Aberrant features of in vivo striatal dynamics in Parkinson's disease.

abstract：:Antiglycolipid IgM antibodies are known to induce formation of "wide spaced" or "expanded" myelin, a distinctive form of dysmyelination characterized by a repeat period approximately two or three times normal, which is seen also in diseases, including multiple sclerosis. To determine whether an antibody directed again...

journal_title：Journal of neuroscience research

authors： Rosenbluth J,Schiff R

更新日期：2009-03-01 00:00:00

abstract：:To study the potential role of Alzheimer precursor protein A4 (APP) and beta-amyloid (A/beta) on aging motor neuron survival, expression of APP, A/beta, and choline acetyltransferase (ChaT) were investigated in aged rats after either distal axotomy or root avulsion injury. Approximately 45% in number of total aged spi...

journal_title：Journal of neuroscience research

authors： Xie Y,Yao Z,Chai H,Wong WM,Wu W

更新日期：2003-08-15 00:00:00

abstract：:Production of hydrogen peroxide as a by-product of the breakdown of catecholamines by the enzyme monoamine oxidase (MAO) has been hypothesized to contribute to the increased proclivity of dopaminergic neurons for oxidative injury. We established clonal dopaminergic PC12 cell lines which have elevated MAO activity leve...

journal_title：Journal of neuroscience research

authors： Wei Q,Yeung M,Jurma OP,Andersen JK

更新日期：1996-12-15 00:00:00

abstract：:The subcellular targeting of mRNAs encoding myelin proteins to the oligodendrocyte processes is an accepted fact in myelin formation. How these messengers are kept silent during their movement to the subcellular domain where they are turned on remains a mystery. This review focuses on aspects of mRNA targeting and spe...

journal_title：Journal of neuroscience research

authors： Boccaccio GL

更新日期：2000-11-15 00:00:00

abstract：:Neurofibromatosis type 2 is a hereditary cancer syndrome characterized by the development of bilateral vestibular schwannomas. Underlying the disease are inactivating mutations of the NF2 tumor suppressor gene, located on chromosome 22, encoding a 595-amino-acid protein. The NF2 protein, also known as merlin or schwan...

journal_title：Journal of neuroscience research

authors： den Bakker MA,Riegman PH,Suurmeijer AP,Vissers CJ,Sainio M,Carpen O,Zwarthoff EC

更新日期：2000-12-15 00:00:00

abstract：:Reference genes are often used to normalize expression of data from real-time quantitative reverse transcription-polymerase chain reaction (RT-qPCR), and only a validation of their stability during a given experimental paradigm leads to reliable interpretations. The present study was thus designed to validate potentia...

journal_title：Journal of neuroscience research

authors： Pernot F,Dorandeu F,Beaup C,Peinnequin A

更新日期：2010-04-01 00:00:00

abstract：:Nonmotor symptoms of cognitive and affective nature are present in premotor and motor stages of Parkinson's disease (PD). Neurogenesis, the generation of new neurons, persists throughout the mammalian life span in the hippocampal dentate gyrus. Adult hippocampal neurogenesis may be severely affected in the course of P...

journal_title：Journal of neuroscience research

authors： Schlachetzki JC,Grimm T,Schlachetzki Z,Ben Abdallah NM,Ettle B,Vöhringer P,Ferger B,Winner B,Nuber S,Winkler J

更新日期：2016-01-01 00:00:00

abstract：:The discharge behavior of neurons depends on a variable expression and sorting pattern of voltage-dependent potassium (Kv) channels that changes during development. The rodent retina represents a neuronal network whose main functions develop after birth. To obtain information about neuronal maturation we analyzed the ...

journal_title：Journal of neuroscience research

authors： Höltje M,Brunk I,Grosse J,Beyer E,Veh RW,Bergmann M,Grosse G,Ahnert-Hilger G

更新日期：2007-01-01 00:00:00

abstract：:Neuron expression of the cytokine tumor necrosis factor-alpha (TNF), and the regulation of the levels of TNF by alpha(2)-adrenergic receptor activation were investigated. Adult rat hippocampal neurons and phorbol ester (PMA)-differentiated SH-SY5Y cells were examined. Intracellular levels of TNF mRNA accumulation, as ...

journal_title：Journal of neuroscience research

authors： Renauld AE,Spengler RN

更新日期：2002-01-15 00:00:00

abstract：:Neurotransmitter transporters are involved in termination of the synaptic neurotransmission and they also play a key role in neuroregulation and brain development. In this report, we describe the developmental distribution of the y-aminobutyric acid transporter GAT3 which transports gamma-aminobutyric acid (GABA) and ...

