Forebrain-specific knockout of B-raf kinase leads to deficits in hippocampal long-term potentiation, learning, and memory.

abstract：:The molecular pathways underlying the neuroprotective effects of preconditioning are promising, potentially drugable targets to promote cell survival. However, these pathways are complex and are not yet fully understood. In this study we have established a paradigm of hypoxic preconditioning based on a chick embryo mo...

journal_title：Journal of neuroscience research

authors： Giusti S,Fiszer de Plazas S

更新日期：2012-02-01 00:00:00

abstract：:The most visible and, until very recently, the only hypothesis regarding the involvement of microglial cells in Alzheimer's disease (AD) pathogenesis is centered around the notion that activated microglia are neurotoxin-producing immune effector cells actively involved in causing the neurodegeneration that is the caus...

journal_title：Journal of neuroscience research

authors： Streit WJ

更新日期：2004-07-01 00:00:00

abstract：:The function of the prion protein is unknown despite suggestions it binds copper. Radioactive copper (Cu(67)) was used to demonstrate that histidine-dependent uptake of copper by cerebellar cells in culture is related to the level of PrP(c) expression. Copper is released by neurones at the synapse. Veratridine-induced...

journal_title：Journal of neuroscience research

authors： Brown DR

更新日期：1999-12-01 00:00:00

abstract：:Injury to the central nervous system (CNS) either from trauma or due to demyelinating/degenerating diseases results in a typical response of astrocytes, termed astrogliosis. This reaction is characterized by astrocyte proliferation, extensive hypertrophy of nuclei, cell body, and cytoplasmic processes and an increase ...

journal_title：Journal of neuroscience research

authors： Ghirnikar RS,Yu AC,Eng LF

更新日期：1994-07-01 00:00:00

abstract：:Isotonic media containing sodium salts from weak organic acids induce cell swelling in several experimental preparations (Grinstein et al., 1984; Jakubovicz et al., 1987). In vivo perfusion of rat dentate gyrus, using a microdialysis probe, with modified Krebs-Ringer bicarbonate solutions in which 50 mM NaCl was isoto...

journal_title：Journal of neuroscience research

authors： Solis JM,Herranz AS,Herreras O,Menéndez N,del Rio RM

更新日期：1990-06-01 00:00:00

abstract：:The applications of neural progenitor cells in clinical therapy for neural degeneration, such as Parkinson's disease, Huntington's disease, and cerebral infarction, have long been explored widely. It had been suggested that these cells may block the apoptosis of ischemia-induced neuronal damage and may themselves resi...

journal_title：Journal of neuroscience research

authors： Hsieh WY,Hsieh YL,Liu DD,Yang SN,Wu JN

更新日期：2003-01-15 00:00:00

abstract：:The expression of GABAB receptors in cultured mouse cerebellar granule cells was investigated in binding experiments using [3H](S,R)-baclofen as well as in functional assessment of the ability of (R)-baclofen to interact with depolarization (15-40 mM KCl) coupled changes in intracellular Ca2+ homeostasis and neurotran...

journal_title：Journal of neuroscience research

authors： Kardos J,Elster L,Damgaard I,Krogsgaard-Larsen P,Schousboe A

更新日期：1994-12-15 00:00:00

abstract：:Ischemic stroke is a leading cause of death and disability in the United States. It is known that males and females respond differently to stroke. Depending on age, the incidence, prevalence, mortality rate, and disability outcome of stroke differ between the sexes. Females generally have strokes at older ages than ma...

journal_title：Journal of neuroscience research

authors： Dotson AL,Offner H

更新日期：2017-01-02 00:00:00

abstract：:In searching for possible differences in the composition of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) forms in dystrophic brain, the distribution of various enzyme molecules in normal (NB) and dystrophic (DB) 129B6F1/J mouse brain has been investigated. The tissue was sequentially extracted with sa...

journal_title：Journal of neuroscience research

authors： Moral-Naranjo MT,Cabezas-Herrera J,Vidal CJ

更新日期：1996-01-15 00:00:00

abstract：:Parkinson's disease (PD) is a movement disorder characterized by a progressive loss of nigrostriatal dopaminergic neurons. Microglia activation and neuroinflammation have been associated with the pathogenesis of PD. Indeed, cytokines have been proposed as candidates that mediate the apoptotic cell death of dopaminergi...

journal_title：Journal of neuroscience research

authors： Bureau G,Longpré F,Martinoli MG

更新日期：2008-02-01 00:00:00

abstract：:Here we assess the potential functional role of increased aquaporin 9 (APQ9) in astrocytes. Increased AQP9 expression was achieved in primary astrocyte cultures by transfection of a plasmid-containing green fluorescent protein fused to either wild-type or mutated human AQP9. Increased AQP9 expression and phosphorylati...

