Evidence for mitochondrial control of neuronal polarity.

abstract：:Remyelination of the central nervous system in multiple sclerosis patients is often incomplete. Remyelination depends on normal oligodendrogenesis and the differentiation of oligodendrocyte precursor cells (OPC) into mature oligodendrocytes (OL). Inhibitor of DNA binding (ID), a transcription factor, is thought to inh...

journal_title：Journal of neuroscience research

authors： Chen XS,Zhang YH,Cai QY,Yao ZX

更新日期：2012-05-01 00:00:00

abstract：:To explore the feasibility of cell type-specific gene expression in oligodendrocytes as a possible therapeutic approach for demyelinating diseases, the cell specificity, tissue specificity, and duration of gene expression were investigated using recombinant adeno-associated viral vectors (rAAV) carrying a green fluore...

journal_title：Journal of neuroscience research

authors： Chen H,McCarty DM,Bruce AT,Suzuki K

更新日期：1999-02-15 00:00:00

abstract：:Immature and mature rat astroglia in culture were assayed for glutamine synthetase (GS) activity after a single exposure to the epileptogen FeCl2. Cells were cultured with both standard and elevated extracellular potassium or glutamate (Glu) concentrations. FeCl2 reduced GS activity below control levels, whereas high ...

journal_title：Journal of neuroscience research

authors： Tiffany-Castiglioni E,Roberts JA,Sheeler-Gough LV

更新日期：1989-12-01 00:00:00

abstract：:The distribution of phosphofructokinase (PFK) in gray and white matter regions of the rat nervous system was evaluated. Determinations of PFK activity revealed that cell body enriched regions (sensorimotor cortex) had a significantly higher level of activity than axonal regions (sciatic nerve, dorsal roots, and optic ...

journal_title：Journal of neuroscience research

authors： Oblinger MM,Foe LG,Kwiatkowska D,Kemp RG

更新日期：1988-09-01 00:00:00

abstract：:Deletion of the tumor suppressor gene p53 has been shown to improve the outcome in experimental models of focal cerebral ischemia and kainate-induced seizures. To evaluate the potential role of p53 in traumatic brain injury, genetically modified mice lacking a functional p53 gene (p53(-/-), n = 9) and their wild-type ...

journal_title：Journal of neuroscience research

authors： Tomasevic G,Raghupathi R,Scherbel U,Wieloch T,McIntosh TK

更新日期：2010-11-15 00:00:00

abstract：:Pyruvate carboxylation was studied in cerebellar astrocytes and granule neurons. The cells were incubated in medium containing [U-(13)C]glucose (2.5 mM) and [U-(13)C]lactate (1 mM) and varying amounts of 3-nitropropionic acid (3-NPA) plus/minus aspartate. 3-NPA alone clearly stopped tricarboxylic acid (TCA) cycle acti...

journal_title：Journal of neuroscience research

authors： Waagepetersen HS,Qu H,Schousboe A,Sonnewald U

更新日期：2001-12-01 00:00:00

abstract：:The induction of heat-shock protein 70 (hsp70) mRNA in the hyperthermic rabbit brain has been examined previously by using Northern blotting and in situ hybridization procedures that measure steady-state levels of mRNA, which may be influenced by transcript stability and transcription rate. In the present investigatio...

journal_title：Journal of neuroscience research

authors： D'Souza CA,Rush SJ,Brown IR

更新日期：1998-06-01 00:00:00

abstract：:We have previously shown that myelin-associated glycoprotein (MAG) inhibits neurite growth from a neuronal cell line. In this study we show that 60% of axonal growth cones of postnatal day 1 hippocampal neurons collapsed when they encountered polystyrene beads coated with recombinant MAG (rMAG). Such collapse was not ...

journal_title：Journal of neuroscience research

authors： Li M,Shibata A,Li C,Braun PE,McKerracher L,Roder J,Kater SB,David S

更新日期：1996-11-15 00:00:00

abstract：:F5 was identified originally as an interleukin-2-regulated gene in L2 cells, a murine helper T-lymphocyte clone. In adult mouse, F5 mRNA was expressed at a modest level in lymphoid tissues, at a high level in mature neurons in the nervous system, but not in other tissues. Although the F5 sequence is highly conserved o...

journal_title：Journal of neuroscience research

authors： Arai M,Cohen JA

更新日期：1993-10-15 00:00:00

abstract：:Male gerbils (Meriones unguiculatus) were bred and reared either grouped under enriched environmental conditions or isolated under impoverished environmental conditions. The objective of the present study was to examine the influence of social environment on structural and functional ontogeny of the medial prefrontal ...

