gammadelta T cells: the overlooked T-cell subset in demyelinating disease.

abstract：:It was previously reported that a monoclonal antibody to beta-amyloid precursor protein (mab22C11; Boehringer Mannheim, Indianapolis, IN) labels an intermediate filament-associated protein (beta APP-IFAP) in cultured human skin fibroblasts (Dooley et al.: J Neurosci Res 33:60-67, 1992). The time course of its expressi...

journal_title：Journal of neuroscience research

authors： Durham HD,Minotti S,Dooley NP,Nalbantoglu J

更新日期：1994-08-15 00:00:00

abstract：:Neuronal ceroid lipofuscinoses (NCLs) are a group of hereditary childhood diseases characterized mainly by lipopigment accumulation and a multisystemic pattern of symptoms including mental retardation, seizures, motor impairment, and blindness. The mnd mouse, carrying a mutation in the Cln8 gene, has been proposed as ...

journal_title：Journal of neuroscience research

authors： Bigini P,Milanese M,Gardoni F,Longhi A,Bonifacino T,Barbera S,Fumagalli E,Di Luca M,Mennini T,Bonanno G

更新日期：2012-06-01 00:00:00

abstract：:The non-receptor protein tyrosine kinase Fyn, which is a member of the Src family of kinases, has been shown to be essential for normal myelination and has been suggested to play a role in oligodendrocyte development. However, oligodendrocyte development has not been studied directly in cells lacking Fyn. Additionally...

journal_title：Journal of neuroscience research

authors： Sperber BR,McMorris FA

更新日期：2001-02-15 00:00:00

abstract：:The contribution of glucose carbon to the biosynthesis of cholesterol and phospholipids in distinct brain regions was studied quantitatively in the adult male rat. Rates of flow of glucose carbon into the lipids in vivo were calculated from two measurements: the curve representing the decrease in plasma 14C-glucose wi...

journal_title：Journal of neuroscience research

authors： Barkai AI

更新日期：1981-01-01 00:00:00

abstract：:Most previous studies on spinal cord injury (SCI) have used rodent models. Direct extrapolation of the results obtained in rodents to clinical cases is difficult, however, because of neurofunctional and anatomic differences between rodents and primates. In the present study, the development of histopathologic changes ...

journal_title：Journal of neuroscience research

authors： Iwanami A,Yamane J,Katoh H,Nakamura M,Momoshima S,Ishii H,Tanioka Y,Tamaoki N,Nomura T,Toyama Y,Okano H

更新日期：2005-04-15 00:00:00

abstract：:Previous studies from our laboratory suggest that Alzheimer's disease sera contain a repertoire of antibodies to the heavy neurofilament subunit (NF-H) and that a subpopulation of these antibodies bind specifically to epitopes highly enriched in NF-H isolated from the purely cholinergic electromotor neurons of Torpedo...

journal_title：Journal of neuroscience research

authors： Faigon M,Hadas E,Alroy G,Chapman J,Auerbach JM,Michaelson DM

更新日期：1991-08-01 00:00:00

abstract：:We generated a new cell line, N38, by conditionally immortalizing mouse oligodendrocytes (OLs) at early stages of maturation. The morphology and marker expression pattern suggest N38 cells are similar to immature OLs. N38 cells were sensitive to changes in serum concentrations, and forcing the cells to differentiate i...

journal_title：Journal of neuroscience research

authors： Bongarzone ER,Byravan S,Givogri MI,Schonmann V,Campagnoni AT

更新日期：2000-11-01 00:00:00

abstract：:New neurons are continuously generated throughout life in the subgranular zone in the dentate gyrus of the mammalian hippocampus and in the subventricular zone of the lateral ventricles. With the aid of new methodologies, significant progress has been made in the characterization of endogenous stem cells (ependymal ce...

journal_title：Journal of neuroscience research

authors： Qin Y,Zhang W,Yang P

更新日期：2015-03-01 00:00:00

abstract：:Experiments were conducted with the aid of intracellular microelectrodes to study physiological properties of neuropile glial cells in the central nervous system of the medicinal leech. The results showed significant contributions of both K+ and Cl- ions to the membrane potential. The transmitter substance 5-hydroxytr...

journal_title：Journal of neuroscience research

authors： Walz W

更新日期：1982-01-01 00:00:00

abstract：:Metabolism of amyloid-beta peptide (A beta) is closely associated with the pathology and etiology of Alzheimer's disease (AD). Neprilysin is the only rate-limiting catabolic peptidase proven by means of reverse genetics to participate in A beta metabolism in vivo. The aim of the present study is to assess whether poss...

