Chemotactic agents induce IL-6Ralpha shedding from polymorphonuclear cells: involvement of a metalloproteinase of the TNF-alpha-converting enzyme (TACE) type.

abstract：:Plasmodium falciparum stimulates peripheral blood gamma delta + T cells from unexposed donors. The responding cells bear V gamma 9+ chains of the T cell receptor, the majority of which, but not all, are associated with V delta 2 chains. We have analyzed whether the precursor frequency of these V gamma 9+ cells approac...

journal_title：European journal of immunology

authors： Goodier M,Krause-Jauer M,Langhorne J

更新日期：1992-10-01 00:00:00

abstract：:The liver and activation-regulated chemokine (LARC), also termed MIP-3alpha and Exodus, is a novel human CC chemokine with a selective chemotactic activity for lymphocytes and dendritic cells. Here we describe genomic and cDNA clones encoding the murine orthologue of LARC (mLARC). The gene consists of four exons and t...

journal_title：European journal of immunology

authors： Tanaka Y,Imai T,Baba M,Ishikawa I,Uehira M,Nomiyama H,Yoshie O

更新日期：1999-02-01 00:00:00

abstract：:To investigate negative selection events during intrathymic ontogeny, we established T cell receptor (TCR)-transgenic mice [N15tg/RAG-2-/- (H-2b)] expressing a single TCR specific for vesicular stomatitis virus nuclear octapeptide N52-59 (VSV8) in the context of the major histocompatibility complex (MHC) class I molec...

journal_title：European journal of immunology

authors： Ghendler Y,Hussey RE,Witte T,Mizoguchi E,Clayton LK,Bhan AK,Koyasu S,Chang HC,Reinherz EL

更新日期：1997-09-01 00:00:00

abstract：:Immunocompetent adult mice infected with lymphocytic choriomeningitis virus (LCMV) generate a strong antiviral cytotoxic T cell response that clears virus from all organs. Although there is good evidence that immune cytotoxic T lymphocytes (CTL) kill target cells in vitro, in vivo it is debated whether antiviral activ...

journal_title：European journal of immunology

authors： Kyburz D,Speiser DE,Battegay M,Hengartner H,Zinkernagel RM

更新日期：1993-07-01 00:00:00

abstract：:CD82, a member of tetraspan family (tetraspanin), is a multifunctional molecule that is involved in cell activation, costimulation, and cell spreading of T cells. Here we show that immobilized anti-CD82 monoclonal antibody (mAb) as well as anti-alpha4beta1 integrin mAb induced tyrosine phosphorylation of pp105/Crk-ass...

journal_title：European journal of immunology

authors： Iwata S,Kobayashi H,Miyake-Nishijima R,Sasaki T,Souta-Kuribara A,Nori M,Hosono O,Kawasaki H,Tanaka H,Morimoto C

更新日期：2002-05-01 00:00:00

abstract：:MHC class II molecules present peptides, derived largely from exogenous antigens, to CD4+ T cells. Complex-generation occurs mainly in the specialized late endosomal MHC class II-rich compartment (MIIC) vesicles of antigen-presenting cells (APC). Dendritic cells (DC) have been reported to store intact antigen in MIIC ...

journal_title：European journal of immunology

authors： Colledge L,Bennett CL,Reay PA,Blackburn CC

更新日期：2002-11-01 00:00:00

abstract：:We have constructed four different deletion mutants of a chimeric mouse-human IgG3 anti-(4-hydroxy-3-nitrophenyl)acetyl/(5-iodo-4 hydroxy-3 nitrophenyl) acetyl (NP/NIP) antibody lacking one or more of the four exons coding for the hinge region. The mutant variants all retained intact hinge region epitopes since they a...

journal_title：European journal of immunology

authors： Sandlie I,Aase A,Westby C,Michaelsen TE

更新日期：1989-09-01 00:00:00

abstract：:We investigated the efficacy of a combination of anti-CD80 and CD86 (CD80 + 86) monoclonal antibodies (mAb), anti-interleukin (IL)-12 mAb, or both, for prophylaxis in a mouse acute graft-versus-host-disease (GVHD) model. The treatment with a combination of anti-CD80 + 86 mAb efficiently reduced the lethality of GVHD, ...

journal_title：European journal of immunology

authors： Saito K,Yagita H,Hashimoto H,Okumura K,Azuma M

更新日期：1996-12-01 00:00:00

abstract：:1Alpha,25-dihydroxyvitamin D3 [1,25-(OH)2D3] exerts several effects on the immune system, by regulating lymphocyte proliferation, differentiation of monocytes and secretion of cytokines as IL-2, granulocyte-macrophage colony-stimulating factor and IFN-gamma in T cells. Here, we analyze the effect of 1,25-(OH)2D3 on IF...

journal_title：European journal of immunology

authors： Cippitelli M,Santoni A

更新日期：1998-10-01 00:00:00

abstract：:Mucosa-associated lymphoid tissue 1 (Malt1) regulates immune cell function by mediating the activation of nuclear factor κB (NF-κB) signaling through both its adaptor and proteolytic function. Malt1 is also a target of its own protease activity and this self-cleavage further contributes to NF-κB activity. Until now, t...