journal_title：Journal of neuroscience research

authors： Jursky F,Nelson N

更新日期：1999-02-01 00:00:00

abstract：:The most visible and, until very recently, the only hypothesis regarding the involvement of microglial cells in Alzheimer's disease (AD) pathogenesis is centered around the notion that activated microglia are neurotoxin-producing immune effector cells actively involved in causing the neurodegeneration that is the caus...

journal_title：Journal of neuroscience research

authors： Streit WJ

更新日期：2004-07-01 00:00:00

abstract：:The expression of many myelin-specific molecules in Schwann cells is profoundly decreased following denervation. This study examines the early reexpression of myelin protein genes associated with reinnervation. Following sciatic nerve crush, the distal, regenerated nerve was divided into appropriate (2.5 or 5 mm) cons...

journal_title：Journal of neuroscience research

authors： Mitchell LS,Griffiths IR,Morrison S,Barrie JA,Kirkham D,McPhilemy K

更新日期：1990-10-01 00:00:00

abstract：:Inhibitory luminopsins (iLMO2) integrate opto- and chemo-genetic approaches and allow for cell-type specific inhibition of neuronal activity. When exposed to a Renilla luciferase substrate, Coelenterazine (CTZ), iLMO2 generates bioluminescence-mediated activation of its amino-terminal halorhodopsin, resulting in neuro...

journal_title：Journal of neuroscience research

authors： Jaiswal PB,Tung JK,Gross RE,English AW

更新日期：2020-03-01 00:00:00

abstract：:Systemic osmotic homeostasis is regulated mainly by neuroendocrine system of arginine-vasopressin (AVP) in mammalians. In the present study, we demonstrated that the immunoreactivity of tissue plasminogen activator (tPA) was observed specifically at neurosecretory granules of AVP-positive magnocellular terminals and t...

journal_title：Journal of neuroscience research

authors： Imamura Y,Morita S,Nakatani Y,Okada K,Ueshima S,Matsuo O,Miyata S

更新日期：2010-07-01 00:00:00

abstract：:Pigment epithelium-derived factor (PEDF) is a neurotrophic protein synthesized and secreted by retinal pigment epithelial (RPE) cells in early embryogenesis and has been shown to be present in the extracellular matrix between the RPE cells and the neural retina. It induces neuronal differentiation and promotes surviva...

journal_title：Journal of neuroscience research

authors： Cao W,Tombran-Tink J,Chen W,Mrazek D,Elias R,McGinnis JF

更新日期：1999-09-15 00:00:00

abstract：:To investigate the function of the dipeptide carnosine in the olfactory system, alterations of carnosine in the primary olfactory nerve after unilateral naris closure or olfactory bulb semilesion were studied by means of immunocytochemistry. After unilateral naris closure, carnosine staining showed no alteration, but ...

journal_title：Journal of neuroscience research

authors： Sakai M,Nagatsu I

更新日期：1993-04-15 00:00:00

abstract：:Primary brain tumors, particularly glioblastomas (GB), remain a challenge for oncology. An element of the malignant brain tumors' aggressive behavior is the fact that GB are among the most densely vascularized tumors. To determine some of the molecular regulations occuring at the brain tumor endothelium level during t...

journal_title：Journal of neuroscience research

authors： Régina A,Jodoin J,Khoueir P,Rolland Y,Berthelet F,Moumdjian R,Fenart L,Cecchelli R,Demeule M,Béliveau R

更新日期：2004-01-15 00:00:00

abstract：:The recent recognition that the p75 neurotrophin receptor, p75((NTR)), can induce apoptotic signals has contributed to the perception that it acts primarily as a death receptor. Although the molecular mechanisms of p75(NTR) signaling remain to be fully characterized, many of the currently identified pathways activated...

journal_title：Journal of neuroscience research

authors： Dobrowsky RT,Carter BD

更新日期：2000-08-01 00:00:00

abstract：:The distribution of both tyrosine hydroxylase (TH) antigen and messenger RNA was investigated in the ventral mesencephalon from human brain using a 35S-labeled human TH cDNA probe and a polyclonal TH antibody. A hybridization signal was detected not only in the perikaryon but also in the neurites, most probably dendri...

journal_title：Journal of neuroscience research

authors： Dumas S,Javoy-Agid F,Hirsch E,Agid Y,Mallet J

更新日期：1990-04-01 00:00:00

abstract：:Sympathetic noradrenergic nerve fibers, stained with antiserum for tyrosine hydroxylase (TH), richly innervate the splenic white pulp. These fibers distribute with the vascular and trabecular systems, and associate mainly with the central artery and its branches, the periarteriolar lymphatic sheath (PALS), the margina...

