2-Phenylethynyl-butyltellurium attenuates amyloid-β peptide(25-35)-induced learning and memory impairments in mice.

abstract：:The objective of the present investigation was to answer the following question: Does the visual cortex affect the neuronal firing of retinal ganglion cells in the rat? To test this hypothesis, the visual cortex was inactivated by a reversible cryoblockade. Action potentials of a ganglion cell were recorded from its a...

journal_title：Journal of neuroscience research

authors： Molotchnikoff S,Tremblay F

更新日期：1983-01-01 00:00:00

abstract：:Muscarinic cholinergic receptors of the M5 subtype are expressed by dopamine-containing neurons of the ventral tegmentum. These M5 receptors modulate the activity of midbrain dopaminergic neurons, which play an important role in mediating reinforcing properties of abused psychostimulants like cocaine. The potential ro...

journal_title：Journal of neuroscience research

authors： Fink-Jensen A,Fedorova I,Wörtwein G,Woldbye DP,Rasmussen T,Thomsen M,Bolwig TG,Knitowski KM,McKinzie DL,Yamada M,Wess J,Basile A

更新日期：2003-10-01 00:00:00

abstract：:Polychlorinated biphenyls (PCBs) cause a wide spectrum of toxic effects in the brain through undefined mechanisms. Exposure to the PCB mixture Aroclor-1254 (A1254) increases the repressor element-1 silencing transcription factor (REST) expression, leading to neuronal death. This study sought to understand the sequence...

journal_title：Journal of neuroscience research

authors： Formisano L,Guida N,Laudati G,Boscia F,Esposito A,Secondo A,Di Renzo G,Canzoniero LM

更新日期：2015-01-01 00:00:00

abstract：:A study was conducted on the adsorption of 14C-ATP to a surface film of a hydrophobic protein derived from synaptic membranes isolated from bovine cerebellum. The adsorption of ATP to the protein film followed a rate law based on diffusion and an energy barrier to adsorption, the rate law being generally applicable to...

journal_title：Journal of neuroscience research

authors： Hoss W,Abood LG

更新日期：1976-01-01 00:00:00

abstract：:The p53 tumor suppressor gene, which is considered the guardian of the genome, encodes a phosphoprotein, which is a sequence-specific transcriptional activator or repressor of target genes. The role of p53 in developmental processes has not been studied extensively, although its expression appears to undergo temporal ...

journal_title：Journal of neuroscience research

authors： Poulaki V,Benekou A,Bozas E,Bolaris S,Stylianopoulou F

更新日期：1999-05-15 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) acutely modulates the efficacy of central glutamatergic synapses via activation of the receptor tyrosine kinase TrkB. On a longer time scale, recent evidence suggests an additional role of TrkB signaling in the formation of excitatory synaptic connections. Here, we have overexp...

journal_title：Journal of neuroscience research

authors： Klau M,Hartmann M,Erdmann KS,Heumann R,Lessmann V

更新日期：2001-11-01 00:00:00

abstract：:Previously, we reported that chelation of intracellular zinc with N, N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine (TPEN)-induced macromolecule synthesis-dependent apoptosis of cultured cortical neurons. According to the current theory of apoptosis, release of mitochondrial cytochrome C into the cytosol is required...

journal_title：Journal of neuroscience research

authors： Ahn YH,Koh JY,Hong SH

更新日期：2000-09-01 00:00:00

abstract：:The olfactory ensheathing cell (OEC) is a unique glial cell able to support neurite outgrowth in the CNS throughout life. The OEC has been described as having both Schwann cell-like and astrocyte-like characteristics. The purpose of this study was to compare gap junctional communication and connexin (Cx) expression in...

journal_title：Journal of neuroscience research

authors： Barnett SC,Thompson RJ,Lakatos A,Pitts J

更新日期：2001-09-15 00:00:00

abstract：:Metabolic fate of [8-14C]adenosine was studied in primary cultures of either astrocytes or neurons from the mouse brain. In astrocytes the main metabolic route was the formation of nucleotides. Thus, synthesis of adenosine triphosphate (ATP) amounted to about 0.2 nmol X min-1 X mg-1 protein. The deamination occurred l...

journal_title：Journal of neuroscience research

authors： Matz H,Hertz L

更新日期：1989-10-01 00:00:00

abstract：:Noise exposure is one of the most common causes of hearing loss. Recent studies found that noise exposure-induced cochlear damage may change the excitability and tonotopic organization of the central auditory system (CAS). This plasticity was suspected to be related to tinnitus and hyperacusis. However, how cochlear d...

