Decreased NR1 phosphorylation and decreased NMDAR function in hibernating Arctic ground squirrels.

abstract：:The relationship between brain myelination and nutritional insufficiency in suckling rats whose dams had a restricted dietary intake was studied. The undernourished pups were characterized by body weight and brain weight that were 40-70% and 82-88% that of controls throughout the suckling period. Myelin concentrations...

journal_title：Journal of neuroscience research

authors： Yeh YY

更新日期：1988-03-01 00:00:00

abstract：:As it displays progressive hair-cell loss and degeneration of spiral ganglion neurons (SGNs) characterized by early-onset progressive hearing loss (ePHL), DBA/2J is an inbred mouse strain widely used in hearing research. Mouse nerve growth factor (mNGF), as a common exogenous nerve growth factor (NGF), has been studie...

journal_title：Journal of neuroscience research

authors： Wang Q,Zhao H,Zheng T,Wang W,Zhang X,Wang A,Li B,Wang Y,Zheng Q

更新日期：2017-10-01 00:00:00

abstract：:We describe here the presence of ubiquitin and its conjugation system in the rat retina. Retinal homogenates and supernatants conjugate [125I]human ubiquitin with either endogenous or exogenous proteins. The conjugating activity is relatively stable over time, requires ATP, and has a pH optimum of approximately 8. The...

journal_title：Journal of neuroscience research

authors： Naash M,Izbicka E,Anderson RE

更新日期：1991-10-01 00:00:00

abstract：:A link between aluminum (Al) exposure and age-related neurological disorders has long been proposed. Although the exact mechanism by which the metal may influence disease processes is unknown, there is evidence that exposure to Al causes an increase in both oxidative stress and inflammatory events. These processes hav...

journal_title：Journal of neuroscience research

authors： Campbell A,Becaria A,Lahiri DK,Sharman K,Bondy SC

更新日期：2004-02-15 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a late-onset progressive neurodegenerative disease affecting motor neurons. About 2% of patients with the disease are associated with mutations in the gene encoding Cu/Zn superoxide dismutase (SOD1). The purpose of this study is to assess the effect of rosemary extract and its ma...

journal_title：Journal of neuroscience research

authors： Shimojo Y,Kosaka K,Noda Y,Shimizu T,Shirasawa T

更新日期：2010-03-01 00:00:00

abstract：:Most cases of early-onset torsion dystonia are caused by deletion of GAG in the coding region of the DYT1 gene encoding torsinA. This autosomal dominant neurologic disorder is characterized by abnormal movements, believed to originate from neuronal dysfunction in the basal ganglia of the human brain. The torsins (tors...

journal_title：Journal of neuroscience research

authors： Hewett J,Ziefer P,Bergeron D,Naismith T,Boston H,Slater D,Wilbur J,Schuback D,Kamm C,Smith N,Camp S,Ozelius LJ,Ramesh V,Hanson PI,Breakefield XO

更新日期：2003-04-15 00:00:00

abstract：:Enriched populations of human microglial cells were isolated from mixed cell cultures prepared from embryonic human telencephalon tissues. Human microglial cells exhibited cell type-specific antigens for macrophage-microglia lineage cells including CD11b (Mac-1), CD68, B7-2 (CD86), HLA-ABC, HLA-DR and ricinus communis...

journal_title：Journal of neuroscience research

authors： Lee YB,Nagai A,Kim SU

更新日期：2002-07-01 00:00:00

abstract：:The objective of the present investigation was to answer the following question: Does the visual cortex affect the neuronal firing of retinal ganglion cells in the rat? To test this hypothesis, the visual cortex was inactivated by a reversible cryoblockade. Action potentials of a ganglion cell were recorded from its a...

journal_title：Journal of neuroscience research

authors： Molotchnikoff S,Tremblay F

更新日期：1983-01-01 00:00:00

abstract：:Isotonic media containing sodium salts from weak organic acids induce cell swelling in several experimental preparations (Grinstein et al., 1984; Jakubovicz et al., 1987). In vivo perfusion of rat dentate gyrus, using a microdialysis probe, with modified Krebs-Ringer bicarbonate solutions in which 50 mM NaCl was isoto...

journal_title：Journal of neuroscience research

authors： Solis JM,Herranz AS,Herreras O,Menéndez N,del Rio RM

更新日期：1990-06-01 00:00:00

abstract：:In the present study we report self-assembly of individual neurofilament (NF) triplet proteins (70K, 150K, and 200K daltons) isolated by anion exchange chromatography from bovine spinal cord. Formation of smooth 10-nm filaments by both NF 150K and NF 70K is shown. Optimal conditions for NK 150K filament formation were...

