Agonists for the peroxisome proliferator-activated receptor-alpha and the retinoid X receptor inhibit inflammatory responses of microglia.

abstract：:Monocarboxylate transporters (MCTs) are involved in the uptake and release of lactate, pyruvate, and ketone bodies. Studies of their distribution at both the mRNA and protein levels have highlighted the specific expression of MCT1, MCT2, and more recently MCT4 in the central nervous system. MCT1 was found strongly exp...

journal_title：Journal of neuroscience research

authors： Pellerin L,Bergersen LH,Halestrap AP,Pierre K

更新日期：2005-01-01 00:00:00

abstract：:Neurotrophins may have a neuroprotective role and are probably involved in the control of axonal sprouting and synaptic plasticity. An antibody raised against a pro-sequence of nerve growth factor (NGF) was tested. In control undisturbed rats, a strong immunoreactivity was detected in scattered cells in and around the...

journal_title：Journal of neuroscience research

authors： Humpel C,Ebendal T,Cao Y,Olson L

更新日期：1993-07-01 00:00:00

abstract：:Programmed cell death involving gene regulation and de novo protein synthesis is a major component of both normal development and a number of disease conditions. Hence, knowledge of its mechanisms, especially transcription factors, that regulate expression of the genes involved in neurodegenerative disorders is of gre...

journal_title：Journal of neuroscience research

authors： Mioduszewska B,Jaworski J,Szklarczyk AW,Klejman A,Kaczmarek L

更新日期：2008-01-01 00:00:00

abstract：:Fractionation of muscle microsomes rich in sarcoplasmic reticulum (SR) by isopicnic centrifugation yielded three types of membranes. Heavy (HM), intermediate (IM), and light membranes (LM), with isopicnic points of 38, 33, and 25% w/w sucrose, were rich in terminal cisternae/triads, longitudinal SR, and T-tubules, res...

journal_title：Journal of neuroscience research

authors： Campoy FJ,Cabezas-Herrera J,Vidal CJ

更新日期：1992-12-01 00:00:00

abstract：:Calcitonin gene-related peptide (CGRP) is the major product of the calcitonin gene in brain and exerts a number of actions in the central nervous system (CNS). In particular the finding that CGRP affects dopamine (DA) release and metabolism has raised the possibility that it may play a role in several neuropsychiatric...

journal_title：Journal of neuroscience research

authors： Mathé AA,Hertel P,Nomikos GG,Gruber S,Mathé JM,Svensson TH

更新日期：1996-11-01 00:00:00

abstract：:In chronic demyelinating lesions of the central nervous system, insufficient generation of oligodendrocytes (OLs) is not due to a lack of oligodendrocyte precursor cells (OPCs), because the accumulation of OPCs and premyelinating OLs can be observed within these lesions. Here we sought to identify the basis for the fa...

journal_title：Journal of neuroscience research

authors： Shimizu T,Tanaka KF,Takebayashi H,Higashi M,Wisesmith W,Ono K,Hitoshi S,Ikenaka K

更新日期：2013-02-01 00:00:00

abstract：:The rate and direction of neurite growth have been shown in a number of studies to be determined by the distribution of adhesive sites on the growth cone. Recent evidence showing that the application of extrinsic electric fields can redistribute membrane molecules and alter both the rate and direction of neurite growt...

journal_title：Journal of neuroscience research

authors： Freeman JA,Manis PB,Snipes GJ,Mayes BN,Samson PC,Wikswo JP Jr,Freeman DB

更新日期：1985-01-01 00:00:00

abstract：:We here reconsider current theories of neural ensembles in the context of recent discoveries about neuronal dendritic physiology. The key physiological observation is that the dendritic plateau potential produces sustained depolarization of the cell body (amplitude 10-20 mV, duration 200-500 ms). Our central hypothesi...

journal_title：Journal of neuroscience research

authors： Antic SD,Hines M,Lytton WW

更新日期：2018-09-01 00:00:00

abstract：:Huntington's disease (HD) is a progressive neurodegenerative disorder caused by an expanded CAG repeat within the huntingtin (HTT) gene. The Q140 and HdhQ150 knock-in HD mouse models were generated such that HdhQ150 mice have an expanded CAG repeat inserted into the mouse Htt gene, whereas in the Q140s, mouse exon 1 H...

journal_title：Journal of neuroscience research

authors： Franich NR,Hickey MA,Zhu C,Osborne GF,Ali N,Chu T,Bove NH,Lemesre V,Lerner RP,Zeitlin SO,Howland D,Neueder A,Landles C,Bates GP,Chesselet MF

更新日期：2019-12-01 00:00:00

abstract：:The effects of extracellular acidification on the synaptic function and neuronal excitability were investigated on the hippocampal CA1 neurons. A decrease of extracellular pH from 7.4 to 6.7 did not alter either the resting membrane potential or the neuronal membrane input resistance. Extracellularly recorded field ex...