journal_title：Journal of neuroscience research

authors： Hirt L,Price M,Mastour N,Brunet JF,Barrière G,Friscourt F,Badaut J

更新日期：2018-02-01 00:00:00

abstract：:Anoxia during delivery is a complication that can disturb infant brain development leading to various types of neurological disorders. Our studies have shown that increased body temperature of newborn rats of both sexes intensifies the postanoxic oxidative stress and prevents triggering the endogenous adaptive respons...

journal_title：Journal of neuroscience research

authors： Kletkiewicz H,Maliszewska J,Jaworski K,Jermacz Ł,Smoliński DJ,Rogalska J

更新日期：2019-10-01 00:00:00

abstract：:The interaction of bovine white matter proteolipid apoproteins with sodium dodecyl sulfate (SDS) was studied. Equilibrium dialysis binding measurements show that the apoprotein binds approximately 1.5 gm SDS per gram protein at high ionic strength (gamma/2 = 0.17). At low ionic strength (gamma/2 = 0.01) the protein bi...

journal_title：Journal of neuroscience research

authors： Sakura JD

更新日期：1981-01-01 00:00:00

abstract：:Nerve growth factor (NGF) has been purified from the guinea pig prostate using a modification of the Bocchini-Angeletti method for isolating 2.5S NGF from mouse submaxillary glands. As with the mouse preparation, guinea pig prostate NGF appears to migrate as a high molecular weight entity at physiological pH. Followin...

journal_title：Journal of neuroscience research

authors： Rubin JS,Bradshaw RA

更新日期：1981-01-01 00:00:00

abstract：:Rapsyn is a key molecule involved in the formation of postsynaptic specializations at the neuromuscular junction, in its absence there are both pre- and post-synaptic deficits including failure to cluster acetylcholine receptors. Recently we have documented increases in both nerve-muscle branching and numbers of moton...

journal_title：Journal of neuroscience research

authors： Bartlett SE,Banks GB,Reynolds AJ,Waters MJ,Hendry IA,Noakes PG

更新日期：2001-06-15 00:00:00

abstract：:CD200, a type I transmembrane glycoprotein, can interact with its receptor CD200R, which plays an inhibitory role in the activation of microglia-the resident macrophages of the central nervous system. In this study, the rat C6 glioma cell line (C6-1) that was previously characterized with high in vivo tumorigenicity w...

journal_title：Journal of neuroscience research

authors： Wang CY,Hsieh YT,Fang KM,Yang CS,Tzeng SF

更新日期：2016-12-01 00:00:00

abstract：:Glial cell-line derived neurotrophic factor (GDNF) is the most potent trophic factor for motoneuron survival and neuromuscular junction formation. GDNF is upregulated in injured or denervated skeletal muscle and returns to normal levels following reinnervation. However, the mechanism by which GDNF is regulated in dene...

journal_title：Journal of neuroscience research

authors： Rosa E,Cha J,Bain JR,Fahnestock M

更新日期：2015-03-01 00:00:00

abstract：:We have recently demonstrated that brain plastic events significantly modify synaptic protein synthesis measured by the incorporation of [(35)S]methionine in brain synaptosomal proteins. Notably, in rats learning a two-way active avoidance task, the local synthesis of two synaptic proteins was selectively enhanced. Be...

journal_title：Journal of neuroscience research

authors： Ferrara E,Cefaliello C,Eyman M,De Stefano R,Giuditta A,Crispino M

更新日期：2009-07-01 00:00:00

abstract：:Long-duration exposure to weightlessness results in bone demineralization, muscle atrophy, cardiovascular deconditioning, altered sensory-motor control, and central nervous system reorganizations. Exercise countermeasures and body loading methods so far employed have failed to prevent these changes. A human mission to...

journal_title：Journal of neuroscience research

authors： Lackner JR,DiZio P

更新日期：2000-10-15 00:00:00

abstract：:Fibroblast growth factors (FGFs) are known to be synthesized in the central nervous system (CNS) and to act on CNS cells in vitro, but less is known about their synthesis, expression, and role in vivo. In this work, using specific anti-acidic fibroblast growth factor (aFGF) antibodies, we have shown for the first time...

journal_title：Journal of neuroscience research

authors： Tourbah A,Oliver L,Jeanny JC,Gumpel M

更新日期：1991-08-01 00:00:00

abstract：:Systemic osmotic homeostasis is regulated mainly by neuroendocrine system of arginine-vasopressin (AVP) in mammalians. In the present study, we demonstrated that the immunoreactivity of tissue plasminogen activator (tPA) was observed specifically at neurosecretory granules of AVP-positive magnocellular terminals and t...

