Regulation of neural cell adhesion molecule polysialylation state by cell-cell contact and protein kinase C delta.

abstract：:The concentration of myelin basic protein (MBP) mRNA in primary cultures of cells dissociated from embryonic mouse cerebra and grown in the presence of varying amounts of thyroid hormone was measured using a 32P-labeled cDNA probe and a dot-blot procedure. The cDNA probe contained 1.85 kilobases of the gene for MBP. T...

journal_title：Journal of neuroscience research

authors： Shanker G,Campagnoni AT,Pieringer RA

更新日期：1987-01-01 00:00:00

abstract：:CD9 is a tetra-membrane-spanning glycoprotein involved in cell adhesion, migration, and proliferation in both the immune and the immature nervous system. In this study, CD9 expression was detected in myelin of mouse brain, starting at postnatal day 16. The amount of CD9 protein continuously increased with age and pers...

journal_title：Journal of neuroscience research

authors： Kagawa T,Mekada E,Shishido Y,Ikenaka K

更新日期：1997-10-15 00:00:00

abstract：:The effect of two different potassium channel blockers, 4-aminopyridine (4-AP) and quinine, on the alpha 2-adrenoceptor mediated modulation of norepinephrine (NE) release was investigated. Pairs of mouse vasa deferentia were loaded with 3H-norepinephrine (3H-NE), superfused continuously, and stimulated electrically. 4...

journal_title：Journal of neuroscience research

authors： Zimanyi I,Folly G,Vizi ES

更新日期：1988-05-01 00:00:00

abstract：:Using morphological, immunocytochemical, and functional parameters we have previously shown that highly purified adult rat microglial cells undergo a process of "activation" when cultured in a serum-containing medium in the absence of added proinflammatory substances or other factors (Slepko and Levi: Glia 16:241-246,...

journal_title：Journal of neuroscience research

authors： Slepko N,Minghetti L,Polazzi E,Nicolini A,Levi G

更新日期：1997-08-01 00:00:00

abstract：:In a number of pathological states of the brain, the activation of the inducible nitric oxide synthase (iNOS) plays a major role. Interleukin (IL)-1beta is believed to be an essential factor in the induction of iNOS. However, little is known about the cascade of events culminating in iNOS expression in vivo. To identi...

journal_title：Journal of neuroscience research

authors： Hartlage-Rübsamen M,Lemke R,Schliebs R

更新日期：1999-08-01 00:00:00

abstract：:The present study examined trophic activities in normal and injured brain which affect the survival and growth of central neurons in culture. Adult rats received bilateral lesions through the angular bundle, severing projections between the entorhinal cortex and the hippocampus. Ten days later, extracts were prepared ...

journal_title：Journal of neuroscience research

authors： Gibbs RB,Needels DL,Yu J,Cotman CW

更新日期：1987-01-01 00:00:00

abstract：:In searching for possible differences in the composition of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) forms in dystrophic brain, the distribution of various enzyme molecules in normal (NB) and dystrophic (DB) 129B6F1/J mouse brain has been investigated. The tissue was sequentially extracted with sa...

journal_title：Journal of neuroscience research

authors： Moral-Naranjo MT,Cabezas-Herrera J,Vidal CJ

更新日期：1996-01-15 00:00:00

abstract：:The limited availability and potential to culture primary human brain cells means that there is still a need for cell lines that reliably model human neurons and glial cells. The human-derived NTera2/D1 (NT2) cell line is a promising tool from which both neuronal (NT2N) and astrocytic (NT2A) cells can be derived in vi...

journal_title：Journal of neuroscience research

authors： Goodfellow CE,Graham SE,Dragunow M,Glass M

更新日期：2011-10-01 00:00:00

abstract：:Scar formation after injury of the brain or spinal cord is a common event. While glial scar formation by astrocytes has been extensively studied, much less is known about the fibrotic scar, in particular after stroke. Platelet-derived growth factor receptor ß-expressing (PDGFRß+ ) pericytes have been suggested as a so...

journal_title：Journal of neuroscience research

authors： Roth M,Enström A,Aghabeick C,Carlsson R,Genové G,Paul G

更新日期：2020-05-01 00:00:00

abstract：:Here we show that rabbit Müller cell differentiation from radial glial progenitor cells is accompanied by a decreasing capability to respond to specific stimuli (depolarization and extracellular adenosine 5'-triphosphate [ATP]) with an elevation of intracellular calcium. Intracellular free calcium was recorded in reti...

journal_title：Journal of neuroscience research

authors： Uckermann O,Grosche J,Reichenbach A,Bringmann A

更新日期：2002-10-15 00:00:00

abstract：:Within the parenchyma of the CNS, the endothelium of all vessels is surrounded by a layer of cells, pericytes in capillaries and periendothelial or intima smooth muscle cells in other vessels. The origin of these cell types, their relationship, and their role are unclear. However, it has been recently shown that genet...

