Prevention of spinal motor neuron death by insulin-like growth factor-1 associating with the signal transduction systems in SODG93A transgenic mice.

abstract：:Astrocytes play a diverse role in central nervous system (CNS) injury. Production of the serine protease inhibitors (serpins) plasminogen activator inhibitor-1 (PAI-1) and protease nexin-1 (PN-1) by astrocytes may counterbalance excessive serine protease activity associated with CNS pathologies such as ischemic stroke...

journal_title：Journal of neuroscience research

authors： Hultman K,Blomstrand F,Nilsson M,Wilhelmsson U,Malmgren K,Pekny M,Kousted T,Jern C,Tjärnlund-Wolf A

更新日期：2010-08-15 00:00:00

abstract：:Oligodendrocytes (OLs) show heterogeneous properties that depend on their location in the central nervous system (CNS). In this regard, the investigation of oligodendrocyte precursor cells (OPCs) derived from human pluripotent stem cells (hPSCs) should be reconsidered, particularly in cases of brain-predominant disord...

journal_title：Journal of neuroscience research

authors： Hermanto Y,Maki T,Takagi Y,Miyamoto S,Takahashi J

更新日期：2019-07-01 00:00:00

abstract：:NOD-like receptors (NLRs) are critical cytoplasmic pattern-recognition receptors (PRRs) that play an important role in the host innate immune response and immunity homeostasis. There is a growing body of evidence that NLRs are involved in a wide range of inflammatory diseases, including cancer, metabolic diseases, and...

journal_title：Journal of neuroscience research

authors： Kong X,Yuan Z,Cheng J

更新日期：2017-08-01 00:00:00

abstract：:The production of collagen-degrading proteases by cultured neonatal rat microglia was examined using an immobilized fibronectin-gelatin matrix coupled to a fluorescent marker and by substrate gel analysis. When microglia were plated onto the surface of the matrix and incubated under resting (nonstimulated) conditions,...

journal_title：Journal of neuroscience research

authors： Colton CA,Keri JE,Chen WT,Monsky WL

更新日期：1993-06-15 00:00:00

abstract：:The expression of many myelin-specific molecules in Schwann cells is profoundly decreased following denervation. This study examines the early reexpression of myelin protein genes associated with reinnervation. Following sciatic nerve crush, the distal, regenerated nerve was divided into appropriate (2.5 or 5 mm) cons...

journal_title：Journal of neuroscience research

authors： Mitchell LS,Griffiths IR,Morrison S,Barrie JA,Kirkham D,McPhilemy K

更新日期：1990-10-01 00:00:00

abstract：:The cellular localization of calpain is important in understanding the roles that calpain may play in physiological function. We, therefore, examined calpain expression, activity, and immunofluorescent localization in primary cultures of rat oligodendrocytes. The mRNA expression of m-calpain was 64.8% (P = 0.0033) and...

journal_title：Journal of neuroscience research

authors： Ray SK,Neuberger TJ,Deadwyler G,Wilford G,DeVries GH,Banik NL

更新日期：2002-11-15 00:00:00

abstract：:Huntington's disease (HD) is a progressive neurodegenerative disorder caused by an expanded CAG repeat within the huntingtin (HTT) gene. The Q140 and HdhQ150 knock-in HD mouse models were generated such that HdhQ150 mice have an expanded CAG repeat inserted into the mouse Htt gene, whereas in the Q140s, mouse exon 1 H...

journal_title：Journal of neuroscience research

authors： Franich NR,Hickey MA,Zhu C,Osborne GF,Ali N,Chu T,Bove NH,Lemesre V,Lerner RP,Zeitlin SO,Howland D,Neueder A,Landles C,Bates GP,Chesselet MF

更新日期：2019-12-01 00:00:00

abstract：:Sildenafil, given shortly before 3,4-methylenedioxymethamphetamine (MDMA), affords protection against 5-hydroxytryptamine (5-HT) depletions caused by this amphetamine derivative by an acute preconditioning-like mechanism. Because acute and delayed preconditionings do not share the same mechanisms, we investigated whet...

journal_title：Journal of neuroscience research

authors： Puerta E,Barros-Miñones L,Hervias I,Gomez-Rodriguez V,Orejana L,Pizarro N,de la Torre R,Jordán J,Aguirre N

更新日期：2012-02-01 00:00:00

abstract：:Factor Xa (FXa) plays a critical role in the coagulation cascade by generation of thrombin. During focal ischemia thrombin levels increase in the brain tissue and cause neural damage. This study examined the hypothesis that administration of the FXa inhibitor, apixaban, following focal ischemic stroke may have therape...

journal_title：Journal of neuroscience research

authors： Bushi D,Chapman J,Wohl A,Stein ES,Feingold E,Tanne D

更新日期：2018-08-01 00:00:00

abstract：:Changes in dopamine (DA) D(1), D(2), D(3), and D(4) receptors and serotonin 5-HT(1A) and 5-HT(2A) receptors in rat forebrain regions were autoradiographically quantified after continuous infusion of JL 13 [(5-(4-methylpiperazin-1-yl)-8-chloro-pyrido[2,3-b][1,5]benzoxazepine fumarate] for 28 days with osmotic minipumps...

