Early postnatal development of rat brain: in vivo diffusion tensor imaging.


:Perinatal hypoxia is a major cause of neurodevelopmental deficits. Neuronal migration patterns are particularly sensitive to perinatal hypoxia/ischemia and are associated with the clinical deficits. The rat model of hypoxia/ischemia at P7 mimics that of perinatal injury in humans. Before assessing the effects of postnatal injury on brain development, it is essential to determine the normal developmental trajectories of various brain structures in individual animals. In vivo longitudinal diffusion tensor imaging (DTI) was performed from postnatal day 0 (P0) to P56 on Wistar rats. The DTI metrics, mean diffusivity (MD), fractional anisotropy (FA), axial (lambdal) and radial (lambdat) diffusivities, were determined for four gray matter and eight white matter structures. The FA of the cortical plate and the body of corpus callosum decreased significantly during the first 3 weeks after birth. The decrease in the cortical plate's FA value was associated mainly with an increase in lambdat. The initial decrease in FA of corpus callosum was associated with a significant decrease in lambdal. The FA of corpus callosum increased during the rest of the observational period, which was mainly associated with a decrease in lambdat. The FA of gray matter structures, hippocampus, caudate putamen, and cortical mantle did not show significant changes between P0 and P56. In contrast, the majority of white matter structures showed significant changes between P0 and P56. These temporal changes in the DTI metrics were related to the neuronal and axonal pruning and myelination that are known to occur in the developing brain.


J Neurosci Res


Bockhorst KH,Narayana PA,Liu R,Ahobila-Vijjula P,Ramu J,Kamel M,Wosik J,Bockhorst T,Hahn K,Hasan KM,Perez-Polo JR




Has Abstract


2008-05-15 00:00:00












  • Toll-like receptors 2 and 3 agonists differentially affect oligodendrocyte survival, differentiation, and myelin membrane formation.

    abstract::Toll-like receptors (TLRs) play a key role in controlling innate immune responses to a wide variety of pathogen-associated molecules as well as endogenous signals. In addition, TLR expression within nonimmune cells has been recognized as as modulator of cell behavior. In this study we have addressed the question of wh...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Bsibsi M,Nomden A,van Noort JM,Baron W

    更新日期:2012-02-01 00:00:00

  • Myelin phagocytosis and remyelination of macrophage-enriched central nervous system aggregate cultures.

    abstract::An increased level of myelin basic protein (MBP) degradation peptide 80-89, representative of myelin breakdown, is detected in myelinating foetal rat brain aggregate cultures supplemented with peritoneal macrophages at a time coinciding with the onset of myelination. During the period of myelination, the proportion of...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Copelman CA,Diemel LT,Gveric D,Gregson NA,Cuzner ML

    更新日期:2001-12-15 00:00:00

  • Elevated serum haptoglobin after traumatic brain injury is synthesized mainly in liver.

    abstract::Haptoglobin (Hp), an acute-phase response protein, is typically increased in the serum of adults after acute tissue injury. It is an antioxidant and may function as an injury-induced neuroprotective protein. However, the source of increased Hp is not clear. To investigate its source, we compared its time course expres...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Yang S,Ma Y,Liu Y,Que H,Zhu C,Liu S

    更新日期:2013-02-01 00:00:00

  • Expression of IGF-I and insulin receptor genes in the rat central nervous system: a developmental, regional, and cellular analysis.

    abstract::Using a solution-hybridization assay and specific oligonucleotidic probes, we have studied IGF-I and insulin receptor mRNAs in the rat central nervous system during development. The expression of mRNAs was maximal at embryonic day 15 and 20 for IGF-I receptors, and at embryonic day 20 and the day of birth for insulin ...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Baron-Van Evercooren A,Olichon-Berthe C,Kowalski A,Visciano G,Van Obberghen E

    更新日期:1991-02-01 00:00:00

  • Substrate specificity and developmental aspects of a presynaptic GABA receptor regulating glutamate release in the rat cerebellum.

    abstract::In order to better characterize the presynaptic GABA receptors regulating glutamate release in the cerebellum [Levi and Gallo, 1981], a number of GABA agonists and GABA transport inhibitors were tested for their ability to potentiate the depolarization-induced release of the glutamate analog D-[3H]aspartate from super...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Aloisi F,Gallo V,Levi G

    更新日期:1983-01-01 00:00:00

  • The role of maternal diet on offspring gut microbiota development: A review.