journal_title：Journal of neuroscience research

authors： Alliot F,Rutin J,Leenen PJ,Pessac B

更新日期：1999-11-01 00:00:00

abstract：:The amino acid glutamate plays a key role in brain function. One of the major roles of glutamate is to mediate fast excitatory neurotransmission via activation of ionotropic glutamate receptors (iGluRs). More recently, however, it has become clear that glutamate also serves a regulatory function through activation of ...

journal_title：Journal of neuroscience research

authors： Winder DG,Conn PJ

更新日期：1996-10-15 00:00:00

abstract：:The aim of the present study was to prepare cultures enriched in type-2 astrocytes (AS) and to analyze some of the properties of these cells over relatively long culture periods. Cultures enriched in type-2 AS were obtained by subculturing, at low cell density and in the presence of fetal calf serum, a cell population...

journal_title：Journal of neuroscience research

authors： Aloisi F,Agresti C,Levi G

更新日期：1988-10-01 00:00:00

abstract：:Fibroblast growth factors (FGFs) are known to act on glial cells in vitro. At the present time, their involvement in the remyelinating process of the adult central nervous system (CNS) is still unknown. In the present study, using immunohistochemistry (IHC), we investigated the evolution in time and space of acidic FG...

journal_title：Journal of neuroscience research

authors： Tourbah A,Baron-Van Evercooren A,Oliver L,Raulais D,Jeanny JC,Gumpel M

更新日期：1992-09-01 00:00:00

abstract：:Our previous study demonstrated that 2-phenylethynyl-butyltellurium (PEBT), an organotellurium compound, enhances memory in mice. In this study, the effects of PEBT on cognitive impairment induced by Aβ25-35 were assessed by Morris water maze and step-down inhibitory avoidance tasks. Mice received a single intracerebr...

journal_title：Journal of neuroscience research

authors： Souza AC,Sari MH,Pinton S,Luchese C,Neto JS,Nogueira CW

更新日期：2013-06-01 00:00:00

abstract：:Dissociated embryonic rat ventral mesencephalon containing the developing A8-A10 dopamine (DA) neurons was cultured alone or in the presence of a 10 mm segment of adult rat sciatic nerve that had been explanted and maintained in separate culture for 72 hours prior to introduction to mesencephalic cultures. Nerve segme...

journal_title：Journal of neuroscience research

authors： Collier TJ,Sladek CD,Gallagher MJ,Gereau RW 4th,Springer JE

更新日期：1990-11-01 00:00:00

abstract：:A previous study demonstrated the release of newly loaded radiolabelled taurine (Tau) from cultured rabbit Müller glia not only following typical cell volume-increasing treatments with high (65 mM) potassium ions or hypotonic media, but also with ammonium chloride (further referred to as ammonia), in a dose-dependent ...

journal_title：Journal of neuroscience research

authors： Faff L,Reichenbach A,Albrecht J

更新日期：1996-10-15 00:00:00

abstract：:The effects of ischemia (removal of oxygen and glucose for 4 h) and anoxia (removal of oxygen alone) on astrocytes were studied in dissociated cultures of E14 spinal cord containing both neurons and astrocytes. In addition, a group of cultures was treated with a low Na+, low Ca2+, and high K+ medium during the 4-h isc...

journal_title：Journal of neuroscience research

authors： Goldberg WJ,Connor JR,Bernstein JJ

更新日期：1987-01-01 00:00:00

abstract：:The contribution of glucose carbon to the biosynthesis of cholesterol and phospholipids in distinct brain regions was studied quantitatively in the adult male rat. Rates of flow of glucose carbon into the lipids in vivo were calculated from two measurements: the curve representing the decrease in plasma 14C-glucose wi...

journal_title：Journal of neuroscience research

authors： Barkai AI

更新日期：1981-01-01 00:00:00

abstract：:Accumulating evidence points to roles for oxidative stress, amyloid beta (Aβ), and mitochondrial dysfunction in the pathogenesis of Alzheimer's disease (AD). In neurons, the base excision repair pathway is the predominant DNA repair (BER) pathway for repairing oxidized base lesions. Apurinic/apyrimidinic endonuclease ...

journal_title：Journal of neuroscience research

authors： Kaur N,Dhiman M,Perez-Polo JR,Mantha AK

更新日期：2015-06-01 00:00:00

abstract：:Nicotinates, pantothenates, riboflavin, vitamins B6 and B12' free (acetyl) and total (free and bound) choline, biopterin, thiamin, biotin, methylated and nonmethylated folates in frontal, temporal, precentral, postcentral, and occipital cortex, thalamus, cerebellum, pons, basal ganglia, and substantia nigra were estim...

