Brain-derived neurotrophic factor mitigates chronic ethanol-induced attenuation of gamma-aminobutyric acid responses in cultured cerebellar granule cells.

abstract：:We have developed tendon chitosan tubes having the ability to bind peptides covalently, and the effectiveness of laminin peptides coupled to these tubular wall on nerve regeneration was examined in vivo. Bridge graft implantation (15 mm) into the sciatic nerve of SD rats was carried out using chitosan tubes having a t...

journal_title：Journal of neuroscience research

authors： Suzuki M,Itoh S,Yamaguchi I,Takakuda K,Kobayashi H,Shinomiya K,Tanaka J

更新日期：2003-06-01 00:00:00

abstract：:Sympathetic noradrenergic nerve fibers, stained with antiserum for tyrosine hydroxylase (TH), richly innervate the splenic white pulp. These fibers distribute with the vascular and trabecular systems, and associate mainly with the central artery and its branches, the periarteriolar lymphatic sheath (PALS), the margina...

journal_title：Journal of neuroscience research

authors： Felten DL,Ackerman KD,Wiegand SJ,Felten SY

更新日期：1987-01-01 00:00:00

abstract：:Insulin-like growth factor II (IGF-II) plays significant roles in the growth and development of mammals through the regulation of mitogenesis and cell survival. Previously, IGF-II mRNA transcripts within the CNS were detected in the choroid plexus and leptomeninges (DeChiara et al., 1991). The objective of this study ...

journal_title：Journal of neuroscience research

authors： Hetts SW,Rosen KM,Dikkes P,Villa-Komaroff L,Mozell RL

更新日期：1997-12-15 00:00:00

abstract：:The phosphorylative neuromodulation of the regulatory subunit of protein kinase type II (R-II) in cytosolic fractions from denervated and sham-operated, contralateral soleus muscles of the rat was evaluated. The denervation-induced increase in the 32P-phosphorylation of R-II is not related to an increased dephosphoryl...

journal_title：Journal of neuroscience research

authors： McLane JA,Squinto SP,Yeoh HC,Held IR

更新日期：1985-01-01 00:00:00

abstract：:The aim of the present study was to prepare cultures enriched in type-2 astrocytes (AS) and to analyze some of the properties of these cells over relatively long culture periods. Cultures enriched in type-2 AS were obtained by subculturing, at low cell density and in the presence of fetal calf serum, a cell population...

journal_title：Journal of neuroscience research

authors： Aloisi F,Agresti C,Levi G

更新日期：1988-10-01 00:00:00

abstract：:The mammalian genome contains both constitutively expressed and heat-shock-inducible members of the hsp70 gene family. Riboprobes derived from members of these two classes of heat shock genes were utilized in Northern blot studies to analyze brain mRNA isolated from control rabbits and rats and from animals subjected ...

journal_title：Journal of neuroscience research

authors： Brown IR,Rush SJ

更新日期：1990-01-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease. Progressive and systemic loss of motor neurons with gliosis in the central nervous system (CNS) is a neuropathological hallmark of ALS. Chondroitin sulfate proteoglycans (CSPGs) are the major components of the extracellular matrix of the mammali...

journal_title：Journal of neuroscience research

authors： Shijo T,Warita H,Suzuki N,Kitajima Y,Ikeda K,Akiyama T,Ono H,Mitsuzawa S,Nishiyama A,Izumi R,Aoki M

更新日期：2018-02-01 00:00:00

abstract：:Axotomy is a powerful stimulus of axon growth and plastic changes. We investigated the potential role of BDNF/trkB signaling in the sprouting of dopaminergic nigral axons in response to axotomy of the medial forebrain bundle. Tyrosine hydroxylase immunohistochemistry revealed the existence of sprouting mechanisms in t...

journal_title：Journal of neuroscience research

authors： García Navia JT,Burguillos MA,Ramón-Cueto A,Machado A,Cano J,Venero JL

更新日期：2008-07-01 00:00:00

abstract：:Glial fibrillary acidic protein (GFAP) is the major constituent of glial filaments and is restricted within the CNS to astrocytes. As with other classes of intermediate filament proteins, the regulation of GFAP expression is poorly understood. Utilizing highly purified cultures of astrocytes and a chemically defined (...

journal_title：Journal of neuroscience research

authors： Morrison RS,De Vellis J,Lee YL,Bradshaw RA,Eng LF

更新日期：1985-01-01 00:00:00

abstract：:Scar formation after injury of the brain or spinal cord is a common event. While glial scar formation by astrocytes has been extensively studied, much less is known about the fibrotic scar, in particular after stroke. Platelet-derived growth factor receptor ß-expressing (PDGFRß+ ) pericytes have been suggested as a so...

