Distribution of mitochondria along small-diameter myelinated central nervous system axons.

abstract：:Oligodendrocyte-specific protein (OSP/claudin-11) is a major component of CNS myelin and has been recently added to the claudin family of tight junction proteins. In this study, the developmental expression of OSP/claudin-11 was determined using in situ hybridization, immunohistochemistry (IH), and Western blot analys...

journal_title：Journal of neuroscience research

authors： Bronstein JM,Chen K,Tiwari-Woodruff S,Kornblum HI

更新日期：2000-05-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) infection in its human host often results in progressive dementia and encephalopathy in adults and children, respectively. The mechanisms underlying virus-induced neurocognitive dysfunction are not fully understood. However, several studies strongly suggest that secretory vi...

journal_title：Journal of neuroscience research

authors： Dong J,Xiong H

更新日期：2006-02-15 00:00:00

abstract：:T cell receptor (TCR) transgenic mice have been used extensively to study T cell development in vivo. Such studies have demonstrated high levels of expression of the TCR transgenes. Although a number of human T cell receptors appear to play a role in the development of autoimmune diseases, in vitro studies have proven...

journal_title：Journal of neuroscience research

authors： Baker AM,Wang Y,Richert JR

更新日期：1996-08-15 00:00:00

abstract：:Previously we reported the amplification of the peripheral myelin protein 22 (PMP22) gene in cell lines of human osteogenic and glioma tumors. PMP22 normally is expressed at high levels in Schwann cells of the peripheral nervous system and is suggested to function as a structural protein of the myelin sheath. One of t...

journal_title：Journal of neuroscience research

authors： Hühne K,Park O,Liehr T,Rautenstrauss B

更新日期：1999-12-01 00:00:00

abstract：:In rodents, oligodendrocytes and myelinating Schwann cells express connexin32 (Cx32) and Cx29, which have different localizations in the two cell types. We show here that, in contrast to Cx32, Cx29 does not form gap junction plaques or functional gap junctions in transfected cells. Furthermore, when expressed together...

journal_title：Journal of neuroscience research

authors： Ahn M,Lee J,Gustafsson A,Enriquez A,Lancaster E,Sul JY,Haydon PG,Paul DL,Huang Y,Abrams CK,Scherer SS

更新日期：2008-04-01 00:00:00

abstract：:In our in vitro model, rasagiline a selective irreversible monoamine oxidase-B (MAO-B) inhibitor, protected nerve growth factor (NGF)-differentiated PC12 cells from cell death under oxygen and glucose deprivation (OGD). The severity of the OGD insult, as expressed by cell death, was time-dependent. Exposure of the cel...

journal_title：Journal of neuroscience research

authors： Abu-Raya S,Blaugrund E,Trembovler V,Shilderman-Bloch E,Shohami E,Lazarovici P

更新日期：1999-11-01 00:00:00

abstract：:The presence of oligodendrocyte precursor cells which cannot be removed from primary cultures by antibody-dependent techniques complicates the interpretation of transplantation experiments designed to examine the potential of astrocytes to influence remyelination (Blakemore et al.; Glia 13:79-91, 1995). In the present...

journal_title：Journal of neuroscience research

authors： Crang AJ,Blakemore WF

更新日期：1997-07-01 00:00:00

abstract：:Stroke is not only a leading cause of mortality and morbidity worldwide it also disproportionally affects women. There are currently over 500,000 more women stroke survivors in the US than men, and elderly women bear the brunt of stroke-related disability. Stroke has dropped to the fifth leading cause of death in men,...

journal_title：Journal of neuroscience research

authors： Spychala MS,Honarpisheh P,McCullough LD

更新日期：2017-01-02 00:00:00

abstract：:Multiple sclerosis (MS) is an immune-mediated demyelinating disorder of unknown etiology. Both genetic-susceptibility and environment exposures, including vitamin D deficiency, Epstein-Barr viral and Herpesvirus (HHV-6) infections are strongly implicated in the activation of T cells and MS-pathogenesis. Despite precis...

journal_title：Journal of neuroscience research

authors： Tiwari S,Lapierre J,Ojha CR,Martins K,Parira T,Dutta RK,Caobi A,Garbinski L,Ceyhan Y,Esteban-Lopez M,El-Hage N

更新日期：2018-12-01 00:00:00

abstract：:Exogenously added gangliosides are known to promote neurite outgrowth in a variety of cell types, including some neuroblastoma cell lines. To study neuritogenesis in SH-SY5Y human neuroblastoma we serum starved the cells for 24 hr and exposed them to gangliosides (GM1, GM3, or GT1b), platelet-derived growth factor (PD...

