Abstract:
:Restless Legs Syndrome (RLS) is a disorder of sensation with a prevalence of around 2-5% of the population. Relevant to understanding the possible pathophysiological mechanism is the fact that RLS is extremely responsive to dopaminergic agents. A second issue is that iron deficiency states may precipitate RLS in as much as 25-30% of people with iron deficiency. Studies looking at basal ganglia dopaminergic function using PET and SPECT techniques have shown a decrease in binding potential for the dopamine receptor and transporter. Similar phenomena occurs in iron-deficient animals. Using MRI techniques and CSF analysis of iron-related protein, studies have suggested a reduction in brain iron concentration occurs in RLS patients. The relevance of CNS iron metabolism to the pathophysiology of RLS is discussed.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Earley CJ,Allen RP,Beard JL,Connor JRdoi
10.1002/1097-4547(20001201)62:5<623::AID-JNR1>3.0.keywords:
subject
Has Abstractpub_date
2000-12-01 00:00:00pages
623-8issue
5eissn
0360-4012issn
1097-4547pii
10.1002/1097-4547(20001201)62:5<623::AID-JNR1>3.0.journal_volume
62pub_type
杂志文章,评审abstract::The concept of the neurovascular unit emphasizes that common signals and substrates underlie the physiology and pathophysiology of neuronal and endothelial compartments in brain. Recent data suggest that activation of the integrin-associated protein CD47 promotes neuronal cell death. Is it possible that CD47 may also ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22076
更新日期:2009-08-15 00:00:00
abstract::Even though ischemic stroke is among the leading causes of death worldwide, the pathogenic mechanisms underlying ischemia reperfusion (I/R) brain injury remain unclear. Gasdermin D (GSDMD), as an important factor of pyroptotic death execution downstream of caspase-11 (noncanonical inflammasome) and caspase-1 (canonica...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.24385
更新日期:2019-06-01 00:00:00
abstract::Cross-linking of alpha-synuclein and Lewy body formation have been implicated in the dopaminergic neuronal cell death observed in Parkinson's disease (PD); the mechanisms responsible, however, are not clear. Reactive oxygen species and advanced glycation end products (AGEs) have been found in the intracellular, alpha-...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21644
更新日期:2008-07-01 00:00:00
abstract::There are a considerable number of studies concerning the behavioral effects of physical exercise on the epileptic brain; however, the intracellular signaling mechanisms involved remain unclear. We investigated the effects of aerobic exercise on hippocampal levels of brain-derived neurotrophic factor (BDNF), expressio...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.24196
更新日期:2018-05-01 00:00:00
abstract::It has been postulated that the pathogenesis of Parkinson's disease (PD) is associated with mitochondrial dysfunction. Rotenone, an inhibitor of mitochondrial complex I, provides models of PD both in vivo and in vitro. We investigated the neuroprotective effect of D-beta-hydroxybutyrate (bHB), a ketone body, against r...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21021
更新日期:2006-11-01 00:00:00
abstract::The c-Jun N-terminal kinase (JNK) is induced by cerebral ischemia and injurious blood components acutely after subarachnoid hemorrhage (SAH). We hypothesized that inhibition of JNK will prevent damage to the neurovascular unit in the early brain injury period after SAH. Ninety-nine male SD rats (300-350 g) were random...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21281
更新日期:2007-05-15 00:00:00
abstract::Ischemia elicits a variety of stress responses in neuronal cells, which result in cell death. wld(S) Mice bear a mutation that significantly delays Wallerian degeneration. This mutation also protects all neuronal cells against other types of stresses resulting in cell death, including ischemia. To clarify the types of...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22792
更新日期:2012-03-01 00:00:00
abstract::Direct brain injections of the N-methyl-D-aspartate receptor agonist quinolinic acid (QA) trigger an excitotoxic cascade characterized by rapid neuronal death and glial/immune cell activation. The present study compared the timing of immediate early gene (IEG; c-fos, c-jun, jun-B, and zif/268) induction with the respo...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490360511
更新日期:1993-12-01 00:00:00
