Structure and function of long-lived olfactory organotypic cultures from postnatal mice.

abstract：:Lentiviral vectors are used widely to direct efficient gene transfer in vivo. We examined cell-specific expression in adult murine white matter after stereotaxic microinjection of four lentiviral constructs. We synthesized vesicular stomatitis virus glycoprotein (VSV-G) pseudotyped lentiviruses with combinations of tw...

journal_title：Journal of neuroscience research

authors： McIver SR,Lee CS,Lee JM,Green SH,Sands MS,Snider BJ,Goldberg MP

更新日期：2005-11-01 00:00:00

abstract：:Previous animal studies have linked white matter damage to certain schizophrenia-like behaviors in cuprizone (CPZ)-exposed mouse. Mitochondrial dysfunction, oxidative stress, neuroinflammation, and oligodendrocyte loss coexist in the brain of such mice. The aim of this study was to examine effects of the antioxidant N...

journal_title：Journal of neuroscience research

authors： Zhang L,Xu S,Huang Q,Xu H

更新日期：2018-05-01 00:00:00

abstract：:Fibroblast growth factor 2 (FGF2) exhibits pleiotropic functions during embryogenesis. In neural development, both pro- and antineurogenic activities of FGF2 have been described in the differentiation of neuronal progenitors into postmitotic neurons. We used cultured neural stem cells (NSCs) derived from rat embryonic...

journal_title：Journal of neuroscience research

authors： Tsai RY,Kim S

更新日期：2005-10-15 00:00:00

abstract：:Fibroblast growth factors (FGFs) are known to act on glial cells in vitro. At the present time, their involvement in the remyelinating process of the adult central nervous system (CNS) is still unknown. In the present study, using immunohistochemistry (IHC), we investigated the evolution in time and space of acidic FG...

journal_title：Journal of neuroscience research

authors： Tourbah A,Baron-Van Evercooren A,Oliver L,Raulais D,Jeanny JC,Gumpel M

更新日期：1992-09-01 00:00:00

abstract：:Evidence indicates that the ubiquitin-proteasome system and the endoplasmic retculum (ER) quality-control system work in concert to ensure that proteins are correctly folded in the ER and that misfolded proteins are retrotransported to the cytosol for degradation by proteasomes. Dysfunction of either system results in...

journal_title：Journal of neuroscience research

authors： Kuang XL,Liu F,Chen H,Li Y,Liu Y,Xiao J,Shan G,Li M,Snider BJ,Qu J,Barger SW,Wu S

更新日期：2014-10-01 00:00:00

abstract：:Epilepsy is one of the leading causes of chronic neurological morbidity worldwide. Acquired epilepsy may result from a number of conditions, such as brain injury, anoxia, tumors, stroke, neurotoxicity, and prolonged seizures. Sex differences have been observed in many seizure types; however, some sex-specific seizure ...

journal_title：Journal of neuroscience research

authors： Samba Reddy D

更新日期：2017-01-02 00:00:00

abstract：:Uptake of 2-deoxy-D-glucose (2-DG) has been studied in synaptosomes from the Long-Evans rat. Although there are some differences, the results are generally similar to those reported for Sprague--Dawley rats. Both D-glucose and 2-DG are taken up by the same carrier, since D-glucose was found to inhibit uptake of 2-DG. ...

journal_title：Journal of neuroscience research

authors： Wheeler DD,Hollingsworth RG

更新日期：1979-01-01 00:00:00

abstract：:A distinct population of white matter progenitor cells (WMPCs), competent but not committed to generate oligodendrocytes, remains ubiquitous in the adult human subcortical white matter. These cells are present in both sexes and into senescence and may constitute as much as 4% of the cells of adult human capsular white...

journal_title：Journal of neuroscience research

authors： Windrem MS,Roy NS,Wang J,Nunes M,Benraiss A,Goodman R,McKhann GM 2nd,Goldman SA

更新日期：2002-09-15 00:00:00

abstract：:Dissociated neurons from the neural tube containing the trigeminal motor nucleus from early chick embryos were cultured on laminin or collagen-polyornithine substrates, with and without nerve growth factor (NGF). Control cultures were grown in similar conditions with cytochrome-C. It was found that neuronal survival w...

journal_title：Journal of neuroscience research

authors： Heaton MB

更新日期：1989-04-01 00:00:00

abstract：:Changes in executive function are at the root of most cognitive problems associated with Parkinson's disease. Because dopaminergic treatment does not necessarily alleviate deficits in executive function, it has been hypothesized that dysfunction of neurotransmitters/systems other than dopamine (DA) may be associated w...

