Abstract：
:Metabolite levels in cerebrospinal fluid from patients with Parkinson disease or Huntington chorea were compared with the levels in healthy controls using proton magnetic resonance spectroscopy. No significant differences were found for any metabolite measured in cerebrospinal fluid from patients with Parkinson disease compared to controls. Slight but significantly reduced levels of both lactate and citrate, however, were found in cerebrospinal fluid from patients with Huntington chorea compared to controls. This suggests possible impairment of both glycolysis and tricarboxylic acid cycle function. The reduction in lactate found in the present study may reflect neuronal loss. The decrease in citrate supports the theory of mitochondrial dysfunction in the brain of patients with Huntington chorea, but also suggests that there may be an important astrocytic component in this disease. If so, it would certainly have implications for neuronal function.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Gårseth M,Sonnewald U,White LR,Rød M,Zwart JA,Nygaard O,Aasly Jdoi
10.1002/1097-4547(20000615)60:6<779::AID-JNR10>3.0keywords:
subject
Has Abstractpub_date
2000-06-15 00:00:00pages
779-82issue
6eissn
0360-4012issn
1097-4547pii
10.1002/1097-4547(20000615)60:6<779::AID-JNR10>3.0journal_volume
60pub_type
杂志文章abstract：:Four new monoclonal antibodies to the extracellular domain of the nerve growth factor receptor (NGFR) have been evaluated for their specificity to NGFR and their utility in localizing NGFR in human brain. All four antibodies, as well as Me20.4, show similar cellular localization and patterns of immunoreactivity in bas...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490270426
更新日期：1990-12-01 00:00:00
abstract：:Apolipoprotein E (apo-E), a protein involved in lipid metabolism and cholesterol transport, has been found to be up-regulated in CNS injury and is associated with Alzheimer's disease in humans. In this study, we show that apo-E is also up-regulated after complete spinal cord transection in the C57BL/6 mouse. In the un...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.10482
更新日期：2003-02-01 00:00:00
abstract：:Prothrombin and its active derivative thrombin are key members of the coagulation system. The only site of extra-hepatic thrombin expression is the central nervous system (CNS), where it is involved in brain development, protection, and regeneration. Thrombin affects various degenerative and ischemic CNS diseases like...
journal_title：Journal of neuroscience research
pub_type： 杂志文章,评审
doi：10.1002/jnr.24049
更新日期：2017-10-01 00:00:00
abstract：:The thyroid hormones triiodothyronine (T3) and L-thyroxine appear to enhance regeneration in the peripheral and central nervous system (CNS). The following experiments examine possible metabolic substrates for the action of T3 on the adult rat CNS after spinal hemisection. The protein incorporation of (3H)lysine after...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490060507
更新日期：1981-01-01 00:00:00
abstract：:Myelin-associated glycoprotein (MAG) is expressed on the innermost myelin membrane wrap, directly apposed to the axon surface. Although it is not required for myelination, MAG enhances long-term axon-myelin stability, helps to structure nodes of Ranvier, and regulates the axon cytoskeleton. In addition to its role in ...
