Intranasal immunization with liposomes induces strong mucosal immune responses in mice.

abstract：:The effect of fractionated total lymphoid irradiation (TLI) on the maturation of B cells was examined in mice. At various times after irradiation of the mice, their spleen cells were tested for the mitogenic responses to dextran sulfate and lipopolysaccharide. In parallel the cells were stained with fluorescent anti-T...

journal_title：European journal of immunology

authors： Zan-Bar I

更新日期：1983-01-01 00:00:00

abstract：:Fourteen noncytotoxic human helper T cell clones were examined for autocrine proliferative responses and cytotoxicity to tumor cells after stimulation with 12-O-tetradecanoylphorbol 13-acetate (TPA) and ionomycin (Io). Although all clones responded to alloantigen, they could be divided into two groups based on their p...

journal_title：European journal of immunology

authors： Pawelec G,Busch F,Reinhold U,Rehbein A,Balko I,Bühring HJ

更新日期：1988-07-01 00:00:00

abstract：:Studies based on either MHC class II-knockout or CD4+ T cell-depleted murine models have demonstrated a critical role for CD4+ T cells in the generation of CD8+ T cell memory. However, it is difficult to extend these findings to immunocompromised humans where a complete loss of CD4+ T cells is rarely observed. Here, w...

journal_title：European journal of immunology

authors： Smith C,Martinez M,Cooper L,Rist M,Zhong J,Khanna R

更新日期：2008-07-01 00:00:00

abstract：:The functional role of the T8 antigen of human T cells was studied by inhibition with anti-T8 monoclonal antibodies (mAb) of the cytotoxic action of T8+ cytotoxic T lymphocyte clones (CTL). All clones were allospecific and directed against HLA-B7. The ability of seven different anti-T8 mAb to inhibit the cytotoxicity ...

journal_title：European journal of immunology

authors： Van Seventer GA,Van Lier RA,Spits H,Ivanyi P,Melief CJ

更新日期：1986-11-01 00:00:00

abstract：:CD4+ alpha beta T cell populations that develop in mice deficient in MHC class II (through 'knockout' of either the Aalpha, or the Abeta chain of the I-A(b) molecule) comprise a major 'single-positive' (SP) CD4+ CD8- subset (60-90%) and a minor 'double-positive' (DP) CD4+ CD8alpha beta+ subset (10-40%). Many DP T cell...

journal_title：European journal of immunology

authors： Krajina T,Leithäuser F,Reimann J

更新日期：2004-03-01 00:00:00

abstract：:In this report, we demonstrate that gp40, a molecule previously shown to be expressed by thymic epithelial cell lines in vitro and by thymic epithelial cells in vivo, is the murine homolog of human Ep-CAM, a calcium-independent homotypic adhesion molecule. gp40 is also expressed at low levels by thymocytes and periphe...

journal_title：European journal of immunology

authors： Nelson AJ,Dunn RJ,Peach R,Aruffo A,Farr AG

更新日期：1996-02-01 00:00:00

abstract：:We examined the ability of oral or parenteral immunization with immune stimulating complexes containing ovalbumin (ISCOMS-OVA) to prime T cell proliferative and cytokine responses. A single subcutaneous immunization with ISCOMS-OVA primed potent antigen-specific proliferative responses in the draining popliteal lymph ...

journal_title：European journal of immunology

authors： Maloy KJ,Donachie AM,Mowat AM

更新日期：1995-10-01 00:00:00

abstract：:Multiple myeloma is a fatal B cell malignancy characterized by the accumulation of plasma cells within the bone marrow. IL-6 is a major survival factor for myeloma cells. Bcl-2 protein family regulates pathways to apoptosis that are activated upon growth factor deprivation. Pro-apoptotic proteins that have only a sing...

journal_title：European journal of immunology

authors： Gomez-Bougie P,Bataille R,Amiot M

更新日期：2004-11-01 00:00:00

abstract：:Synthetic peptides encoding protective pathogen-derived epitopes represent--in principle--an ideal approach to T-cell vaccination. Empirically, however, these strategies have not been successful. In the current study, we profiled the early activation of CD8+ T cells by MHC class I-restricted peptide immunization to be...

journal_title：European journal of immunology

authors： Overstreet MG,Freyberger H,Cockburn IA,Chen YC,Tse SW,Zavala F

更新日期：2010-01-01 00:00:00

abstract：:Changes in the epigenetic landscape of immune cells are a crucial component of gene activation during the induction of inflammatory responses, therefore it has been hypothesized that epigenetic modulation could be employed to restore homeostasis in inflammatory scenarios. Fungal pathogens cause a large burden of morbi...

journal_title：European journal of immunology

authors： Domínguez-Andrés J,Ferreira AV,Jansen T,Smithers N,Prinjha RK,Furze RC,Netea MG