journal_title：Journal of neuroscience research

authors： Hynds DL,Burry RW,Yates AJ

更新日期：1997-03-15 00:00:00

abstract：:Previous studies have shown that treating rat cortical neurons in primary culture with apolipoprotein E (apoE) peptide increased cytoplasmic Ca2+ by 2 mechanisms: 1) an influx of extracellular Ca2+ resulting from the activation of a cell surface Ca2+ channel; and 2) release of Ca2+ from internal Ca2+ stores via a G-pr...

journal_title：Journal of neuroscience research

authors： Wang X,Luebbe P,Gruenstein E,Zemlan F

更新日期：1998-03-01 00:00:00

abstract：:Nerve growth factor (NGF) is the best-characterized neurotrophic substance and has recently been shown to influence cholinergic neurons in the basal forebrain. Hippocampus and neocortex, the primary targets for these central neurons, have further been found to contain high levels of NGF. Using enzyme immunoassay and a...

journal_title：Journal of neuroscience research

authors： Lärkfors L,Strömberg I,Ebendal T,Olson L

更新日期：1987-01-01 00:00:00

abstract：:We used intracellular recording to investigate the functional interaction between protein kinase C (PKC) and protein kinase A (PKA) signal transduction cascades in the control of transmitter release in the neuromuscular synapses from adult rats. Our results indicate that: 1) PKA and PKC are independently involved in a...

journal_title：Journal of neuroscience research

authors： Santafé MM,Garcia N,Lanuza MA,Tomàs M,Tomàs J

更新日期：2009-02-15 00:00:00

abstract：:We have used adult mouse superior cervical ganglia (SCG) to study the role of mitogen activated protein (MAP) kinase activity during axonal outgrowth in vitro. An initial peak in activity within the first hours of culture was followed by a substantially higher activity after 1 to 2 days, a time when axons were activel...

journal_title：Journal of neuroscience research

authors： Svensson B,Ekström PA

更新日期：1998-05-15 00:00:00

abstract：:Oxidative stress results in protein oxidation and is implicated in cerebral disease, such as Parkinson's disease, Alzheimer's disease, and ischemic stroke. Sulfiredoxin-1 (Srxn1) is an endogenous antioxidant protein that has neuroprotective effects. The mechanisms of Srxn1 in oxidative stress have not been well studie...

journal_title：Journal of neuroscience research

authors： Li Q,Yu S,Wu J,Zou Y,Zhao Y

更新日期：2013-06-01 00:00:00

abstract：:Brain slices obtained from young rats were incubated with different radioactive precursors, in the presence and absence of L-cycloserine (an inhibitor of the synthesis of sphingosine) in order to explore the possibility that transport of proteolipids--and specifically of the major myelin proteolipid PLP--to the myelin...

journal_title：Journal of neuroscience research

authors： Pasquini JM,Guarna MM,Besio-Moreno MA,Iturregui MT,Oteiza PI,Soto EF

更新日期：1989-03-01 00:00:00

abstract：:Essential to understanding the roles proteins and structural elements play at the synapse is to understand the development, remodeling and reinnervation of peripheral neuromuscular junctions. It has, however, been a challenging task to label and visualize neuromuscular junctions. In this paper we demonstrate how adeno...

journal_title：Journal of neuroscience research

authors： Jacob JM,Zhou Q,Liu Y

更新日期：2000-07-01 00:00:00

abstract：:We have proposed that lactate is a "volume transmitter" in the brain and underpinned this by showing that the lactate receptor, G-protein-coupled receptor 81 (GPR81, also known as HCA1 or HCAR1), which promotes lipid storage in adipocytes, is also active in the mammalian brain. This includes the cerebral neocortex and...

journal_title：Journal of neuroscience research

authors： Morland C,Lauritzen KH,Puchades M,Holm-Hansen S,Andersson K,Gjedde A,Attramadal H,Storm-Mathisen J,Bergersen LH

更新日期：2015-07-01 00:00:00

abstract：:To identify and characterize the lineage potential of rat neural retina progenitor cells (NRPCs) in vitro and engrafted into rats with retinal degeneration, NRPCs were isolated from neural retinas of embryonic day 17 Long Evans rats and cultured in serum-free or serum-containing media with fibroblast growth factor 2 a...

journal_title：Journal of neuroscience research

authors： Yang P,Seiler MJ,Aramant RB,Whittemore SR

更新日期：2002-08-15 00:00:00

abstract：:The growth and differentiation of neural precursor cells in the central nervous system (CNS) are regulated by their response to polypeptide growth factors which interact with specific transmembrane receptor tyrosine kinases (RTKs). We demonstrate that rat oligodendrocyte-type 2 astrocyte (O-2A) glial progenitor cells,...

