The murine homolog of human Ep-CAM, a homotypic adhesion molecule, is expressed by thymocytes and thymic epithelial cells.


:In this report, we demonstrate that gp40, a molecule previously shown to be expressed by thymic epithelial cell lines in vitro and by thymic epithelial cells in vivo, is the murine homolog of human Ep-CAM, a calcium-independent homotypic adhesion molecule. gp40 is also expressed at low levels by thymocytes and peripheral T cells. In the adult thymus, gp40 expression was inversely related to the state of thymocyte maturation, with the highest levels associated with CD4-CD8- and CD4+CD8+ thymocyte populations. Ultrastructural immunohistochemistry revealed gp40 localization to areas of thymocyte/epithelial contact and demonstrated that gp40 is also expressed by thymic dendritic cells. During fetal development, thymocytes at days 14-16 of gestation expressed high levels of gp40. At later stages, the observed decline in the frequency of gp40+ cells and levels of expression correlated with the emergence of alpha beta+ thymocytes by day 18 of gestation. In short-term cultures, stimulation of unfractionated adult thymocytes with concanavalin A increased gp40 expression, particularly among CD3hi and CD3int thymocyte populations. This demonstration that Ep-CAM, initially considered to be expressed primarily by epithelial cells, is also expressed by thymocytes, T cells and antigen-presenting cells, raises the possibility that Ep-CAM may contribute to adhesive interactions between thymocytes and epithelial cells or dendritic cells, either in the context of thymocyte development or peripheral T cell trafficking and function.


Eur J Immunol


Nelson AJ,Dunn RJ,Peach R,Aruffo A,Farr AG




Has Abstract


1996-02-01 00:00:00












  • Sequences of the mouse F protein alleles and identification of a T cell epitope.

    abstract::F protein is found predominantly in the liver and is of unknown function. The protein has been of interest to immunologists in the areas of self tolerance and the immunogenetics of the anti-F protein response. In the mouse there are two alleles (F1 and F2), and although mice are completely tolerant to the self form of...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Schofield JP,Vijayakumar RK,Oliveira DB

    更新日期:1991-05-01 00:00:00

  • Functional diversity and clonal frequencies of reactivity in the available antibody repertoire.

    abstract::The present experiments address functional antibody diversity and clonal distribution in murine available repertoires. IgM-containing supernatants were prepared by unbiased, polyclonal stimulation of resting splenic B cells from C57BL/6 mice, to ensure similar numbers of responding clones/culture and equivalent growth...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Nobrega A,Grandien A,Haury M,Hecker L,Malanchère E,Coutinho A

    更新日期:1998-04-01 00:00:00

  • Age- and strain-dependent polymorphism in IgE antibody against the phosphorylcholine hapten.

    abstract::The magnitude of the IgE antibody response against the phosphorylcholine (PC) hapten and the rate of age-related change of IgE formation is polymorphic in the three long-lived and six relatively short-lived strains of mice studied. Long-lived mice showed an early increase, followed by a decline in the levels of anti-P...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Gerber V,Ponnappan U,Heusser CH,Blaser K,Cinader B

    更新日期:1986-06-01 00:00:00

  • T cell-replacing factor in specific antibody responses to influenza virus by human blood B cells.

    abstract::In man, B cell maturation factors obtained from T cells or T cell lines have been shown to induce antibody formation in mitogen or anti-immunoglobulin activated B cells, and in some continuous B cell lines, but the relationships between these factors and B cell differentiation factors in antigen-specific antibody resp...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Callard RE,Booth RJ,Brown MH,McCaughan GW

    更新日期:1985-01-01 00:00:00

  • Tolerance of self induced in thymus organ culture.

    abstract::F liver protein occurs in serum at low concentration, and therefore induces tolerance of self only in T cells. T cells which mature in cultured thymus lobes in the absence of this protein become reactive towards it but can be prevented from doing so by exposure to the protein while in culture. The threshold of toleran...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Robertson K,Simon K,Schneider S,Timms E,Mitchison A

    更新日期:1992-01-01 00:00:00

  • The effect of TGF-beta1 on immune responses of naïve versus memory CD4+ Th1/Th2 T cells.

    abstract::The role of TGF-beta1 in the regulation of T cell responses has been perplexing, possibly because it is dependent on the type of T cell being regulated and its cytokine microenvironment. In the present study, we demonstrate that TGF-beta1 has a profound inhibitory effect on naive CD4+ T cell undergoing differentiation...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Lúdvíksson BR,Seegers D,Resnick AS,Strober W

