The murine homolog of human Ep-CAM, a homotypic adhesion molecule, is expressed by thymocytes and thymic epithelial cells.


:In this report, we demonstrate that gp40, a molecule previously shown to be expressed by thymic epithelial cell lines in vitro and by thymic epithelial cells in vivo, is the murine homolog of human Ep-CAM, a calcium-independent homotypic adhesion molecule. gp40 is also expressed at low levels by thymocytes and peripheral T cells. In the adult thymus, gp40 expression was inversely related to the state of thymocyte maturation, with the highest levels associated with CD4-CD8- and CD4+CD8+ thymocyte populations. Ultrastructural immunohistochemistry revealed gp40 localization to areas of thymocyte/epithelial contact and demonstrated that gp40 is also expressed by thymic dendritic cells. During fetal development, thymocytes at days 14-16 of gestation expressed high levels of gp40. At later stages, the observed decline in the frequency of gp40+ cells and levels of expression correlated with the emergence of alpha beta+ thymocytes by day 18 of gestation. In short-term cultures, stimulation of unfractionated adult thymocytes with concanavalin A increased gp40 expression, particularly among CD3hi and CD3int thymocyte populations. This demonstration that Ep-CAM, initially considered to be expressed primarily by epithelial cells, is also expressed by thymocytes, T cells and antigen-presenting cells, raises the possibility that Ep-CAM may contribute to adhesive interactions between thymocytes and epithelial cells or dendritic cells, either in the context of thymocyte development or peripheral T cell trafficking and function.


Eur J Immunol


Nelson AJ,Dunn RJ,Peach R,Aruffo A,Farr AG




Has Abstract


1996-02-01 00:00:00












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    pub_type: 杂志文章


    authors: Lubrano di Ricco M,Ronin E,Collares D,Divoux J,Grégoire S,Wajant H,Gomes T,Grinberg-Bleyer Y,Baud V,Marodon G,Salomon BL

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    pub_type: 临床试验,杂志文章


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    authors: Kyburz D,Speiser DE,Battegay M,Hengartner H,Zinkernagel RM

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    pub_type: 杂志文章


    authors: Chan BM,Ra CS,Hu WN,McNeill K,Miller HR,Befus D,Kinet JP,Froese A

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    authors: Marquardt N,Wilk E,Pokoyski C,Schmidt RE,Jacobs R

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    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Dabhi VM,Lindahl KF

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    journal_title:European journal of immunology

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    authors: Lorré K,Van Damme J,Ceuppens JL

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  • Two highly divergent ancient allelic lineages of the transporter associated with antigen processing (TAP) gene in Xenopus: further evidence for co-evolution among MHC class I region genes.

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    journal_title:European journal of immunology

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    authors: Ho P,Zhang L,Wei X,Seah GT

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    journal_title:European journal of immunology

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