journal_title：Journal of neuroscience research

authors： Gardner EE,Dahl D,Bignami A

更新日期：1984-01-01 00:00:00

abstract：:In order to better characterize the presynaptic GABA receptors regulating glutamate release in the cerebellum [Levi and Gallo, 1981], a number of GABA agonists and GABA transport inhibitors were tested for their ability to potentiate the depolarization-induced release of the glutamate analog D-[3H]aspartate from super...

journal_title：Journal of neuroscience research

authors： Aloisi F,Gallo V,Levi G

更新日期：1983-01-01 00:00:00

abstract：:Neuron expression of the cytokine tumor necrosis factor-alpha (TNF), and the regulation of the levels of TNF by alpha(2)-adrenergic receptor activation were investigated. Adult rat hippocampal neurons and phorbol ester (PMA)-differentiated SH-SY5Y cells were examined. Intracellular levels of TNF mRNA accumulation, as ...

journal_title：Journal of neuroscience research

authors： Renauld AE,Spengler RN

更新日期：2002-01-15 00:00:00

abstract：:The effects of treatment with a high dose of nandrolone or testosterone on nerve growth factor (NGF) levels and NGF low-affinity receptor (p75-NGFr) distribution in the brain were analyzed. Nandrolone, subcutaneously injected in rats for several weeks, caused an increase of NGF levels in the hippocampus and septum and...

journal_title：Journal of neuroscience research

authors： Tirassa P,Thiblin I,Agren G,Vigneti E,Aloe L,Stenfors C

更新日期：1997-01-15 00:00:00

abstract：:The function of the prion protein is unknown despite suggestions it binds copper. Radioactive copper (Cu(67)) was used to demonstrate that histidine-dependent uptake of copper by cerebellar cells in culture is related to the level of PrP(c) expression. Copper is released by neurones at the synapse. Veratridine-induced...

journal_title：Journal of neuroscience research

authors： Brown DR

更新日期：1999-12-01 00:00:00

abstract：:Both protein kinase C (PKC) and ceramide play a critical role in cell signaling, but the relationship between PKC and ceramide is unclear. Low concentrations of ceramide were observed to transiently stimulate PKC zeta activity in vitro and in vivo, whereas high doses of ceramide lead to inhibition of PKC zeta. Inhibit...

journal_title：Journal of neuroscience research

authors： Wang YM,Seibenhener ML,Vandenplas ML,Wooten MW

更新日期：1999-02-01 00:00:00

abstract：:The phosphorylative neuromodulation of the regulatory subunit of protein kinase type II (R-II) in cytosolic fractions from denervated and sham-operated, contralateral soleus muscles of the rat was evaluated. The denervation-induced increase in the 32P-phosphorylation of R-II is not related to an increased dephosphoryl...

journal_title：Journal of neuroscience research

authors： McLane JA,Squinto SP,Yeoh HC,Held IR

更新日期：1985-01-01 00:00:00

abstract：:In order to study the voltage-dependent ion channels in microglia, and their possible modulation by pro-inflammatory substances like lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma) we employed the patch-clamp technique on purified rat microglial cell subcultures grown for 1 - 5 days in control condition or a...

journal_title：Journal of neuroscience research

authors： Visentin S,Agresti C,Patrizio M,Levi G

更新日期：1995-11-01 00:00:00

abstract：:Toll-like receptors (TLRs) play a key role in controlling innate immune responses to a wide variety of pathogen-associated molecules as well as endogenous signals. In addition, TLR expression within nonimmune cells has been recognized as as modulator of cell behavior. In this study we have addressed the question of wh...

journal_title：Journal of neuroscience research

authors： Bsibsi M,Nomden A,van Noort JM,Baron W

更新日期：2012-02-01 00:00:00

abstract：:Cerebral vasospasm is a potentially incapacitating or lethal complication in patients with aneurysmal subarachnoid hemorrhage (SAH). The development of effective preventative and therapeutic interventions has been largely hindered by the fact that the underlying pathogenic mechanisms of cerebral vasospasm remain poorl...

journal_title：Journal of neuroscience research

authors： Kolias AG,Sen J,Belli A

更新日期：2009-01-01 00:00:00

abstract：:CD9 is a tetra-membrane-spanning glycoprotein involved in cell adhesion, migration, and proliferation in both the immune and the immature nervous system. In this study, CD9 expression was detected in myelin of mouse brain, starting at postnatal day 16. The amount of CD9 protein continuously increased with age and pers...