journal_title：Journal of neuroscience research

authors： Roth M,Enström A,Aghabeick C,Carlsson R,Genové G,Paul G

更新日期：2020-05-01 00:00:00

abstract：:Manganese (Mn) is an essential metal and plays an important role in the brain. To evaluate Mn uptake into the brain during development and aging, 54Mn concentrations in the brain of rats aged from 5 days to 95 weeks were measured after injection of 54MnCl2. 54Mn concentration in the brain of 5-day-old rats was the hig...

journal_title：Journal of neuroscience research

authors： Takeda A,Ishiwatari S,Okada S

更新日期：1999-04-01 00:00:00

abstract：:Although gangliosides have been reported to enhance recovery from 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced lesions of the substantia nigra, evidence as to whether the administered gangliosides actually reach this or any other site of lesion in the central nervous system (CNS) at which they putativel...

journal_title：Journal of neuroscience research

authors： Saulino MF,Schengrund CL

更新日期：1994-02-15 00:00:00

abstract：:Human P0 is the main myelin glycoprotein of the peripheral nervous system. It can bind six different glycans, all linked to Asn(93) , the unique glycosylation site. Other myelin glycoproteins, also with a single glycosylation site (PMP22 at Asn(36) , MOG at Asn(31) ), bind only one glycan. The MAG has 10 glycosylation...

journal_title：Journal of neuroscience research

authors： Sedzik J,Jastrzebski JP,Grandis M

更新日期：2015-01-01 00:00:00

abstract：:The structures associated with learning and memory have been widely studied for over 100 years. The idea of the famous neuropsychologist K.S. Lashley, that learning and memory are stored diffusely in the brain, dominated neuroscience in the early half of Twentieth Century. Since Scoville reported in 1957 a persistent ...

journal_title：Journal of neuroscience research

authors： Shu SY,Wu YM,Bao XM,Leonard B

更新日期：2003-03-01 00:00:00

abstract：:Adult neurogenesis is influenced by blood-borne factors. In this context, greater or lesser vascular permeability along neurogenic niches would expose differentially neural stem cells (NSCs), transit amplifying cells (TACs), and neuroblasts to such factors. Here we evaluate endothelial cell morphology and vascular per...

journal_title：Journal of neuroscience research

authors： Colín-Castelán D,Ramírez-Santos J,Gutiérrez-Ospina G

更新日期：2016-02-01 00:00:00

abstract：:Multiple neurodegenerative disorders are associated with altered mitochondrial bioenergetics. Although mitochondrial O(2) consumption is frequently measured in isolated mitochondria, isolated synaptic nerve terminals (synaptosomes), or cultured cells, the absence of mature brain circuitry is a remaining limitation. He...

journal_title：Journal of neuroscience research

authors： Schuh RA,Clerc P,Hwang H,Mehrabian Z,Bittman K,Chen H,Polster BM

更新日期：2011-12-01 00:00:00

abstract：:The Rho GTPases are important regulators of neurite outgrowth and pathfinding. We have recently reported that a Rho-family guanine nucleotide exchange factor, GEFT, modulates dendrite spine morphology and basal neurite outgrowth in primary hippocampal neurons and Neuro2A cells, respectively. Here we demonstrate that G...

journal_title：Journal of neuroscience research

authors： Bryan BA,Cai Y,Liu M

更新日期：2006-05-15 00:00:00

abstract：:The concept of the neurovascular unit emphasizes that common signals and substrates underlie the physiology and pathophysiology of neuronal and endothelial compartments in brain. Recent data suggest that activation of the integrin-associated protein CD47 promotes neuronal cell death. Is it possible that CD47 may also ...

journal_title：Journal of neuroscience research

authors： Xing C,Lee S,Kim WJ,Wang H,Yang YG,Ning M,Wang X,Lo EH

更新日期：2009-08-15 00:00:00

abstract：:Neural precursor cells (NPCs) critically regulate brain morphogenesis and recent studies have revealed an unexpectedly high frequency of NPC chromosomal abnormalities and apoptosis in the developing brain. We have shown previously that the apoptotic response of NPCs to genotoxic agents is dependent on p53 and caspase-...

journal_title：Journal of neuroscience research

authors： D'Sa C,Klocke BJ,Cecconi F,Lindsten T,Thompson CB,Korsmeyer SJ,Flavell RA,Roth KA