journal_title：Journal of neuroscience research

authors： Winterfeld KT,Teuchert-Noodt G,Dawirs RR

更新日期：1998-04-15 00:00:00

abstract：:Although it has been well established that the drug efflux pump P-glycoprotein (P-gp) protects the brain against the entry of cytotoxic drugs, its real in situ localization, i.e., at brain capillary endothelial cells or on astrocyte foot processes, is still controversial. The aim of this study was to compare the expre...

journal_title：Journal of neuroscience research

authors： Declèves X,Regina A,Laplanche JL,Roux F,Boval B,Launay JM,Scherrmann JM

更新日期：2000-06-01 00:00:00

abstract：:Asphyxia during delivery produces long-term deficits in brain development, including hippocampus. We investigated hippocampal plasticity after perinatal asphyxia, measuring postnatal apoptosis and neurogenesis. Asphyxia was performed by immersing rat fetuses with uterine horns removed from ready-to-deliver rats into a...

journal_title：Journal of neuroscience research

authors： Morales P,Fiedler JL,Andrés S,Berrios C,Huaiquín P,Bustamante D,Cardenas S,Parra E,Herrera-Marschitz M

更新日期：2008-09-01 00:00:00

abstract：:Peroxides are generated continuously in cells that consume oxygen. Among the different peroxides, hydrogen peroxide is the molecule that is formed in highest quantities. In addition, organic hydroperoxides are synthesized as products of cellular metabolism. Generation and disposal of peroxides is a very important proc...

journal_title：Journal of neuroscience research

authors： Dringen R,Pawlowski PG,Hirrlinger J

更新日期：2005-01-01 00:00:00

abstract：:Reference genes are often used to normalize expression of data from real-time quantitative reverse transcription-polymerase chain reaction (RT-qPCR), and only a validation of their stability during a given experimental paradigm leads to reliable interpretations. The present study was thus designed to validate potentia...

journal_title：Journal of neuroscience research

authors： Pernot F,Dorandeu F,Beaup C,Peinnequin A

更新日期：2010-04-01 00:00:00

abstract：:We investigated the possible mechanisms how interferon (IFN)-beta may control T cell infiltration in the CNS in experimental autoimmune encephalomyelitis (EAE). Adoptive transfer (AT) EAE was induced in groups of six female Lewis rats. Animals were treated with 3 x 10(5) units of recombinant rat IFN-beta s.c. once at ...

journal_title：Journal of neuroscience research

authors： Schmidt J,Stürzebecher S,Toyka KV,Gold R

更新日期：2001-07-01 00:00:00

abstract：:Following the identification of the nociceptin/orphanin FQ (N/OFQ) peptide (NOP) as an endogenous ligand for the NOP receptor, ample evidence has revealed unique functional profiles of the N/OFQ-NOP receptor system. NOP receptors are expressed in key neural substrates involved in pain and reward modulation. In nonhuma...

journal_title：Journal of neuroscience research

authors： Kiguchi N,Ding H,Ko MC

更新日期：2020-04-07 00:00:00

abstract：:Anoxia during delivery is a complication that can disturb infant brain development leading to various types of neurological disorders. Our studies have shown that increased body temperature of newborn rats of both sexes intensifies the postanoxic oxidative stress and prevents triggering the endogenous adaptive respons...

journal_title：Journal of neuroscience research

authors： Kletkiewicz H,Maliszewska J,Jaworski K,Jermacz Ł,Smoliński DJ,Rogalska J

更新日期：2019-10-01 00:00:00

abstract：:Green fluorescent protein (GFP) transgenic zebrafish technology has been employed to directly visualize and analyze dynamic developmental processes, such as cell migration and morphogenesis. Stable transgenic zebrafish that express GFP in oligodendrocytes can be a valuable tool to visualize complex myelination process...

journal_title：Journal of neuroscience research

authors： Yoshida M,Macklin WB

更新日期：2005-07-01 00:00:00

abstract：:The blood-brain barrier (BBB) refers to the network of microvessels that selectively restricts the passage of substances between the circulation and the central nervous system (CNS). This microvascular network is comprised of arterioles, capillaries and venules, yet the respective contribution of each of these to the ...

journal_title：Journal of neuroscience research

authors： Macdonald JA,Murugesan N,Pachter JS

更新日期：2010-05-15 00:00:00

abstract：:Calcium-activated neutral proteinase (CANP) activity was determined in cytosolic and membranous subcellular fractions of transformed Schwann cells (tSc). The muM and mM Ca(2+)-sensitive (mu- and mCANP) forms of CANP were separated by DEAE and phenyl Sepharose column chromatography, the latter step enabling removal of ...