journal_title：Journal of neuroscience research

authors： Baker H,Frank O,Chen T,Feingold S,DeAngelis B,Baker E

更新日期：1984-01-01 00:00:00

abstract：:The precise function of APP (Alzheimer's amyloid precursor protein) remains to be fully elucidated, but various lines of evidence suggest that it may be involved in cell adhesion processes. Because APP is a transmembrane glycoprotein, variations in its expression level may have direct bearing on its putative role in c...

journal_title：Journal of neuroscience research

authors： Rebelo S,Henriques AG,da Cruz e Silva EF,da Cruz e Silva OA

更新日期：2004-05-01 00:00:00

abstract：:Astrocytes are the predominant cell type in the vicinity of glutamatergic synapses, where they monitor and maintain low levels of glutamate. Synaptic homeostasis of glutamate involves its removal from the synaptic cleft via high-affinity glutamate transporters, glutamate transporter-1 (GLT-1)/excitatory amino acid tra...

journal_title：Journal of neuroscience research

authors： Sandhu JK,Sikorska M,Walker PR

更新日期：2002-06-01 00:00:00

abstract：:Fast-scan cyclic voltammetry (FSCV) is an established method for measuring dopamine (DA) levels in the brain in real time. However, it is difficult to discriminate DA from other monoamines such as serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE). We report a novel DA-specific biosensor consisting of a car...

journal_title：Journal of neuroscience research

authors： Ishida A,Imamura A,Ueda Y,Shimizu T,Marumoto R,Jung CG,Hida H

更新日期：2018-05-01 00:00:00

abstract：:Nicotine has been reported to be neuroprotective in experimental and epidemiological studies. In addition to nicotine, tobacco and cigarette smoke contain cembranoids, which are antagonists of neuronal nicotinic receptors (nAChR). Exposure of hippocampal slices to N-methyl-D-aspartate (NMDA) decreases the population s...

journal_title：Journal of neuroscience research

authors： Ferchmin PA,Hao J,Perez D,Penzo M,Maldonado HM,Gonzalez MT,Rodriguez AD,de Vellis J

更新日期：2005-12-01 00:00:00

abstract：:A study was conducted on the adsorption of 14C-ATP to a surface film of a hydrophobic protein derived from synaptic membranes isolated from bovine cerebellum. The adsorption of ATP to the protein film followed a rate law based on diffusion and an energy barrier to adsorption, the rate law being generally applicable to...

journal_title：Journal of neuroscience research

authors： Hoss W,Abood LG

更新日期：1976-01-01 00:00:00

abstract：:Double immunofluorescence studies using antibodies against NF-L and peripherin revealed three distinct subpopulations of neurons in rat dorsal root ganglia (DRG). In the adult rat, 46% of the DRG neurons were small and peripherin-positive (NF-L-negative), and 48% were large and NF-L-positive (peripherin-negative). Abo...

journal_title：Journal of neuroscience research

authors： Goldstein ME,House SB,Gainer H

更新日期：1991-09-01 00:00:00

abstract：:Currently, presymtomatic hematopoietic stem and progenitor cell transplantation (HSPCT) is the only therapeutic modality that alleviates Krabbe's disease (KD)-induced central nervous system damage. However, all HSPCT-treated patients exhibit severe deterioration in peripheral nervous system function characterized by m...

journal_title：Journal of neuroscience research

authors： Hu P,Li Y,Nikolaishvili-Feinberg N,Scesa G,Bi Y,Pan D,Moore D,Bongarzone ER,Sands MS,Miller R,Kafri T

更新日期：2016-11-01 00:00:00

abstract：:The mammalian genome contains both constitutively expressed and heat-shock-inducible members of the hsp70 gene family. Riboprobes derived from members of these two classes of heat shock genes were utilized in Northern blot studies to analyze brain mRNA isolated from control rabbits and rats and from animals subjected ...

journal_title：Journal of neuroscience research

authors： Brown IR,Rush SJ

更新日期：1990-01-01 00:00:00

abstract：:The objective of this study was to compare cerebrospinal fluid (CSF) levels of the light subtype of the neurofilament proteins (NFL), tau, and beta-amyloid42 (Abeta42) in individuals with moderate or severe white matter changes (WMC) and in those with mild or no WMC. Twenty-two patients with Alzheimer's disease (AD), ...

journal_title：Journal of neuroscience research

authors： Sjögren M,Blomberg M,Jonsson M,Wahlund LO,Edman A,Lind K,Rosengren L,Blennow K,Wallin A

更新日期：2001-11-01 00:00:00