journal_title：Journal of neuroscience research

authors： Pflibsen L,Stang KA,Sconce MD,Wilson VB,Hood RL,Meshul CK,Mitchell SH

更新日期：2015-12-01 00:00:00

abstract：:Chronic alcohol consumption has adverse effects on the central nervous system, affecting some hippocampal and hypothalamic functions. In this study we tempted to demonstrate that some of these modifications could involve impairment of neurotrophic factors. Three experimental groups of male Sprague Dawley rats were stu...

journal_title：Journal of neuroscience research

authors： Tapia-Arancibia L,Rage F,Givalois L,Dingeon P,Arancibia S,Beaugé F

更新日期：2001-01-15 00:00:00

abstract：:We have investigated the involvement of c-Jun in cell death induced by exposure of primary cultures of murine cerebellar granule cells to the glutamate receptor agonist kainate (KA) and evaluated its possible use as a marker for apoptosis. Using cerebellar granule cell neurones from postnatal day 7 mice, we found that...

journal_title：Journal of neuroscience research

authors： Cheung NS,Carroll FY,Larm JA,Beart PM,Giardina SF

更新日期：1998-04-01 00:00:00

abstract：:Adult neurogenesis is influenced by blood-borne factors. In this context, greater or lesser vascular permeability along neurogenic niches would expose differentially neural stem cells (NSCs), transit amplifying cells (TACs), and neuroblasts to such factors. Here we evaluate endothelial cell morphology and vascular per...

journal_title：Journal of neuroscience research

authors： Colín-Castelán D,Ramírez-Santos J,Gutiérrez-Ospina G

更新日期：2016-02-01 00:00:00

abstract：:Mutations in the beta-amyloid precursor protein (APP) gene cause familial Alzheimer's disease (AD). Although amyloid beta peptide (Abeta) is the principal constituent of senile plaques in AD, other cleavage products of APP are also implicated in playing a role in the pathogenesis of AD. C-terminal fragments of APP (AP...

journal_title：Journal of neuroscience research

authors： Lee JP,Chang KA,Kim HS,Kim SS,Jeong SJ,Suh YH

更新日期：2000-05-15 00:00:00

abstract：:We describe here the presence of ubiquitin and its conjugation system in the rat retina. Retinal homogenates and supernatants conjugate [125I]human ubiquitin with either endogenous or exogenous proteins. The conjugating activity is relatively stable over time, requires ATP, and has a pH optimum of approximately 8. The...

journal_title：Journal of neuroscience research

authors： Naash M,Izbicka E,Anderson RE

更新日期：1991-10-01 00:00:00

abstract：:Cyclooxygenase-2 (COX-2), a key enzyme in prostanoid biosynthesis, may represent an important therapeutic target in Alzheimer's disease (AD). In the present study, we explored the regulation of COX-2 in the hippocampal formation in sporadic AD. Using semiquantitative immunocytochemical techniques, we found that in AD ...

journal_title：Journal of neuroscience research

authors： Ho L,Pieroni C,Winger D,Purohit DP,Aisen PS,Pasinetti GM

更新日期：1999-08-01 00:00:00

abstract：:Multiple unit activity (MUA) was obtained from gonadotropic areas of the hypothalamus in quail. Pellets of radioluminous paint (RLP) were implanted unilaterally either in the nucleus tuberis or in the n. posterior medialis hypothalami. Control data were obtained from birds receiving nonluminous material (RP). Spontane...

journal_title：Journal of neuroscience research

authors： Oliver J,Baylé JD

更新日期：1976-01-01 00:00:00

abstract：:Lithium, the most prevalent treatment for manic-depressive illness, might have a neuroprotective effect after brain injury. In culture, lithium can exert neurotoxic effects associated with reduction in polyamine synthesis but neuroprotective effects as cultured neurons mature. Cumulative evidence suggests that lithium...

journal_title：Journal of neuroscience research

authors： Gilad GM,Gilad VH

更新日期：2007-02-15 00:00:00

abstract：:In a military setting, traumatic brain injury (TBI) is frequently caused by blast waves that can trigger a series of neuronal biochemical changes. Although many animal models have been used to study the effects of primary blast waves, elucidating the mechanisms of damage in a whole-animal model is extremely complex. I...

journal_title：Journal of neuroscience research

authors： Zander NE,Piehler T,Boggs ME,Banton R,Benjamin R

更新日期：2015-09-01 00:00:00

abstract：:In 2000, a landmark case report described the concurrent restoration of consciousness and thalamo-frontal connectivity after severe brain injury (Laureys et al., ). Being a single case however, this study could not disambiguate whether the result was specific to the restoration of consciousness per se as opposed to th...

