Involvement of caspase-like proteinases in apoptosis of neuronal PC12 cells and primary cultured microglia induced by 6-hydroxydopamine.

abstract：:Disturbances in neuronal calcium homeostasis have been implicated in a variety of neuropathological conditions, including cerebral ischemia, hypoglycemia, and epilepsy, and possibly constitute part of the cell death process associated with chronic neurodegenerative disorders. We investigated if endoplasmic reticulum (...

journal_title：Journal of neuroscience research

authors： Hernández-Fonseca K,Massieu L

更新日期：2005-10-15 00:00:00

abstract：:The effects of hyposmotic conditions on taurine uptake and release were studied in mice cultured cerebellar granule cells. The effect of DIDS (4,4'-diisothiocyanatostilbene-2,2'-disulfonate) and of the divalent cations Mg++ and Mn++ on the hyposmolarity-induced changes in these parameters was investigated. Mg++ (20 mM...

journal_title：Journal of neuroscience research

authors： Schousboe A,Sánchez Olea R,Morán J,Pasantes-Morales H

更新日期：1991-12-01 00:00:00

abstract：:Brain zinc homeostasis is strictly controlled under healthy conditions, indicating the importance of zinc for physiological function in the brain. A part of zinc in the brain exists in the synaptic vesicles, is released from a subclass of glutamatergic neurons (i.e., zincergic neurons), and serves as a signal factor (...

journal_title：Journal of neuroscience research

authors： Takeda A,Fujii H,Minamino T,Tamano H

更新日期：2014-07-01 00:00:00

abstract：:The transplantation of dopaminergic (DA) progenitors derived from pluripotent stem cells improves the behavior of Parkinson's disease model animals. However, the survival of DA progenitors is low, and the final yield of DA neurons is only approximately 0.3%-2% the number of transplanted cells. Zonisamide (ZNS) increas...

journal_title：Journal of neuroscience research

authors： Miyawaki Y,Samata B,Kikuchi T,Nishimura K,Takahashi J

更新日期：2020-08-01 00:00:00

abstract：:A growing body of evidence suggests that neurotrophins (NTs) play a critical role in synaptic plasticity and other activity dependent processes in the CNS. Release of these growth factors by neurons and neuroendocrine cells was recently shown to occur via the regulated secretory pathway, representing a possible mechan...

journal_title：Journal of neuroscience research

authors： Möller JC,Krüttgen A,Heymach JV Jr,Ghori N,Shooter EM

更新日期：1998-02-15 00:00:00

abstract：:Nerve growth factor (NGF) has been purified from the guinea pig prostate using a modification of the Bocchini-Angeletti method for isolating 2.5S NGF from mouse submaxillary glands. As with the mouse preparation, guinea pig prostate NGF appears to migrate as a high molecular weight entity at physiological pH. Followin...

journal_title：Journal of neuroscience research

authors： Rubin JS,Bradshaw RA

更新日期：1981-01-01 00:00:00

abstract：:To scale up human neural stem/progenitor cell (NSPC) cultures for clinical use, we need to know how long these cells can live ex vivo without losing their ability to proliferate and differentiate; thus, a convenient method is needed to estimate the proliferative activity of human NSPCs grown in neurosphere cultures, a...

journal_title：Journal of neuroscience research

authors： Kanemura Y,Mori H,Kobayashi S,Islam O,Kodama E,Yamamoto A,Nakanishi Y,Arita N,Yamasaki M,Okano H,Hara M,Miyake J

更新日期：2002-09-15 00:00:00

abstract：:Glial fibrillary acidic protein (GFAP) is the major constituent of glial filaments and is restricted within the CNS to astrocytes. As with other classes of intermediate filament proteins, the regulation of GFAP expression is poorly understood. Utilizing highly purified cultures of astrocytes and a chemically defined (...

journal_title：Journal of neuroscience research

authors： Morrison RS,De Vellis J,Lee YL,Bradshaw RA,Eng LF

更新日期：1985-01-01 00:00:00

abstract：:SH-SY5Y cells differentiate into neuronal-like cells and express marker proteins like growth-associated protein (GAP-43) and neuropeptide tyrosine when treated with a low concentration (16 nM) of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) in the presence of growth factors or serum. Both control and d...

journal_title：Journal of neuroscience research

authors： Parrow V,Fagerström S,Meyerson G,Nånberg E,Påhlman S

更新日期：1995-08-15 00:00:00

abstract：:Oligodendrocyte-specific protein (OSP/claudin-11) is a major component of CNS myelin and has been recently added to the claudin family of tight junction proteins. In this study, the developmental expression of OSP/claudin-11 was determined using in situ hybridization, immunohistochemistry (IH), and Western blot analys...