更新日期：2019-11-01 00:00:00

abstract：:ME3738 is a new compound that attenuates liver disease in several models of acute and chronic liver inflammation. We used the concanavalin A (Con A) model to elucidate the molecular mechanisms of ME3738 to block liver cell damage. Pretreatment of BALB/c mice with ME3738 prior to Con A injection resulted in a significa...

journal_title：European journal of immunology

authors： Klein C,Wüstefeld T,Heinrich PC,Streetz KL,Manns MP,Trautwein C

更新日期：2003-08-01 00:00:00

abstract：:Leishmaniasis is currently classified as category 1 disease, i.e. emerging and uncontrolled. Since the importance of persistent infection for maintaining an effective long-lasting protective response is controversial, the present study asks whether immunisation with non-persistent parasites leads to protection against...

journal_title：European journal of immunology

authors： Kedzierski L,Curtis JM,Doherty PC,Handman E,Kedzierska K

更新日期：2008-11-01 00:00:00

abstract：:Macrophage-chemotactic factor (MChF)-producing T cell hybridomas were established. These hybridomas produced MChF upon the specific antigenic stimulation with phosphorylcholine (PC)-conjugated protein in the presence of I-Ed-positive antigen-presenting cells. The hybridomas also secreted MChF after co-culture with con...

journal_title：European journal of immunology

authors： Harita S,Sugimura K,Watanabe T

更新日期：1984-08-01 00:00:00

abstract：:CBA/J mice immunized with thyroglobulin (Tg) develop an experimental autoimmune thyroiditis (EAT) with lymphocytic infiltration of the thyroid glands, autoantibodies to Tg and occurrence of EAT-specific T cells. When these mice were treated for 4 weeks after immunization with 1 mg/week of a monoclonal antibody (mAb) t...

journal_title：European journal of immunology

authors： Tang H,Mignon-Godefroy K,Meroni PL,Garotta G,Charreire J,Nicoletti F

更新日期：1993-01-01 00:00:00

abstract：:The MHC class II molecule H2-A(s), expressed in the SJL mouse strain, is the principle restriction element of autoreactive CD4(+) T cells mediating experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. We deduced the H2-A(s) ligand motif from the analysis of naturally processed self peptide...

journal_title：European journal of immunology

authors： Kalbus M,Fleckenstein BT,Offenhäusser M,Blüggel M,Melms A,Meyer HE,Rammensee HG,Martin R,Jung G,Sommer N

更新日期：2001-02-01 00:00:00

abstract：:A reverse hemolytic plaque assay has been developed which specifically detects secretion of human immune interferon (Hu IFN-gamma) at the single cell level. Unstimulated peripheral blood lymphocytes from healthy adult volunteers spontaneously secreted IFN-gamma. Stimulation of these cells with concanavalin A, phytohem...

journal_title：European journal of immunology

authors： Palacios R,Martinez-Maza O,De Ley M

更新日期：1983-03-01 00:00:00

abstract：:Immunization leads to the generation of both antibody-forming cells (AFC) and memory B cells which are thought to arise in germinal centers within lymphoid follicles. The findings that the precursors to memory B cells reside in the J11Dlo subpopulation of the spleens in non-immune mice and that this subpopulation is d...

journal_title：European journal of immunology

authors： Linton PJ,Lo D,Lai L,Thorbecke GJ,Klinman NR

更新日期：1992-05-01 00:00:00

abstract：:Thymectomy was performed on the urodele amphibian Pleurodeles waltlii Michah. from the 5th to the 20th week of larval development. Thymectomized animals were allografted at 7 months of age. The results obtained are as follows: (1) Pleurodeles thymectomized before 10 weeks always tolerated allografts: (2) Pleurodeles t...

journal_title：European journal of immunology

authors： Fache B,Charlemagne J

更新日期：1975-02-01 00:00:00

abstract：:The antagonistic effects of macrophage (M phi)-derived interleukin 1 (IL 1) and prostaglandin E2 (PGE2) on thymocyte proliferation were uncoupled and studied. Elimination of PGE2 from the culture medium of prostaglandin E2-stimulated M phi was achieved by dialysis of the media or by indomethacin treatment of the M phi...

journal_title：European journal of immunology

authors： Hayari Y,Kukulansky T,Globerson A

更新日期：1985-01-01 00:00:00

abstract：:Interleukin (IL)-6 transsignaling plays a pivotal role in the shift from neutrophil to monocyte recruitment at the inflammatory site. Release of neutrophil IL-6 receptor-alpha (IL-6Ralpha, CD126) in its soluble form is a key step of IL-6 transsignaling, however, its physiological inducers are poorly known. Here, we ob...