journal_title：Journal of neuroscience research

authors： Niu Y,Kumaraguru A,Wang R,Sun W

更新日期：2013-02-01 00:00:00

abstract：:The thrombospondin (TSP) family of extracellular matrix glycoproteins are widely expressed in the developing and adult central nervous system although their function remains poorly defined. We have used cell culture techniques to analyse the expression and function of TSPs in glial cells derived from myelinated region...

journal_title：Journal of neuroscience research

authors： Scott-Drew S,ffrench-Constant C

更新日期：1997-10-15 00:00:00

abstract：:Transection of the hindlimb dorsal column fibers leads to a partial deafferentation of the neurons of the nucleus gracilis, the first relay of the ascending dorsal column-medial lemniscal (DC-ML) neural network. In response to the deafferentation, a synaptic renewal cycle is initiated and the neurons of the nucleus gr...

journal_title：Journal of neuroscience research

authors： Riley LA,Bernstein JJ

更新日期：1995-03-01 00:00:00

abstract：:Culturing sympathetic ganglion neurons in vitro may modify phenotypic expression of some neurotransmitters. For dorsal root ganglia (DRG), contradictory results have been reported; most studies have used immature material. We have therefore performed a detailed immunocytochemical analysis of the transmitter content of...

journal_title：Journal of neuroscience research

authors： Schoenen J,Delree P,Leprince P,Moonen G

更新日期：1989-04-01 00:00:00

abstract：:Systemic osmotic homeostasis is regulated mainly by neuroendocrine system of arginine-vasopressin (AVP) in mammalians. In the present study, we demonstrated that the immunoreactivity of tissue plasminogen activator (tPA) was observed specifically at neurosecretory granules of AVP-positive magnocellular terminals and t...

journal_title：Journal of neuroscience research

authors： Imamura Y,Morita S,Nakatani Y,Okada K,Ueshima S,Matsuo O,Miyata S

更新日期：2010-07-01 00:00:00

abstract：:Quercetin, a strong free radical scavenger, is investigated for neuroprotective effects in a Neuro 2a cell line conditionally transfected with 16Q huntingtin (Htt) and 150Q Htt, which express the protein upon stimulation. Cells were protected from death by a 20-µM dose of quercetin on the second day of Htt induction, ...

journal_title：Journal of neuroscience research

authors： Chakraborty J,Rajamma U,Jana N,Mohanakumar KP

更新日期：2015-10-01 00:00:00

abstract：:We have recently demonstrated that brain plastic events significantly modify synaptic protein synthesis measured by the incorporation of [(35)S]methionine in brain synaptosomal proteins. Notably, in rats learning a two-way active avoidance task, the local synthesis of two synaptic proteins was selectively enhanced. Be...

journal_title：Journal of neuroscience research

authors： Ferrara E,Cefaliello C,Eyman M,De Stefano R,Giuditta A,Crispino M

更新日期：2009-07-01 00:00:00

abstract：:Adenosine signalling has an important role in cochlear protection from oxidative stress. In most tissues, intracellular adenosine kinase (ADK) is the primary route of adenosine metabolism and the key regulator of intracellular and extracellular adenosine levels. The present study provides the first evidence for ADK di...

journal_title：Journal of neuroscience research

authors： Vlajkovic SM,Guo CX,Dharmawardana N,Wong AC,Boison D,Housley GD,Thorne PR

更新日期：2010-09-01 00:00:00

abstract：:Inhibitors of differentiation (Id) play an essential role in the neurogenesis of the central nervous system. However, the expression and function of Id in the development of cochlear sensory epithelial cells have yet to be elucidated. In this study, we demonstrate the Id1 gene was expressed in the rapidly growing otoc...

journal_title：Journal of neuroscience research

authors： Ozeki M,Hamajima Y,Feng L,Ondrey FG,Schlentz E,Lin J

更新日期：2007-02-15 00:00:00

abstract：:Nerve growth factor (NGF) has a modulating effect on immune function, which may occur as a consequence of binding to the NGF receptor (NGF-R). To determine if mRNA for the gene coding for p75NGFR (low affinity NGF-R) is present in lymphocytes, Northern blot analysis of mRNA from human peripheral blood lymphocytes (PBL...

journal_title：Journal of neuroscience research

authors： Kittur SD,Song L,Endo H,Adler WH

更新日期：1992-07-01 00:00:00

abstract：:Astrocytes are the most abundant glial cell in the central nervous system. They modulate synaptic function through a variety of mechanisms, and yet remain relatively understudied with respect to overall neuronal circuit function. Exploiting the tractability of the mouse olfactory system, we manipulated astrocyte activ...

journal_title：Journal of neuroscience research

authors： Ung K,Tepe B,Pekarek B,Arenkiel BR,Deneen B

更新日期：2020-08-01 00:00:00

abstract：:In contrast to its known anti-apoptotic activity in sympathetic neurons, immortal neuronal cell lines, and primary cultured immature neurons of the central nervous system (CNS), the role of Bcl-2 in CNS neurons in the adult brain is poorly understood. In the present study, we examined effects of overexpression of Bcl-...

