Abstract:
:Granulocyte colony-stimulating factor (G-CSF) is a hematopoietic cytokine that also possesses neurotrophic and antiapoptotic properties. G-CSF has been reported to decrease amyloid burden significantly, promote hippocampal neurogenesis, and improve spatial learning in a mouse model of Alzheimer's disease. To understand better the effects of G-CSF on hippocampal-dependent learning, the present study focused on electrophysiological correlates of neuroplasticity, long-term potentiation (LTP), and long-term depression (LTD). Two cohorts of transgenic APP/PS1 mice, with or without prior bone marrow transplantation from Tg GFP mice, were treated in vivo for 2 weeks with G-CSF or vehicle. After completion of the treatments, hippocampal slices were prepared for electrophysiological studies of LTP and LTD. LTP was induced and maintained in both G-CSF-treated and vehicle-treated groups of Tg APP/PS1. In contrast, LTD could not be induced in vehicle-treated Tg APP/PS1 mice, but G-CSF treatment restored LTD. The LTP and LTD results obtained from the cohort of bone marrow-grafted Tg APP/PS1 mice did not differ from those from nongrafted Tg APP/PS1 mice. The mechanism by which G-CSF restores LTD is not known, but it is possible that its capacity to reduce amyloid plaques results in increased soluble oligomers of amyloid-β (A-β), which in turn may facilitate LTD. This mechanism would be consistent with the recent report that soluble A-β oligomers promote LTD in hippocampal slices.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Song S,Wang X,Sava V,Weeber EJ,Sanchez-Ramos Jdoi
10.1002/jnr.23378subject
Has Abstractpub_date
2014-08-01 00:00:00pages
975-80issue
8eissn
0360-4012issn
1097-4547journal_volume
92pub_type
杂志文章abstract::Evidence indicates that the ubiquitin-proteasome system and the endoplasmic retculum (ER) quality-control system work in concert to ensure that proteins are correctly folded in the ER and that misfolded proteins are retrotransported to the cytosol for degradation by proteasomes. Dysfunction of either system results in...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.23413
更新日期:2014-10-01 00:00:00
abstract::The high circulating levels of leptin in neonatal rodents do not seem to be regulating energy balance at this age, but rather may play an important role for brain development. We tested the hypothesis that high neonatal leptin levels modify hippocampal function and production of synaptic proteins with possible long-te...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21173
更新日期:2007-03-01 00:00:00
abstract::This study was undertaken in order to establish the presence of pluripotential neuroblasts in the developing chick CNS. This has been suggested by our previous observations that expression of emerging neuronal phenotypes in the chick embryo CNS is affected by exposure to neurotrophic substances (i.e., GHRH, SRIF, NGF,...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490410516
更新日期:1995-08-01 00:00:00
abstract::The central nervous system (CNS) is considered a nonpermissive environment for axonal regeneration because of the presence of myelin and associated repulsive molecules. However, neural cells transplanted to the CNS preferably migrate and extend their fibers in white matter areas. We previously showed that white matter...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20743
更新日期:2006-03-01 00:00:00
abstract::Light microscopic anterograde tracing studies indicate that neurons in the central nucleus of the amygdala (CNA) project to a region of the dorsal pontine tegmentum ventral to the superior cerebellar peduncle which contains noradrenergic dendrites of the nucleus locus coeruleus (LC). However, it has not been establish...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19960801)45:3<289::AID-JNR
更新日期:1996-08-01 00:00:00
abstract::Astrocytes play a diverse role in central nervous system (CNS) injury. Production of the serine protease inhibitors (serpins) plasminogen activator inhibitor-1 (PAI-1) and protease nexin-1 (PN-1) by astrocytes may counterbalance excessive serine protease activity associated with CNS pathologies such as ischemic stroke...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22412
更新日期:2010-08-15 00:00:00
abstract::Spinocerebellar ataxia type 1 (SCA1) is a devastating neurodegenerative disorder in which an abnormally expanded polyglutamine tract is inserted into causative ataxin-1 proteins. We have previously shown that SCA1 knockin (SCA1-KI) mice over 6 months of age exhibit a degeneration of motor neuron axons and their encasi...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.23698
更新日期:2016-03-01 00:00:00
