Abstract:
:The effects of phorbol 12-tetradecanoyl-13-acetate (TPA) and dibutyryl cAMP on the glutamate transport present in chick Bergmann glial cell (BGC) cultures were examined. TPA produced a significant decrease in [3H]-D-aspartate uptake, while dibutyryl cAMP treatment elicited a slight reduction in the transport. This effect was dose and time dependent and sensitive to staurosporine, a Ca2+/diacylglycerol-dependent protein kinase C (PKC) inhibitor. Long-term exposure of the culture to TPA results in a dramatic fall of the transporter activity and a decrease in the amount of the transporter protein. These findings suggest that PKC is involved in transport modulation and possibly in the regulation of the transporter gene expression.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
González MI,Ortega Adoi
10.1002/(SICI)1097-4547(19971115)50:4<585::AID-JNRsubject
Has Abstractpub_date
1997-11-15 00:00:00pages
585-90issue
4eissn
0360-4012issn
1097-4547pii
10.1002/(SICI)1097-4547(19971115)50:4<585::AID-JNRjournal_volume
50pub_type
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