    abstract::In offspring, an adequate maternal diet is important for neurodevelopment. One mechanism by which maternal diet impacts neurodevelopment is through its dynamic role in the development of the gut microbiota. Communication between the gut, and its associated microbiota, and the brain is facilitated by the vagus nerve, i...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章,评审


    authors: Al Rubaye H,Adamson CC,Jadavji NM

    更新日期:2021-01-01 00:00:00

  • Neurofilament protein in cerebrospinal fluid: a marker of white matter changes.

    abstract::The objective of this study was to compare cerebrospinal fluid (CSF) levels of the light subtype of the neurofilament proteins (NFL), tau, and beta-amyloid42 (Abeta42) in individuals with moderate or severe white matter changes (WMC) and in those with mild or no WMC. Twenty-two patients with Alzheimer's disease (AD), ...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Sjögren M,Blomberg M,Jonsson M,Wahlund LO,Edman A,Lind K,Rosengren L,Blennow K,Wallin A

    更新日期:2001-11-01 00:00:00

  • Purification of the 33,000-dalton ligand binding-protein constituent of the lymphoblast substance P receptor.

    abstract::Substance P (SP) acts as an immunoregulator by binding to specific functional cell surface receptors on a subpopulation of human T-helper lymphocytes. Receptors with similar properties have also been characterized on the human IM-9 B-lymphoblast cell line. Four distinct proteins of molecular weight (MW) 33,000, 58,000...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: McGillis JP,Organist ML,Scriven KH,Payan DG

    更新日期:1987-01-01 00:00:00

  • Effects of unilateral vestibular ganglionectomy on glutaminase activity in the vestibular nerve root and vestibular nuclear complex of the rat.

    abstract::The metabolism of glutamate, the most likely neurotransmitter of vestibular ganglion cells, includes synthesis from glutamine by the enzyme glutaminase. We used microdissection combined with a fluorometric assay to measure glutaminase activity in the vestibular nerve root and nuclei of rats with unilateral vestibular ...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Godfrey DA,Xu J,Godfrey MA,Li H,Rubin AM

    更新日期:2004-08-15 00:00:00

  • Glutamate and metabotropic glutamate receptors associated with innervation of the uterine cervix during pregnancy: receptor antagonism inhibits c-Fos expression in rat lumbosacral spinal cord at parturition.

    abstract::Dorsal root ganglia (DRG) neurons connect the spinal cord and uterine cervix, and are activated at parturition with subsequent stimulation of secondary neurons in the spinal dorsal horn and autonomic areas. Neuropeptide neurotransmitters and receptors have been studied in these areas, but amino acid transmitters, e.g....

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Ghosh C,Storey-Workley M,Usip S,Hafemeister J,Miller KE,Papka RE

    更新日期:2007-05-01 00:00:00

  • Blockade of dopamine D1 receptors in male rats disrupts morphine reward in pain naïve but not in chronic pain states.

    abstract::The rewarding effect of opiates is mediated through dissociable neural systems in drug naïve and drug-dependent states. Neuroadaptations associated with chronic drug use are similar to those produced by chronic pain, suggesting that opiate reward could also involve distinct mechanisms in chronic pain and pain-naïve st...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Grenier P,Mailhiot MC,Cahill CM,Olmstead MC

    更新日期:2019-11-12 00:00:00

  • Iron-enriched oligodendrocytes: a reexamination of their spatial distribution.

    abstract::Previous histochemical studies of iron in the brain demonstrated iron enrichment in oligodendrocytes, but the iron-enriched oligodendrocytes had a spatially restricted distribution that excluded major white matter tracts. In this study we used techniques designed to permeabilize tissue, combined with iron histochemist...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: LeVine SM,Macklin WB

    更新日期:1990-08-01 00:00:00

  • Small-molecule inhibitors of bone morphogenic protein and activin/nodal signals promote highly efficient neural induction from human pluripotent stem cells.

    abstract::The balance of bone morphogenic protein (BMP), transforming growth factor-β (TGFβ)/activin/nodal, and Wnt signals regulates the early lineage segregation of human embryonic stem cells (ESCs). Here we demonstrate that a combination of small-molecule inhibitors of BMP (Dorsomorphin) and TGFβ/activin/nodal (SB431542) sig...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Morizane A,Doi D,Kikuchi T,Nishimura K,Takahashi J

    更新日期:2011-02-01 00:00:00

  • Fatty acid and long-chain base composition of gangliosides isolated from adult human brain.

    abstract::A series of major and minor ganglioside species were isolated from a single human adult brain and analyzed for their lipophilic composition. Hematosides, GM3 and GD3, each showing double bands on thin-layer chromatograms, were separated into the upper band and lower band fractions to be analyzed for the heterogeneity ...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Ando S,Yu RK