journal_title：Journal of neuroscience research

authors： Ida JA Jr,Dubois-Dalcq M,McKinnon RD

更新日期：1993-12-01 00:00:00

abstract：:Growing evidence suggests that decreased brain-derived neurotrophic factor (BDNF) levels are associated with Alzheimer's disease (AD) pathogenesis. Therefore, BDNF gene therapy is considered to be a promising therapeutic strategy for treating AD. Sendai virus (SeV) is a type I parainfluenza virus that does not interac...

journal_title：Journal of neuroscience research

authors： Iwasaki Y,Negishi T,Inoue M,Tashiro T,Tabira T,Kimura N

更新日期：2012-05-01 00:00:00

abstract：:Neurotrophins may have a neuroprotective role and are probably involved in the control of axonal sprouting and synaptic plasticity. An antibody raised against a pro-sequence of nerve growth factor (NGF) was tested. In control undisturbed rats, a strong immunoreactivity was detected in scattered cells in and around the...

journal_title：Journal of neuroscience research

authors： Humpel C,Ebendal T,Cao Y,Olson L

更新日期：1993-07-01 00:00:00

abstract：:Cytomegalovirus (CMV) is a major cause of congenital brain disease, and its neuropathogenesis may be related to viral infection of rapidly dividing, susceptible neural precursor cells (NPCs). In the present study, we evaluated the susceptibility of human fetal brain-derived NPCs (nestin(+), A2B5(+), CD133(+)) to infec...

journal_title：Journal of neuroscience research

authors： Cheeran MC,Hu S,Ni HT,Sheng W,Palmquist JM,Peterson PK,Lokensgard JR

更新日期：2005-12-15 00:00:00

abstract：:Monocyte chemoattractant protein-1 (MCP-1, CCL2) is a well-defined chemokine implicated in the pathology of various neurodegenerative diseases and brain injuries, such as Alzheimer's disease, multiple sclerosis, stroke, and traumatic injury. We investigated the effect of the activation of P2 purinoceptors on MCP-1 pro...

journal_title：Journal of neuroscience research

authors： Katayama T,Ito M,Kaneko S,Satoh M,Uehara T,Minami M

更新日期：2009-05-15 00:00:00

abstract：:Microglia, the resident macrophages of the central nervous system, are the primary cells to respond to injury in the brain, both in inflammation, e.g., in multiple sclerosis, and trauma. Chemokines are potential mediators of microglial cell recruitment to sites of injury; thus, the ability of microglia to migrate in r...

journal_title：Journal of neuroscience research

authors： Cross AK,Woodroofe MN

更新日期：1999-01-01 00:00:00

abstract：:Glial cell-line derived neurotrophic factor (GDNF) is the most potent trophic factor for motoneuron survival and neuromuscular junction formation. GDNF is upregulated in injured or denervated skeletal muscle and returns to normal levels following reinnervation. However, the mechanism by which GDNF is regulated in dene...

journal_title：Journal of neuroscience research

authors： Rosa E,Cha J,Bain JR,Fahnestock M

更新日期：2015-03-01 00:00:00

abstract：:Using subtype-specific Ca-channel blockers, we have characterised the voltage-sensitive Ca2+ currents as well as neurotransmitter release from cultured mouse cerebellar granule cells. The whole cell version of the patch clamp technique was adapted to monitor the isolated Ca-channel currents. The currents were activate...

journal_title：Journal of neuroscience research

authors： Varming T,Christopherson P,Schousboe A,Drejer J

更新日期：1997-04-01 00:00:00

abstract：:Barbiturates are regularly used as an anesthetic for animal experimentation and clinical procedures and are frequently provided with solubilizing compounds, such as ethanol and propylene glycol, which have been reported to affect brain function and, in the case of (1)H NMR experiments, originate undesired resonances i...

journal_title：Journal of neuroscience research

authors： Lei H,Duarte JM,Mlynarik V,Python A,Gruetter R

更新日期：2010-02-01 00:00:00

abstract：:The companion study showed that acoustic overstimulation of adult chinchillas, with a noise level sufficient to damage the cochlea, led to cytological changes and degeneration of synaptic endings in the cochlear nucleus within 1-16 weeks. In the present study, the same stimulus was used to study the long-term effects ...

journal_title：Journal of neuroscience research

authors： Kim JJ,Gross J,Potashner SJ,Morest DK

更新日期：2004-09-15 00:00:00

abstract：:A low concentration of transition metal ions Co2+ and Ni2+ increases the inward current density in neurons from the land snail Helix aspersa. The currents were measured using a single electrode voltage-clamp/internal perfusion method under conditions in which the external Na+ was replaced by Tris+, the predominant ext...

journal_title：Journal of neuroscience research

authors： Kim YK,Woodruff ML

更新日期：1991-04-01 00:00:00