Brain neocortex influence on the mononuclear phagocyte system.


:The cerebral neocortex is known to modulate asymmetrically certain components of the immune system. It was previously shown that large ablation of the left cortex reduces B and T cell-mediated responses, whereas symmetrical right lesions enhance these responses. We have studied the immunomodulatory role of the brain cortex on the mononuclear phagocytic system. Resident and BCG-activated macrophages were investigated in female C3H/He mice at 8-10 weeks after right or left cortical ablation. After an intraperitoneal injection of BCG, the number of peritoneal macrophages was found to be lower in both right- and left-lesioned mice, the difference being stronger and more significant in left-lesioned animals than in sham-operated controls. Furthermore, the oxidative metabolism as assessed by chemiluminescence was depressed only in left-lesioned mice. On the other hand, cortical lesions were shown to have no effect on either the number or the endocytic activity of resident peritoneal macrophages. The possible implication of the brain neocortex on infectious diseases was assayed by using the Trypasonoma musculi model, in which macrophages are known to be effective in parasite eradication. Although the number of peritoneal macrophages was significantly depressed after left cortical lesions 11 days after T. musculi inoculation, the course of the infection was not modified significantly. Our results argue in favor of brain neocortex modulation of the mononuclear system.


J Neurosci Res


Neveu PJ,Barnéoud P,Georgiades O,Vitiello S,Vincendeau P,Le Moal M




Has Abstract


1989-02-01 00:00:00












  • Profound increase in sensitivity to glutamatergic- but not cholinergic agonist-induced seizures in transgenic mice with astrocyte production of IL-6.

    abstract::Transgenic mice with glial fibrillary acidic protein (GFAP) promoter driven-astrocyte production of the cytokines interleukin-6 (IL-6) and tumor necrosis factor (TNF) were used to determine whether the pre-existing production of these cytokines in vivo might modulate the sensitivity of neurons to excitotoxic agents. L...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Samland H,Huitron-Resendiz S,Masliah E,Criado J,Henriksen SJ,Campbell IL

    更新日期:2003-07-15 00:00:00

  • Distribution of mitochondria along small-diameter myelinated central nervous system axons.

    abstract::Small-diameter myelinated CNS axons are preferentially affected in multiple sclerosis (MS) and in the hereditary spastic paraplegias (HSP), in which the distal axon degenerates. Mitochondrial dysfunction has been implicated in the pathogenesis of these and other disorders involving axonal degeneration. The aim of this...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Edgar JM,McCulloch MC,Thomson CE,Griffiths IR

    更新日期:2008-08-01 00:00:00

  • Cytokines, chemokines, and cytokine receptors in human microglia.

    abstract::Enriched populations of human microglial cells were isolated from mixed cell cultures prepared from embryonic human telencephalon tissues. Human microglial cells exhibited cell type-specific antigens for macrophage-microglia lineage cells including CD11b (Mac-1), CD68, B7-2 (CD86), HLA-ABC, HLA-DR and ricinus communis...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Lee YB,Nagai A,Kim SU

    更新日期:2002-07-01 00:00:00

  • Detection of increased tissue concentrations of nerve growth factor with an improved extraction procedure.

    abstract::Nerve growth factor (NGF) is a protein essential for the survival and normal function of sympathetic neurons. Two-site immunoassays have been developed over the past decade in several laboratories and used to estimate its endogenous concentrations in a variety of effector tissues. However, levels appear restricted to ...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Zettler C,Bridges DC,Zhou XF,Rush RA

    更新日期:1996-12-01 00:00:00

  • Agonists for the peroxisome proliferator-activated receptor-alpha and the retinoid X receptor inhibit inflammatory responses of microglia.

    abstract::The peroxisome proliferator-activated receptor-alpha (PPAR-alpha) plays a key role in lipid metabolism and inflammation. Recently, we demonstrated that administration of the PPAR-alpha agonists gemfibrozil and fenofibrate, inhibit the clinical signs of experimental autoimmune encephalomyelitis (EAE), the animal model ...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Xu J,Storer PD,Chavis JA,Racke MK,Drew PD

