Glial transporters for glutamate, glycine and GABA I. Glutamate transporters.

abstract：:Ionotropic N-methyl-D-aspartate (NMDA) receptor agonists, L-aspartic acid (L-Asp) and NMDA, have been shown to inhibit histamine-stimulated acid secretion, but their effect on gastric mucosal blood flow (GMBF) is largely unknown. The aim of this study was to investigate whether L-Asp and NMDA inhibit histamine-stimula...

journal_title：Journal of neuroscience research

authors： Tsai LH,Lee YJ,Wu JY

更新日期：2004-09-01 00:00:00

abstract：:Although serotonin regulates synthesis of the neurotrophic factor S-100 beta by astrocytes, its ability to affect nerve growth factor (NGF) synthesis has never been examined. We report here that there is a correlation between the effect of serotonin on cyclic adenosine monophosphate (cAMP) content and on NGF content i...

journal_title：Journal of neuroscience research

authors： Krzan M,Wu VW,Schwartz JP

更新日期：2001-05-01 00:00:00

abstract：:Perinatal hypoxia is a major cause of neurodevelopmental deficits. Neuronal migration patterns are particularly sensitive to perinatal hypoxia/ischemia and are associated with the clinical deficits. The rat model of hypoxia/ischemia at P7 mimics that of perinatal injury in humans. Before assessing the effects of postn...

journal_title：Journal of neuroscience research

authors： Bockhorst KH,Narayana PA,Liu R,Ahobila-Vijjula P,Ramu J,Kamel M,Wosik J,Bockhorst T,Hahn K,Hasan KM,Perez-Polo JR

更新日期：2008-05-15 00:00:00

abstract：:Six different types of spectral responses were recorded from horizontal cells under mesopic conditions in perfused retina, isolated from the dark-adapted mojarra (Eugerres plumieri). They were tentatively termed photopic Lr-, Lg1-, Lg2-, Lb-, and C-type, and scotopic L-type. The Lr-, Lg-, and Lb-type responses showed ...

journal_title：Journal of neuroscience research

authors： Negishi K,Salas R,Parthe V,Drujan BD

更新日期：1988-01-01 00:00:00

abstract：:During surgical intervention in medically refractory temporal lobe epilepsy (TLE) patients, diagnosed with either mesial temporal lobe sclerosis (MTS)- or tumor (T)-associated TLE, biopsies were taken from the anterior temporal neocortex and the hippocampal region. Synaptosomes, isolated from these biopsies were used ...

journal_title：Journal of neuroscience research

authors： Hoogland G,Hens JJ,De Wit M,van Veelen CW,van Huffelen AC,Gispen WH,de Graan PN

更新日期：2000-06-01 00:00:00

abstract：:The cerebral neocortex is known to modulate asymmetrically certain components of the immune system. It was previously shown that large ablation of the left cortex reduces B and T cell-mediated responses, whereas symmetrical right lesions enhance these responses. We have studied the immunomodulatory role of the brain c...

journal_title：Journal of neuroscience research

authors： Neveu PJ,Barnéoud P,Georgiades O,Vitiello S,Vincendeau P,Le Moal M

更新日期：1989-02-01 00:00:00

abstract：:Nitric oxide (NO) is produced by the enzyme nitric oxide synthase (NOS) and has been implicated in inter- and intracellular communication in the nervous system. The present study was undertaken to assess the effects of sodium nitroprusside (SNP) and hydroxylamine (HOA), NO donors, on a dopamine (DA)-induced K+ current...

journal_title：Journal of neuroscience research

authors： Sawada M,Ichinose M,Stefano GB

更新日期：1997-11-01 00:00:00

abstract：:Quantitative evaluation of gamma-aminobutyric acid immunoreactivity (GABA-IR) in the hindlimb representation of the rat somatosensory cortex after 14 days of exposure to hypergravity (hyper-G) was conducted by using computer-assisted image processing. The area of GABA-IR axosomatic terminals apposed to pyramidal cells...

journal_title：Journal of neuroscience research

authors： D'Amelio F,Wu LC,Fox RA,Daunton NG,Corcoran ML,Polyakov I

更新日期：1998-07-15 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-alpha), a proinflammatory cytokine, has been implicated in the pathogenesis of several disorders and injuries in the central nervous system (CNS). Unlike IGF-I, which promotes CNS growth, TNF-alpha causes brain growth retardation and neural damage. Recently TNF-alpha has been shown to ...

journal_title：Journal of neuroscience research

authors： Ye P,Price W,Kassiotis G,Kollias G,D'Ercole AJ

更新日期：2003-03-01 00:00:00

abstract：:Migraine is a common neurological disorder with significantly higher incidence and prevalence in women than men. The presentation of the disease in women is modulated by changes in sex hormones from adolescence to pregnancy and menopause. Yet, the effect of sex influences has often been neglected in both basic and cli...

