Abstract:
:We have previously shown that Na+, K(+)-ATPase activity in hypothalamus is increased after administration of an acute dose of desipramine, a noradrenaline uptake inhibitor (Viola et al., Cell Molec Neurobiol 9:263-271, 1989). In this report the same treatment (10 mg per kg) was applied to evaluate 3H-ouabain binding in rat brain sections by quantitative autoradiography. Results disclosed an increase in the number of ouabain binding sites in hypothalamus but not in cerebral cortex. Concomitantly, such acute DMI treatment enhanced K(+)-stimulated-p-nitrophenylphosphatase activity in hypothalamus membranes whereas it failed to modify cerebral cortex membranes. A direct interaction of DMI with the enzyme was ruled out since in vitro DMI is known to inhibit the enzyme. It may be speculated that DMI indirectly stimulates Na+, K(+)-ATPase through the increase in noradrenaline which acts in turn on the external phosphorylated site of the enzyme.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Viola MS,Antonelli MC,Enero MA,Rodríguez de Lores Arnaiz Gdoi
10.1002/(sici)1097-4547(19970101)47:1<77::aid-jnr8subject
Has Abstractpub_date
1997-01-01 00:00:00pages
77-82issue
1eissn
0360-4012issn
1097-4547pii
10.1002/(SICI)1097-4547(19970101)47:1<77::AID-JNR8journal_volume
47pub_type
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