Abstract:
:The chemokines, macrophage inflammatory protein-1 (MIP-1) and its subunit MIP-1 beta, induce an intense fever in the rat when they are injected directly into the anterior hypothalamic, pre-optic area (AH/POA), a region containing thermosensitive neurons. The purpose of this study was to compare the central action on body temperature (Tb) of MIP-1 beta with that of interleukin-6 (IL-6), which also has been implicated in the cerebral mechanism underlying the pathogenesis of fever. Following the stereotaxic implantation in the AH/POA of guide cannulae for repeated micro-injections, radio transmitters which monitor Tb continuously were inserted intraperitoneally in each of 15 male Sprague-Dawley rats. Each micro-injection was made in a site in the AH/POA in a volume of 1.0 microliter of pyrogen-free artificial CSF, recombinant murine MIP-1 beta, or recombinant human IL-6. MIP-1 beta in a dose of 25 pg evoked an intense fever characterized by a short latency, a mean maximum rise in Tb of 2.4 +/- 0.21 degrees C reached by 3.7 +/- 0.42 hr, and a duration exceeding 6.5 hr. Injected into homologous sites in the AH/POA, IL-6 induced a dose dependent fever of similar latency and a mean maximal increase in Tb of 1.2 +/- 0.25 degrees C, 1.8 +/- 0.15 degrees C, and 2.1 +/- 0.22 degrees C and duration of 6.2 +/- 1.28 hr, 6.7 +/- 0.49 hr, and 6.8 +/- 0.65 hr when given in doses of 25, 50, and 100 ng, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Myers RD,Lopez-Valpuesta FJ,Miñano FJ,Wooten MH,Barwick VS,Wolpe SDdoi
10.1002/jnr.490390105subject
Has Abstractpub_date
1994-09-01 00:00:00pages
31-7issue
1eissn
0360-4012issn
1097-4547journal_volume
39pub_type
杂志文章abstract::Astrocytes are glial cells that are distributed throughout the central nervous system in an arrangement optimal for chemical and physical interaction with neuronal synapses and brain blood supply vessels. Neurotransmission modulates astrocytic excitability by activating an array of cell surface receptors and transport...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.24075
更新日期:2017-12-01 00:00:00
abstract::Neuroanatomical studies suggest that neuronal atrophy and destruction occur over the course of many years in neurodegenerative conditions such as schizophrenia and Alzheimer's disease. In schizophrenia, early intervention with atypical neuroleptics such as olanzapine has been shown to prevent development of some of th...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10668
更新日期:2003-08-01 00:00:00
abstract::Prothrombin and its active derivative thrombin are key members of the coagulation system. The only site of extra-hepatic thrombin expression is the central nervous system (CNS), where it is involved in brain development, protection, and regeneration. Thrombin affects various degenerative and ischemic CNS diseases like...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.24049
更新日期:2017-10-01 00:00:00
abstract::NRAGE, also denominated as MAGE-D1 or Dlxin-1, is firstly identified as a molecule interacting with NGF low affinity receptor p75NTR. It facilitates cell cycle arrest and NGF-dependent neuronal apoptosis. Here we report that NRAGE is downregulated while p75NTR is upregulated during the process of NGF-induced neuronal ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22340
更新日期:2010-06-01 00:00:00
abstract::The two inbred strains of mice C57BL/6 (alcohol-preferring) and DBA/2 (alcohol-avoiding) mice have been shown to differ significantly in their preference for alcohol (EtOH). We have previously demonstrated the differences in the density and the affinity of cannabinoid (CB1) receptors in the brains of the two inbred C5...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.1094
更新日期:2001-05-15 00:00:00
abstract::Our previous work indicated that in E14 embryonic rat spinal cord cultures ciliary neuronotrophic factor (CNTF) exerted (1) a survival-promoting effect on motor neurons and on a large population of unidentified neurons, and (2) a regulatory role on the expression of ChAT and low affinity NGF receptor (LNGFR) in a popu...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490300314
更新日期:1991-11-01 00:00:00
abstract::In the following review, we address difficulties that have arisen when attempting to convert the myelin multilayers into vesicles. The emphasis is on CNS myelin of adult mammals although both central nervous system (CNS) and peripheral nervous system (PNS) myelin are considered. The ability to prepare vesicle of myeli...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.490410202
更新日期:1995-06-01 00:00:00