更新日期：2003-11-01 00:00:00

abstract：:We have used adult mouse superior cervical ganglia (SCG) to study the role of mitogen activated protein (MAP) kinase activity during axonal outgrowth in vitro. An initial peak in activity within the first hours of culture was followed by a substantially higher activity after 1 to 2 days, a time when axons were activel...

journal_title：Journal of neuroscience research

authors： Svensson B,Ekström PA

更新日期：1998-05-15 00:00:00

abstract：:Bovine cerebrum, including the corpus callosum, and a human oligodendroglioma were investigated by an immunohistochemical technique to determine the distribution of 2':3'-cyclic nucleotide 3'-phosphodiesterase (CNP). Also, three human oligodendrogliomas (ODG) were characterized by an immunoblot procedure to identify a...

journal_title：Journal of neuroscience research

authors： Sheedlo HJ,Yaghmai F,Wolfe L 3rd,Sprinkle TJ

更新日期：1985-01-01 00:00:00

abstract：:An early and essential step in the formation of functional neuronal circuits is the establishment of cell polarity, a process involving the morphological and functional differentiation of the axon (axonogenesis). We now report that treatment of cultured embryonic hippocampal neurons with ethidium bromide (EtBr; an age...

journal_title：Journal of neuroscience research

authors： Mattson MP,Partin J

更新日期：1999-04-01 00:00:00

abstract：:CD200, a type I transmembrane glycoprotein, can interact with its receptor CD200R, which plays an inhibitory role in the activation of microglia-the resident macrophages of the central nervous system. In this study, the rat C6 glioma cell line (C6-1) that was previously characterized with high in vivo tumorigenicity w...

journal_title：Journal of neuroscience research

authors： Wang CY,Hsieh YT,Fang KM,Yang CS,Tzeng SF

更新日期：2016-12-01 00:00:00

abstract：:Dissociated neurons from the neural tube containing the trigeminal motor nucleus from early chick embryos were cultured on laminin or collagen-polyornithine substrates, with and without nerve growth factor (NGF). Control cultures were grown in similar conditions with cytochrome-C. It was found that neuronal survival w...

journal_title：Journal of neuroscience research

authors： Heaton MB

更新日期：1989-04-01 00:00:00

abstract：:The relationship between brain myelination and nutritional insufficiency in suckling rats whose dams had a restricted dietary intake was studied. The undernourished pups were characterized by body weight and brain weight that were 40-70% and 82-88% that of controls throughout the suckling period. Myelin concentrations...

journal_title：Journal of neuroscience research

authors： Yeh YY

更新日期：1988-03-01 00:00:00

abstract：:Previously, we reported the presence of multiple neurotransmitters in subclones of SN6, a septal cholinergic hybrid cell line. To obtain information concerning the functionality of these transmitters, we measured transmitter contents, activities of transmitter-producing enzymes, and the effect of serum-free culture me...

journal_title：Journal of neuroscience research

authors： Gallyas F Jr,Satoh J,Endoh M,Kunishita T,Tabira T

更新日期：1995-12-15 00:00:00

abstract：:Preterm birth results in significant cognitive and motor disabilities, but recent evidence suggests that there is variable recovery over time. One possibility that may explain this variable recovery entails variable neurogenic responses in the subventricular zone (SVZ) following the period of chronic hypoxia experienc...

journal_title：Journal of neuroscience research

authors： Li Q,Michaud M,Stewart W,Schwartz M,Madri JA

更新日期：2008-05-01 00:00:00

abstract：:Macrophages play critical roles in both degenerative and regenerative processes following peripheral nerve injury. These include phagocytosis of debris, stimulation of Schwann cell dedifferentiation and proliferation, and salvage of myelin lipids for reutilization during regeneration. To better define the role of macr...

journal_title：Journal of neuroscience research

authors： Venezie RD,Toews AD,Morell P

更新日期：1995-01-01 00:00:00

abstract：:Following the identification of the nociceptin/orphanin FQ (N/OFQ) peptide (NOP) as an endogenous ligand for the NOP receptor, ample evidence has revealed unique functional profiles of the N/OFQ-NOP receptor system. NOP receptors are expressed in key neural substrates involved in pain and reward modulation. In nonhuma...

journal_title：Journal of neuroscience research

authors： Kiguchi N,Ding H,Ko MC

更新日期：2020-04-07 00:00:00

abstract：:Experiments were conducted with the aid of intracellular microelectrodes to study physiological properties of neuropile glial cells in the central nervous system of the medicinal leech. The results showed significant contributions of both K+ and Cl- ions to the membrane potential. The transmitter substance 5-hydroxytr...

journal_title：Journal of neuroscience research

authors： Walz W

更新日期：1982-01-01 00:00:00