journal_title：Journal of neuroscience research

authors： Moran-Gates T,Massari C,Graulich A,Liégeois JF,Tarazi FI

更新日期：2006-08-15 00:00:00

abstract：:The incidence of dementia and obstructive sleep apnea (OSA) increases with age. Late-onset Alzheimer's disease (AD) is an irreversible neurodegenerative disease of the elderly characterized by amyloid β (Aβ) plaques and neurofibrillary tangles. The disease involves widespread synaptic loss in the neocortex and the hip...

journal_title：Journal of neuroscience research

authors： Daulatzai MA

更新日期：2015-12-01 00:00:00

abstract：:PC12 cells can differentiate into neuron-like cells after treatment with either nerve growth factor (NGF) or transduction with a retrovirus which expresses the K-ras oncogene. The concomitant treatment of NGF plus ras differentiates PC12 cells further than either agent alone with respect to neurite outgrowth, acetylch...

journal_title：Journal of neuroscience research

authors： Tao-Cheng JH,Dosemeci A,Bressler JP,Brightman MW,Simpson DL

更新日期：1995-10-15 00:00:00

abstract：:1-Methyl-4-phenyl-1,2,3,6-tetrahyrdropyridine (MPTP)-exposed cats develop severe Parkinsonism that spontaneously resolves in 4-6 weeks. The present study examined the extent to which compensatory changes in tyrosine hydroxylase (TH) and dopamine transporter (DAT) gene and protein expression may underlie this behaviora...

journal_title：Journal of neuroscience research

authors： Rothblat DS,Schroeder JA,Schneider JS

更新日期：2001-08-01 00:00:00

abstract：:The immunohistochemical distribution of microtubule-associated protein 2 (MAP2), being normally restricted to nerve cell bodies and dendrites, became altered in rat dorsal root ganglia and spinal cord neurons in cultures infected with rhesus rotavirus. MAP2 appeared in axons of both sources of neurons as displayed wit...

journal_title：Journal of neuroscience research

authors： Weclewicz K,Svensson L,Billger M,Holmberg K,Wallin M,Kristensson K

更新日期：1993-10-01 00:00:00

abstract：:This investigation explores the central nervous system protein-synthetic responses to hemisection of the spinal cord. Adult male rats hemisected at mid T2 were given intravenous injections of 14C-leucine at 0.7, 30, or 70 days postoperative. Four hours later the T1, T2, T3, and C6 segments of the spinal cord and right...

journal_title：Journal of neuroscience research

authors： Luttge WG,Mannis MJ,Bernstein JJ

更新日期：1975-01-01 00:00:00

abstract：:Although they likely involve activation of N-methyl-D-aspartate (NMDA) receptors, the mechanisms giving rise to perinatal hypoxic-ischemic-induced damages remained unclear. The purpose of the present study was to investigate in vivo the mechanisms regulating the glutamate-induced release of toxic hydroxyl radicals (.O...

journal_title：Journal of neuroscience research

authors： Cambonie G,Laplanche L,Kamenka JM,Barbanel G

更新日期：2000-10-01 00:00:00

abstract：:In cultured Schwann cells, single-channel and whole-cell K+ currents can be activated by depolarizing the membrane to values more negative than -50 mV. In elevated extracellular K+ concentration ([K+]o), however, single-channel activity and whole-cell currents could be recorded at more negative potentials. Thus, the t...

journal_title：Journal of neuroscience research

authors： Verkhratsky A,Hoppe D,Kettenmann H

更新日期：1991-02-01 00:00:00

abstract：:To determine whether acute hyperglycemia changes the hyperemic response to functional activation of brain, the area and magnitude of the activation were measured in healthy volunteers maintained at euglycemia and then at hyperglycemia using the hyperglycemic clamp technique. Activation of the visual cortex (8-16 Hz) w...

journal_title：Journal of neuroscience research

authors： Gruetter R,Uğurbil K,Seaquist ER

更新日期：2000-10-15 00:00:00

abstract：:L-deprenyl protects neurons in a number of in vivo and in vitro models and it has been postulated that it ameliorates some neurodegenerative disorders. Superoxide dismutase (SOD) is one of the enzymes responsible for the inactivation of oxygen free radicals, and one of the mechanisms of the effect of L-deprenyl is tho...

journal_title：Journal of neuroscience research

authors： Li XM,Juorio AV,Qi J,Boulton AA

更新日期：1998-07-15 00:00:00

abstract：:Immature and mature rat astroglia in culture were assayed for glutamine synthetase (GS) activity after a single exposure to the epileptogen FeCl2. Cells were cultured with both standard and elevated extracellular potassium or glutamate (Glu) concentrations. FeCl2 reduced GS activity below control levels, whereas high ...