abstract::Cisplatin is a highly effective chemotherapeutic agent but with significant ototoxic side effects. Apoptosis is an important mechanism of cochlear hair cell loss following exposure to an ototoxic level of cisplatin. The present study investigated the effects of the cannabinoid receptor 2 (CB2) ligand JWH-015 on cispla...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21168
更新日期:2007-03-01 00:00:00
abstract::Metabolic abnormalities found in epileptogenic tissue provide considerable evidence of brain hypometabolism, while major risk factors for acquired epilepsy all share brain hypometabolism as one common outcome, suggesting that a breakdown of brain energy homeostasis may actually precede epileptogenesis. However, a caus...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.24019
更新日期:2017-11-01 00:00:00
abstract::Lipoic acid plays a crucial role as antioxidant and metabolic component of enzymes involved in glucose metabolism of different cell types. Choline alphoscerate (α-glyceryl-phosphoryl-choline [αGPC]) is a semisynthetic derivative of phosphatidylcholines representing, among acetilcholine precursors, a cholinergic drug. ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.23289
更新日期:2014-01-01 00:00:00
abstract::Changes in executive function are at the root of most cognitive problems associated with Parkinson's disease. Because dopaminergic treatment does not necessarily alleviate deficits in executive function, it has been hypothesized that dysfunction of neurotransmitters/systems other than dopamine (DA) may be associated w...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.23638
更新日期:2015-12-01 00:00:00
abstract::Experiments were conducted to determine whether the intensity of cyclic light exposure to the retina over a long period of time affects retinoid-dependent accumulation of lipofuscin in the retinal pigment epithelium (RPE). Albino rats were maintained from weaning on diets either containing (+A) or lacking (-A) retinyl...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19990701)57:1<106::AID-JNR
更新日期:1999-07-01 00:00:00
abstract::Brain-derived neurotrophic factor (BDNF) is well known to play a critical role in cognition. Its role in mood disorders, including post stroke depression (PSD), is also recognized with more evidence surfacing. In patients with PSD, their serum BNDF level is lower than in those without depression. Furthermore, antidepr...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.24510
更新日期:2020-03-01 00:00:00
abstract::In cultured Schwann cells, single-channel and whole-cell K+ currents can be activated by depolarizing the membrane to values more negative than -50 mV. In elevated extracellular K+ concentration ([K+]o), however, single-channel activity and whole-cell currents could be recorded at more negative potentials. Thus, the t...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490280208
更新日期:1991-02-01 00:00:00
abstract::The high circulating levels of leptin in neonatal rodents do not seem to be regulating energy balance at this age, but rather may play an important role for brain development. We tested the hypothesis that high neonatal leptin levels modify hippocampal function and production of synaptic proteins with possible long-te...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21173
更新日期:2007-03-01 00:00:00
abstract::Bovine cerebrum, including the corpus callosum, and a human oligodendroglioma were investigated by an immunohistochemical technique to determine the distribution of 2':3'-cyclic nucleotide 3'-phosphodiesterase (CNP). Also, three human oligodendrogliomas (ODG) were characterized by an immunoblot procedure to identify a...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490130309
更新日期:1985-01-01 00:00:00
abstract::Small-diameter myelinated CNS axons are preferentially affected in multiple sclerosis (MS) and in the hereditary spastic paraplegias (HSP), in which the distal axon degenerates. Mitochondrial dysfunction has been implicated in the pathogenesis of these and other disorders involving axonal degeneration. The aim of this...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21672
更新日期:2008-08-01 00:00:00
abstract::Previous studies on the NG2 chondroitin sulfate proteoglycan have shown that NG2 is expressed on A2B5-positive O2A progenitor cells, which are known to respond to platelet-derived growth factor (PDGF). In the accompanying paper (Nishiyama et al.; J Neurosci Res 43:299-314, 1996) we show that on O2A progenitors in the ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19960201)43:3<315::AID-JNR
更新日期:1996-02-01 00:00:00
abstract::Acrylamide (ACR) is an environmental toxicant and prototypic tool for studying mechanisms of peripheral neuropathies. Reductions in fast anterograde axonal transport (faAXT) are thought to be a critical step leading to axonal degeneration. Kinesin and microtubules (MT) were evaluated as molecular sites of action using...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19961001)46:1<7::AID-JNR2>