    更新日期:2000-07-01 00:00:00

  • Classical transplantation tolerance in the adult: the interaction between myeloablation and immunosuppression.

    abstract::Allogeneic bone marrow transplantation in the neonate is an effective way of inducing permanent tolerance to donor tissue. To do the same in the immunocompetent adult requires immunosuppression to counter host-versus-graft alloreactivity. Conditioning with monoclonal antibodies (mAb) to CD4 and CD8 has been sufficient...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Leong LY,Qin S,Cobbold SP,Waldmann H

    更新日期:1992-11-01 00:00:00

  • Host variation in cytokine responses to superantigens determine the severity of invasive group A streptococcal infection.

    abstract::Cytokines elicited by superantigens have been suggested to play a central role in severe systemic clinical manifestations of gram-positive sepsis. Here we provide evidence for a potent inflammatory cytokine response in acute invasive group A streptococcal infections, and show a direct correlation between the magnitude...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Norrby-Teglund A,Chatellier S,Low DE,McGeer A,Green K,Kotb M

    更新日期:2000-11-01 00:00:00

  • IFN-γ directly inhibits murine B-cell precursor leukemia-initiating cell proliferation early in life.

    abstract::The early-life immune environment has been implicated as a modulator of acute lymphoblastic leukemia (ALL) development in children, with infection being associated with significant changes in ALL risk. Furthermore, polymorphisms in several cytokine genes, including IL-10 and IFN-γ, are associated with leukemia develop...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Fidanza M,Seif AE,Jo S,Kariminia A,Rolf N,Sly LM,Grupp SA,Reid GSD

    更新日期:2017-05-01 00:00:00

  • [Kohlhernie - neue Ansätze zur Bekämpfung der gefürchteten Kohlerkrankung]

    abstract::Durch Pflanzenkrankheiten entstehen weltweit hohe Ernteverluste. Eine der häufigsten Infektionen in der Familie der Kreuzb&luml;tengewächse wird durch den Pilz Plasmodiophora brassicae verursacht. Die Krankheit äußert sich in Form von Wurzeltumoren, den "Kohlherniegallen". Da es auf verseuchten Böden zu hohen Ernteaus...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Ludwig-Müller J

    更新日期:2000-01-01 00:00:00

  • Major histocompatibility complex class II-restricted presentation of a cytosolic antigen by autophagy.

    abstract::Biochemical and functional studies have demonstrated major histocompatibility complex (MHC) class II-restricted presentation of peptides derived from cytosolic proteins, but the underlying processing and presentation pathways have remained elusive. Here we show that endogenous presentation of an epitope derived from t...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Nimmerjahn F,Milosevic S,Behrends U,Jaffee EM,Pardoll DM,Bornkamm GW,Mautner J

    更新日期:2003-05-01 00:00:00

  • Human T cell leukemia virus type I Tax enhances IL-4 gene expression in T cells.

    abstract::The human T cell leukemia virus type-1 (HTLV-1) is the etiologic agent of adult T cell leukemia (ATL). Since the HTLV-I-encoded transactivator Tax has been shown to activate many cellular genes including cytokine genes interleukin (IL-)1alpha, 2, 5, 6, 8, 10 and 15, we ask whether Tax also affects IL-4 expression. In ...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Li-Weber M,Giaisi M,Chlichlia K,Khazaie K,Krammer PH

    更新日期:2001-09-01 00:00:00

  • Genetic control of sensitivity to Moloney leukemia virus in mice. III. The three H-2 linked Rmv genes are immune response genes controlling the antiviral antibody response.

    abstract::It has been shown previously that three different H-2-associated genes control the resistance to viremia and leukemia in Moloney virus-infected mice: Rmv. 1, mapping to the I-A or less probably K regions; Rmv. 2, mapping to the I-C, S or G regions and Rmv. 3, mapping to the D or T regions. Experiments have been perfo...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Debré P,Boyer B,Gisselbrecht S,Bismuth A,Lévy JP

    更新日期:1980-12-01 00:00:00

  • Effects of levamisole on spontaneous rosette-forming cells in murine spleen.

    abstract::Levamisole, an anti-anergic chemotherapeutic agent, is shown to depress the azathioprine sensitivity of rosette-forming cells (RFC) in the spleen of normal mice, and to restore the azathioprine sensitivity of RFC in the spleen of adult thymectomized mice. Using the fully active dose of 1.25 mg/kg i.v., the restoration...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: van Ginckel RF,Hoebeke J