abstract::Physiological responses to acute stress proceed with the activation of the hypothalamus-pituitary-adrenal gland (HPA) system. Many brain regions are known to modulate the HPA axis activation in stress responses, but the detailed neural circuits and signaling system in the upstream of the HPA axis have to be explored f...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22119
更新日期:2009-10-01 00:00:00
abstract::Glial cell-line derived neurotrophic factor (GDNF) is the most potent trophic factor for motoneuron survival and neuromuscular junction formation. GDNF is upregulated in injured or denervated skeletal muscle and returns to normal levels following reinnervation. However, the mechanism by which GDNF is regulated in dene...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.23512
更新日期:2015-03-01 00:00:00
abstract::It is believed that the impact of stress on interleukin-1β (IL-1β) depends on the ontogenetic age. This study examines the influence of acute or chronic exposure to forced-swim (FS) stress or high-light open-field (HL-OF) stimulation on the expression of IL-1β. Double immunofluorescence staining was used to reveal the...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.23428
更新日期:2014-11-01 00:00:00
abstract::There is evidence that zinc may be involved in the pathogenesis of Parkinson's disease by an apoptotic pathway. However, the mechanisms underlying zinc-induced apoptosis are unknown. Previous studies showed that 6-hydroxydopamine (6-OHDA)-enhanced potassium channels are involved in apoptosis of dopaminergic neurons. O...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21854
更新日期:2009-02-01 00:00:00
abstract::Glutamate is an important regulator of dendrite development; however, during cerebral ischemia, massive glutamate release can lead to neurodegeneration and death. An early consequence of glutamate excitotoxicity is dendrite injury, which often precedes cell death. We examined the effect of glutamate on dendrite growth...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10797
更新日期:2003-12-01 00:00:00
abstract::Using [3H]-dopamine (DA) as the ligand of choice, we have shown that rat lymphocytes possess DA binding sites. The binding of [3H]-DA was specific, saturable, and of high affinity. The specific binding in membranes obtained from Con A-activated lymphoblasts was greater than the binding in respective unactivated lympho...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490180112
更新日期:1987-01-01 00:00:00
abstract::This study aimed at determining, based on independent predictors of taste intensity and emotional response, whether individual personality traits could affect prediction models of overall liking and preference rank toward basic taste solutions. Sixty-seven participants rated taste intensities (TI) of four basic-taste ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.24321
更新日期:2019-03-01 00:00:00
abstract::Regional estimates of type I and type II vestibular hair cells (HC) and supporting cell (SC) numbers were obtained from the horizontal crista ampullaris by using design-based stereology in human. Cristae were microdissected from temporal bones obtained post-mortem (N=16, age range 26-98 years). Three groups were made ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20652
更新日期:2005-11-01 00:00:00
abstract::Astroglial cells play an important role in maintaining neuronal function in the adult and in the developing nervous system. Ethanol exposure induces profound alterations in the astrogliogenesis process, affecting important cell functions, including intracellular protein trafficking. Because the actin cytoskeleton play...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10594
更新日期:2003-05-15 00:00:00
abstract::Pinealocytes of various mammalian species contain abundant synaptic-like microvesicles (SLMVs) which are considered the endocrine equivalent of neuronal synaptic vesicles. Although the pinealocytes may thus be a suitable cellular model for experimental in vitro studies of SLMVs, nothing is known about the presence of ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(sici)1097-4547(19970301)47:5<509::aid-jnr
更新日期:1997-03-01 00:00:00
abstract::Vascular smooth muscle (VSM) cells comprise one of the primary targets of the sympathetic nervous system and have been shown to secrete nerve growth factor (NGF). There is increasing evidence that changes in the levels of NGF in the adult may underlie certain pathological conditions. To investigate the potential role ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:
更新日期:1997-02-01 00:00:00
abstract::Efficient functioning of maintenance and repair processes seem to be crucial for both survival and physical quality of life. This is accomplished by a complex network of the so-called longevity assurance processes, under control of several genes termed vitagenes. These include members of the heat shock protein system,...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20386