journal_title：European journal of immunology

authors： Marin V,Montero-Julian F,Grès S,Bongrand P,Farnarier C,Kaplanski G

更新日期：2002-10-01 00:00:00

abstract：:DT9301-0229737 the TcR are believed to provide the peptide fragments bound to major histocompatibility (MHC) molecules. TcR have an immunoglobulin (Ig)-like structure and, in an analogous manner to antigen recognition by Ig, the third complementarity determining regions (CDR3) of the TcR are believed to provide the pr...

journal_title：European journal of immunology

authors： Jones CM,Lake RA,Lamb JR,Faith A

更新日期：1994-05-01 00:00:00

abstract：:NK cells play important roles in immune surveillance against malignancy and virus-infected cells. NK cell functions are affected in patients infected with HIV-1; however, whether there is direct interaction between NK cells and HIV-1 remains controversial. In this study the expression of CD4, an important receptor for...

journal_title：European journal of immunology

authors： Harada H,Goto Y,Ohno T,Suzu S,Okada S

更新日期：2007-08-01 00:00:00

abstract：:In this study, we investigated whether the phenotype-related differentiation of human 2H4+ (CD45R) naive cells to 2H4- (CDw29) memory CD4 cells corresponded to modulation of interleukin (IL) 2, IL 4, interferon (IFN)-gamma and granulocyte-monocyte colony-stimulating factor (GM-CSF) gene expression, a phenomenon which ...

journal_title：European journal of immunology

authors： Bettens F,Walker C,Gauchat JF,Gauchat D,Wyss T,Pichler WJ

更新日期：1989-09-01 00:00:00

abstract：:We investigated the efficacy of a combination of anti-CD80 and CD86 (CD80 + 86) monoclonal antibodies (mAb), anti-interleukin (IL)-12 mAb, or both, for prophylaxis in a mouse acute graft-versus-host-disease (GVHD) model. The treatment with a combination of anti-CD80 + 86 mAb efficiently reduced the lethality of GVHD, ...

journal_title：European journal of immunology

authors： Saito K,Yagita H,Hashimoto H,Okumura K,Azuma M

更新日期：1996-12-01 00:00:00

abstract：:Mouse peritoneal macrophages activated with interferon-gamma (IFN-gamma) and lipopolysaccharide produce substantial amounts of nitric oxide (NO), which correlates with the elimination of the intracellular protozoan parasite Leishmania major. Both the production of NO and the leishmanicidal function of the activated ma...

journal_title：European journal of immunology

authors： Li Y,Severn A,Rogers MV,Palmer RM,Moncada S,Liew FY

更新日期：1992-02-01 00:00:00

abstract：:IL-18 was originally described as a cytokine which induced IFN-gamma production by established Th1 cells in an IL-12-independent manner. However, subsequent studies demonstrated that exogenous IL-18 in the absence of IL-12 failed to drive Th1 differentiation of naive cells and induced IFN-gamma from established Th1 ce...

journal_title：European journal of immunology

authors： Chang JT,Segal BM,Nakanishi K,Okamura H,Shevach EM

更新日期：2000-04-01 00:00:00

abstract：:Previous studies from our laboratory have shown that some in vitro maintained Leishmania major-specific L3T4+ T cells were capable of exacerbating cutaneous leishmaniasis after adoptive transfer to normal syngeneic mice. Results presented in this report show that these cells released substantial amounts of interleukin...

journal_title：European journal of immunology

authors： Feng ZY,Louis J,Kindler V,Pedrazzini T,Eliason JF,Behin R,Vassalli P

更新日期：1988-08-01 00:00:00

abstract：:The expression and action of Fas/Fas ligand (FasL) in multiple sclerosis has been postulated as a major pathway leading to inflammatory demyelination. To formally test this hypothesis, C57BL/6-lpr and -gld mice, which due to gene mutation express Fas and FasL in an inactive form, were immunized with myelin oligodendro...

journal_title：European journal of immunology

authors： Malipiero U,Frei K,Spanaus KS,Agresti C,Lassmann H,Hahne M,Tschopp J,Eugster HP,Fontana A

更新日期：1997-12-01 00:00:00

abstract：:Animal models for HIV research have been indispensible in fulfilling Koch's postulate and in exploring issues of viral infectivity and pathogenesis, sequence divergence, route(s) of acquisition, tissue distribution and tropism, immunogenicity and protection capacity of vaccine candidates, escape from adaptive immunity...

journal_title：European journal of immunology

authors： Haigwood NL

更新日期：2009-08-01 00:00:00

abstract：:Global transcriptional technologies have revolutionised the study of lymphoid cell populations, but human γδ T lymphocytes specific for phosphoantigens remain far less deeply characterised by these methods despite the great therapeutic potential of these cells. Here we analyse the transcriptome of circulating TCRVγ(+)...

journal_title：European journal of immunology

authors： Pont F,Familiades J,Déjean S,Fruchon S,Cendron D,Poupot M,Poupot R,L'faqihi-Olive F,Prade N,Ycart B,Fournié JJ

更新日期：2012-01-01 00:00:00