    更新日期:1976-04-01 00:00:00

  • Mannose-capped lipoarabinomannan- and prostaglandin E2-dependent expansion of regulatory T cells in human Mycobacterium tuberculosis infection.

    abstract::We evaluated the role of regulatory T cells (CD4(+) CD25(+) Foxp3(+) cells, Tregs) in human Mycobacterium tuberculosis infection. Tregs were expanded in response to M. tuberculosis in healthy tuberculin reactors, but not in tuberculin-negative individuals. The M. tuberculosis mannose-capped lipoarabinomannan (ManLAM) ...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Garg A,Barnes PF,Roy S,Quiroga MF,Wu S,García VE,Krutzik SR,Weis SE,Vankayalapati R

    更新日期:2008-02-01 00:00:00

  • Poxvirus semaphorin A39R inhibits phagocytosis by dendritic cells and neutrophils.

    abstract::The poxvirus A39R protein is a member of the semaphorin family that binds to Plexin C1, a molecule expressed on neutrophils and dendritic cells (DC). We previously showed that binding of A39R to Plexin C1 induces local rearrangement of the actin cytoskeleton and inhibits integrin-mediated adhesion, leading to cell ret...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Walzer T,Galibert L,De Smedt T

    更新日期:2005-02-01 00:00:00

  • Division of human helper T cells into two sets on the basis of the induction of anti-tumor cytotoxicity by phorbol ester and calcium ionophore.

    abstract::Fourteen noncytotoxic human helper T cell clones were examined for autocrine proliferative responses and cytotoxicity to tumor cells after stimulation with 12-O-tetradecanoylphorbol 13-acetate (TPA) and ionomycin (Io). Although all clones responded to alloantigen, they could be divided into two groups based on their p...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Pawelec G,Busch F,Reinhold U,Rehbein A,Balko I,Bühring HJ

    更新日期:1988-07-01 00:00:00

  • The APO-1/Fas (CD95) receptor is expressed in homozygous MRL/lpr mice.

    abstract::APO-1/Fas (CD95) is a transmembrane receptor that transduces apoptotic signals within various cells including T and B cells. The APO-1 gene was found to be defective in lpr mice. In these mice insertion of a retrotransposon gives rise to transcription of an abnormal mRNA and only a fraction of wild-type APO-1 mRNA. It...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Mariani SM,Matiba B,Armandola EA,Krammer PH

    更新日期:1994-12-01 00:00:00

  • Presentation of an exogenous antigen by major histocompatibility complex class I molecules.

    abstract::Cytotoxic T lymphocytes (CTL) generally recognize peptides derived from endogenously expressed proteins in association with nascent major histocompatibility complex (MHC) class I molecules. In contrast, peptides derived from exogenous proteins associate with MHC class II following endocytosis to an endosomal compartme...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Ulmer JB,Donnelly JJ,Liu MA

    更新日期:1994-07-01 00:00:00

  • Functional maturation of recent thymic emigrants in the periphery: development of alloreactivity correlates with the cyclic expression of CD45RC isoforms.

    abstract::The transition from fully developed CD4+CD8- single-positive (SP) thymocytes into fully mature recirculating peripheral T cells is both poorly understood with regard to the expression of restricted isoforms (CD45R) of the leukocyte common antigen and in terms of T cell function. The present investigation monitored the...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Yang CP,Bell EB

    更新日期:1992-09-01 00:00:00

  • Mitochondrial reactive oxygen species suppress humoral immune response through reduction of CD19 expression in B cells in mice.

    abstract::Reactive oxygen species (ROS) are implicated in the modulation of diverse processes including immune responses. To evaluate the effects of metabolic ROS produced by mitochondria on B-cell function and development, we created transgenic (Tg) mice expressing a phosphorylation-defective mutant of succinate dehydrogenase ...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Ogura M,Inoue T,Yamaki J,Homma MK,Kurosaki T,Homma Y

    更新日期:2017-02-01 00:00:00

  • Depletion of NK cells results in disseminating lethal infection with Bordetella pertussis associated with a reduction of antigen-specific Th1 and enhancement of Th2, but not Tr1 cells.

    abstract::IFN-gamma plays a critical role in protection against Bordetella pertussis, but Th1 cells are only detectable after the infection has started to resolve, suggesting a protective role for innate IFN-gamma early in infection. Here, we demonstrate significant recruitment of NK cells and NKT cells into the lungs following...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Byrne P,McGuirk P,Todryk S,Mills KH

    更新日期:2004-09-01 00:00:00

  • Inhibition of B cell proliferation with anti-CD19 monoclonal antibodies: anti-CD19 antibodies do not interfere with early signaling events triggered by anti-IgM or interleukin 4.