更新日期:2005-02-15 00:00:00
abstract::The concept of the neurovascular unit emphasizes that common signals and substrates underlie the physiology and pathophysiology of neuronal and endothelial compartments in brain. Recent data suggest that activation of the integrin-associated protein CD47 promotes neuronal cell death. Is it possible that CD47 may also ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22076
更新日期:2009-08-15 00:00:00
abstract::Insulin-like growth factors, IGF-I and IGF-II, are potent regulators of oligodendrocyte development. Most of the IGF present in vivo is bound to members of a family of six high-affinity IGF-binding proteins (IGFBPs), which can either potentiate or inhibit IGF action, depending on other conditions. Additionally, serum ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19971201)50:5<721::AID-JNR
更新日期:1997-12-01 00:00:00
abstract::Our aim has been to investigate the ability of the rat brain to retain its level of neurotransmitter release over life. We have investigated the neurotransmitter release from the rat brain synaptosomes prelabeled with 3H-DA, 3H-NA, or 3H-5HT, and perfused with Krebs-Ringer medium alone (basal release) or containing a ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490340314
更新日期:1993-02-15 00:00:00
abstract::The prenatal and early postnatal stages represent a critical time window for human brain development. Interestingly, this window partly overlaps with the maturation of the intestinal flora (microbiota) that play a critical role in the bidirectional communication between the central and the enteric nervous systems (mic...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.24616
更新日期:2020-07-01 00:00:00
abstract::Microglia are prominently involved in neural degenerative diseases of the CNS and the retina. In this study, we determined the activation and phagocytotic function of different subtypes of retinal microglial cells at 1 week and 1 month following optic axotomy. Fluorescent DiI crystals were placed at the stumps of the ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10713
更新日期:2003-09-15 00:00:00
abstract::The contribution of glucose carbon to the biosynthesis of cholesterol and phospholipids in distinct brain regions was studied quantitatively in the adult male rat. Rates of flow of glucose carbon into the lipids in vivo were calculated from two measurements: the curve representing the decrease in plasma 14C-glucose wi...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490060505
更新日期:1981-01-01 00:00:00
abstract::Fibroblast growth factors (FGFs) are known to be synthesized in the central nervous system (CNS) and to act on CNS cells in vitro, but less is known about their synthesis, expression, and role in vivo. In this work, using specific anti-acidic fibroblast growth factor (aFGF) antibodies, we have shown for the first time...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490290417
更新日期:1991-08-01 00:00:00
abstract::Accumulating evidence indicates an immunosuppressive role for CD4(+)CD25(+) regulatory T cells (Tregs) in autoimmune diseases. Although an impaired Treg function in patients with relapsing-remitting multiple sclerosis (RR-MS) has been reported recently, no information is available so far about Treg function in the pro...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20852
更新日期:2006-06-01 00:00:00
abstract::We present here a fast protocol that could be used to obtain highly purified cultures of maximal proliferating adult rat Schwann cells. These adult rat Schwann cells can be transfected in a nonbiological way using the physical transfection method of electroporation. Schwann cells are decisive in recovery of peripheral...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20166
更新日期:2004-08-01 00:00:00
abstract::Increased serum level of homocysteine, a sulfur-containing amino acid, is considered a risk factor in vascular disorders and in dementias. The effect of homocysteine and metabolically related compounds on brain production of kynurenic acid (KYNA), an endogenous antagonist of glutamate ionotropic receptors, was studied...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20359
更新日期:2005-02-01 00:00:00
abstract::To study the potential role of Alzheimer precursor protein A4 (APP) and beta-amyloid (A/beta) on aging motor neuron survival, expression of APP, A/beta, and choline acetyltransferase (ChaT) were investigated in aged rats after either distal axotomy or root avulsion injury. Approximately 45% in number of total aged spi...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10667
更新日期:2003-08-15 00:00:00