journal_title：Journal of neuroscience research

authors： Crone JS,Bio BJ,Vespa PM,Lutkenhoff ES,Monti MM

更新日期：2018-04-01 00:00:00

abstract：:We have developed a transgenic mouse expressing the Cre recombinase under control of a tetracycline-responsive promoter. Using a CamKIIalpha-driven tTA transgenic strain and a lacZ reporter mouse, we obtained the expected neuronal pattern of recombination in the olfactory lobe, cortex, striatum, hippocampus and Purkin...

journal_title：Journal of neuroscience research

authors： Lindeberg J,Mattsson R,Ebendal T

更新日期：2002-04-15 00:00:00

abstract：:The growth cone, the motile tip of developing neuronal processes, is considered responsible for the exact guidance of axons and synaptogenesis. High activity of tyrosine kinases in growth cones may contribute to the functions of growth cones. Our previous work revealed that vinculin is one of the endogenous substrates...

journal_title：Journal of neuroscience research

authors： Igarashi M,Komiya Y

更新日期：1991-09-01 00:00:00

abstract：:The cellular localization of calpain is important in understanding the roles that calpain may play in physiological function. We, therefore, examined calpain expression, activity, and immunofluorescent localization in primary cultures of rat oligodendrocytes. The mRNA expression of m-calpain was 64.8% (P = 0.0033) and...

journal_title：Journal of neuroscience research

authors： Ray SK,Neuberger TJ,Deadwyler G,Wilford G,DeVries GH,Banik NL

更新日期：2002-11-15 00:00:00

abstract：:Inhibitory luminopsins (iLMO2) integrate opto- and chemo-genetic approaches and allow for cell-type specific inhibition of neuronal activity. When exposed to a Renilla luciferase substrate, Coelenterazine (CTZ), iLMO2 generates bioluminescence-mediated activation of its amino-terminal halorhodopsin, resulting in neuro...

journal_title：Journal of neuroscience research

authors： Jaiswal PB,Tung JK,Gross RE,English AW

更新日期：2020-03-01 00:00:00

abstract：:There are two types of calcium-activated neutral protease (CANP), m-CANP and mu-CANP, following the nomenclature of Suzuki et al to show that each requires mM and microM Ca2+, respectively, for its activation. We found mu-CANP activity in a crude CANP fraction extracted from the peripheral nerve, which degraded the ne...

journal_title：Journal of neuroscience research

authors： Kamakura K,Ishiura S,Suzuki K,Sugita H,Toyokura Y

更新日期：1985-01-01 00:00:00

abstract：:The increase in myelin basic protein (MBP) synthesis observed in brain aggregate cultures supplemented with macrophages is reflected in elevated supernatant protein levels of the key promoters of oligodendrocyte proliferation, fibroblast growth factor-2 (FGF-2) and platelet-derived growth factor-AA (PDGF-AA), during t...

journal_title：Journal of neuroscience research

authors： Diemel LT,Jackson SJ,Cuzner ML

更新日期：2003-12-15 00:00:00

abstract：:Metabolic fate of [8-14C]adenosine was studied in primary cultures of either astrocytes or neurons from the mouse brain. In astrocytes the main metabolic route was the formation of nucleotides. Thus, synthesis of adenosine triphosphate (ATP) amounted to about 0.2 nmol X min-1 X mg-1 protein. The deamination occurred l...

journal_title：Journal of neuroscience research

authors： Matz H,Hertz L

更新日期：1989-10-01 00:00:00

abstract：:The cell line PC12, derived from a rat pheochromocytoma, has served as a model for studies on the mechanism of action of nerve growth factor, as well as for the exploration of neuronal differentiation in general. When treated with nanomolar concentrations of nerve growth factor, these neoplastic chromaffin-like cells ...

journal_title：Journal of neuroscience research

authors： Simpson DL,Dickens G,Doll S,Koizumi S,Tocco M,Okuda O,Oshima M,Rudkin BB,Brightman M,Guroff G

更新日期：1991-04-01 00:00:00

abstract：:Neuron-glia interactions at paranodal junctions play important roles in action potential propagation. Among their many functions, they contribute to the passive electrical properties of myelinated nerve fibers and actively regulate the polarized distribution of ion channels along axons. Despite their importance, relat...

journal_title：Journal of neuroscience research

authors： Ogawa Y,Rasband MN

更新日期：2009-11-15 00:00:00

abstract：:The metabolism of glutamate, the most likely neurotransmitter of vestibular ganglion cells, includes synthesis from glutamine by the enzyme glutaminase. We used microdissection combined with a fluorometric assay to measure glutaminase activity in the vestibular nerve root and nuclei of rats with unilateral vestibular ...

journal_title：Journal of neuroscience research

authors： Godfrey DA,Xu J,Godfrey MA,Li H,Rubin AM

更新日期：2004-08-15 00:00:00