    abstract::The 95-kDa antigen recognized by the anti-CD19 panel of monoclonal antibodies is found on the surface of most cells of the B cell lineage. Anti-CD19 antibodies inhibit B cell proliferation in response to anti-Ig plus interleukin 4 (IL4), but enhance the response to mitogenic concentrations of either phorbol 12-myrista...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Rigley KP,Callard RE

    更新日期:1991-03-01 00:00:00

  • Suppressive and pro-inflammatory roles for IL-4 in the pathogenesis of experimental drug-induced liver injury.

    abstract::The pathogenesis of immune-mediated drug-induced liver injury (DILI) following halogenated anesthetics, carbamazepine or alcohol has not been fully elucidated. Detecting cytochrome P450 2E1 (CYP2E1) IgG4 auto-antibodies in anesthetic DILI patients suggests a role for IL-4 in this hapten-mediated process. We investigat...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Njoku DB,Li Z,Washington ND,Mellerson JL,Talor MV,Sharma R,Rose NR

    更新日期:2009-06-01 00:00:00

  • Prevention of immunoglobulin production by allotype-dependent T cells.

    abstract::Adoptive lymphocyte transfers between Iga, Igb and Igd allotype-congenic mouse strains revealed host barriers against the production of certain donor allotypes. First, as recipients of Igb cells, Iga and Igd mice permitted the production of donor Ig-4b but not that of Ig-1 b. The apparent mediators of this Ig-1 b barr...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Bosma MJ,Bosma GC,Owen JL

    更新日期:1978-08-01 00:00:00

  • Curative treatment of experimental autoimmune thyroiditis by in vivo administration of plasmid DNA coding for interleukin-10.

    abstract::The autoimmune response in experimental autoimmune thyroiditis (EAT) is characterized by a lymphocyte infiltration of the thyroid gland and by the appearance of circulating autoantibodies to thyroglobulin (Tg). Cytokines play a crucial role in the immunoregulation and pathology of EAT. Systemic administration of IL-10...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Batteux F,Trebeden H,Charreire J,Chiocchia G

    更新日期:1999-03-01 00:00:00

  • Thymocyte death by neglect: contribution of engulfing macrophages.

    abstract::The thymus provides the microenvironment in which thymocytes develop into mature T cells, and interactions with thymic stromal cells are thought to provide the necessary signals for thymocyte maturation. Recognition of self-MHC by T cells is a basic requirement for mature T-cell functions, and those thymocytes that do...

    journal_title:European journal of immunology

    pub_type: 杂志文章,评审


    authors: Szondy Z,Garabuczi É,Tóth K,Kiss B,Köröskényi K

    更新日期:2012-07-01 00:00:00

  • Dichotomy between factors inducing the immunosuppressive enzyme IL-4-induced gene 1 (IL4I1) in B lymphocytes and mononuclear phagocytes.

    abstract::MPhi and DC are key elements in the control of tissue homeostasis and response to insult. In this work, we demonstrate that MPhi and DC are the major producers of the phenylalanine catabolizing enzyme IL-4-induced gene 1 (IL4I1) under inflammatory conditions. IL4I1 was first described in B cells, which indeed can prod...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Marquet J,Lasoudris F,Cousin C,Puiffe ML,Martin-Garcia N,Baud V,Chereau F,Farcet JP,Molinier-Frenkel V,Castellano F

    更新日期:2010-09-01 00:00:00

  • Autoimmune diseases linked to abnormal K+ channel expression in double-negative CD4-CD8- T cells.

    abstract::Using the patch-clamp technique in combination with fluorescence microscopy we have found an abnormality in voltage-gated K+ channel expression in T cells that represents the first molecular marker linking three disparate autoimmune diseases in mice. CD4-CD8-Thy-1.2+ (double-negative or DN) lymphocytes from every know...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Chandy KG,Cahalan MD,Grissmer S

    更新日期:1990-04-01 00:00:00

  • A monoclonal antibody against a new differentiation antigen of thymocytes.

    abstract::B14-2-14 is a monoclonal cytotoxic IgM antibody which reacts with thymocytes of all mouse strains tested. The fraction of positive cells (by visual immunofluorescence) varies between strains from about 25-45% in A.CA to 65-85% in C57BL/6, and high levels are dominant in F1 hybrids. In the periphery, the antigen is fou...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Sidman CL,Forni L,Köhler G,Langhorne J,Lindahl KF

    更新日期:1983-06-01 00:00:00