journal_title：European journal of immunology

authors： Baens M,Stirparo R,Lampi Y,Verbeke D,Vandepoel R,Cools J,Marynen P,de Bock CE,Bornschein S

更新日期：2018-10-01 00:00:00

abstract：:Natural interferon-producing cells (NIPC), also called plasmacytoid dendritic cells, are the most potent producers of IFN-alpha in response to viral and bacterial components, serving an important function in innate immune defences. The present work demonstrates that NIPC responsiveness can be primed by immunisation, i...

journal_title：European journal of immunology

authors： Balmelli C,Vincent IE,Rau H,Guzylack-Piriou L,McCullough K,Summerfield A

更新日期：2005-08-01 00:00:00

abstract：:KARAP/DAP12 is a broadly distributed transmembrane signaling polypeptide with an immunoreceptor tyrosine-based activation motif, and is non-covalently associated with a variety of activating surface receptors. We report here the characterization of transgenic mice that overexpress KARAP/DAP12 polypeptides in both myel...

journal_title：European journal of immunology

authors： Lucas M,Daniel L,Tomasello E,Guia S,Horschowski N,Aoki N,Figarella-Branger D,Gomez S,Vivier E

更新日期：2002-09-01 00:00:00

abstract：:Two out of five murine IgG3 anti-trinitrophenyl (TNP) monoclonal antibodies (mAb) obtained either by immunization with TNP-keyhole limpet hemocyanin (KLH) (CB1, CB5, CB6 and 4H10) or with dinitrophenyl-lipopolysaccharide (9A6), exhibited anti-IgG rheumatoid factor (RF) activity (CB6 and 4H10). The anti-IgG activity of...

journal_title：European journal of immunology

authors： Reininger L,Spertini F,Shibata T,Jaton JC,Izui S

更新日期：1989-11-01 00:00:00

abstract：:The transcriptional repressor Gfi1 is a nuclear zinc-finger protein that is expressed in T cell precursors in the thymus, but is down-regulated in mature, resting T cells. Gfi1 expression rises transiently to levels seen in thymocytes upon antigenic activation. We show here that lack of Gfi1 causes delayed cell cycle ...

journal_title：European journal of immunology

authors： Pargmann D,Yücel R,Kosan C,Saba I,Klein-Hitpass L,Schimmer S,Heyd F,Dittmer U,Möröy T

更新日期：2007-12-01 00:00:00

abstract：:Major advances in preventing, delaying, or curing individual pathologies are responsible for an increasingly long life span in the developed parts of our planet, and indeed reaching eight to nine decades of life is nowadays extremely frequent. However, medical and sanitary advances have not prevented or delayed the un...

journal_title：European journal of immunology

authors： Pinti M,Appay V,Campisi J,Frasca D,Fülöp T,Sauce D,Larbi A,Weinberger B,Cossarizza A

更新日期：2016-10-01 00:00:00

abstract：:Plasticity and heterogeneity are hallmarks of myelomonocytic differentiation and polarized activation. Evidence published in this issue of the European Journal of Immunology, together with other recent data, add new elements and perspectives to the current understanding of mononuclear phagocyte differentiation and act...

journal_title：European journal of immunology

authors： Mantovani A,Sica A,Locati M

更新日期：2007-01-01 00:00:00

abstract：:The MHC class Ib molecule H2-M3 presents N-formylated peptides from the N terminus of proteins encoded by the mitochondrial genome to CTL. A panel of CTL specific for a peptide derived from a mitochondrial protein, either COI or ND1, was used to determine the optimal peptide length for sensitizing antigen-deficient ta...

journal_title：European journal of immunology

authors： Dabhi VM,Lindahl KF

更新日期：1998-11-01 00:00:00

abstract：:DNA vaccination is an efficient way to induce CD8+ T cell memory, but it is still unclear to what extent such memory responses afford protection in vivo. To study this, we induced CD8+ memory responses directed towards defined viral epitopes, using DNA vaccines encoding immunodominant MHC class I-restricted epitopes o...

journal_title：European journal of immunology

authors： Bartholdy C,Stryhn A,Hansen NJ,Buus S,Thomsen AR

更新日期：2003-07-01 00:00:00

abstract：:Regulatory T cells (Treg) provide protection from autoimmune disease, graft-versus-host disease, transplant rejection and overwhelming tissue destruction during infections. Conversely, high Treg numbers enable cancer cells to evade the host immune response. Thus, Treg are seen as an important tool to manipulate the im...

journal_title：European journal of immunology

authors： Banham AH,Powrie FM,Suri-Payer E

更新日期：2006-11-01 00:00:00

abstract：:We have investigated the effects of intravenous immunoglobulin (IVIg), a therapeutic preparation of normal human polyspecific IgG, on the synthesis and release of cytokines by peripheral blood monocytes. IVIg was found to selectively induce gene transcription and secretion of interleukin-1 receptor antagonist (IL-1ra)...