journal_title：Journal of neuroscience research

authors： Pavlovic JM,Akcali D,Bolay H,Bernstein C,Maleki N

更新日期：2017-01-02 00:00:00

abstract：:The chemokines, macrophage inflammatory protein-1 (MIP-1) and its subunit MIP-1 beta, induce an intense fever in the rat when they are injected directly into the anterior hypothalamic, pre-optic area (AH/POA), a region containing thermosensitive neurons. The purpose of this study was to compare the central action on b...

journal_title：Journal of neuroscience research

authors： Myers RD,Lopez-Valpuesta FJ,Miñano FJ,Wooten MH,Barwick VS,Wolpe SD

更新日期：1994-09-01 00:00:00

abstract：:Encephalitogenic T cells from Lewis rats use a restricted T cell receptor (TCR) gene combination, Vbeta8.2 and Valpha2. The oral administration of myelin basic protein (MBP) to Lewis rats prior to encephalitogenic challenge results in a marked inhibition of clinical neurologic signs of encephalitis, reduced central ne...

journal_title：Journal of neuroscience research

authors： Goldman-Brezinski S,Brezinski K,Zhang XM,Gienapp I,Cox K,Heber-Katz E,Whitacre C

更新日期：1998-01-01 00:00:00

abstract：:Systemic osmotic homeostasis is regulated mainly by neuroendocrine system of arginine-vasopressin (AVP) in mammalians. In the present study, we demonstrated that the immunoreactivity of tissue plasminogen activator (tPA) was observed specifically at neurosecretory granules of AVP-positive magnocellular terminals and t...

journal_title：Journal of neuroscience research

authors： Imamura Y,Morita S,Nakatani Y,Okada K,Ueshima S,Matsuo O,Miyata S

更新日期：2010-07-01 00:00:00

abstract：:Statins are potent cholesterol biosynthesis inhibitors that exert protective effects in humans and in experimental models of stroke. The mechanisms involved in these protective actions are not completely understood. This study evaluates whether atorvastatin (ATV) treatment affects the GluN1 and GluN2B subunits of the ...

journal_title：Journal of neuroscience research

authors： Gutierrez-Vargas JA,Muñoz-Manco JI,Garcia-Segura LM,Cardona-Gómez GP

更新日期：2014-11-01 00:00:00

abstract：:Parallel corticostriatonigral circuits have been proposed that separately process motor, cognitive, and emotional-motivational information. Functional integration requires that interactions exist between neurons participating in these circuits. This makes it imperative to study the complex anatomical substrate underly...

journal_title：Journal of neuroscience research

authors： Wouterlood FG,Engel A,Daal M,Houwen G,Meinderts A,Jordà Siquier T,Beliën JAM,van Dongen YC,Scheel-Krüger J,Thierry AM,Groenewegen HJ,Deniau JM

更新日期：2018-09-01 00:00:00

abstract：:Barbiturates are regularly used as an anesthetic for animal experimentation and clinical procedures and are frequently provided with solubilizing compounds, such as ethanol and propylene glycol, which have been reported to affect brain function and, in the case of (1)H NMR experiments, originate undesired resonances i...

journal_title：Journal of neuroscience research

authors： Lei H,Duarte JM,Mlynarik V,Python A,Gruetter R

更新日期：2010-02-01 00:00:00

abstract：:We have studied the characteristics of pH(i) regulation at different stages of rat oligodendrocyte differentiation in primary culture. pH(i) was measured at 37 degrees C using the pH-sensitive fluorescent probe BCECF. In immature oligodendrocyte progenitor (OLP), three distinct ionic mechanisms were involved in pH(i) ...

journal_title：Journal of neuroscience research

authors： Boussouf A,Gaillard S

更新日期：2000-03-15 00:00:00

abstract：:We studied the effects of electrical stimulation of the inferior alveolar nerve (IAN) on cardiovascular responses in cats. There was statistical correlation between cardiovascular response and prestimulus mean arterial blood pressure (MABP) and heart rate (HR). A trigeminal depressor response (TDR) was induced when th...

journal_title：Journal of neuroscience research

authors： Ohshita N,Nakajo N,Takemura M

更新日期：2004-06-15 00:00:00

abstract：:The role of insulin-like growth factor-1 (IGF-1) in amyotrophic lateral sclerosis (ALS) and its mechanism of action are important from both pathogenic and therapeutic points of view. The present study investigated the changes of IGF-1Rbeta and the key intracellular downstream protein insulin receptor substrate-1 (IRS-...

journal_title：Journal of neuroscience research

authors： Narai H,Nagano I,Ilieva H,Shiote M,Nagata T,Hayashi T,Shoji M,Abe K

更新日期：2005-11-15 00:00:00

abstract：:The number of older people who are suffering from memory impairment is increasing among populations throughout the world. Alzheimer's disease (AD) affects about 5% of people over 65 years old. The hippocampus, a brain area critical for learning and memory, is especially vulnerable to damage in the early stages of AD. ...

journal_title：Journal of neuroscience research

authors： Esfandiary E,Karimipour M,Mardani M,Alaei H,Ghannadian M,Kazemi M,Mohammadnejad D,Hosseini N,Esmaeili A