journal_title：Journal of neuroscience research

authors： Felten DL,Ackerman KD,Wiegand SJ,Felten SY

更新日期：1987-01-01 00:00:00

abstract：:Nerve growth factor (NGF) has been purified from the guinea pig prostate using a modification of the Bocchini-Angeletti method for isolating 2.5S NGF from mouse submaxillary glands. As with the mouse preparation, guinea pig prostate NGF appears to migrate as a high molecular weight entity at physiological pH. Followin...

journal_title：Journal of neuroscience research

authors： Rubin JS,Bradshaw RA

更新日期：1981-01-01 00:00:00

abstract：:We have demonstrated recently that atypical antipsychotics possess neuroprotective actions in H2O2-mediated and serum-withdrawal models of cell death. In the present study, we compared the ability of atypical and typical antipsychotics to protect against an insult mediated by Abeta(25-35), an apoptogenic fragment of t...

journal_title：Journal of neuroscience research

authors： Wei Z,Mousseau DD,Richardson JS,Dyck LE,Li XM

更新日期：2003-12-15 00:00:00

abstract：:In a military setting, traumatic brain injury (TBI) is frequently caused by blast waves that can trigger a series of neuronal biochemical changes. Although many animal models have been used to study the effects of primary blast waves, elucidating the mechanisms of damage in a whole-animal model is extremely complex. I...

journal_title：Journal of neuroscience research

authors： Zander NE,Piehler T,Boggs ME,Banton R,Benjamin R

更新日期：2015-09-01 00:00:00

abstract：:Granulocyte colony-stimulating factor (G-CSF) and its related mechanisms were investigated to assess the potential for this factor to exert neuroprotective effects against spinal cord injury in mice. Recombinant human granulocyte colony-stimulating factor (rhG-CSF) was injected into mice spinal cord hemisection models...

journal_title：Journal of neuroscience research

authors： Guo Y,Liu S,Wang P,Zhang H,Wang F,Bing L,Gao J,Yang J,Hao A

更新日期：2014-06-01 00:00:00

abstract：:The olfactory ensheathing cell (OEC) is a unique glial cell able to support neurite outgrowth in the CNS throughout life. The OEC has been described as having both Schwann cell-like and astrocyte-like characteristics. The purpose of this study was to compare gap junctional communication and connexin (Cx) expression in...

journal_title：Journal of neuroscience research

authors： Barnett SC,Thompson RJ,Lakatos A,Pitts J

更新日期：2001-09-15 00:00:00

abstract：:Rho-GTPase has been implicated in the apoptosis of many cell types, including neurons, but the mechanism by which it acts is not fully understood. Here, we investigate the roles of Rho and ROCK in apoptosis during transplantation of embryonic stem cell-derived neural precursor cells. We find that dissociation of neura...

journal_title：Journal of neuroscience research

authors： Koyanagi M,Takahashi J,Arakawa Y,Doi D,Fukuda H,Hayashi H,Narumiya S,Hashimoto N

更新日期：2008-02-01 00:00:00

abstract：:N-cadherin and beta-catenin are involved in cell adhesion and cell cycle in tumor cells and neural crest. Both are expressed at key stages of Schwann cell (SC) development, but little is known about their function in the SC lineage. We studied the role of these molecules in adult rat derived SC-embryonic dorsal root g...

journal_title：Journal of neuroscience research

authors： Gess B,Halfter H,Kleffner I,Monje P,Athauda G,Wood PM,Young P,Wanner IB

更新日期：2008-03-01 00:00:00

abstract：:Macroautophagy is an evolutionally conserved membrane trafficking pathway that delivers intracellular materials to lysosomes for degradation and recycling. Rab7, as a member of the Rab GTPase superfamily, has a unique role in the regulation of macroautophagy, especially in modulating autophagy flux. The functional sta...

journal_title：Journal of neuroscience research

authors： Wen H,Zhan L,Chen S,Long L,Xu E

更新日期：2017-10-01 00:00:00

abstract：:We suggest that a dysregulation of energy metabolism in the brain of genetic absence epilepsy rats from Strasbourg (GAERS) could create a specific cerebral environment that would favor the expression of spike-and-wave discharges (SWD) in the thalamocortical loop, largely dependent on glutamatergic and gamma-aminobutyr...

journal_title：Journal of neuroscience research

authors： Dufour F,Nalecz KA,Nalecz MJ,Nehlig A

更新日期：2001-12-01 00:00:00

abstract：:Amyotrophic lateral sclerosis is an age-related neurological disease, characterized by neurofilament (NF) accumulation in primary axons followed by degeneration of motor neurons. To elucidate age-related factors that might lead to pathological NF accumulation, NFs were compared between young and aged rats. Electron mi...

journal_title：Journal of neuroscience research

authors： Uchida A,Yorifuji H,Lee VM,Kishimoto T,Hisanaga S

更新日期：1999-10-15 00:00:00