Abstract：
:Insulin-like growth factor II (IGF-II) plays significant roles in the growth and development of mammals through the regulation of mitogenesis and cell survival. Previously, IGF-II mRNA transcripts within the CNS were detected in the choroid plexus and leptomeninges (DeChiara et al., 1991). The objective of this study was to determine the expression pattern of IGF-II mRNA in different cell types of the cerebellum during development. We report here that the IGF-II gene is transcribed in granule and glial cells within the cerebellar parenchyma at various times during the early postnatal period in mice. IGF-II gene expression is further regulated by parent-specific imprinting such that only the paternal IGF-II allele is expressed in granule cells. In contrast, choroid plexus and leptomeninges express IGF-II mRNAs biallelically, indicating that cell type-specific regulation of genomic imprinting occurs within the mammalian CNS.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Hetts SW,Rosen KM,Dikkes P,Villa-Komaroff L,Mozell RLdoi
10.1002/(SICI)1097-4547(19971215)50:6<958::AID-JNRsubject
Has Abstractpub_date
1997-12-15 00:00:00pages
958-66issue
6eissn
0360-4012issn
1097-4547pii
10.1002/(SICI)1097-4547(19971215)50:6<958::AID-JNRjournal_volume
50pub_type
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