Brain neocortex influence on the mononuclear phagocyte system.


:The cerebral neocortex is known to modulate asymmetrically certain components of the immune system. It was previously shown that large ablation of the left cortex reduces B and T cell-mediated responses, whereas symmetrical right lesions enhance these responses. We have studied the immunomodulatory role of the brain cortex on the mononuclear phagocytic system. Resident and BCG-activated macrophages were investigated in female C3H/He mice at 8-10 weeks after right or left cortical ablation. After an intraperitoneal injection of BCG, the number of peritoneal macrophages was found to be lower in both right- and left-lesioned mice, the difference being stronger and more significant in left-lesioned animals than in sham-operated controls. Furthermore, the oxidative metabolism as assessed by chemiluminescence was depressed only in left-lesioned mice. On the other hand, cortical lesions were shown to have no effect on either the number or the endocytic activity of resident peritoneal macrophages. The possible implication of the brain neocortex on infectious diseases was assayed by using the Trypasonoma musculi model, in which macrophages are known to be effective in parasite eradication. Although the number of peritoneal macrophages was significantly depressed after left cortical lesions 11 days after T. musculi inoculation, the course of the infection was not modified significantly. Our results argue in favor of brain neocortex modulation of the mononuclear system.


J Neurosci Res


Neveu PJ,Barnéoud P,Georgiades O,Vitiello S,Vincendeau P,Le Moal M




Has Abstract


1989-02-01 00:00:00












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    abstract::Contrary to widely held beliefs, the gene encoding proteolipid protein (PLP), the major structural protein of central nervous system myelin, is expressed in Schwann cells and their tumors. Proteolipid mRNA was identified in human acoustic neuromas and in rat and rabbit sciatic nerves using a human PLP cDNA as a probe....

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Puckett C,Hudson L,Ono K,Friedrich V,Benecke J,Dubois-Dalcq M,Lazzarini RA

    更新日期:1987-01-01 00:00:00

  • Elevated serum haptoglobin after traumatic brain injury is synthesized mainly in liver.

    abstract::Haptoglobin (Hp), an acute-phase response protein, is typically increased in the serum of adults after acute tissue injury. It is an antioxidant and may function as an injury-induced neuroprotective protein. However, the source of increased Hp is not clear. To investigate its source, we compared its time course expres...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Yang S,Ma Y,Liu Y,Que H,Zhu C,Liu S

    更新日期:2013-02-01 00:00:00

  • Diffusion tensor imaging of patients with proteolipid protein 1 gene mutations.

    abstract::Pelizaeus-Merzbacher disease (PMD) is an X-linked disorder of the central nervous system (CNS) caused by a wide variety of mutations affecting proteolipid protein 1 (PLP1). We assessed the effects of PLP1 mutations on water diffusion in CNS white matter by using diffusion tensor imaging. Twelve patients with different...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Laukka JJ,Makki MI,Lafleur T,Stanley J,Kamholz J,Garbern JY

    更新日期:2014-12-01 00:00:00

  • Immune system-related CD9 is expressed in mouse central nervous system myelin at a very late stage of myelination.

    abstract::CD9 is a tetra-membrane-spanning glycoprotein involved in cell adhesion, migration, and proliferation in both the immune and the immature nervous system. In this study, CD9 expression was detected in myelin of mouse brain, starting at postnatal day 16. The amount of CD9 protein continuously increased with age and pers...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Kagawa T,Mekada E,Shishido Y,Ikenaka K

    更新日期:1997-10-15 00:00:00

  • Music intervention improves spatial learning and memory and alters serum proteomics profiling in rats.

    abstract::Music has a long history of healing or mitigating physical and mental illness in the clinical setting. We aimed to test changes in behavioral cognition and serum proteomics in rats undergoing music intervention (MI). The Morris water maze (MWM) was used to evaluate spatial learning and memory in rats. Serum protein ex...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Xiong X,Han L,Liu S,Miao J,Luo M,Xue M,Wang X,Ni L,Yang J,Huang C

    更新日期:2018-10-01 00:00:00

  • Multilamellar packing of myelin modeled by lipid-bound MBP.

    abstract::Membrane compaction and adhesion at the major dense line (cytoplasmic apposition) of myelin, particularly in the central nervous system (CNS), is typically attributed to myelin basic protein (MBP). To explore the role of MBP in myelin membrane adhesion, we attempted to reconstitute the major dense line of myelin from ...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Riccio P,Fasano A,Borenshtein N,Bleve-Zacheo T,Kirschner DA

    更新日期:2000-02-15 00:00:00

  • Mu-type calcium-activated neutral protease in the rat peripheral nerve.

    abstract::Previously we reported results of an incubation experiment with neurofilaments that supported the existence of a mu-type of Ca2+-activated neutral protease in the rat peripheral nerve; it was active with microM order Ca2+ (mu-CANP). This time, we partially purified the mu-CANP from a crude CANP fraction of rat periphe...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Kamakura K,Ishiura S,Sugita H