更新日期:1996-10-01 00:00:00
abstract::Heme oxygenase-1 (HO-1) is a stress protein induced in response to a variety of oxidative challenges. After treatment of the hybrid septal cells SN 56 with beta-amyloid peptide (beta-AP1-40) or hydrogen peroxide (H2O2), we detected high levels of reactive oxygen species, accompanied by a significant elevation in HO-1 ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19990615)56:6<652::AID-JNR
更新日期:1999-06-15 00:00:00
abstract::The transport kinetics of the excitatory sulphur-containing amino acid (SAA) transmitter candidates, L-cysteine sulphinate (L-CSA), L-cysteate (L-CA), L-homocysteine sulphinate (L-HCSA), and L-homocysteate (L-HCA), together with their plasma membrane carrier specificity, was studied in cerebrocortical synaptosome frac...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490320108
更新日期:1992-05-01 00:00:00
abstract::The Rho GTPases are important regulators of neurite outgrowth and pathfinding. We have recently reported that a Rho-family guanine nucleotide exchange factor, GEFT, modulates dendrite spine morphology and basal neurite outgrowth in primary hippocampal neurons and Neuro2A cells, respectively. Here we demonstrate that G...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20814
更新日期:2006-05-15 00:00:00
abstract::The male preponderance in autism prevalence has brought together the disparate topics of sex/gender and autism research. Two directions of neuroimaging studies on the relationships between sex/gender and autism may inform male-specific risk mechanisms and female-specific protective mechanisms of autism. First, we revi...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.23948
更新日期:2017-01-02 00:00:00
abstract::Traumatic brain injuries (TBIs) pose a massive burden of disease and continue to be a leading cause of morbidity and mortality throughout the world. A major obstacle in developing effective treatments is the lack of comprehensive understanding of the underlying mechanisms that mediate tissue damage and recovery after ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.24054
更新日期:2018-04-01 00:00:00
abstract::Traumatic brain injury (TBI) is the major cause of physical disability and emotional vulnerability. Treatment of TBI is lacking due to its multimechanistic etiology, including derailed mitochondrial and cellular energy metabolism. Previous studies from our laboratory show that an endogenous nitric oxide (NO) metabolit...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.24279
更新日期:2018-12-01 00:00:00
abstract::Cognitive decline in Parkinson's disease (PD) is a common sequela of the disorder that has a large impact on patient well-being. Its physiological etiology, however, remains elusive. Our study used graph theory analysis to investigate the large-scale topological patterns of the extrastriatal dopamine D2 receptor netwo...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.24760
更新日期:2020-12-03 00:00:00
abstract::L-deprenyl protects neurons in a number of in vivo and in vitro models and it has been postulated that it ameliorates some neurodegenerative disorders. Superoxide dismutase (SOD) is one of the enzymes responsible for the inactivation of oxygen free radicals, and one of the mechanisms of the effect of L-deprenyl is tho...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19980715)53:2<235::AID-JNR
更新日期:1998-07-15 00:00:00
abstract::The effects of fetal asphyxia on cerebral function and development, involve the transition from fetal to neonatal life. Changes in cerebral glucose metabolism may be an early postnatal indicator of fetal asphyxia. The objective is to develop an experimental lamb model involving the transition from fetal to neonatal li...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10051
更新日期:2001-12-01 00:00:00
abstract::This paper describes a novel technique to identify and study neurons that express specific mRNAs. The method is called Live FISH because it is like fluorescent in situ hybridization (FISH) but can be applied to living tissues. In Live FISH, molecular beacons, which fluoresce only in the presence of the complementary m...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22191
更新日期:2010-01-01 00:00:00
abstract::Transferrin is the second most abundant plasma protein and functions to transport iron. It is an essential constituent in culture media for virtually all cells. In a recent study, we reported that transferrin (Tf) is specifically located in oligodendrocytes in the rat nervous system. This investigation examines immuno...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490170108
更新日期:1987-01-01 00:00:00