journal_title：Journal of neuroscience research

authors： Hsu KS,Liang YC,Huang CC

更新日期：2000-11-01 00:00:00

abstract：:The effects of ischemia (removal of oxygen and glucose for 4 h) and anoxia (removal of oxygen alone) on astrocytes were studied in dissociated cultures of E14 spinal cord containing both neurons and astrocytes. In addition, a group of cultures was treated with a low Na+, low Ca2+, and high K+ medium during the 4-h isc...

journal_title：Journal of neuroscience research

authors： Goldberg WJ,Connor JR,Bernstein JJ

更新日期：1987-01-01 00:00:00

abstract：:The C57BL/6 mice strain is known to be reputedly resistant to induction of experimental autoimmune neuritis (EAN), an animal model of Guillain-Barré syndrome in human by bovine peripheral myelin (BPM), and P2 protein or the P2 protein peptide 57-81. The P0 peptide 180-199 is a stronger neuritogenic antigen than the P2...

journal_title：Journal of neuroscience research

authors： Zou LP,Ljunggren HG,Levi M,Nennesmo I,Wahren B,Mix E,Winblad B,Schalling M,Zhu J

更新日期：2000-12-01 00:00:00

abstract：:Myelin-associated glycoprotein (MAG) is expressed on the innermost myelin membrane wrap, directly apposed to the axon surface. Although it is not required for myelination, MAG enhances long-term axon-myelin stability, helps to structure nodes of Ranvier, and regulates the axon cytoskeleton. In addition to its role in ...

journal_title：Journal of neuroscience research

authors： Schnaar RL,Lopez PH

更新日期：2009-11-15 00:00:00

abstract：:The prenatal and early postnatal stages represent a critical time window for human brain development. Interestingly, this window partly overlaps with the maturation of the intestinal flora (microbiota) that play a critical role in the bidirectional communication between the central and the enteric nervous systems (mic...

journal_title：Journal of neuroscience research

authors： Eltokhi A,Janmaat IE,Genedi M,Haarman BCM,Sommer IEC

更新日期：2020-07-01 00:00:00

abstract：:The potassium-induced stimulation of oxygen consumption in brain slices has a threshold value of 15-20 mM potassium, and it reaches its maximum at 35-50 mM. Although this phenomenon now has been known for almost 50 years, its physiological role remains undetermined. One reason for this may be that the high concentrati...

journal_title：Journal of neuroscience research

authors： Hertz L,Kjeldsen CS

更新日期：1985-01-01 00:00:00

abstract：:Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that form a subfamily within the steroid hormone receptor group. Recent work has shown that one member of this group, PPARgamma, plays a central role in adipocyte differentiation. As oligodendrocytes are major lipid-producin...

journal_title：Journal of neuroscience research

authors： Granneman J,Skoff R,Yang X

更新日期：1998-03-01 00:00:00

abstract：:Alcohol-related events have been proposed to be under neurochemical control. For example, the concentration of methionine enkephalin (Met-enkephalin) in brain has been inversely correlated with ethanol consumption in alcohol-preferring and alcohol-nonpreferring mice. The concentrations of Met-enkephalin are controlled...

journal_title：Journal of neuroscience research

authors： Plotkin SR,Banks WA,Waguespack PJ,Kastin AJ

更新日期：1997-05-01 00:00:00

abstract：:Perceptually similar stimuli, despite not being consciously distinguishable, may result in distinct cortical brain activations. Hypothesizing that perceptually similar tastes are discriminable by electroencephalography (EEG), we recorded 22 human participants' response to equally intense sweet-tasting stimuli: caloric...

journal_title：Journal of neuroscience research

authors： Andersen CA,Kring ML,Andersen RH,Larsen ON,Kjaer TW,Kidmose U,Møller S,Kidmose P

更新日期：2019-03-01 00:00:00

abstract：:Pigment epithelium-derived factor (PEDF) is a neurotrophic protein synthesized and secreted by retinal pigment epithelial (RPE) cells in early embryogenesis and has been shown to be present in the extracellular matrix between the RPE cells and the neural retina. It induces neuronal differentiation and promotes surviva...

journal_title：Journal of neuroscience research

authors： Cao W,Tombran-Tink J,Chen W,Mrazek D,Elias R,McGinnis JF

更新日期：1999-09-15 00:00:00

abstract：:Taurine, 2-aminoethanesulfonic acid, is present at high concentrations in many invertebrate and vertebrate systems and has several biological functions. In addition, it has been related to a neuroprotective role against several diseases such as epilepsy. In the present work, we treated mice with taurine and examined i...