    更新日期:1986-01-01 00:00:00

  • GM1 ganglioside protects nucleus basalis from excitotoxin damage: reduced cortical cholinergic losses and animal mortality.

    abstract::Ten days after bilateral injections of ibotenic acid into the nucleus basalis, rats injected daily (i.m.) with ganglioside GM1 were protected from anterograde degeneration of cholinergic projections to the fronto-lateral cortex. This protection was reflected by reduced losses (associated with ibotenic acid lesions) of...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Mahadik SP,Vilim F,Korenovsky A,Karpiak SE

    更新日期:1988-08-01 00:00:00

  • Histone acetylation inhibitors promote axon growth in adult dorsal root ganglia neurons.

    abstract::Intrinsic mechanisms that guide damaged axons to regenerate following spinal cord injury remain poorly understood. Manipulation of posttranslational modifications of key proteins in mature neurons could reinvigorate growth machinery after injury. One such modification is acetylation, a reversible process controlled by...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Lin S,Nazif K,Smith A,Baas PW,Smith GM

    更新日期:2015-08-01 00:00:00

  • Intensity of chronic cerebral hypoperfusion determines white/gray matter injury and cognitive/motor dysfunction in mice.

    abstract::We sought to establish a mouse model of subcortical ischemic vascular dementia (SIVD) that develops predominant white matter (WM) injury and cognitive dysfunction induced by chronic cerebral hypoperfusion. Adult C57Bl/6 male (n = 48) mice were subjected to bilateral common carotid artery stenosis with external microco...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Miki K,Ishibashi S,Sun L,Xu H,Ohashi W,Kuroiwa T,Mizusawa H

    更新日期:2009-04-01 00:00:00

  • Elevated serotonin is involved in hyperactivity but not in the paradoxical effect of amphetamine in mice neonatally lesioned with 6-hydroxydopamine.

    abstract::The neonatal lesion with 6-hydroxydopamine (6-OHDA) in rodents induces juvenile hyperactivity and paradoxical hypolocomotor response to psychostimulants, in striking contrast to what is observed when similar lesions are carried out in adults. The early disruption of central dopaminergic pathways is followed by increas...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Avale ME,Nemirovsky SI,Raisman-Vozari R,Rubinstein M

    更新日期:2004-10-15 00:00:00

  • Growth cone migration across extracellular matrix components depends on integrin, but migration across glioma cells does not.

    abstract::To promote neurite elongation, nerve growth cones must adhere to other surfaces. A complex of integral membrane glycoproteins mediates cell binding to the extracellular glycoproteins fibronectin and laminin (Horwitz et al., J Cell Biol 101:2134-2144, 1985). The receptor complex, named integrin, binds to fibronectin by...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Letourneau PC,Pech IV,Rogers SL,Palm SL,McCarthy JB,Furcht LT

    更新日期:1988-10-01 00:00:00

  • Caspase-11 mediates ischemia-induced astrocyte death: involvement of endoplasmic reticulum stress and C/EBP homologous protein.

    abstract::Astrocytes are essential cells for maintaining brain integrity. We have recently shown that the transcription factor C/EBP homologous protein (CHOP), associated with endoplasmic reticulum (ER) stress, plays a key role in the astrocyte death induced by ischemia. Meanwhile, mediators of apoptosis downstream of CHOP in t...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Fradejas N,Pastor MD,Burgos M,Beyaert R,Tranque P,Calvo S

    更新日期:2010-04-01 00:00:00

  • Nerve growth factor-mediated increases in protein methylation occur predominantly at type I arginine methylation sites and involve protein arginine methyltransferase 1.

    abstract::Nerve growth factor (NGF)-specific signal transduction leads to changes in protein methylation during neuronal differentiation of PC12 cells (Cimato et al. [1997] J. Cell Biol. 138:1089-1103). In the present work, we demonstrate that, among NGF-regulated proteins, arginine methylation is more prevalent than carboxylme...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Cimato TR,Tang J,Xu Y,Guarnaccia C,Herschman HR,Pongor S,Aletta JM

    更新日期:2002-02-15 00:00:00

  • ID2: A negative transcription factor regulating oligodendroglia differentiation.

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    journal_title:Journal of neuroscience research

    pub_type: 杂志文章,评审


    authors: Chen XS,Zhang YH,Cai QY,Yao ZX

    更新日期:2012-05-01 00:00:00

  • EEG discrimination of perceptually similar tastes.

    abstract::Perceptually similar stimuli, despite not being consciously distinguishable, may result in distinct cortical brain activations. Hypothesizing that perceptually similar tastes are discriminable by electroencephalography (EEG), we recorded 22 human participants' response to equally intense sweet-tasting stimuli: caloric...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Andersen CA,Kring ML,Andersen RH,Larsen ON,Kjaer TW,Kidmose U,Møller S,Kidmose P

    更新日期:2019-03-01 00:00:00

  • Progenitor cells derived from the adult human subcortical white matter disperse and differentiate as oligodendrocytes within demyelinated lesions of the rat brain.

    abstract::A distinct population of white matter progenitor cells (WMPCs), competent but not committed to generate oligodendrocytes, remains ubiquitous in the adult human subcortical white matter. These cells are present in both sexes and into senescence and may constitute as much as 4% of the cells of adult human capsular white...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Windrem MS,Roy NS,Wang J,Nunes M,Benraiss A,Goodman R,McKhann GM 2nd,Goldman SA

    更新日期:2002-09-15 00:00:00

  • Cytokines, chemokines, and cytokine receptors in human microglia.

