Abstract:
:Haptoglobin (Hp), an acute-phase response protein, is typically increased in the serum of adults after acute tissue injury. It is an antioxidant and may function as an injury-induced neuroprotective protein. However, the source of increased Hp is not clear. To investigate its source, we compared its time course expression profile in serum from rats with or without traumatic brain injury (TBI). Elevated Hp levels revealed by proteomic analysis were confirmed by Western blot, semiquantitative PCR, and real-time PCR. We found that Hp protein and mRNA levels were increased after TBI in both serum and liver, especially in liver. Both in vivo and in vitro data showed that Hp expression was increased in rat and human (HL7702) liver cells upon treatment with TBI serum. Addition of anti-interleukin-6 (IL-6) antibody downregulated the expression of Hp in liver cells induced by serum derived from rats and in liver of rats after TBI. These findings suggest that the increased Hp in serum came from the liver in response to TBI and that IL-6 is an important mediator of this induction.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Yang S,Ma Y,Liu Y,Que H,Zhu C,Liu Sdoi
10.1002/jnr.23159subject
Has Abstractpub_date
2013-02-01 00:00:00pages
230-9issue
2eissn
0360-4012issn
1097-4547journal_volume
91pub_type
杂志文章abstract::Apolipoprotein E (ApoE) is the major brain lipoprotein and plays an important role in lipid transport. ApoE-deficient mice whose apoE gene has been knocked out have distinct cognitive and neurochemical deficits, and their recovery from brain injury is impaired. In the present study we examined the possibility that the...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:
更新日期:1999-11-15 00:00:00
abstract::We have investigated the involvement of c-Jun in cell death induced by exposure of primary cultures of murine cerebellar granule cells to the glutamate receptor agonist kainate (KA) and evaluated its possible use as a marker for apoptosis. Using cerebellar granule cell neurones from postnatal day 7 mice, we found that...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19980401)52:1<69::AID-JNR7
更新日期:1998-04-01 00:00:00
abstract::PC12 cells can differentiate into neuron-like cells after treatment with either nerve growth factor (NGF) or transduction with a retrovirus which expresses the K-ras oncogene. The concomitant treatment of NGF plus ras differentiates PC12 cells further than either agent alone with respect to neurite outgrowth, acetylch...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490420306
更新日期:1995-10-15 00:00:00
abstract::The close homologue of L1 (CHL1) is a member of the L1 family of cell recognition molecules. The protein is expressed by a variety of nerve cell types and subpopulations of glial cells in vivo and promotes elongation of neurites and survival of nerve cells in vitro. Here we demonstrate that glial cells up-regulate exp...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10533
更新日期:2003-03-15 00:00:00
abstract::In order to quantify the changes that occur in the cholinergic central nervous system with aging, we have compared acetylcholine (Ach) formation in brain cortex slice preparations from 2-year-old aged CBF-1 mouse brains and compared the findings with those in 2-4-month-old young adult mouse brain slices. Incorporation...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490150209
更新日期:1986-01-01 00:00:00
abstract::Recombinant adeno-associated viral (AAV)-mediated therapeutic gene transfer to dorsal root ganglia (DRG) is an effective and safe tool for treating chronic pain. However, AAV with various constitutively active promoters leads to transgene expression predominantly to neurons, while glial cells are refractory to AAV tra...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.24183
更新日期:2018-03-01 00:00:00
abstract::Neurodevelopmental disorders (NDDs) such as intellectual disability and autism spectrum disorder consistently show a male bias in prevalence, but it remains unclear why males and females are affected with different frequency. While many behavioral studies of transgenic NDD models have focused only on males, the requir...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.24577
更新日期:2021-01-01 00:00:00
abstract::Previous studies from our laboratory suggest that Alzheimer's disease sera contain a repertoire of antibodies to the heavy neurofilament subunit (NF-H) and that a subpopulation of these antibodies bind specifically to epitopes highly enriched in NF-H isolated from the purely cholinergic electromotor neurons of Torpedo...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490290409