journal_title：Journal of neuroscience research

authors： Imamura Y,Morita S,Nakatani Y,Okada K,Ueshima S,Matsuo O,Miyata S

更新日期：2010-07-01 00:00:00

abstract：:Cell death in outer hair cells of the mammalian inner ear induced by aminoglycoside antibiotics is mediated by reactive oxygen species (ROS) and can be prevented by antioxidants. The current study investigates the role of the nuclear factor (NF)-kappaB pathway in cell death or survival in adult CBA mice. Kanamycin (70...

journal_title：Journal of neuroscience research

authors： Jiang H,Sha SH,Schacht J

更新日期：2005-03-01 00:00:00

abstract：:The C57BL/6 mice strain is known to be reputedly resistant to induction of experimental autoimmune neuritis (EAN), an animal model of Guillain-Barré syndrome in human by bovine peripheral myelin (BPM), and P2 protein or the P2 protein peptide 57-81. The P0 peptide 180-199 is a stronger neuritogenic antigen than the P2...

journal_title：Journal of neuroscience research

authors： Zou LP,Ljunggren HG,Levi M,Nennesmo I,Wahren B,Mix E,Winblad B,Schalling M,Zhu J

更新日期：2000-12-01 00:00:00

abstract：:Adrenal chromaffin cell (ACC) transplants, alone or combined with levodopa treatment, were used in attempted therapy for Parkinson's disease (PD). In a previous study, we demonstrated that levodopa caused chromaffin cell death either by necrosis or by apoptosis in cell culture. Here we report the beneficial effect of ...

journal_title：Journal of neuroscience research

authors： Corona-Morales AA,Castell A,Escobar A,Drucker-Colín R,Zhang L

更新日期：2003-01-01 00:00:00

abstract：:The extracellular matrix surrounds different neuronal compartments in the mature nervous system. In a variety of vertebrates, most brain regions are loaded with a distinct type of extracellular matrix around the somatodendritic part of neurons, termed perineuronal nets. The present study reports that chondrotin sulfat...

journal_title：Journal of neuroscience research

authors： Lendvai D,Morawski M,Brückner G,Négyessy L,Baksa G,Glasz T,Patonay L,Matthews RT,Arendt T,Alpár A

更新日期：2012-02-01 00:00:00

abstract：:Recent evidence has demonstrated that neural stem cells (NSC) can be expanded from a variety of sources, including embryos, fetuses, and adult bone marrow and brain tissue. We have previously reported the generation of adult rat bone marrow-derived cellular spheres that are morphologically and phenotypically similar t...

journal_title：Journal of neuroscience research

authors： Zeng Z,Yuan X,Liu G,Zeng X,Zeng X,Ng H,Chen H,Jiang T,Akasaki Y,Kessey K,Black KL,Yu JS

更新日期：2007-02-01 00:00:00

abstract：:The present study analyzed the in vitro effects induced by sodium L-lactate on human astrocytes and the SH-SY5Y cell line, when added at concentrations of 5, 10, and 25 mmol/liter. Expression of brain-derived neurotrophic factor (BDNF), inducible nitric oxide synthase (iNOS), and heat shock protein 70 kDa (HSP70) was ...

journal_title：Journal of neuroscience research

authors： Coco M,Caggia S,Musumeci G,Perciavalle V,Graziano AC,Pannuzzo G,Cardile V

更新日期：2013-02-01 00:00:00

abstract：:Asphyxia during delivery produces long-term deficits in brain development, including hippocampus. We investigated hippocampal plasticity after perinatal asphyxia, measuring postnatal apoptosis and neurogenesis. Asphyxia was performed by immersing rat fetuses with uterine horns removed from ready-to-deliver rats into a...

journal_title：Journal of neuroscience research

authors： Morales P,Fiedler JL,Andrés S,Berrios C,Huaiquín P,Bustamante D,Cardenas S,Parra E,Herrera-Marschitz M

更新日期：2008-09-01 00:00:00

abstract：:A rodent model of Parkinson's disease, the 1-methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine treated mouse, was used to determine whether striatal dopamine levels recover following grafting adrenal medulla into the striatum. Four types of grafts were performed: 1) adult mouse adrenal medulla, 2) adult adrenal me...

journal_title：Journal of neuroscience research

authors： Bohn MC,Kanuicki M

更新日期：1990-03-01 00:00:00

abstract：:Neurotrophic factors regulate the developmental survival and differentiation of specific neuronal populations. Brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) are members of the nerve growth factor (NGF) protein family, also known as the neurotrophins. Insights into the different roles of neurotroph...

journal_title：Journal of neuroscience research

authors： Escandón E,Burton LE,Szönyi E,Nikolics K

更新日期：1993-04-15 00:00:00