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    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Lee YB,Nagai A,Kim SU

    更新日期:2002-07-01 00:00:00

  • The involvement of thrombin in the pathogenesis of glioblastoma.

    abstract::Prothrombin and its active derivative thrombin are key members of the coagulation system. The only site of extra-hepatic thrombin expression is the central nervous system (CNS), where it is involved in brain development, protection, and regeneration. Thrombin affects various degenerative and ischemic CNS diseases like...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章,评审


    authors: Krenzlin H,Lorenz V,Alessandri B

    更新日期:2017-10-01 00:00:00

  • Mitochondrial nuclear receptors and transcription factors: who's minding the cell?

    abstract::Mitochondria are power organelles generating biochemical energy, ATP, in the cell. Mitochondria play a variety of roles, including integrating extracellular signals and executing critical intracellular events, such as neuronal cell survival and death. Increasing evidence suggests that a cross-talk mechanism between mi...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章,评审


    authors: Lee J,Sharma S,Kim J,Ferrante RJ,Ryu H

    更新日期:2008-04-01 00:00:00

  • Activation of ryanodine receptors is required for PKA-mediated downregulation of A-type K+ channels in rat hippocampal neurons.

    abstract::A-type K+ channels (IA channels) contribute to learning and memory mechanisms by regulating neuronal excitabilities in the CNS, and their expression level is targeted by Ca2+ influx via synaptic NMDA receptors (NMDARs) during long-term potentiation (LTP). However, it is not clear how local synaptic Ca2+ changes induce...

    journal_title:Journal of neuroscience research

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    authors: Yang YS,Jeon SC,Kang MS,Kim SH,Eun SY,Jin SH,Jung SC

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  • Inflammatory markers in women with postpartum depressive symptoms.

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    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Bränn E,Fransson E,White RA,Papadopoulos FC,Edvinsson Å,Kamali-Moghaddam M,Cunningham JL,Sundström-Poromaa I,Skalkidou A

    更新日期:2020-07-01 00:00:00

  • ADAMs family members as amyloid precursor protein alpha-secretases.

    abstract::In the non-amyloidogenic pathway, the Alzheimer's amyloid precursor protein (APP) is cleaved within the amyloid-beta domain by alpha-secretase precluding deposition of intact amyloid-beta peptide. The large ectodomain released from the cell surface by the action of alpha-secretase has several neuroprotective propertie...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章,评审


    authors: Allinson TM,Parkin ET,Turner AJ,Hooper NM

    更新日期:2003-11-01 00:00:00

  • Src, ras, and rac mediate the migratory response elicited by NGF and PMA in PC12 cells.

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    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Altun-Gultekin ZF,Wagner JA

    更新日期:1996-05-15 00:00:00

  • Laminar variation in neuronal viability and trophic dependence in neocortical slices.

    abstract::Organotypic slices are used frequently in studies of central nervous system development and function because they provide excellent experimental access with significant preservation of cellular context and relationships. Within a slice, however, a variety of factors may cause individual classes of neurons to respond d...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Niblock MM,Brunso-Bechtold JK,Riddle DR

    更新日期:2001-09-01 00:00:00

  • Fatty acid and long-chain base composition of gangliosides isolated from adult human brain.

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    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Ando S,Yu RK

    更新日期:1984-01-01 00:00:00

  • Characterization of beta-adrenoceptors in the Syrian hamster Harderian gland: sexual differences and effects of either castration or superior cervical ganglionectomy.

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    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Pangerl A,Pangerl B,Buzzell GR,Jones DJ,Reiter RJ

    更新日期:1989-04-01 00:00:00

  • Reorientation of prostanoid production accompanies "activation" of adult microglial cells in culture.

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    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Slepko N,Minghetti L,Polazzi E,Nicolini A,Levi G

    更新日期:1997-08-01 00:00:00

  • Comparison of the agonist binding site of homomeric, heteromeric, and chimeric GluR1(o) and GluR3(o) AMPA receptors.

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    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Banke TG,Schousboe A,Pickering DS

    更新日期:1997-07-15 00:00:00

  • Neural progenitor cells resist excitatory amino acid-induced neurotoxicity.

    abstract::The applications of neural progenitor cells in clinical therapy for neural degeneration, such as Parkinson's disease, Huntington's disease, and cerebral infarction, have long been explored widely. It had been suggested that these cells may block the apoptosis of ischemia-induced neuronal damage and may themselves resi...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Hsieh WY,Hsieh YL,Liu DD,Yang SN,Wu JN

    更新日期:2003-01-15 00:00:00