更新日期:1991-08-01 00:00:00
abstract::Recent experiments have shown that Arg, Lys, and Leu can be incorporated posttranslationally into proteins of regenerating sciatic nerves of rats. The present experiments investigate a mixture of 15 radioactive amino acids to determine if additional amino acids can be conjugated posttranslationally to proteins of rege...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490250407
更新日期:1990-04-01 00:00:00
abstract::Toll-like receptors (TLRs) play an essential role in initiating intracellular type I interferon (IFN)-mediated innate immunity against viral infections. We examined whether human neuronal cells (primary human neurons, NT2-N and CHP-212 cells) express TLRs and mount type I IFN-mediated innate immunity against herpes si...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22110
更新日期:2009-10-01 00:00:00
abstract::Insulin-like growth factors, IGF-I and IGF-II, are potent regulators of oligodendrocyte development. Most of the IGF present in vivo is bound to members of a family of six high-affinity IGF-binding proteins (IGFBPs), which can either potentiate or inhibit IGF action, depending on other conditions. Additionally, serum ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19971201)50:5<721::AID-JNR
更新日期:1997-12-01 00:00:00
abstract::In the non-amyloidogenic pathway, the Alzheimer's amyloid precursor protein (APP) is cleaved within the amyloid-beta domain by alpha-secretase precluding deposition of intact amyloid-beta peptide. The large ectodomain released from the cell surface by the action of alpha-secretase has several neuroprotective propertie...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.10737
更新日期:2003-11-01 00:00:00
abstract::An inflammatory response involving activated microglia in neuritic beta-amyloid plaques is found in Alzheimer's disease (AD) brain. Because HDL lipoproteins have been shown to carry the beta-amyloid peptide (Abeta) in plasma and CSF, we have investigated the influence of plasma high-density lipoprotein (HDL) and lipid...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:
更新日期:1999-08-15 00:00:00
abstract::Damselfish neurofibromatosis is a naturally occurring disease of a tropical marine fish species. Affected fish exhibit peripheral nerve sheath tumors which contain morphologically abnormal Schwann cells (SC), similar to tumors encountered in the human disease neurofibromatosis type 1. Unitary A-type K channels in cell...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:
更新日期:1997-05-15 00:00:00
abstract::Inhibitory luminopsins (iLMO2) integrate opto- and chemo-genetic approaches and allow for cell-type specific inhibition of neuronal activity. When exposed to a Renilla luciferase substrate, Coelenterazine (CTZ), iLMO2 generates bioluminescence-mediated activation of its amino-terminal halorhodopsin, resulting in neuro...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.24109
更新日期:2020-03-01 00:00:00
abstract::Axonal injury is often characterized by axonal transport defects and abnormal accumulation of intra-axonal components. Nitric oxide (NO) has a key role in mediating inflammatory axonopathy in many neurodegenerative diseases, but little is known about how nitrosative/oxidative stress affects axonal transport or whether...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.23556
更新日期:2015-06-01 00:00:00
abstract::Tissue culture media with serum generally cause excessive astrocyte proliferation in neonatal brain cultures, and often fail to support neonatal neurons. Published serum-free media for brain cultures contain sodium pyruvate, which interferes with lactate dehydrogenase (LDH) assays for cell death. We wanted to use neon...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490410212
更新日期:1995-06-01 00:00:00
abstract::The balance of bone morphogenic protein (BMP), transforming growth factor-β (TGFβ)/activin/nodal, and Wnt signals regulates the early lineage segregation of human embryonic stem cells (ESCs). Here we demonstrate that a combination of small-molecule inhibitors of BMP (Dorsomorphin) and TGFβ/activin/nodal (SB431542) sig...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22547
更新日期:2011-02-01 00:00:00
abstract::The inflammatory response initiated after spinal cord injury (SCI) is characterized by the accumulation of macrophages at the impact site. Monocyte chemoattractant protein-1 (MCP-1) is a strong candidate for mediating chemotaxis of monocytes to the injured nervous system. To help in defining the role of MCP-1 in infla...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10269