journal_title：Journal of neuroscience research
pub_type： 杂志文章,评审
doi：10.1002/jnr.21992
更新日期：2009-11-15 00:00:00
abstract：:Amyloid plaques, found in characteristically large numbers in specific brain areas of Alzheimer's disease (AD) and Down's Syndrome (DS) patients, are composed of a 41-43 amino acid peptide, A4, derived from a transmembrane glycoprotein, amyloid precursor protein (APP). In transformed cells APP has been shown to be cle...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490290115
更新日期：1991-05-01 00:00:00
abstract：:Intrinsic mechanisms that guide damaged axons to regenerate following spinal cord injury remain poorly understood. Manipulation of posttranslational modifications of key proteins in mature neurons could reinvigorate growth machinery after injury. One such modification is acetylation, a reversible process controlled by...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.23573
更新日期：2015-08-01 00:00:00
abstract：:To examine the role of platelet-derived growth factor (PDGF) in the in vivo regulation of Schwann cell proliferation, steady-state levels of mRNAs encoding PDGF A and B chains, and PDGF alpha and beta receptors were measured in immature and adult rat sciatic nerves and in cultured rat Schwann cells. PDGF B chain and P...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490310206
更新日期：1992-02-01 00:00:00
abstract：:The applications of neural progenitor cells in clinical therapy for neural degeneration, such as Parkinson's disease, Huntington's disease, and cerebral infarction, have long been explored widely. It had been suggested that these cells may block the apoptosis of ischemia-induced neuronal damage and may themselves resi...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.10476
更新日期：2003-01-15 00:00:00
abstract：:Data from a study in which 12 chronic mental patients and 12 control subject were given D-[3-14C] glucose intravenously in our arterio-venous technique for determining cerebral metabolism in vivo were reexamined. Previously unpublished whole-blood lactate determinations in these experiments indicated a cerebral produc...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490060209
更新日期：1981-01-01 00:00:00
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journal_title：Journal of neuroscience research
pub_type： 杂志文章,评审
doi：10.1002/1097-4547(20001015)62:2<169::AID-JNR2>3.0.
更新日期：2000-10-15 00:00:00
abstract：:Enriched populations of human microglial cells were isolated from mixed cell cultures prepared from embryonic human telencephalon tissues. Human microglial cells exhibited cell type-specific antigens for macrophage-microglia lineage cells including CD11b (Mac-1), CD68, B7-2 (CD86), HLA-ABC, HLA-DR and ricinus communis...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.10253
更新日期：2002-07-01 00:00:00
abstract：:Recent evidence has demonstrated that neural stem cells (NSC) can be expanded from a variety of sources, including embryos, fetuses, and adult bone marrow and brain tissue. We have previously reported the generation of adult rat bone marrow-derived cellular spheres that are morphologically and phenotypically similar t...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.21131
更新日期：2007-02-01 00:00:00
abstract：:Axonal injury is often characterized by axonal transport defects and abnormal accumulation of intra-axonal components. Nitric oxide (NO) has a key role in mediating inflammatory axonopathy in many neurodegenerative diseases, but little is known about how nitrosative/oxidative stress affects axonal transport or whether...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.23556
更新日期：2015-06-01 00:00:00
abstract：:The hippocampus is an important brain region involved in memory and learning. Brain-derived neurotrophic factor (BDNF), tyrosine kinase receptor B (TrkB), and phospho-p44/p42 mitogen-activated protein kinase (MAPK) are known to contribute to hippocampal memory/learning. The present study aimed to clarify the effects o...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.24216
更新日期：2018-06-01 00:00:00
abstract：:Systemic osmotic homeostasis is regulated mainly by neuroendocrine system of arginine-vasopressin (AVP) in mammalians. In the present study, we demonstrated that the immunoreactivity of tissue plasminogen activator (tPA) was observed specifically at neurosecretory granules of AVP-positive magnocellular terminals and t...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.22370
更新日期：2010-07-01 00:00:00
abstract：:Nerve growth factor (NGF) is the best-characterized neurotrophic substance and has recently been shown to influence cholinergic neurons in the basal forebrain. Hippocampus and neocortex, the primary targets for these central neurons, have further been found to contain high levels of NGF. Using enzyme immunoassay and a...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490180404
更新日期：1987-01-01 00:00:00
abstract：:The Dale's law postulates that a neuron releases the same neurotransmitter from all its branches. In the case of multiple neurotransmitters it would require all transmitters to be released from all branches. The retinal cholinergic amacrine cells contain and release gamma-aminobutyric (GABA) and, therefore, if GABA an...
journal_title：Journal of neuroscience research
pub_type： 杂志文章,评审
doi：10.1002/(sici)1097-4547(19991115)58:4<475::aid-jnr
更新日期：1999-11-15 00:00:00
abstract：:Recent data indicate that molecular mimicry may play a role in the pathogenesis of human-T-lymphotropic virus type-1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP), an immune-mediated disease of the central nervous system (CNS). Specifically, HAM/TSP patients developed antibodies that cross-reac...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.20137
更新日期：2004-07-01 00:00:00
abstract：:Despite consistent observations of sex differences in depression and related emotional disorders, we do not yet know how these sex differences modulate the effects of genetic polymorphisms implicated in risk for these disorders. This Mini-Review focuses on genetic polymorphisms of the serotonergic system to illustrate...