abstract::The potassium-induced stimulation of oxygen consumption in brain slices has a threshold value of 15-20 mM potassium, and it reaches its maximum at 35-50 mM. Although this phenomenon now has been known for almost 50 years, its physiological role remains undetermined. One reason for this may be that the high concentrati...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490140108
更新日期:1985-01-01 00:00:00
abstract::The central nervous system (CNS) is considered a nonpermissive environment for axonal regeneration because of the presence of myelin and associated repulsive molecules. However, neural cells transplanted to the CNS preferably migrate and extend their fibers in white matter areas. We previously showed that white matter...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20743
更新日期:2006-03-01 00:00:00
abstract::To study the influence of cell surface-associated molecules on intercellular communication, C6 glioma cells were cultured both on plastic and on substrata of paraformaldehyde-fixed B104 neuroblastoma cells. By then comparing the phenotypic expression of these "cocultured" C6 cells with cells cultured on tissue culture...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490070403
更新日期:1982-01-01 00:00:00
abstract::Individuals who regularly shift their sleep timing, like night and/or shift-workers suffer from circadian desynchrony and are at risk of developing cardiometabolic diseases and cancer. Also, shift-work is are suggested to be a risk factor for the development of mood disorders such as the burn out syndrome, anxiety, an...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.24741
更新日期:2021-02-01 00:00:00
abstract::The distribution of phosphofructokinase (PFK) in gray and white matter regions of the rat nervous system was evaluated. Determinations of PFK activity revealed that cell body enriched regions (sensorimotor cortex) had a significantly higher level of activity than axonal regions (sciatic nerve, dorsal roots, and optic ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490210105
更新日期:1988-09-01 00:00:00
abstract::Glial and glia-derived cells express a variety of receptors for neurotransmitters and hormones, the majority of which evoke both Ca(2+) release from intracellular stores and Ca(2+) entry across the plasma membrane. We investigated the links between histamine H(1) receptor activation, Ca(2+) release from intracellular ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21784
更新日期:2008-11-15 00:00:00
abstract::To investigate the mechanism underlying the regulation of claudin-5, a tight junction protein that participates primarily in the constitution of the blood-brain barrier by bradykinin (BK), we established a primary culture of rat brain microvascular endothelial cells (BMECs). BMECs were treated with 10(-5) M BK, and ch...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.23350
更新日期:2014-05-01 00:00:00
abstract::An elevated expression of c-fos nuclear protooncogene (immediate early gene) has been shown repeatedly to correlate with long-term neuronal responses. This paper reviews recent data suggesting that neuronal plasticity, including learning and memory formation, may involve c-fos expression as well. On the basis of biolo...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.490340402
更新日期:1993-03-01 00:00:00
abstract::Brain zinc homeostasis is strictly controlled under healthy conditions, indicating the importance of zinc for physiological function in the brain. A part of zinc in the brain exists in the synaptic vesicles, is released from a subclass of glutamatergic neurons (i.e., zincergic neurons), and serves as a signal factor (...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.23385
更新日期:2014-07-01 00:00:00
abstract::Early studies of murine experimental autoimmune encephalomyelitis (EAE) induced with myelin basic protein (MBP) divide various mouse strains into either "susceptible" or "resistant" phenotypes. Resistance is defined as lack of encephalitogenic responses after active immunization or adoptive transfer. It is now becomin...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19960915)45:6<690::AID-JNR
更新日期:1996-09-15 00:00:00
abstract::The higher prevalence and risk for Alzheimer's disease in women relative to men has been partially attributed to the precipitous decline in gonadal hormone levels that occurs in women following the menopause. Although considerable attention has been focused on the consequence of estrogen loss, and thus estrogen's neur...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21370
更新日期:2007-08-15 00:00:00
