically bind to microgram quantities of antigen molecules adsorbed onto the surface of plastic microtiter plates. The binding of hybridoma cells to nonantigen is optimally below 5%, similar binding of non-antibody-producing cells is 4-7%, compared to the binding of the hybridoma...

journal_title：Journal of neuroscience research

authors： Najbauer J,Tigyi GJ,Nemeth P

更新日期：1986-01-01 00:00:00

abstract：:Apoptosis is a form of cell death historically defined by morphological and biochemical changes that occur in the cell body and nucleus. However, in contrast to nonneuronal cells in which apoptosis has been most intensively studied, neurons exhibit elaborate morphologies with synaptic connections often located at site...

journal_title：Journal of neuroscience research

authors： Mattson MP,Duan W

更新日期：1999-10-01 00:00:00

abstract：:The molecular pathways underlying the neuroprotective effects of preconditioning are promising, potentially drugable targets to promote cell survival. However, these pathways are complex and are not yet fully understood. In this study we have established a paradigm of hypoxic preconditioning based on a chick embryo mo...

journal_title：Journal of neuroscience research

authors： Giusti S,Fiszer de Plazas S

更新日期：2012-02-01 00:00:00

abstract：:Oxidative stress results in protein oxidation and is implicated in cerebral disease, such as Parkinson's disease, Alzheimer's disease, and ischemic stroke. Sulfiredoxin-1 (Srxn1) is an endogenous antioxidant protein that has neuroprotective effects. The mechanisms of Srxn1 in oxidative stress have not been well studie...

journal_title：Journal of neuroscience research

authors： Li Q,Yu S,Wu J,Zou Y,Zhao Y

更新日期：2013-06-01 00:00:00

abstract：:The central nervous system (CNS) is considered a nonpermissive environment for axonal regeneration because of the presence of myelin and associated repulsive molecules. However, neural cells transplanted to the CNS preferably migrate and extend their fibers in white matter areas. We previously showed that white matter...

journal_title：Journal of neuroscience research

authors： Fang Z,Forslund N,Takenaga K,Lukanidin E,Kozlova EN

更新日期：2006-03-01 00:00:00

abstract：:Seventeen white patients from the Stanford Sleep Disorders Clinic complaining of excessive daytime somnolence (EDS) were selected for restriction-fragment-length polymorphism (RFLP) studies. Fourteen of the patients with clinically diagnosed narcolepsy were seropositive for DR2. RFLP analysis of these patients compare...

journal_title：Journal of neuroscience research

authors： Holloman JD,Bell JI,Kilduff TS,Dement WC,Guilleminault C,McDevitt HO

更新日期：1987-01-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a late-onset progressive neurodegenerative disease affecting motor neurons. About 2% of patients with the disease are associated with mutations in the gene encoding Cu/Zn superoxide dismutase (SOD1). The purpose of this study is to assess the effect of rosemary extract and its ma...

journal_title：Journal of neuroscience research

authors： Shimojo Y,Kosaka K,Noda Y,Shimizu T,Shirasawa T

更新日期：2010-03-01 00:00:00

abstract：:Synaptic circuitry in the upper dorsal horn, disorganized due to transganglionic degenerative atrophy (evoked by blockade of retrograde axoplasmic transport in the related peripheral nerve), begins to be reestablished by a process of regenerative synaptoneogenesis as soon as retrograde transport is resumed. Central ax...

journal_title：Journal of neuroscience research

authors： Knyihár-Csillik E,Kreutzberg GW,Csillik B

更新日期：1989-01-01 00:00:00

abstract：:Both IgCAMs and the actin cytoskeleton play critical roles in neuronal growth cone motility and guidance. However, it is unclear how IgCAM receptors transduce signals from the plasma membrane to induce actin remodeling. Previous studies have shown that local clustering and immobilization of apCAM, the Aplysia homolog ...

journal_title：Journal of neuroscience research

authors： Decourt B,Munnamalai V,Lee AC,Sanchez L,Suter DM

更新日期：2009-04-01 00:00:00

abstract：:Disturbances in neuronal calcium homeostasis have been implicated in a variety of neuropathological conditions, including cerebral ischemia, hypoglycemia, and epilepsy, and possibly constitute part of the cell death process associated with chronic neurodegenerative disorders. We investigated if endoplasmic reticulum (...

journal_title：Journal of neuroscience research

authors： Hernández-Fonseca K,Massieu L

更新日期：2005-10-15 00:00:00

abstract：:Understanding the pathway for amyloid percursor protein (APP) catabolism has become an important line of investigation. APP is a ubiquitous membrane bound protein that is rapidly cleaved at the membrane, yielding a secreted protein identical to protease nexin II and an internalized 11.5 kDa 100 residue C terminal deri...