journal_title：Journal of neuroscience research

authors： Iwata N,Takaki Y,Fukami S,Tsubuki S,Saido TC

更新日期：2002-11-01 00:00:00

abstract：:Uptake of 2-deoxy-D-glucose (2-DG) has been studied in synaptosomes from the Long-Evans rat. Although there are some differences, the results are generally similar to those reported for Sprague--Dawley rats. Both D-glucose and 2-DG are taken up by the same carrier, since D-glucose was found to inhibit uptake of 2-DG. ...

journal_title：Journal of neuroscience research

authors： Wheeler DD,Hollingsworth RG

更新日期：1979-01-01 00:00:00

abstract：:FE65 is a key "adapter" protein that links a multiprotein complex to an intracellular domain of beta-amyloid precursor protein (betaPP). Its overexpression modulates the trafficking of betaPP and facilitates the generation of beta-amyloid (Abeta). FE65 is predominantly expressed in brain tissues. An exon 9-inclusive i...

journal_title：Journal of neuroscience research

authors： Hu Q,Jin LW,Starbuck MY,Martin GM

更新日期：2000-04-01 00:00:00

abstract：:Mice heterozygously deficient in the major myelin component P0 are an established model of an inherited neuropathy and show signs of myelin degeneration in motor nerves. Unlike the case in patients, the sensory nerves are only mildly affected in the mouse mutants and do not show features indicative of myelin degenerat...

journal_title：Journal of neuroscience research

authors： Samsam M,Frei R,Marziniak M,Martini R,Sommer C

更新日期：2002-01-15 00:00:00

abstract：:Extracellular matrix molecules take part in functional isolation and stabilization of neuronal compartments but form a vivid interface between neuronal elements at the same time. Previous studies have shown that the accumulation of extracellular matrix, especially its typical phenotypic form, termed perineuronal nets,...

journal_title：Journal of neuroscience research

authors： Gáti G,Morawski M,Lendvai D,Jäger C,Négyessy L,Arendt T,Alpár A

更新日期：2010-11-15 00:00:00

abstract：:Persephin (PSP) is the most recently discovered member of the GDNF family of neurotrophic factors. We have used an RT-PCR approach to start addressing the putative functional significance of PSP by determining sites of its synthesis in the neonatal rat brain. Generally, two transcripts were found. Sequence analysis of...

journal_title：Journal of neuroscience research

authors： Jaszai J,Farkas L,Galter D,Reuss B,Strelau J,Unsicker K,Krieglstein K

更新日期：1998-08-15 00:00:00

abstract：:The objective of this study was to compare cerebrospinal fluid (CSF) levels of the light subtype of the neurofilament proteins (NFL), tau, and beta-amyloid42 (Abeta42) in individuals with moderate or severe white matter changes (WMC) and in those with mild or no WMC. Twenty-two patients with Alzheimer's disease (AD), ...

journal_title：Journal of neuroscience research

authors： Sjögren M,Blomberg M,Jonsson M,Wahlund LO,Edman A,Lind K,Rosengren L,Blennow K,Wallin A

更新日期：2001-11-01 00:00:00

abstract：:The expression of different muscarinic receptor subtypes was analyzed in immature Schwann cells obtained from sciatic nerve of 2-day neonatal rats. By using RT-PCR analysis, we demonstrated the presence of M1, M2, M3, and M4 receptor subtypes in cultured Schwann cells, with M2 displaying the highest expression levels....

journal_title：Journal of neuroscience research

authors： Loreti S,Vilaró MT,Visentin S,Rees H,Levey AI,Tata AM

更新日期：2006-07-01 00:00:00

abstract：:We have performed proteomic analysis in the cerebrospinal fluid in an animal model of Parkinson's disease induced by axotomy of the medial forebrain bundle. In this model, the degeneration of dopaminergic neurons was completed in 14 days, with a loss of about 50% dopaminergic neurons in the substantia nigra and a loss...

journal_title：Journal of neuroscience research

authors： Rite I,Argüelles S,Venero JL,García-Rodriguez S,Ayala A,Cano J,Machado A

更新日期：2007-12-01 00:00:00

abstract：:The effects of phorbol 12-tetradecanoyl-13-acetate (TPA) and dibutyryl cAMP on the glutamate transport present in chick Bergmann glial cell (BGC) cultures were examined. TPA produced a significant decrease in [3H]-D-aspartate uptake, while dibutyryl cAMP treatment elicited a slight reduction in the transport. This eff...

journal_title：Journal of neuroscience research

authors： González MI,Ortega A

更新日期：1997-11-15 00:00:00

abstract：:The effect of the potent soluble guanylyl cyclase (sGC) inhibitor 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) on neurite outgrowth and retraction was investigated in PC12 cells and SH-SY5Y human neuroblastoma cells. ODQ inhibited neurite outgrowth and triggered neurite retraction in the cells stimulated with ner...