journal_title：European journal of immunology

authors： Ruiz de Souza V,Carreno MP,Kaveri SV,Ledur A,Sadeghi H,Cavaillon JM,Kazatchkine MD,Haeffner-Cavaillon N

更新日期：1995-05-01 00:00:00

abstract：:The specificity of the IgM receptor expressed by human T cells cultured in IgM-free media has been investigated. IgM receptors have been detected using a rosette system with ox erythrocytes coated with rabbit antibody (EA(IgM)), and the inhibitory capacity of different IgM fragments in the rosette system has been test...

journal_title：European journal of immunology

authors： Ferrarini M,Moretta L,Mingari MC,Tonda P,Pernis B

更新日期：1976-07-01 00:00:00

abstract：:The pathogenesis of the decline of CD4 lymphocyte counts accompanying the typical course of HIV-1 infection is not completely defined and might be related to a differential susceptibility of naive and memory cells to HIV-1 exposure. Here, we examined the effects induced by heat-inactivated HIV-1 virions on these lymph...

journal_title：European journal of immunology

authors： Masci AM,Paz FL,Borriello A,Cassano S,Della Pietra V,Stoiber H,Matarese G,Della Ragione F,Zappacosta S,Racioppi L

更新日期：1999-06-01 00:00:00

abstract：:An immunoglobulin epsilon-chain fragment was synthesized in E. coli by cloning and expression of the gene coding for the second, third and fourth constant domains of the human IgE heavy chain. The bacterial CH2-4 polypeptide product was assembled by oxidation into a covalently linked dimeric epsilon-chain molecule pre...

journal_title：European journal of immunology

authors： Coleman JW,Helm BA,Stanworth DR,Gould HJ

更新日期：1985-09-01 00:00:00

abstract：:During the course of many human autoimmune diseases, antibodies which recognize negatively charged epitopes on self antigens are detected. Trypanosoma cruzi, an intracellular protozoan parasite capable of infecting a wide variety of vertebrates, is the cause of Chagas disease in humans. Infection with the parasite fre...

journal_title：European journal of immunology

authors： Kahn S,Kahn M,Eisen H

更新日期：1992-12-01 00:00:00

abstract：:The capacity of human peripheral blood lymphocytes (PBL) to bind antigen-IgG antibody (EA(IgG)) and antigen-IgM antibody (EA(IgM)) complexes was investigated using a rosette technique with ox erythrocytes coated with rabbit IgG or IgM antibody. It was found that while EA(IgG)-rosette-forming cells (RFC) were detected ...

journal_title：European journal of immunology

authors： Moretta L,Ferrarini M,Durante ML,Mingari MC

更新日期：1975-08-01 00:00:00

abstract：:Monoclonal antibodies (mAb) derived from BALB/c mice immunized with human anti-HLA-A2 cloned cytotoxic T lymphocytes (CTL) were screened for their ability to block, in the absence of complement, the cytolytic activity of the immunizing CTL clone. Eight cytolysis-inhibiting mAb have been derived. One of these was direc...

journal_title：European journal of immunology

authors： Malissen B,Rebai N,Liabeuf A,Mawas C

更新日期：1982-09-01 00:00:00

abstract：:E-selectin is an endothelium-specific inducible adhesion molecule which binds several inflammatory cell types, including neutrophils, monocytes, natural killer cells and a subset of memory T cells. E-selectin is important in the initial rolling interaction of these cells on inflamed endothelium. The transient kinetics...

journal_title：European journal of immunology

authors： Noble KE,Panayiotidis P,Collins PW,Hoffbrand AV,Yong KL

更新日期：1996-12-01 00:00:00

abstract：:Antigen stimulation induces specific CD4 T cells to change from a resting phenotype (CD45RC+) to a "memory" phenotype (CD45RC-), an isoform switch that is reversible and regulated by persisting antigen. We show here that CD4 T cells responsible for mediating allograft rejection undergo a similar CD45RC+ to CD45RC- swi...

journal_title：European journal of immunology

authors： Yang CP,Bell EB

更新日期：1999-07-01 00:00:00

abstract：:Cervical thymus mimics the thoracic thymus in supporting T-cell development and exists in a subset of mice and humans. Importantly, it remains unknown whether the cervical thymus can generate T cells that are self-tolerant in the complete absence of signals from the thoracic thymus. Using a fetal liver reconstitution ...

journal_title：European journal of immunology

authors： Smolarchuk C,Zhu LF,Chan WF,Anderson CC

更新日期：2014-08-01 00:00:00

abstract：:Mutations of forkhead box p3 (FOXP3), the master gene for naturally occurring regulatory T cells (nTregs), are responsible for the impaired function of nTregs, resulting in an autoimmune disease known as the immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome. The relevance of other periphe...

journal_title：European journal of immunology

authors： Passerini L,Di Nunzio S,Gregori S,Gambineri E,Cecconi M,Seidel MG,Cazzola G,Perroni L,Tommasini A,Vignola S,Guidi L,Roncarolo MG,Bacchetta R

更新日期：2011-04-01 00:00:00