journal_title：Journal of neuroscience research
pub_type： 杂志文章,评审
doi：10.1002/jnr.23877
更新日期：2017-01-02 00:00:00
abstract：:Chronic alcohol consumption has adverse effects on the central nervous system, affecting some hippocampal and hypothalamic functions. In this study we tempted to demonstrate that some of these modifications could involve impairment of neurotrophic factors. Three experimental groups of male Sprague Dawley rats were stu...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/1097-4547(20010115)63:2<200::AID-JNR1012>3
更新日期：2001-01-15 00:00:00
abstract：:After hemisection of the spinal cord in rats, alterations in amino acid incorporation into protein have been observed in brain and spinal cord. Proteins mediating these changes have been studied in the present experiment. Male, Long-Evans hooded rats were given either a laminectomy and dura incision (sham) at spinal s...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490050108
更新日期：1980-01-01 00:00:00
abstract：:Nuclear inclusions formed by proteins with expanded polyglutamine tracts are found in several neurodegenerative diseases. The effect of nuclear inclusions formed by these disease proteins on the functional organization of the nucleus is only partially understood. In particular, it is not known whether polyglutamine di...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.21369
更新日期：2007-08-15 00:00:00
abstract：:Mitotic activity persists in various regions of the adult mammal CNS. While evidences of neurogenesis appeared, many studies focused on the features of the adult stem cells from germinative areas such as the subventricular zone of the lateral ventricles, the dentate gyrus of the hippocampus, the cortex, the fourth ven...
journal_title：Journal of neuroscience research
pub_type： 杂志文章,评审
doi：10.1002/jnr.20040
更新日期：2004-04-15 00:00:00
abstract：:Regional estimates of type I and type II vestibular hair cells (HC) and supporting cell (SC) numbers were obtained from the horizontal crista ampullaris by using design-based stereology in human. Cristae were microdissected from temporal bones obtained post-mortem (N=16, age range 26-98 years). Three groups were made ...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.20652
更新日期：2005-11-01 00:00:00
abstract：:Growing evidence suggests that decreased brain-derived neurotrophic factor (BDNF) levels are associated with Alzheimer's disease (AD) pathogenesis. Therefore, BDNF gene therapy is considered to be a promising therapeutic strategy for treating AD. Sendai virus (SeV) is a type I parainfluenza virus that does not interac...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.22830
更新日期：2012-05-01 00:00:00
abstract：:The higher prevalence and risk for Alzheimer's disease in women relative to men has been partially attributed to the precipitous decline in gonadal hormone levels that occurs in women following the menopause. Although considerable attention has been focused on the consequence of estrogen loss, and thus estrogen's neur...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.21370
更新日期：2007-08-15 00:00:00
abstract：:To investigate the function of the dipeptide carnosine in the olfactory system, alterations of carnosine in the primary olfactory nerve after unilateral naris closure or olfactory bulb semilesion were studied by means of immunocytochemistry. After unilateral naris closure, carnosine staining showed no alteration, but ...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490340608
更新日期：1993-04-15 00:00:00
abstract：:Convergent lines of evidence have recently highlighted β3-adrenoreceptors (ARs) as a potentially critical target in the regulation of nervous and behavioral functions, including memory consolidation, anxiety, and depression. Nevertheless, the role of β3-ARs in the cerebellum has been never investigated. To address thi...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.24712
更新日期：2020-11-01 00:00:00
abstract：:A cholinergically disrupted laboratory animal has been produced by administration of the cholinotoxin ethylcholine aziridinium mustard (AF64A), which produced a dysfunction in the cholinergic forebrain system. After AF64A treatment, a reduction of choline acetyl transferase (ChAT) activity was measured in the hippocam...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/(SICI)1097-4547(19990115)55:2<178::AID-JNR
更新日期：1999-01-15 00:00:00