    更新日期:1984-01-01 00:00:00

  • Localization of constitutive and hyperthermia-inducible heat shock mRNAs (hsc70 and hsp70) in the rabbit cerebellum and brainstem by non-radioactive in situ hybridization.

    abstract::Neural expression of constitutive hsc70 mRNA and hyperthermia-inducible hsp70 mRNA is examined using radioactive and non-radioactive in situ hybridization procedures. A strong induction of hsp70 mRNA was noted in cell populations in cerebellar layers and in the brainstem which demonstrated expression of mRNA encoding ...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Foster JA,Rush SJ,Brown IR

    更新日期:1995-08-01 00:00:00

  • Types of cholecystokinin-containing periglomerular cells in the mouse olfactory bulb.

    abstract::The periglomerular cells (PG) of the olfactory bulb (OB) are involved in the primary processing and the refinement of sensory information from the olfactory epithelium. The neurochemical composition of these neurons has been studied in depth in many species, and over the last decades such studies have focused mainly o...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Baltanás FC,Curto GG,Gómez C,Díaz D,Murias AR,Crespo C,Erdelyi F,Szabó G,Alonso JR,Weruaga E

    更新日期:2011-01-01 00:00:00

  • Microarray analysis of gene expression in proliferating Schwann cells: synergistic response of a specific subset of genes to the mitogenic action of heregulin plus forskolin.

    abstract::Cultured Schwann cells treated with heregulin growth factor require costimulation with a cyclic adenosine monophosphate-elevating agent to produce maximal cell proliferation. Gene chip expression analysis was used to identify genes that are induced or repressed when Schwann cells are treated with heregulin and/or fors...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Schworer CM,Masker KK,Wood GC,Carey DJ

    更新日期:2003-08-15 00:00:00

  • Phosphorylation of MARCKS (80-kDa) protein, a major substrate for protein kinase C in oligodendroglial progenitors.

    abstract::We have recently reported a potent mitogenic stimulation of oligodendroglial (OL) progenitors by the protein kinase C (PKC) activating phorbol ester, i.e., phorbol 12-myristate 13-acetate (PMA) (Bhat NR, J Neurosci Res 22:20-27, 1989). The present study deals with PMA-induced protein phosphorylation reactions in cultu...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Bhat NR

    更新日期:1991-10-01 00:00:00

  • Characterization of kinases involved in the phosphorylation of aggregated α-synuclein.

    abstract::α-Synuclein (α-syn) is the major component of pathological inclusions characteristic of several neurodegenerative disorders, such as Parkinson's disease. The major posttranslational modification of α-syn is phosphorylation at S129, and previous studies estimate that approximately 90% of α-syn in proteinaceous, patholo...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Waxman EA,Giasson BI

    更新日期:2011-02-01 00:00:00

  • Isatin binding proteins in rat brain: in situ imaging, quantitative characterization of specific [3H]isatin binding, and proteomic profiling.

    abstract::Isatin (indole-2,3-dione) is an endogenous indole that has a distinct and discontinuous distribution in the brain and in other mammalian tissues and body fluids. Its output is increased under conditions of stress and anxiety. Its biological targets remain poorly characterized, although [(3)H]isatin binding sites have ...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Crumeyrolle-Arias M,Buneeva O,Zgoda V,Kopylov A,Cardona A,Tournaire MC,Pozdnev V,Glover V,Medvedev A

    更新日期:2009-09-01 00:00:00

  • Metabolically derived aspartate--elevated extracellular levels in vivo in lodoacetate poisoning.

    abstract::Glycolysis was blocked in the hippocampus of the otherwise unaffected rabbit by perfusion of a previously implanted thin dialysis tube with a medium containing 0.1 mM iodoacetate. The perfusate from the dialysis tube was analyzed for free amino acids with liquid chromatographic separation of ortophthaldialdehyde deriv...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Sandberg M,Nyström B,Hamberger A

    更新日期:1985-01-01 00:00:00

  • Histamine-induced Ca2+ entry in human astrocytoma U373 MG cells: evidence for involvement of store-operated channels.

    abstract::Glial and glia-derived cells express a variety of receptors for neurotransmitters and hormones, the majority of which evoke both Ca(2+) release from intracellular stores and Ca(2+) entry across the plasma membrane. We investigated the links between histamine H(1) receptor activation, Ca(2+) release from intracellular ...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Barajas M,Andrade A,Hernandez-Hernandez O,Felix R,Arias-Montaño JA