journal_title：Journal of neuroscience research

authors： Banik NL,DeVries GH,Neuberger T,Russell T,Chakrabarti AK,Hogan EL

更新日期：1991-07-01 00:00:00

abstract：:Previous observations have demonstrated decreased in vivo and in vitro protein synthesis by brain ribosomal systems following long-term ethanol ingestion. For further investigation of the properties of brain ribosomes, the 40S and 60S ribosomal subunits were successfully isolated from control and chronic 10% ethanol-d...

journal_title：Journal of neuroscience research

authors： Tewari S,Murray S,Noble EP

更新日期：1978-01-01 00:00:00

abstract：:The normal innervation of structures in mouse foot pads was investigated with immunohistochemistry and confocal microscopy. Nerves were visualized by incubating Zamboni fixed, thick, frozen sections with antibodies to protein gene product 9.5 (PGP 9.5), vasoactive intestinal peptide, substance P, calcitonin gene-relat...

journal_title：Journal of neuroscience research

authors： Navarro X,Verdú E,Wendelscafer-Crabb G,Kennedy WR

更新日期：1995-05-01 00:00:00

abstract：:Oligodendrocytes generate and maintain myelin, which is essential for axonal function and protection of the mammalian central nervous system. To advance our molecular understanding of differentiation by these cells, we screened libraries of pharmacologically active compounds and identified inducers of differentiation ...

journal_title：Journal of neuroscience research

authors： Joubert L,Foucault I,Sagot Y,Bernasconi L,Duval F,Alliod C,Frossard MJ,Pescini Gobert R,Curchod ML,Salvat C,Nichols A,Pouly S,Rommel C,Roach A,Hooft van Huijsduijnen R

更新日期：2010-09-01 00:00:00

abstract：:Transplanting neural stem cells (NSC) to the damaged brain has been regarded as a potential treatment for neurodegenerative diseases such as Alzheimer's disease (AD), a condition characterized by memory loss. We hypothesized that transplantation of NSC into the hippocampal regions of APP + PS1 transgenic (Tg) mice, a ...

journal_title：Journal of neuroscience research

authors： Zhang W,Wang GM,Wang PJ,Zhang Q,Sha SH

更新日期：2014-02-01 00:00:00

abstract：:Cultures of dissociated hypothalamic cells taken from rat fetuses of 19 days of gestation were studied using time-lapse recording and sequential microphotography from 1 to 5 days in vitro (DIV) and at 7 and 21 DIV. Cultures were seeded with cells taken from fetuses grouped by sex or sexually mixed; experimental cultur...

journal_title：Journal of neuroscience research

authors： Díaz H,Lorenzo A,Carrer HF,Cáceres A

更新日期：1992-10-01 00:00:00

abstract：:The N-methyl-D-aspartate receptor (NMDAR) is a major neurotransmitter receptor in the central nervous system (CNS), with functional roles in learning, memory, and sensation. Several mechanisms potentiate NMDARs, and NMDAR hyperexcitability plays pathophysiological roles in many conditions, such as neurodegenerative di...

journal_title：Journal of neuroscience research

authors： Mattar PA,Holmes KD,Dekaban GA

更新日期：2003-12-01 00:00:00

abstract：:Trophic factors, such as the neurotrophins, CNTF, and GDNF, represent unique families of proteins that are essential for the development of the vertebrate nervous system. Surprisingly, there is little evidence to date that these proteins exist in Drosophila melanogaster and Caenorhabditis elegans, even though other po...

journal_title：Journal of neuroscience research

authors： Chao MV

更新日期：2000-02-01 00:00:00

abstract：:Glial cell line-derived neurotrophic factor (GDNF) has been shown to be a preferentially selective neurotrophic factor for dopamine (DA) neurons. In the present study, we have examined the distribution of GDNF mRNA expression in several major DA-containing cell body and terminal areas and the regulation of GDNF mRNA e...

journal_title：Journal of neuroscience research

authors： Tang YP,Ma YL,Chao CC,Chen KY,Lee EH

更新日期：1998-09-01 00:00:00

abstract：:We have previously shown that the phorbol ester, TPA, which activates protein kinase C, causes, in PC12 cells, a transcriptional activation of tyrosine hydroxylase (TH), the key enzyme in catecholamine synthesis. The study has now been extended to examine the processes that underlie this transcriptional stimulation an...

journal_title：Journal of neuroscience research

authors： Icard-Liepkalns C,Biguet NF,Vyas S,Robert JJ,Sassone-Corsi P,Mallet J

更新日期：1992-06-01 00:00:00

abstract：:Tissue culture media with serum generally cause excessive astrocyte proliferation in neonatal brain cultures, and often fail to support neonatal neurons. Published serum-free media for brain cultures contain sodium pyruvate, which interferes with lactate dehydrogenase (LDH) assays for cell death. We wanted to use neon...

journal_title：Journal of neuroscience research

authors： Martin FC,Wiley CA

更新日期：1995-06-01 00:00:00