Abstract:
:Heme oxygenase-1 (HO-1) is a stress protein induced in response to a variety of oxidative challenges. After treatment of the hybrid septal cells SN 56 with beta-amyloid peptide (beta-AP1-40) or hydrogen peroxide (H2O2), we detected high levels of reactive oxygen species, accompanied by a significant elevation in HO-1 expression. Levels of HO-1 increased and then decreased following cell loss. Pretreatment of SN 56 cells with HO-1 antisense oligonucleotides dramatically decreased the immunoreactivity of HO-1 and significantly enhanced the cytotoxicity of beta-AP1-40 and H2O2. In contrast, pretreatment with hemin, an HO-1 inducer, increased the expression of HO-1 and decreased the beta-AP1-40- and H2O2-induced cytotoxicity. These findings support the importance of HO-1 in protecting neurons against oxidative stress-induced injury.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Le WD,Xie WJ,Appel SHdoi
10.1002/(SICI)1097-4547(19990615)56:6<652::AID-JNRkeywords:
subject
Has Abstractpub_date
1999-06-15 00:00:00pages
652-8issue
6eissn
0360-4012issn
1097-4547pii
10.1002/(SICI)1097-4547(19990615)56:6<652::AID-JNRjournal_volume
56pub_type
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