    更新日期:2005-08-01 00:00:00

  • gammadelta T cells: the overlooked T-cell subset in demyelinating disease.

    abstract::gammadelta T cells represent a small subpopulation of T cells expressing a restricted repertoire of T-cell receptors and, unlike alphabeta T cells, function more as cells of the innate immune system. These cells are found in skin and mucosal sites as well as secondary lymphoid tissues and frequently act as first line ...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章,评审


    authors: Wohler JE,Smith SS,Barnum SR

    更新日期:2010-01-01 00:00:00

  • Vitamin content of some normal human brain segments.

    abstract::Nicotinates, pantothenates, riboflavin, vitamins B6 and B12' free (acetyl) and total (free and bound) choline, biopterin, thiamin, biotin, methylated and nonmethylated folates in frontal, temporal, precentral, postcentral, and occipital cortex, thalamus, cerebellum, pons, basal ganglia, and substantia nigra were estim...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Baker H,Frank O,Chen T,Feingold S,DeAngelis B,Baker E

    更新日期:1984-01-01 00:00:00

  • Aminopeptidase N mediates the utilization of the GSH precursor CysGly by cultured neurons.

    abstract::Neurons in culture rely on the supply of exogenous cysteine for their glutathione synthesis. After application of cysteine to neuron-rich primary cultures, the glutathione content was doubled after a 4-hr incubation. The dipeptide cysteinylglycine (CysGly) was able to substitute for cysteine as exogenous glutathione p...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Dringen R,Gutterer JM,Gros C,Hirrlinger J

    更新日期:2001-12-01 00:00:00

  • Ligands for EPH-related tyrosine kinase receptors are developmentally regulated in the CNS.

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    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Carpenter MK,Shilling H,VandenBos T,Beckmann MP,Cerretti DP,Kott JN,Westrum LE,Davison BL,Fletcher FA

    更新日期:1995-10-01 00:00:00

  • Axonal dependency of the postnatal upregulation in neurofilament expression.

    abstract::A coordinated up-regulation in the expression of all three neurofilament (NF) proteins occurs during postnatal development in the rat (Schlaepfer and Bruce, J Neurosci Res [in press], 1990a). In the present study, sciatic nerves were transected in neonatal rats in order to determine the effects of axotomy on the postn...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Schwartz ML,Shneidman PS,Bruce J,Schlaepfer WW

    更新日期:1990-10-01 00:00:00

  • Developmental expression of the neurotransmitter transporter GAT3.

    abstract::Neurotransmitter transporters are involved in termination of the synaptic neurotransmission and they also play a key role in neuroregulation and brain development. In this report, we describe the developmental distribution of the y-aminobutyric acid transporter GAT3 which transports gamma-aminobutyric acid (GABA) and ...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Jursky F,Nelson N

    更新日期:1999-02-01 00:00:00

  • Transcriptional repression of the growth-associated T alpha1 alpha-tubulin gene by target contact.

    abstract::In this report, we address the molecular mechanisms that regulate axonal growth by focusing on the gene for one of the major axonal cytoskeletal proteins, T alpha1 alpha-tubulin. During the developmental growth of sympathetic neurons, transcription of a beta-galactosidase transgene driven by the T alpha1 promoter (T a...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Wu W,Gloster A,Miller FD

    更新日期:1997-06-01 00:00:00

  • Cell-specific expression of neutral glycosphingolipids in vertebrate brain: immunochemical localization of 3-O-acetyl-sphingosine-series glycolipid(s) in myelin and oligodendrocytes.

    abstract::The tissue- and cell-specific expression of three neutral glycosphingolipids, gangliotetraosylceramide (GA1), gangliopentaosylceramide (GalNAc-GA1), and the novel 3-O-acetyl-sphingosine-series glycolipid (FMC-5), were examined with monospecific polyclonal antibodies. Immunohistochemical studies of rodent brain cross-s...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Dasgupta S,Bhat NR,Spicer SS,Hogan EL,Furuya S,Hirabayashi Y