    更新日期:2008-11-15 00:00:00

  • Identification and preliminary characterization of ubiquitin C terminal hydrolase 1 (UCHL1) as a biomarker of neuronal loss in aneurysmal subarachnoid hemorrhage.

    abstract::By using two different approaches, ubiquitin C-terminal hydrolase 1 (UCHL1) was identified as a potential cerebrospinal fluid (CSF) biomarker of neuronal loss in aneurysmal subarachnoid hemorrhage (ASAH) and presumably other CNS damage and disease states. Appropriate antibodies and a sensitive ELISA were generated, an...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Lewis SB,Wolper R,Chi YY,Miralia L,Wang Y,Yang C,Shaw G

    更新日期:2010-05-15 00:00:00

  • Impaired sensory function in heterozygous P0 knockout mice is associated with nodal changes in sensory nerves.

    abstract::Mice heterozygously deficient in the major myelin component P0 are an established model of an inherited neuropathy and show signs of myelin degeneration in motor nerves. Unlike the case in patients, the sensory nerves are only mildly affected in the mouse mutants and do not show features indicative of myelin degenerat...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Samsam M,Frei R,Marziniak M,Martini R,Sommer C

    更新日期:2002-01-15 00:00:00

  • Sex-dependent and differential responses to acute restraint stress of corticotropin-releasing factor-producing neurons in the rat paraventricular nucleus, central amygdala, and bed nucleus of the stria terminalis.

    abstract::Male and female rodents respond differently to acute stress. We tested our hypothesis that this sex difference is based on differences in stress sensitivity of forebrain areas, by determining possible effects of a single acute psychogenic stressor (1-hr restraint stress) on neuronal gene expression (c-Fos and FosB imm...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Sterrenburg L,Gaszner B,Boerrigter J,Santbergen L,Bramini M,Roubos EW,Peeters BW,Kozicz T

    更新日期:2012-01-01 00:00:00

  • Localization of NGF receptors in normal and Alzheimer's basal forebrain with monoclonal antibodies against the truncated form of the receptor.

    abstract::Four new monoclonal antibodies to the extracellular domain of the nerve growth factor receptor (NGFR) have been evaluated for their specificity to NGFR and their utility in localizing NGFR in human brain. All four antibodies, as well as Me20.4, show similar cellular localization and patterns of immunoreactivity in bas...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Loy R,Heyer D,Clagett-Dame M,DiStefano PS

    更新日期:1990-12-01 00:00:00

  • Neurotrophin-3 enhances neurite outgrowth in cultured hippocampal pyramidal neurons.

    abstract::Low density dissociated cultures of embryonic rat hippocampal cells were used to study the effects of neurotrophin-3 (NT-3) on neuronal morphogenesis. The results obtained indicate that NT-3 enhances neurite outgrowth and branching; this is a dose-dependent effect, detected in approximately 50% of the neurons, and pre...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Morfini G,DiTella MC,Feiguin F,Carri N,Cáceres A

    更新日期:1994-10-01 00:00:00

  • Neural progenitor cells resist excitatory amino acid-induced neurotoxicity.

    abstract::The applications of neural progenitor cells in clinical therapy for neural degeneration, such as Parkinson's disease, Huntington's disease, and cerebral infarction, have long been explored widely. It had been suggested that these cells may block the apoptosis of ischemia-induced neuronal damage and may themselves resi...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Hsieh WY,Hsieh YL,Liu DD,Yang SN,Wu JN

    更新日期:2003-01-15 00:00:00

  • Nanoscale intracortical iron injection induces chronic epilepsy in rodent.

    abstract::We studied the electrophysiological, hemodynamic, and cytomorphological consequences of microhemorrhagic brain injury induced by a nanoscale iron injection. Of particular interest were the etiology, development, and treatment of epilepsy associated with this injury. We developed an animal model of chronic epilepsy usi...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Jo A,Heo C,Schwartz TH,Suh M

    更新日期:2014-03-01 00:00:00

  • Role of c-Jun N-terminal kinase in early brain injury after subarachnoid hemorrhage.

    abstract::The c-Jun N-terminal kinase (JNK) is induced by cerebral ischemia and injurious blood components acutely after subarachnoid hemorrhage (SAH). We hypothesized that inhibition of JNK will prevent damage to the neurovascular unit in the early brain injury period after SAH. Ninety-nine male SD rats (300-350 g) were random...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Yatsushige H,Ostrowski RP,Tsubokawa T,Colohan A,Zhang JH

    更新日期:2007-05-15 00:00:00