journal_title：Journal of neuroscience research

authors： Kagawa T,Mekada E,Shishido Y,Ikenaka K

更新日期：1997-10-15 00:00:00

abstract：:The striatum plays an important role in learning, selecting, and executing actions. As a major input hub of the basal ganglia, it receives and processes a diverse array of signals related to sensory, motor, and cognitive information. Aberrant neural activity in this area is implicated in a wide variety of neurological...

journal_title：Journal of neuroscience research

authors： Lee K,Masmanidis SC

更新日期：2019-12-01 00:00:00

abstract：:Molecular and behavioral timekeeping is regulated by the circadian system which includes the brain's suprachiasmatic nucleus (SCN) that translates environmental light information into neuronal and endocrine signals aligning peripheral tissue rhythms to the time of day. Despite the critical role of circadian rhythms in...

journal_title：Journal of neuroscience research

authors： Yaw AM,Duong TV,Nguyen D,Hoffmann HM

更新日期：2021-01-01 00:00:00

abstract：:Brain injury and neuroinflammation are pathophysiologic contributors to acute and chronic neurologic disorders, which are progressive diseases not fully understood. Mammalian metallothioneins I and II (MT-I&II) have significant neuroprotective functions, but the precise mechanisms underlying these effects are still un...

journal_title：Journal of neuroscience research

authors： Penkowa M,Tio L,Giralt M,Quintana A,Molinero A,Atrian S,Vasák M,Hidalgo J

更新日期：2006-05-01 00:00:00

abstract：:This experiment was directed toward determining the relative effectiveness of discrete and diffuse pain stimuli in influencing perception and behavior. Shocks to the footpads were used to activate the discrete pain pathways and shocks to the upper canine teeth to activate the diffuse pain pathways. In the first phase ...

journal_title：Journal of neuroscience research

authors： Anderson KV,Pearl GS,Honeycutt C

更新日期：1976-01-01 00:00:00

abstract：:The inflammatory response initiated after spinal cord injury (SCI) is characterized by the accumulation of macrophages at the impact site. Monocyte chemoattractant protein-1 (MCP-1) is a strong candidate for mediating chemotaxis of monocytes to the injured nervous system. To help in defining the role of MCP-1 in infla...

journal_title：Journal of neuroscience research

authors： Ma M,Wei T,Boring L,Charo IF,Ransohoff RM,Jakeman LB

更新日期：2002-06-15 00:00:00

abstract：:The brain is both central in orchestrating the response to stress, and, a very sensitive target when such response is not controlled. In fact, stress has long been associated with the onset and/or exacerbation of several neuropsychiatric disorders such as anxiety, depression, and drug addiction. The hippocampus is a k...

journal_title：Journal of neuroscience research

authors： Alviña K,Jodeiri Farshbaf M,Mondal AK

更新日期：2021-01-01 00:00:00

abstract：:Traumatic brain injuries (TBIs) pose a massive burden of disease and continue to be a leading cause of morbidity and mortality throughout the world. A major obstacle in developing effective treatments is the lack of comprehensive understanding of the underlying mechanisms that mediate tissue damage and recovery after ...

journal_title：Journal of neuroscience research

authors： Bogoslovsky T,Bernstock JD,Bull G,Gouty S,Cox BM,Hallenbeck JM,Maric D

更新日期：2018-04-01 00:00:00

abstract：:Integrins comprise a large family of cell adhesion molecules that mediate interactions between the extracellular environment and the cytoplasm. During the last decade, analysis of the expression and function of these molecules has revealed that integrins regulate many aspects of cell behavior including cell death, pro...

journal_title：Journal of neuroscience research

authors： Milner R,Campbell IL

更新日期：2002-08-01 00:00:00

abstract：:With the use of an antiserum directed against the human smooth muscle-associated protein 8 (SMAP8) fragment SMAP8(98-138), Western blot and immunohistochemical studies revealed SMAP8 expression in the rat brain. A band with a molecular size of about 45 kDa was detected in tissues from the rat hypothalamus and a weaker...

journal_title：Journal of neuroscience research

authors： Brailoiu GC,Dun SL,Mizuo K,Brailoiu E,Yang J,Chang JK,Dun NJ

更新日期：2007-06-01 00:00:00

abstract：:A mouse monoclonal antibody (5B9), directed against a carbohydrate epitope of human epidermal growth factor receptor (EGFR), recognized an 81-kDalton glycoprotein in buffer-soluble and detergent-solubilized rat brain extracts (BE). The glycoprotein was more abundant in extracts prepared from injured brain than in thos...

journal_title：Journal of neuroscience research

authors： Río C,Pérez-Cerdá F,Matute C,Nieto-Sampedro M

更新日期：1995-04-15 00:00:00