journal_title：Journal of neuroscience research

authors： Wang HD,Fukuda T,Suzuki T,Hashimoto K,Liou SY,Momoi T,Kosaka T,Yamamoto K,Nakanishi H

更新日期：1999-07-01 00:00:00

abstract：:The 14-3-3 proteins exist predominantly in the brain and may play regulatory roles in cellular processes of growth, differentiation, survival, and apoptosis. The biological functions, however, of the various 14-3-3 isoforms (beta, epsilon, eta, gamma, and zeta) in the brain remain unclear. We have reported previously ...

journal_title：Journal of neuroscience research

authors： Chen XQ,Liu S,Qin LY,Wang CR,Fung YW,Yu AC

更新日期：2005-01-01 00:00:00

abstract：:The gene mutated in the mouse open brain (opb) phenotype antagonizes sonic hedgehog-mediated signaling and encodes a small GTPase of the Rab family, Rab23. To date, the brain expression profile and exact mechanism of function of the Rab23 protein has remained unknown. Specific antibodies generated against Rab23 showed...

journal_title：Journal of neuroscience research

authors： Guo A,Wang T,Ng EL,Aulia S,Chong KH,Teng FY,Wang Y,Tang BL

更新日期：2006-05-01 00:00:00

abstract：:The transplantation of dopaminergic (DA) progenitors derived from pluripotent stem cells improves the behavior of Parkinson's disease model animals. However, the survival of DA progenitors is low, and the final yield of DA neurons is only approximately 0.3%-2% the number of transplanted cells. Zonisamide (ZNS) increas...

journal_title：Journal of neuroscience research

authors： Miyawaki Y,Samata B,Kikuchi T,Nishimura K,Takahashi J

更新日期：2020-08-01 00:00:00

abstract：:We have developed a silicone nerve regeneration chamber that is partitioned into two compartments by a strip of nitrocellulose paper. The modified two-compartment chamber allows the investigation of the effects on rat sciatic nerve regeneration of trophic or growth factors that are initially bound to the nitrocellulos...

journal_title：Journal of neuroscience research

authors： Danielsen N,Pettmann B,Vahlsing HL,Manthorpe M,Varon S

更新日期：1988-07-01 00:00:00

abstract：:The potassium-induced stimulation of oxygen consumption in brain slices has a threshold value of 15-20 mM potassium, and it reaches its maximum at 35-50 mM. Although this phenomenon now has been known for almost 50 years, its physiological role remains undetermined. One reason for this may be that the high concentrati...

journal_title：Journal of neuroscience research

authors： Hertz L,Kjeldsen CS

更新日期：1985-01-01 00:00:00

abstract：:Convergent lines of evidence have recently highlighted β3-adrenoreceptors (ARs) as a potentially critical target in the regulation of nervous and behavioral functions, including memory consolidation, anxiety, and depression. Nevertheless, the role of β3-ARs in the cerebellum has been never investigated. To address thi...

journal_title：Journal of neuroscience research

authors： Lippiello P,Hoxha E,Cristiano C,Malvicini E,Stanley A,Russo R,Tempia F,Miniaci MC

更新日期：2020-11-01 00:00:00

abstract：:To study the influence of cell surface-associated molecules on intercellular communication, C6 glioma cells were cultured both on plastic and on substrata of paraformaldehyde-fixed B104 neuroblastoma cells. By then comparing the phenotypic expression of these "cocultured" C6 cells with cells cultured on tissue culture...

journal_title：Journal of neuroscience research

authors： Ciment G,de Vellis J

更新日期：1982-01-01 00:00:00

abstract：:Stroke is not only a leading cause of mortality and morbidity worldwide it also disproportionally affects women. There are currently over 500,000 more women stroke survivors in the US than men, and elderly women bear the brunt of stroke-related disability. Stroke has dropped to the fifth leading cause of death in men,...

journal_title：Journal of neuroscience research

authors： Spychala MS,Honarpisheh P,McCullough LD

更新日期：2017-01-02 00:00:00

abstract：:Amyloid beta-peptide (A beta) likely causes functional alterations in neurons well prior to their death. Nuclear factor-kappaB (NF-kappaB), a transcription factor that is known to play important roles in cell survival and apoptosis, has been shown to be modulated by A beta in neurons and glia, but the mechanism is unk...

journal_title：Journal of neuroscience research

authors： Kawamoto EM,Lepsch LB,Boaventura MF,Munhoz CD,Lima LS,Yshii LM,Avellar MC,Curi R,Mattson MP,Scavone C

更新日期：2008-03-01 00:00:00