更新日期:2002-06-15 00:00:00
abstract::The two inbred strains of mice C57BL/6 (alcohol-preferring) and DBA/2 (alcohol-avoiding) mice have been shown to differ significantly in their preference for alcohol (EtOH). We have previously demonstrated the differences in the density and the affinity of cannabinoid (CB1) receptors in the brains of the two inbred C5...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.1094
更新日期:2001-05-15 00:00:00
abstract::The minimal requirements for the regeneration of optic nerve fibers in vitro were established in a serum-free retinal explant preparation. This serum-free preparation was developed as a prerequisite for testing the growth-promoting activity of tissue extracts prepared from the primary target of regenerating fibers. Ex...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490080221
更新日期:1982-01-01 00:00:00
abstract::Factor Xa (FXa) plays a critical role in the coagulation cascade by generation of thrombin. During focal ischemia thrombin levels increase in the brain tissue and cause neural damage. This study examined the hypothesis that administration of the FXa inhibitor, apixaban, following focal ischemic stroke may have therape...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.24253
更新日期:2018-08-01 00:00:00
abstract::An elevated expression of c-fos nuclear protooncogene (immediate early gene) has been shown repeatedly to correlate with long-term neuronal responses. This paper reviews recent data suggesting that neuronal plasticity, including learning and memory formation, may involve c-fos expression as well. On the basis of biolo...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.490340402
更新日期:1993-03-01 00:00:00
abstract::Double immunofluorescence studies using antibodies against NF-L and peripherin revealed three distinct subpopulations of neurons in rat dorsal root ganglia (DRG). In the adult rat, 46% of the DRG neurons were small and peripherin-positive (NF-L-negative), and 48% were large and NF-L-positive (peripherin-negative). Abo...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490300111
更新日期:1991-09-01 00:00:00
abstract::Evidence indicates that the ubiquitin-proteasome system and the endoplasmic retculum (ER) quality-control system work in concert to ensure that proteins are correctly folded in the ER and that misfolded proteins are retrotransported to the cytosol for degradation by proteasomes. Dysfunction of either system results in...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.23413
更新日期:2014-10-01 00:00:00
abstract::Brain ageing leads to atrophy and degeneration of the cholinergic nervous system, resulting in profound neurobehavioral and cognitive dysfunction from decreased acetylcholine biosynthesis and reduced secretion of growth and neurotrophic factors. Human adipose tissue-derived mesenchymal stem cells (ADMSCs) were intrave...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.23182
更新日期:2013-05-01 00:00:00
abstract::To scale up human neural stem/progenitor cell (NSPC) cultures for clinical use, we need to know how long these cells can live ex vivo without losing their ability to proliferate and differentiate; thus, a convenient method is needed to estimate the proliferative activity of human NSPCs grown in neurosphere cultures, a...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10377
更新日期:2002-09-15 00:00:00
abstract::The tissue- and cell-specific expression of three neutral glycosphingolipids, gangliotetraosylceramide (GA1), gangliopentaosylceramide (GalNAc-GA1), and the novel 3-O-acetyl-sphingosine-series glycolipid (FMC-5), were examined with monospecific polyclonal antibodies. Immunohistochemical studies of rodent brain cross-s...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21419
更新日期:2007-10-01 00:00:00
abstract::Neuroanatomical studies suggest that neuronal atrophy and destruction occur over the course of many years in neurodegenerative conditions such as schizophrenia and Alzheimer's disease. In schizophrenia, early intervention with atypical neuroleptics such as olanzapine has been shown to prevent development of some of th...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10668
更新日期:2003-08-01 00:00:00
abstract::In previous studies, we have shown that a traumatic lesion to the hippocampus of adult mice induces the transitory expression of TNF alpha and IL-1 alpha by neurons of different brain areas and also by glial cells at the site of injury. The aim of the present study was to establish whether the expression of TNF alpha ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490430113
更新日期:1996-01-01 00:00:00