更新日期：2014-04-01 00:00:00

abstract：:Cell transplantation offers a potential new treatment for stroke. Animal studies using models that produce ischemic damage in both the striatum and the frontal cortex have shown beneficial effects when hNT cells (postmitotic immature neurons) were transplanted into the ischemic striatum. In this study, we investigated...

journal_title：Journal of neuroscience research

authors： Bliss TM,Kelly S,Shah AK,Foo WC,Kohli P,Stokes C,Sun GH,Ma M,Masel J,Kleppner SR,Schallert T,Palmer T,Steinberg GK

更新日期：2006-05-01 00:00:00

abstract：:Dopamine has been implicated as a potential mediating factor in a variety of neurodegenerative disorders. Dopamine can be oxidized to form a reactive dopamine quinone that can covalently modify cellular macromolecules including protein and DNA. This oxidation can be enhanced through various enzymes including tyrosinas...

journal_title：Journal of neuroscience research

authors： Xu Y,Stokes AH,Roskoski R Jr,Vrana KE

更新日期：1998-12-01 00:00:00

abstract：:Cytoskeletal structures under the cell membrane carry out pivotal roles in the maintenance and remodeling of the cell structures. Reforming of the cytoskeletal networks after partial extraction of membrane components could be a good clue to identify molecular components pertaining the interaction of cytoskeleton with ...

journal_title：Journal of neuroscience research

authors： Taguchi K,Yoshinaka K,Yoshino K,Yonezawa K,Maekawa S

更新日期：2005-07-15 00:00:00

abstract：:Fibroblast growth factors (FGFs) are known to act on glial cells in vitro. At the present time, their involvement in the remyelinating process of the adult central nervous system (CNS) is still unknown. In the present study, using immunohistochemistry (IHC), we investigated the evolution in time and space of acidic FG...

journal_title：Journal of neuroscience research

authors： Tourbah A,Baron-Van Evercooren A,Oliver L,Raulais D,Jeanny JC,Gumpel M

更新日期：1992-09-01 00:00:00

abstract：:Heat shock proteins (HSPs) are stress-responsive proteins that serve as important molecules contributing to cellular "protein triage." We and others have reported an increase of selected HSPs in multiple sclerosis (MS) lesions. However, the exact expression pattern of HSP family genes in MS is not known. The aim of ou...

journal_title：Journal of neuroscience research

authors： Mycko MP,Brosnan CF,Raine CS,Fendler W,Selmaj KW

更新日期：2012-10-01 00:00:00

abstract：:We recently reported that a new monoclonal antibody, 4F2, which labels oligodendroglial lineage cells, recognizes a DEAD-box RNA helicase Ddx54 and that Ddx54 binds to myelin basic protein (MBP) in brain and cultured oligodendrocytes. To elucidate the biological function of Ddx54, we generated a recombinant adenovirus...

journal_title：Journal of neuroscience research

authors： Zhan R,Yamamoto M,Ueki T,Yoshioka N,Tanaka K,Morisaki H,Seiwa C,Yamamoto Y,Kawano H,Tsuruo Y,Watanabe K,Asou H,Aiso S

更新日期：2013-03-01 00:00:00

abstract：:The induction of an inflammatory response and release of cytokines such as TNF may be involved in the age-related etiology of Alzheimer disease (AD). In the brain, microglia have been shown to produce a wide variety of immune mediators, including the pro-inflammatory cytokine tumor necrosis factor (TNF). We hypothesiz...

journal_title：Journal of neuroscience research

authors： Viel JJ,McManus DQ,Smith SS,Brewer GJ

更新日期：2001-06-01 00:00:00

abstract：:Low density dissociated cultures of embryonic rat hippocampal cells were used to study the effects of neurotrophin-3 (NT-3) on neuronal morphogenesis. The results obtained indicate that NT-3 enhances neurite outgrowth and branching; this is a dose-dependent effect, detected in approximately 50% of the neurons, and pre...

journal_title：Journal of neuroscience research

authors： Morfini G,DiTella MC,Feiguin F,Carri N,Cáceres A

更新日期：1994-10-01 00:00:00

abstract：:Neurons in culture rely on the supply of exogenous cysteine for their glutathione synthesis. After application of cysteine to neuron-rich primary cultures, the glutathione content was doubled after a 4-hr incubation. The dipeptide cysteinylglycine (CysGly) was able to substitute for cysteine as exogenous glutathione p...

journal_title：Journal of neuroscience research

authors： Dringen R,Gutterer JM,Gros C,Hirrlinger J

更新日期：2001-12-01 00:00:00

abstract：:Astrocytes purified from the neonatal rat brain were cultured for up to 3 weeks prior to being treated with agents that can induce reactive changes in astrocytes. These agents included dibutyryl cAMP, interleukin-1 beta, and macrophage conditioned media. After treating astrocytes for 3 days, the agents were removed an...

journal_title：Journal of neuroscience research

authors： Miller C,Tsatas O,David S

更新日期：1994-05-01 00:00:00