journal_title：Journal of neuroscience research

authors： Wolozin B,Bacic M,Merrill MJ,Lesch KP,Chen C,Lebovics RS,Sunderland T

更新日期：1992-09-01 00:00:00

abstract：:Growth cones are essential for neuronal pathfinding during embryonic development and again after injury, when they aid in neuronal regeneration. This study was aimed at investigating the role of kinases in the earliest events in neuronal regeneration, namely, the formation of new growth cones from injured neuronal pro...

journal_title：Journal of neuroscience research

authors： Geddis MS,Rehder V

更新日期：2003-10-15 00:00:00

abstract：:During surgical intervention in medically refractory temporal lobe epilepsy (TLE) patients, diagnosed with either mesial temporal lobe sclerosis (MTS)- or tumor (T)-associated TLE, biopsies were taken from the anterior temporal neocortex and the hippocampal region. Synaptosomes, isolated from these biopsies were used ...

journal_title：Journal of neuroscience research

authors： Hoogland G,Hens JJ,De Wit M,van Veelen CW,van Huffelen AC,Gispen WH,de Graan PN

更新日期：2000-06-01 00:00:00

abstract：:Using subtype-specific Ca-channel blockers, we have characterised the voltage-sensitive Ca2+ currents as well as neurotransmitter release from cultured mouse cerebellar granule cells. The whole cell version of the patch clamp technique was adapted to monitor the isolated Ca-channel currents. The currents were activate...

journal_title：Journal of neuroscience research

authors： Varming T,Christopherson P,Schousboe A,Drejer J

更新日期：1997-04-01 00:00:00

abstract：:Regulatory factor X4 variant 3 (RFX4_v3) is a recently identified transcription factor specifically expressed in the brain. Gene disruption in mice demonstrated that interruption of a single allele (heterozygous, +/-) prevented formation of the subcommissural organ (SCO), resulting in congenital hydrocephalus, whereas...

journal_title：Journal of neuroscience research

authors： Zhang D,Zeldin DC,Blackshear PJ

更新日期：2007-12-01 00:00:00

abstract：:Although increased neurogenesis has been described in rodent models of focal traumatic brain injury (TBI), the neurogenic response occurring after diffuse TBI uncomplicated by focal injury has not been examined to date, despite the pervasiveness of this distinct type of brain injury in the TBI patient population. Here...

journal_title：Journal of neuroscience research

authors： Bye N,Carron S,Han X,Agyapomaa D,Ng SY,Yan E,Rosenfeld JV,Morganti-Kossmann MC

更新日期：2011-07-01 00:00:00

abstract：:Although gangliosides have been reported to enhance recovery from 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced lesions of the substantia nigra, evidence as to whether the administered gangliosides actually reach this or any other site of lesion in the central nervous system (CNS) at which they putativel...

journal_title：Journal of neuroscience research

authors： Saulino MF,Schengrund CL

更新日期：1994-02-15 00:00:00

abstract：:Previously, we have demonstrated a novel interaction between Galpha(o) protein and Purkinje cell protein-2 (Pcp2, also known as L7) in vitro and in transfected cells (Luo and Denker [1999] J. Biol. Chem. 274:10685-10688). Pcp2 is uniquely expressed in cerebellar Purkinje cells and in retinal bipolar neurons, and it ma...

journal_title：Journal of neuroscience research

authors： Redd KJ,Oberdick J,McCoy J,Denker BM,Luo Y

更新日期：2002-12-01 00:00:00

abstract：:As a neurotransmitter and neuromodulator, serotonin (5-HT) influences neuronal outgrowth in the nervous systems of several species. In PC12 cells, 5-HT is known to have neuritogenic effects, although the signal transduction pathway responsible for these effects is not understood. In this study, we hypothesized that a ...

journal_title：Journal of neuroscience research

authors： Homma K,Kitamura Y,Ogawa H,Oka K

更新日期：2006-08-01 00:00:00

abstract：:Haptoglobin (Hp), an acute-phase response protein, is typically increased in the serum of adults after acute tissue injury. It is an antioxidant and may function as an injury-induced neuroprotective protein. However, the source of increased Hp is not clear. To investigate its source, we compared its time course expres...

journal_title：Journal of neuroscience research

authors： Yang S,Ma Y,Liu Y,Que H,Zhu C,Liu S

更新日期：2013-02-01 00:00:00

abstract：:The distribution of neuronal intermediate filament proteins in the developing mouse olfactory bulb and olfactory epithelium was characterized by immunocytochemical approach. Antibodies against alpha-internexin, neurofilament triplet proteins (NFTPs; NF-L, NF-M, and NF-H) and peripherin were used to determine their exp...

journal_title：Journal of neuroscience research

authors： Chien CL,Lee TH,Lu KS

更新日期：1998-11-01 00:00:00