Effect of hyperthermia on the transcription rate of heat-shock genes in the rabbit cerebellum and retina assayed by nuclear run-ons.

abstract：:Sphingolipidoses are a class of inherited diseases that result from the toxic accumulation of undigested sphingolipids in lysosomes and other cellular membranes. Sphingolipids are particularly enriched in cells of the nervous system, and their excessive accumulation during disease has a significant impact on the nervo...

journal_title：Journal of neuroscience research

authors： Sural-Fehr T,Bongarzone ER

更新日期：2016-11-01 00:00:00

abstract：:The neurotrophins are important for their long-term effects on the survival and differentiation of many types of neurons during development. They also appear to protect mature neurons from injury caused by nutrient or oxygen deprivation. More recently, the neurotrophins have been implicated in such short-term processe...

journal_title：Journal of neuroscience research

authors： Jiang H,Guroff G

更新日期：1997-11-01 00:00:00

abstract：:The Shaw subfamily of potassium channel genes, including Kv3.1, are highly expressed within the auditory nuclei of the brainstem, where they have been implicated in the characteristic response properties of particular types of neurons. Potassium currents carried by Kv3.1 are voltage-dependent, have a high activation t...

journal_title：Journal of neuroscience research

authors： Hendriks R,Morest DK,Kaczmarek LK

更新日期：1999-12-15 00:00:00

abstract：:Nerve growth factor (NGF) is a protein essential for the survival and normal function of sympathetic neurons. Two-site immunoassays have been developed over the past decade in several laboratories and used to estimate its endogenous concentrations in a variety of effector tissues. However, levels appear restricted to ...

journal_title：Journal of neuroscience research

authors： Zettler C,Bridges DC,Zhou XF,Rush RA

更新日期：1996-12-01 00:00:00

abstract：:Isatin (indole-2,3-dione) is an endogenous indole that has a distinct and discontinuous distribution in the brain and in other mammalian tissues and body fluids. Its output is increased under conditions of stress and anxiety. Its biological targets remain poorly characterized, although [(3)H]isatin binding sites have ...

journal_title：Journal of neuroscience research

authors： Crumeyrolle-Arias M,Buneeva O,Zgoda V,Kopylov A,Cardona A,Tournaire MC,Pozdnev V,Glover V,Medvedev A

更新日期：2009-09-01 00:00:00

abstract：:Cultured astrocytes from neonatal rat cerebral hemispheres are depolarized by the excitatory neurotransmitter glutamate. In this study we have used selective agonists of different neuronal glutamate receptor subtypes, namely, the N-methyl-D-aspartate (NMDA), kainate, and quisqualate type, to characterize pharmacologic...

journal_title：Journal of neuroscience research

authors： Backus KH,Kettenmann H,Schachner M

更新日期：1989-03-01 00:00:00

abstract：:In situ cDNA:mRNA hybridization is a technique that has been developed for the visualization of cDNA:mRNA hybrids in individual cells. To use this technique to answer questions of regulation in heterogeneous populations of cells in the brain, it must be combined with other procedures allowing for the identification of...

journal_title：Journal of neuroscience research

authors： Wilcox JN,Roberts JL,Chronwall BM,Bishop JF,O'Donohue T

更新日期：1986-01-01 00:00:00

abstract：:Relationships among different intensities of electroshock treatment (EST), EEG-recordable primary after discharge (PAD), and beta-adrenergic binding in various brain regions were investigated in adult rats. Different intensities of EST (1-2, 6-8, 20-30 mamp) were applied through ear-clip electrodes for 7 consecutive d...

journal_title：Journal of neuroscience research

authors： Perumal AS,Barkai AI

更新日期：1982-01-01 00:00:00

abstract：:Lithium, the most prevalent treatment for manic-depressive illness, might have a neuroprotective effect after brain injury. In culture, lithium can exert neurotoxic effects associated with reduction in polyamine synthesis but neuroprotective effects as cultured neurons mature. Cumulative evidence suggests that lithium...

journal_title：Journal of neuroscience research

authors： Gilad GM,Gilad VH

更新日期：2007-02-15 00:00:00

abstract：:The remarkable quantities of myelin membrane produced by oligodendrocytes has led us to examine the mechanisms involved in the sorting and transport of proteins and lipids during myelinogenesis. Noting that it has been proposed that proteins destined for the apical surface of polarized epithelial cells co-cluster with...

journal_title：Journal of neuroscience research

authors： Kim T,Fiedler K,Madison DL,Krueger WH,Pfeiffer SE

更新日期：1995-10-15 00:00:00

abstract：:There are two types of calcium-activated neutral protease (CANP), m-CANP and mu-CANP, following the nomenclature of Suzuki et al to show that each requires mM and microM Ca2+, respectively, for its activation. We found mu-CANP activity in a crude CANP fraction extracted from the peripheral nerve, which degraded the ne...