journal_title：Journal of neuroscience research

authors： Bronstein JM,Chen K,Tiwari-Woodruff S,Kornblum HI

更新日期：2000-05-01 00:00:00

abstract：:The N-methyl-D-aspartate receptor (NMDAR) is a major neurotransmitter receptor in the central nervous system (CNS), with functional roles in learning, memory, and sensation. Several mechanisms potentiate NMDARs, and NMDAR hyperexcitability plays pathophysiological roles in many conditions, such as neurodegenerative di...

journal_title：Journal of neuroscience research

authors： Mattar PA,Holmes KD,Dekaban GA

更新日期：2003-12-01 00:00:00

abstract：:The termination of chemical neurotransmission in the CNS involves the rapid removal of neurotransmitter from synapses by specific transport systems. Such mechanism operates for the three major amino acid neurotransmitters glutamate, gamma-aminobutyric acid (GABA) and glycine. To date, five different high-affinity Na(+...

journal_title：Journal of neuroscience research

authors： Gadea A,López-Colomé AM

更新日期：2001-03-15 00:00:00

abstract：:Heme oxygenase-1 (HO-1) is a stress protein induced in response to a variety of oxidative challenges. After treatment of the hybrid septal cells SN 56 with beta-amyloid peptide (beta-AP1-40) or hydrogen peroxide (H2O2), we detected high levels of reactive oxygen species, accompanied by a significant elevation in HO-1 ...

journal_title：Journal of neuroscience research

authors： Le WD,Xie WJ,Appel SH

更新日期：1999-06-15 00:00:00

abstract：:Human T-cell lymphotropic virus type I (HTLV-I) may infect up to 10% of peripheral blood T cells in patients with HTLV-I myelopathy. To examine the impact of HTLV-I infection on the abilities of T cells to present and respond to peptide antigen, we HTLV-I infected and subcloned a myelin basic protein peptide 84-102 (M...

journal_title：Journal of neuroscience research

authors： Scholz C,Hafler DA,Höllsberg P

更新日期：1996-09-15 00:00:00

abstract：:Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that form a subfamily within the steroid hormone receptor group. Recent work has shown that one member of this group, PPARgamma, plays a central role in adipocyte differentiation. As oligodendrocytes are major lipid-producin...

journal_title：Journal of neuroscience research

authors： Granneman J,Skoff R,Yang X

更新日期：1998-03-01 00:00:00

abstract：:The vesicular acetylcholine transporter (VAChT) is a transmembrane protein required, in cholinergic neurons, for selective storage of acetylcholine into synaptic vesicles. Although dorsal root ganglion (DRG) neurons utilize neuropeptides and amino acids for neurotransmission, we have previously demonstrated the presen...

journal_title：Journal of neuroscience research

authors： Tata AM,De Stefano ME,Tomassy GS,Vilaró MT,Levey AI,Biagioni S

更新日期：2004-01-15 00:00:00

abstract：:Astroglial participation in the regional differences of vulnerability to alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)-induced neurodegeneration was investigated in the rat hippocampus and medial septum using L-alpha-aminoadipate (alpha-AA) as a specific astroglial toxin. alpha-AA was microinjected i...

journal_title：Journal of neuroscience research

authors： Rodríguez MJ,Martínez-Sánchez M,Bernal F,Mahy N

更新日期：2004-08-01 00:00:00

abstract：:The increase in myelin basic protein (MBP) synthesis observed in brain aggregate cultures supplemented with macrophages is reflected in elevated supernatant protein levels of the key promoters of oligodendrocyte proliferation, fibroblast growth factor-2 (FGF-2) and platelet-derived growth factor-AA (PDGF-AA), during t...

journal_title：Journal of neuroscience research

authors： Diemel LT,Jackson SJ,Cuzner ML

更新日期：2003-12-15 00:00:00

abstract：:Lithium, the most prevalent treatment for manic-depressive illness, might have a neuroprotective effect after brain injury. In culture, lithium can exert neurotoxic effects associated with reduction in polyamine synthesis but neuroprotective effects as cultured neurons mature. Cumulative evidence suggests that lithium...

journal_title：Journal of neuroscience research

authors： Gilad GM,Gilad VH

更新日期：2007-02-15 00:00:00

abstract：:The male preponderance in autism prevalence has brought together the disparate topics of sex/gender and autism research. Two directions of neuroimaging studies on the relationships between sex/gender and autism may inform male-specific risk mechanisms and female-specific protective mechanisms of autism. First, we revi...

