Abstract：
:Maternal stress exerts long-lasting psychiatric and somatic on offspring, which persist into adulthood. However, the effect of maternal stress on the postnatal growth of pups has not been widely reported. In this study, we found that maternal immobilization stress (IS) during lactation resulted in low body weight of male mouse offspring, which persisted after weaning. Despite free access to chow, IS induced maternal malnutrition and decreased the serum insulin-like growth factor-1 (IGF-1) levels in the mothers and in the pups. mRNA expression analysis of anterior pituitary hormones in the pups revealed that growth hormone (GH) and prolactin (PRL), but no other hormones, were decreased by IS. Expression of the pituitary transcription factor PIT1 and isoforms of PITX2, which are essential for the development and function of GH-producing somatotropes and PRL-producing lactotropes, was decreased, whereas that of PROP1, which is critical for the earlier stages of pituitary development, was unchanged. Immunohistochemistry also showed a decrease in pituitary PRL protein expression. These results suggest that stress in a postpartum mother has persistent effects on the body weight of the offspring. Reduced PRL expression in the offspring's pituitary gland may play a role in these effects.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Gao P,Ishige A,Murakami Y,Nakata H,Oka J,Munakata K,Yamamoto M,Nishimura K,Watanabe Kdoi
10.1002/jnr.22550subject
Has Abstractpub_date
2011-03-01 00:00:00pages
329-40issue
3eissn
0360-4012issn
1097-4547journal_volume
89pub_type
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journal_title：Journal of neuroscience research
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490410609
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490100107
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更新日期：2002-12-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490130111
更新日期：1985-01-01 00:00:00
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journal_title：Journal of neuroscience research
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doi：10.1002/jnr.1094
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journal_title：Journal of neuroscience research
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journal_title：Journal of neuroscience research
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journal_title：Journal of neuroscience research
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更新日期：2007-10-01 00:00:00
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