journal_title：Journal of neuroscience research

authors： Kamakura K,Ishiura S,Suzuki K,Sugita H,Toyokura Y

更新日期：1985-01-01 00:00:00

abstract：:The excitability of the motor cortex is a function of single cell excitability, synaptic strength, and the balance between excitatory cells and inhibitory cells. Sustained periods of sensory stimulation enhance the excitability in the motor cortex. This adaptation, which represents an early change in cortical network ...

journal_title：Journal of neuroscience research

authors： Manto M,Oulad ben Taib N,Luft AR

更新日期：2006-02-01 00:00:00

abstract：:NG2 chondroitin sulfate proteoglycan is a surface marker of oligodendroglial progenitor cells (OPCs) in various species. In contrast to well-studied rat OPCs, however, we found that purified mouse NG2 surface positive cells (NG2(+) cells) require additional activation of cyclic AMP (cAMP) signaling for survival in a m...

journal_title：Journal of neuroscience research

authors： Horiuchi M,Lindsten T,Pleasure D,Itoh T

更新日期：2010-04-01 00:00:00

abstract：:The existence of endogenous neural progenitor cells (NPCs) in the adult spinal cord (sc) provides the potential for tailored repair therapies after spinal cord injury (SCI). This study investigates the impact of inflammatory mediators on properties of NPC cultures derived from adult rats after SCI. The Infinite Horizo...

journal_title：Journal of neuroscience research

authors： Knerlich-Lukoschus F,Krossa S,Krause J,Mehdorn HM,Scheidig A,Held-Feindt J

更新日期：2015-04-01 00:00:00

abstract：:Vascular smooth muscle (VSM) cells comprise one of the primary targets of the sympathetic nervous system and have been shown to secrete nerve growth factor (NGF). There is increasing evidence that changes in the levels of NGF in the adult may underlie certain pathological conditions. To investigate the potential role ...

journal_title：Journal of neuroscience research

authors： Creedon DJ,Tuttle JB

更新日期：1997-02-01 00:00:00

abstract：:We used a modified pial vessel disruption (PVD) protocol with adult male Wistar rats to mimic small-vessel stroke in the cerebral cortex. Within 3 weeks, this lesion develops into a single lacuna-like cavity, which is fluid-filled and encapsulated by reactive astrocytes. Minocycline treatment that commences 1 hr after...

journal_title：Journal of neuroscience research

authors： Cayabyab FS,Gowribai K,Walz W

更新日期：2013-07-01 00:00:00

abstract：:In eukaryotes, mitochondria are critical for cellular bioenergetics and mediating apoptosis. The transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha) is an important regulator of mitochondrial biogenesis and function. However, the role of PGC-1alpha in neuronal a...

journal_title：Journal of neuroscience research

authors： Liang J,Yang Y,Zhu X,Wang X,Chen R

更新日期：2010-07-01 00:00:00

abstract：:People showing symptoms of attention deficit hyperactivity disorder (ADHD) often present an impairment of reaction time and response inhibition. These executive functions are influenced by nicotinergic acetylcholine receptors (nAchr) as mediators of cholinergic signaling, and show differences between both sexes. We ex...

journal_title：Journal of neuroscience research

authors： Schote AB,A L Sayk C,Pabst K,Meier JK,Frings C,Meyer J

更新日期：2019-02-01 00:00:00

abstract：:Taurine, 2-aminoethanesulfonic acid, is present at high concentrations in many invertebrate and vertebrate systems and has several biological functions. In addition, it has been related to a neuroprotective role against several diseases such as epilepsy. In the present work, we treated mice with taurine and examined i...

journal_title：Journal of neuroscience research

authors： Junyent F,Romero R,de Lemos L,Utrera J,Camins A,Pallàs M,Auladell C

更新日期：2010-01-01 00:00:00

abstract：:Dopaminergic afferents from the mesencephalic areas, such as ventral tegmental area (VTA), synapse with the gamma-aminobutyric acid (GABA)-ergic interneurons in the prefrontal cortex (PFC). Pharmacological and electrophysiological data show that the reinforcement, the dependence-producing properties, as well as the ps...

journal_title：Journal of neuroscience research

authors： Li SP,Park MS,Kim JH,Kim MO

更新日期：2004-12-15 00:00:00

abstract：:Forty-seven rats were cannulated permanently in either the globus pallidus or neostriatum and subsequently injected with carbachol, scopolamine, or carbachol plus scopolamine. The injection of carbachol (1 mug) into the globus pallidus produced transient hyperkinetic phasic dyskinesias (84%) followed in some cases by ...