journal_title：Journal of neuroscience research

authors： Tiffany-Castiglioni E,Roberts JA,Sheeler-Gough LV

更新日期：1989-12-01 00:00:00

abstract：:The induction of heat-shock protein 70 (hsp70) mRNA in the hyperthermic rabbit brain has been examined previously by using Northern blotting and in situ hybridization procedures that measure steady-state levels of mRNA, which may be influenced by transcript stability and transcription rate. In the present investigatio...

journal_title：Journal of neuroscience research

authors： D'Souza CA,Rush SJ,Brown IR

更新日期：1998-06-01 00:00:00

abstract：:Monocyte chemoattractant protein-1 (MCP-1, CCL2) is a well-defined chemokine implicated in the pathology of various neurodegenerative diseases and brain injuries, such as Alzheimer's disease, multiple sclerosis, stroke, and traumatic injury. We investigated the effect of the activation of P2 purinoceptors on MCP-1 pro...

journal_title：Journal of neuroscience research

authors： Katayama T,Ito M,Kaneko S,Satoh M,Uehara T,Minami M

更新日期：2009-05-15 00:00:00

abstract：:Acute intoxication with large ammonia doses leads to activation of NMDA receptors in the brain, resulting in oxidative stress and disturbance of mitochondrial function. Altered mitochondrial function is a crucial step in some mechanisms of cellular apoptosis. This study assesses whether ammonia intoxication in vivo le...

journal_title：Journal of neuroscience research

authors： Kosenko E,Kaminsky Y,Solomadin I,Marov N,Venediktova N,Felipo V,Montoliu C

更新日期：2007-08-15 00:00:00

abstract：:Neurotrophins may have a neuroprotective role and are probably involved in the control of axonal sprouting and synaptic plasticity. An antibody raised against a pro-sequence of nerve growth factor (NGF) was tested. In control undisturbed rats, a strong immunoreactivity was detected in scattered cells in and around the...

journal_title：Journal of neuroscience research

authors： Humpel C,Ebendal T,Cao Y,Olson L

更新日期：1993-07-01 00:00:00

abstract：:Vascular smooth muscle (VSM) cells comprise one of the primary targets of the sympathetic nervous system and have been shown to secrete nerve growth factor (NGF). There is increasing evidence that changes in the levels of NGF in the adult may underlie certain pathological conditions. To investigate the potential role ...

journal_title：Journal of neuroscience research

authors： Creedon DJ,Tuttle JB

更新日期：1997-02-01 00:00:00

abstract：:The mutant hypogonadal (hpg) mouse lacks a functioning gene for the neurohormone gonadotropin releasing hormone (GnRH). Previous studies from our laboratory had indicated that the initiation and maintenance of reproductive function in these mice could be brought about by the implantation of normal fetal grafts into ad...

journal_title：Journal of neuroscience research

authors： Silverman RC,Gibson MJ,Silverman AJ

更新日期：1992-01-01 00:00:00

abstract：:Mouse sciatic nerves were transected and 3 hr to 16 days later proximal segments were removed and homogenized. Supernatants of these segments or of normal sciatic nerves were added to Schwann cells maintained in Dulbecco's modified Eagle's medium (DMEM) + 15% fetal calf serum (FCS). After 6 days, Schwann cells were so...

journal_title：Journal of neuroscience research

authors： Zhang QL,Lin PX,Chang Y,Webster HD

更新日期：1994-04-01 00:00:00

abstract：:Neural expression of constitutive hsc70 mRNA and hyperthermia-inducible hsp70 mRNA is examined using radioactive and non-radioactive in situ hybridization procedures. A strong induction of hsp70 mRNA was noted in cell populations in cerebellar layers and in the brainstem which demonstrated expression of mRNA encoding ...

journal_title：Journal of neuroscience research

authors： Foster JA,Rush SJ,Brown IR

更新日期：1995-08-01 00:00:00

abstract：:Brain slices obtained from young rats were incubated with different radioactive precursors, in the presence and absence of L-cycloserine (an inhibitor of the synthesis of sphingosine) in order to explore the possibility that transport of proteolipids--and specifically of the major myelin proteolipid PLP--to the myelin...

journal_title：Journal of neuroscience research

authors： Pasquini JM,Guarna MM,Besio-Moreno MA,Iturregui MT,Oteiza PI,Soto EF

更新日期：1989-03-01 00:00:00

abstract：:We have previously shown that the phorbol ester, TPA, which activates protein kinase C, causes, in PC12 cells, a transcriptional activation of tyrosine hydroxylase (TH), the key enzyme in catecholamine synthesis. The study has now been extended to examine the processes that underlie this transcriptional stimulation an...

journal_title：Journal of neuroscience research

authors： Icard-Liepkalns C,Biguet NF,Vyas S,Robert JJ,Sassone-Corsi P,Mallet J

更新日期：1992-06-01 00:00:00