journal_title：Journal of neuroscience research

authors： Lee HG,Kim SY,Kim du S,Seo SR,Lee SI,Shin DM,De Smet P,Seo JT

更新日期：2009-01-01 00:00:00

abstract：:We have developed an animal model of learning and memory impairment associated with activation of microglia in the mouse brain. Injection of lipopolysaccharide into the CA1 region of the mouse hippocampus resulted in an increased production of inflammatory cytokines, such as interleukin-1β. Immunostaining for interleu...

journal_title：Journal of neuroscience research

authors： Tanaka S,Kondo H,Kanda K,Ashino T,Nakamachi T,Sekikawa K,Iwakura Y,Shioda S,Numazawa S,Yoshida T

更新日期：2011-04-01 00:00:00

abstract：:Neural expression of constitutive hsc70 mRNA and hyperthermia-inducible hsp70 mRNA is examined using radioactive and non-radioactive in situ hybridization procedures. A strong induction of hsp70 mRNA was noted in cell populations in cerebellar layers and in the brainstem which demonstrated expression of mRNA encoding ...

journal_title：Journal of neuroscience research

authors： Foster JA,Rush SJ,Brown IR

更新日期：1995-08-01 00:00:00

abstract：:Hepatocyte growth factor (HGF) is a potent mitogen for mature hepatocytes, and it has multi-functional effects in a variety of cells in various organs. HGF stimulates DNA synthesis and promotes cell migration and morphogenesis in several cell types including the olfactory system. To characterize the potential mitogeni...

journal_title：Journal of neuroscience research

authors： Yan H,Nie X,Kocsis JD

更新日期：2001-11-15 00:00:00

abstract：:Corticosteroids, released from the adrenal gland in response to stress, bind to receptors that act as transcription factors to alter gene expression and, subsequently, protein synthesis. Using [(35)S]-methionine-cysteine incorporation to measure protein synthesis in hippocampal slices incubated under ischemic conditio...

journal_title：Journal of neuroscience research

authors： Barr CS,Dokas LA

更新日期：2001-08-15 00:00:00

abstract：:Spinal cord injury (SCI) is a devastating condition characterized by disruption of axonal connections, failure of axonal regeneration, and loss of motor and sensory function. The therapeutic promise of neural stem cells has been focused on cell replacement, but many obstacles remain in obtaining neuronal integration f...

journal_title：Journal of neuroscience research

authors： Bonner JF,Blesch A,Neuhuber B,Fischer I

更新日期：2010-05-01 00:00:00

abstract：:In offspring, an adequate maternal diet is important for neurodevelopment. One mechanism by which maternal diet impacts neurodevelopment is through its dynamic role in the development of the gut microbiota. Communication between the gut, and its associated microbiota, and the brain is facilitated by the vagus nerve, i...

journal_title：Journal of neuroscience research

authors： Al Rubaye H,Adamson CC,Jadavji NM

更新日期：2021-01-01 00:00:00

abstract：:The iron transport protein, transferrin, and the iron storage protein ferritin were examined immunohistochemically along with iron in a number of brain regions from normal and aged humans. Two age groups were examined: a middle-aged group (28-49 years), and an older group (60-90 years). Transferrin, ferritin, and iron...

journal_title：Journal of neuroscience research

authors： Connor JR,Menzies SL,St Martin SM,Mufson EJ

更新日期：1990-12-01 00:00:00

abstract：:An experimental model based on kainic acid (KA) injections replicates many phenomenological features of human temporal lobe epilepsy, the most common type of epilepsy in adults. Taurine, 2-aminoethanesulfonic acid, present in high concentrations in many invertebrate and vertebrate systems, is believed to serve several...

journal_title：Journal of neuroscience research

authors： Junyent F,Utrera J,Romero R,Pallàs M,Camins A,Duque D,Auladell C

更新日期：2009-05-01 00:00:00

abstract：:Transgenic mice with glial fibrillary acidic protein (GFAP) promoter driven-astrocyte production of the cytokines interleukin-6 (IL-6) and tumor necrosis factor (TNF) were used to determine whether the pre-existing production of these cytokines in vivo might modulate the sensitivity of neurons to excitotoxic agents. L...

journal_title：Journal of neuroscience research

authors： Samland H,Huitron-Resendiz S,Masliah E,Criado J,Henriksen SJ,Campbell IL

更新日期：2003-07-15 00:00:00

abstract：:The prenatal and early postnatal stages represent a critical time window for human brain development. Interestingly, this window partly overlaps with the maturation of the intestinal flora (microbiota) that play a critical role in the bidirectional communication between the central and the enteric nervous systems (mic...

journal_title：Journal of neuroscience research

authors： Eltokhi A,Janmaat IE,Genedi M,Haarman BCM,Sommer IEC

更新日期：2020-07-01 00:00:00