journal_title：Journal of neuroscience research

authors： Lai MC,Lerch JP,Floris DL,Ruigrok AN,Pohl A,Lombardo MV,Baron-Cohen S

更新日期：2017-01-02 00:00:00

abstract：:Human fetal brain is a potential source of neural stem cells (NSCs) for cell replacement therapy in neurodegenerative diseases. We explored whether NSCs isolated from cortex and striatum of human fetuses, aged 6-9 weeks post-conception, maintain their regional identity and differentiate into specific neuron types in c...

journal_title：Journal of neuroscience research

authors： Kallur T,Darsalia V,Lindvall O,Kokaia Z

更新日期：2006-12-01 00:00:00

abstract：:We have developed a silicone nerve regeneration chamber that is partitioned into two compartments by a strip of nitrocellulose paper. The modified two-compartment chamber allows the investigation of the effects on rat sciatic nerve regeneration of trophic or growth factors that are initially bound to the nitrocellulos...

journal_title：Journal of neuroscience research

authors： Danielsen N,Pettmann B,Vahlsing HL,Manthorpe M,Varon S

更新日期：1988-07-01 00:00:00

abstract：:Cell death in outer hair cells of the mammalian inner ear induced by aminoglycoside antibiotics is mediated by reactive oxygen species (ROS) and can be prevented by antioxidants. The current study investigates the role of the nuclear factor (NF)-kappaB pathway in cell death or survival in adult CBA mice. Kanamycin (70...

journal_title：Journal of neuroscience research

authors： Jiang H,Sha SH,Schacht J

更新日期：2005-03-01 00:00:00

abstract：:The type 1 metabotropic glutamate receptor (mGluR1) plays an import role in the synaptic physiology and development of cerebellar Purkinje neurons. mGluR1 expression occurs early in the developmental program of Purkinje neurons, at an age that precedes expression of the dendritic structure. Few studies have investigat...

journal_title：Journal of neuroscience research

authors： Netzeband JG,Gruol DL

更新日期：2008-02-01 00:00:00

abstract：:The purpose of this study was to determine how oligodendrocytes die following Fas receptor activation. An immortalized human oligodendrocyte hybrid line (MO3.13) was challenged with Fas ligand (FasL), and cell death was assessed by flow cytometry and DNA gel electrophoresis. Caspase activation was determined by either...

journal_title：Journal of neuroscience research

authors： Li W,Maeda Y,Ming X,Cook S,Chapin J,Husar W,Dowling P

更新日期：2002-07-15 00:00:00

abstract：:Traumatic Brain Injury (TBI) is the most frequent cause of death and disability in young adults and children in the developed world, occurring in over 1.7 million persons and resulting in 50,000 deaths in the United States alone. The Centers for Disease Control and Prevention estimate that between 3.2 and 5.3 million ...

journal_title：Journal of neuroscience research

authors： Sulhan S,Lyon KA,Shapiro LA,Huang JH

更新日期：2020-01-01 00:00:00

abstract：:Calcium/calmodulin-dependent serine kinase (CASK), a causative gene in X-linked mental retardation, carries out multiple functions in neurons, including vesicle trafficking of ion channels, synapse formation, and gene transcription. From a yeast two-hybrid screen, Krüppel-like zinc finger protein B cell lymphoma/COUP-...

journal_title：Journal of neuroscience research

authors： Kuo TY,Hong CJ,Chien HL,Hsueh YP

更新日期：2010-08-15 00:00:00

abstract：:The use of trimethadione (TMO) as a protector in hyperbaric oxygen toxicity in the conscious rat has been examined in detail. The oxidation-reduction state of pyridine nucleotides was measured simultaneously with the EEG activity from the surface of the brain cortex. From the data obtained, a few parameters were calcu...

journal_title：Journal of neuroscience research

authors： Mayevsky A

更新日期：1975-01-01 00:00:00

abstract：:In eukaryotes, mitochondria are critical for cellular bioenergetics and mediating apoptosis. The transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha) is an important regulator of mitochondrial biogenesis and function. However, the role of PGC-1alpha in neuronal a...

journal_title：Journal of neuroscience research

authors： Liang J,Yang Y,Zhu X,Wang X,Chen R

更新日期：2010-07-01 00:00:00

abstract：:The mast cell, an immunocompetent cell that contributes to neurogenic inflammation in a variety of tissues, including synovium, is found in close proximity to peripheral terminals of unmyelinated primary afferents and sympathetic postganglionic nerve terminals. In this study we evaluated the hypothesis that the densit...

journal_title：Journal of neuroscience research

authors： Levine JD,Coderre TJ,Covinsky K,Basbaum AI

更新日期：1990-07-01 00:00:00