    更新日期:2007-10-01 00:00:00

  • Proton magnetic resonance spectroscopy of cerebrospinal fluid in neurodegenerative disease: indication of glial energy impairment in Huntington chorea, but not Parkinson disease.

    abstract::Metabolite levels in cerebrospinal fluid from patients with Parkinson disease or Huntington chorea were compared with the levels in healthy controls using proton magnetic resonance spectroscopy. No significant differences were found for any metabolite measured in cerebrospinal fluid from patients with Parkinson diseas...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Gårseth M,Sonnewald U,White LR,Rød M,Zwart JA,Nygaard O,Aasly J

    更新日期:2000-06-15 00:00:00

  • Inherited demyelinating peripheral neuropathies: relating myelin packing abnormalities to P0 molecular defects.

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    authors: Kirschner DA,Szumowski K,Gabreëls-Festen AA,Hoogendijk JE,Bolhuis PA

    更新日期:1996-11-15 00:00:00

  • Down-regulation of caveolin-1 in glioma vasculature: modulation by radiotherapy.

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    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


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    更新日期:2004-01-15 00:00:00

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    journal_title:Journal of neuroscience research

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    authors: Knyihár-Csillik E,Kreutzberg GW,Csillik B

    更新日期:1989-01-01 00:00:00

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    authors: Herndon CA,Ankenbruck N,Fromm L

    更新日期:2014-02-01 00:00:00

  • Monocyte recruitment and myelin removal are delayed following spinal cord injury in mice with CCR2 chemokine receptor deletion.

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    journal_title:Journal of neuroscience research

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    authors: Ma M,Wei T,Boring L,Charo IF,Ransohoff RM,Jakeman LB

    更新日期:2002-06-15 00:00:00

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    journal_title:Journal of neuroscience research

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    authors: Skiba MC,Lyerla TA,Konola JT,Raghavan S

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    journal_title:Journal of neuroscience research

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    authors: Scerbo MJ,Rupil LL,Bibolini MJ,Roth GA,Monferran CG

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    abstract::In contrast to its known anti-apoptotic activity in sympathetic neurons, immortal neuronal cell lines, and primary cultured immature neurons of the central nervous system (CNS), the role of Bcl-2 in CNS neurons in the adult brain is poorly understood. In the present study, we examined effects of overexpression of Bcl-...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Wang HD,Fukuda T,Suzuki T,Hashimoto K,Liou SY,Momoi T,Kosaka T,Yamamoto K,Nakanishi H

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    authors: Pavlovic JM,Akcali D,Bolay H,Bernstein C,Maleki N

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    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Baltanás FC,Curto GG,Gómez C,Díaz D,Murias AR,Crespo C,Erdelyi F,Szabó G,Alonso JR,Weruaga E

    更新日期:2011-01-01 00:00:00

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    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Dummula K,Vinukonda G,Xu H,Hu F,Zia MT,Braun A,Shi Q,Wolk J,Ballabh P

    更新日期:2010-05-01 00:00:00

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    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Seino Y,Kawarabayashi T,Wakasaya Y,Watanabe M,Takamura A,Yamamoto-Watanabe Y,Kurata T,Abe K,Ikeda M,Westaway D,Murakami T,Hyslop PS,Matsubara E,Shoji M

    更新日期:2010-12-01 00:00:00

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    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Shi L,Song N,Jiang H,Wang J,Ma Z,Xie J

    更新日期:2009-02-01 00:00:00

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    journal_title:Journal of neuroscience research

    pub_type: 杂志文章,评审


    authors: Sedzik J,Jastrzebski JP,Grandis M

    更新日期:2015-01-01 00:00:00

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    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Hoogland G,Hens JJ,De Wit M,van Veelen CW,van Huffelen AC,Gispen WH,de Graan PN

    更新日期:2000-06-01 00:00:00