journal_title：Journal of neuroscience research

authors： Springer P,Dill RE

更新日期：1975-01-01 00:00:00

abstract：:We have recently demonstrated that brain plastic events significantly modify synaptic protein synthesis measured by the incorporation of [(35)S]methionine in brain synaptosomal proteins. Notably, in rats learning a two-way active avoidance task, the local synthesis of two synaptic proteins was selectively enhanced. Be...

journal_title：Journal of neuroscience research

authors： Ferrara E,Cefaliello C,Eyman M,De Stefano R,Giuditta A,Crispino M

更新日期：2009-07-01 00:00:00

abstract：:We here reconsider current theories of neural ensembles in the context of recent discoveries about neuronal dendritic physiology. The key physiological observation is that the dendritic plateau potential produces sustained depolarization of the cell body (amplitude 10-20 mV, duration 200-500 ms). Our central hypothesi...

journal_title：Journal of neuroscience research

authors： Antic SD,Hines M,Lytton WW

更新日期：2018-09-01 00:00:00

abstract：:Previous studies have shown that the mechanical wounding of 3-week-old cultured rat astrocytes results in cell proliferation and hypertrophy resembling astrocyte responses to a brain injury in vivo. We now report the effects of basic fibroblast growth factor (bFGF) and an anti-bFGF antibody on astrocyte morphology, pr...

journal_title：Journal of neuroscience research

authors： Hou YJ,Yu AC,Garcia JM,Aotaki-Keen A,Lee YL,Eng LF,Hjelmeland LJ,Menon VK

更新日期：1995-02-15 00:00:00

abstract：:An increased level of myelin basic protein (MBP) degradation peptide 80-89, representative of myelin breakdown, is detected in myelinating foetal rat brain aggregate cultures supplemented with peritoneal macrophages at a time coinciding with the onset of myelination. During the period of myelination, the proportion of...

journal_title：Journal of neuroscience research

authors： Copelman CA,Diemel LT,Gveric D,Gregson NA,Cuzner ML

更新日期：2001-12-15 00:00:00

abstract：:The number of older people who are suffering from memory impairment is increasing among populations throughout the world. Alzheimer's disease (AD) affects about 5% of people over 65 years old. The hippocampus, a brain area critical for learning and memory, is especially vulnerable to damage in the early stages of AD. ...

journal_title：Journal of neuroscience research

authors： Esfandiary E,Karimipour M,Mardani M,Alaei H,Ghannadian M,Kazemi M,Mohammadnejad D,Hosseini N,Esmaeili A

更新日期：2014-04-01 00:00:00

abstract：:Zinc concentration and (65)Zn uptake in the brain of rats fed zinc-deficient diet for 12 weeks were examined, based on a previous finding of the impairment of learning behavior by the zinc deprivation. Zinc concentrations in the brain, except for the hippocampal formation, did not decrease significantly in zinc-defici...

journal_title：Journal of neuroscience research

authors： Takeda A,Minami A,Takefuta S,Tochigi M,Oku N

更新日期：2001-03-01 00:00:00

abstract：:Astrocytes play a diverse role in central nervous system (CNS) injury. Production of the serine protease inhibitors (serpins) plasminogen activator inhibitor-1 (PAI-1) and protease nexin-1 (PN-1) by astrocytes may counterbalance excessive serine protease activity associated with CNS pathologies such as ischemic stroke...

journal_title：Journal of neuroscience research

authors： Hultman K,Blomstrand F,Nilsson M,Wilhelmsson U,Malmgren K,Pekny M,Kousted T,Jern C,Tjärnlund-Wolf A

更新日期：2010-08-15 00:00:00

abstract：:Sky (also known as "Tyro3" and "Rse") is a member of the Axl/Sky/Mer receptor tyrosine kinase family and has two immunoglobulin-like repeats and two fibronectin type III-like repeats in the extracellular domain. Gas6 is a ligand for all members of the Axl family, each of which (Axl, Sky, and c-Mer) has different affin...

journal_title：Journal of neuroscience research

authors： Funakoshi H,Yonemasu T,Nakano T,Matumoto K,Nakamura T

更新日期：2002-04-15 00:00:00

abstract：:Nerve growth factor (NGF) has a modulating effect on immune function, which may occur as a consequence of binding to the NGF receptor (NGF-R). To determine if mRNA for the gene coding for p75NGFR (low affinity NGF-R) is present in lymphocytes, Northern blot analysis of mRNA from human peripheral blood lymphocytes (PBL...

journal_title：Journal of neuroscience research

authors： Kittur SD,Song L,Endo H,Adler WH

更新日期：1992-07-01 00:00:00