abstract::Six different types of spectral responses were recorded from horizontal cells under mesopic conditions in perfused retina, isolated from the dark-adapted mojarra (Eugerres plumieri). They were tentatively termed photopic Lr-, Lg1-, Lg2-, Lb-, and C-type, and scotopic L-type. The Lr-, Lg-, and Lb-type responses showed ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490200214
更新日期:1988-01-01 00:00:00
abstract::Recent studies have indicated that embryonic stem cells (ESCs) can be a source for the replacement of spiral ganglion neurons (SGNs), auditory primary neurons, and neurite projections from ESC-derived neurons to auditory sensory epithelia. However, the potential of ESC-derived neurons for synapse formation with audito...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21754
更新日期:2008-11-01 00:00:00
abstract::Glucocorticoid hormones affect gene expression directly at the level of transcription via intracellular receptors that translocate to the nucleus in the presence of steroid. In the brain, two types of high-affinity receptors bind glucocorticoids, the type I, mineralocorticoid receptor and the type II, glucocorticoid r...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490270315
更新日期:1990-11-01 00:00:00
abstract::It is believed that the impact of stress on interleukin-1β (IL-1β) depends on the ontogenetic age. This study examines the influence of acute or chronic exposure to forced-swim (FS) stress or high-light open-field (HL-OF) stimulation on the expression of IL-1β. Double immunofluorescence staining was used to reveal the...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.23428
更新日期:2014-11-01 00:00:00
abstract::Brain ageing leads to atrophy and degeneration of the cholinergic nervous system, resulting in profound neurobehavioral and cognitive dysfunction from decreased acetylcholine biosynthesis and reduced secretion of growth and neurotrophic factors. Human adipose tissue-derived mesenchymal stem cells (ADMSCs) were intrave...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.23182
更新日期:2013-05-01 00:00:00
abstract::Increased serum level of homocysteine, a sulfur-containing amino acid, is considered a risk factor in vascular disorders and in dementias. The effect of homocysteine and metabolically related compounds on brain production of kynurenic acid (KYNA), an endogenous antagonist of glutamate ionotropic receptors, was studied...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20359
更新日期:2005-02-01 00:00:00
abstract::Laminin mediates neural adhesion and process formation. A possible signal transduction pathway for laminin was investigated in both NG108-15 and PC12 neuronal cells using radiolabeling studies as well as various stimulators and inhibitors of phosphatases and kinases. Using [32P]-ortho-phosphate, laminin caused a decre...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490270321
更新日期:1990-11-01 00:00:00
abstract::Netrin-1 regulates axon extension during embryonic development and is expressed by neurons and myelinating oligodendrocytes in the adult CNS. To investigate the potential role of netrin-1 after spinal cord injury, we examined the expression of netrin-1 and netrin receptors after sagittal myelotomy in adult rats. This ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21070
更新日期:2006-12-01 00:00:00
abstract::Brain-derived neurotrophic factor (BDNF) is an extensively studied protein that is evolutionarily conserved and widely distributed in the brain of vertebrates. It acts via its cognate receptors TrkB and p75NTR and plays a central role in the developmental neurogenesis, neuronal survival, proliferation, differentiation...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.24536
更新日期:2020-05-01 00:00:00
abstract::Fatty acid amide hydrolase (FAAH) is a membrane-bound enzyme activity that degrades neuromodulatory fatty acid amides, including oleamide and anandamide. A single 2.5-kb FAAH mRNA is distributed throughout the rat CNS and accumulates progressively between embryonic day 14 and postnatal day 10, remains high until postn...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19971215)50:6<1047::AID-JN
更新日期:1997-12-15 00:00:00
abstract::Sympathetic noradrenergic nerve fibers, stained with antiserum for tyrosine hydroxylase (TH), richly innervate the splenic white pulp. These fibers distribute with the vascular and trabecular systems, and associate mainly with the central artery and its branches, the periarteriolar lymphatic sheath (PALS), the margina...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490180107
更新日期:1987-01-01 00:00:00