journal_title：Journal of neuroscience research

authors： Junyent F,Romero R,de Lemos L,Utrera J,Camins A,Pallàs M,Auladell C

更新日期：2010-01-01 00:00:00

abstract：:The role of axons in the expression of the major myelin glycoprotein, P0, has been investigated using neuron/Schwann cell cultures. These cultures were either nonmyelinating or myelinating due to growth in defined medium or in medium containing serum and chick embryo extract, respectively. The neurons and Schwann cell...

journal_title：Journal of neuroscience research

authors： Brunden KR,Windebank AJ,Poduslo JF

更新日期：1990-06-01 00:00:00

abstract：:Only a few proteins are known to be exclusively expressed in central nervous system (CNS) myelin. A novel surface membrane protein expressed only in CNS myelin and oligodendrocytes of higher vertebrates has been identified by a monoclonal antibody. This CNS myelin/oligodendrocyte-specific protein, MOSP, has a molecula...

journal_title：Journal of neuroscience research

authors： Dyer CA,Hickey WF,Geisert EE Jr

更新日期：1991-04-01 00:00:00

abstract：:Heat shock protein 60 (HSP60) and HSP10 are mitochondrial chaperonin proteins and are responsible for the folding of newly imported proteins and 13 polypeptides encoded by mitochondrial DNA. The expressions of HSP60 and HSP10 are regulated simultaneously because these genes are localized head to head on chromosome, se...

journal_title：Journal of neuroscience research

authors： Kim SW,Lee JK

更新日期：2007-05-01 00:00:00

abstract：:Adenosine signalling has an important role in cochlear protection from oxidative stress. In most tissues, intracellular adenosine kinase (ADK) is the primary route of adenosine metabolism and the key regulator of intracellular and extracellular adenosine levels. The present study provides the first evidence for ADK di...

journal_title：Journal of neuroscience research

authors： Vlajkovic SM,Guo CX,Dharmawardana N,Wong AC,Boison D,Housley GD,Thorne PR

更新日期：2010-09-01 00:00:00

abstract：:Organotypic slices are used frequently in studies of central nervous system development and function because they provide excellent experimental access with significant preservation of cellular context and relationships. Within a slice, however, a variety of factors may cause individual classes of neurons to respond d...

journal_title：Journal of neuroscience research

authors： Niblock MM,Brunso-Bechtold JK,Riddle DR

更新日期：2001-09-01 00:00:00

abstract：:The c-Jun N-terminal kinase (JNK) is induced by cerebral ischemia and injurious blood components acutely after subarachnoid hemorrhage (SAH). We hypothesized that inhibition of JNK will prevent damage to the neurovascular unit in the early brain injury period after SAH. Ninety-nine male SD rats (300-350 g) were random...

journal_title：Journal of neuroscience research

authors： Yatsushige H,Ostrowski RP,Tsubokawa T,Colohan A,Zhang JH

更新日期：2007-05-15 00:00:00

abstract：:The extension of filopodia from growth cones of regenerating neurites from rat superior cervical ganglion neurons in tissue culture was studied. Cultures were grown on a thin layer of fibrous collagen and maintained in a medium containing serum and nerve growth factor. Time-lapse cinematography and computer-assisted m...

journal_title：Journal of neuroscience research

authors： Argiro V,Bunge MB,Johnson MI

更新日期：1985-01-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a progressive and fatal disease caused by the selective death of motor neurons. Between 5% and 10% of ALS patients have a genetically inherited form of the disease known as familial ALS (FALS), and approximately 20% of FALS patients have mutations in the SOD1 gene. Although the m...

journal_title：Journal of neuroscience research

authors： Morimoto N,Nagai M,Miyazaki K,Kurata T,Takehisa Y,Ikeda Y,Kamiya T,Okazawa H,Abe K

更新日期：2009-03-01 00:00:00

abstract：:Human fetal brain is a potential source of neural stem cells (NSCs) for cell replacement therapy in neurodegenerative diseases. We explored whether NSCs isolated from cortex and striatum of human fetuses, aged 6-9 weeks post-conception, maintain their regional identity and differentiate into specific neuron types in c...

journal_title：Journal of neuroscience research

authors： Kallur T,Darsalia V,Lindvall O,Kokaia Z

更新日期：2006-12-01 00:00:00

abstract：:The ED1 monoclonal antibody recognizes an antigen in lysosomal membranes of phagocytes. The expression of this antigen in cells increases during phagocytic activity. Here we describe the expression of ED1-immunoreactivity during the various stages of both acute (monophasic) and chronic relapsing experimental autoimmun...

journal_title：Journal of neuroscience research

authors： Bauer J,Sminia T,Wouterlood FG,Dijkstra CD

更新日期：1994-07-01 00:00:00