Rapid constitutive generation of a specific peptide-MHC class II complex from intact exogenous protein in immature murine dendritic cells.

abstract：:We have determined the cell cycle position of individual mouse leukemia L 1210 cells by cytophotometric and autoradiographic techniques and simultaneously determined the amount of histocompatibility antigens expressed on the surface of individual cells by quantitative immunofluorescence. Interferon treatment of L 1210...

journal_title：European journal of immunology

authors： Killander D,Lindahl P,Lundin L,Leary P,Gresser I

更新日期：1976-01-01 00:00:00

abstract：:Peptide ligands presented by MHC class I molecules are generated in a cascade of proteolytic events starting with the proteasome in the cytosol and frequently terminating with trimming aminopeptidases in the endoplasmic reticulum. Several cytosolic proteases can carry out intermediate proteolytic steps between these s...

journal_title：European journal of immunology

authors： Endert Pv

更新日期：2008-03-01 00:00:00

abstract：:The development and the differentiation of CD8(+) T cells are dependent on IL-15. Here, we have studied the source and mechanism of how IL-15 modulates CD8(+) T cell-mediated Th1 immune responses by employing two delayed-type hypersensitivity (DTH) models. IL-15-deficient (IL-15(-/-)) mice or mice treated with soluble...

journal_title：European journal of immunology

authors： Rückert R,Brandt K,Bulanova E,Mirghomizadeh F,Paus R,Bulfone-Paus S

更新日期：2003-12-01 00:00:00

abstract：:Ab-restricted, H-Y-specific T cell clones from C57BL/6 mice were found to use predominantly V beta 6 T cell receptor genes, conferring Mls-1a reactivity. However, the expression of Mls-1a as a self antigen in (DBA/2 x C57BL/6)F1 mice did not turn these mice into nonresponders to H-Y. Instead of V beta 6, they used oth...

journal_title：European journal of immunology

authors： Frangoulis B,Pla M,Rammensee HG

更新日期：1989-03-01 00:00:00

abstract：:Disseminated infections by the opportunistic yeast Cryptococcus neoformans are characterized by accumulation in tissues of glucuronoxylomannan (GXM), the major component of the capsular polysaccharide. We investigated binding, uptake, and disposal of GXM by peripheral blood neutrophils and monocytes, and the effect of...

journal_title：European journal of immunology

authors： Monari C,Retini C,Casadevall A,Netski D,Bistoni F,Kozel TR,Vecchiarelli A

更新日期：2003-04-01 00:00:00

abstract：:The role of the invariant chain (Ii), an MHC class II-associated chaperone, in B cell development is controversial. Ii deficient mice (Ii(-/-) mice) show a defect in B cell development. This defect has been attributed to the absence of a fragment liberated from the Ii by intramembranous proteolysis. It was proposed th...

journal_title：European journal of immunology

authors： Maehr R,Kraus M,Ploegh HL

更新日期：2004-08-01 00:00:00

abstract：:Upon treatment with lipopolysaccharide (LPS), primary B cells proliferate and differentiate into plasma cells with concomitant up-regulation of immunoglobulin (Ig) gene expression. Here we examine the role of the Igkappa 3' enhancer in this process using a kappa3'-enhancer-driven beta-globin reporter gene in transgeni...

journal_title：European journal of immunology

authors： Meyer KB

更新日期：1999-03-01 00:00:00

abstract：:The nonobese diabetic (NOD) mouse is a relevant model for studying human insulin-dependent diabetes mellitus (IDDM). The selective destruction of insulin-secreting cells in this model is subsequent to an autoimmune reaction directed towards the beta cells inside the islets of Langerhans of the pancreas. Given the key ...

journal_title：European journal of immunology

authors： Sempé P,Bédossa P,Richard MF,Villà MC,Bach JF,Boitard C

更新日期：1991-05-01 00:00:00

abstract：:When cytotoxic titrations were made of rabbit anti-mouse brain and anti-Thy-1.2 sera against mouse lymphoid cells in the presence of sodium barbital or xylocaine, it was observed that a proportion of T cells were much more sensitive (50 x) than the remainder. This effect could be detected with ethidium or fluorescein ...

journal_title：European journal of immunology

authors： Lee SK,Singh J,Taylor RB

更新日期：1975-04-01 00:00:00

abstract：:NK cells and cytotoxic T lymphocytes can induce apoptosis in virus-infected and transformed target cells via the granule exocytosis pathway. The key components of the cytolytic granules are perforin and several serine esterases, termed granzymes. While the cellular distribution of human granzymes A (GrA) and B (GrB) h...

journal_title：European journal of immunology

authors： Bratke K,Kuepper M,Bade B,Virchow JC Jr,Luttmann W

更新日期：2005-09-01 00:00:00

abstract：:HLA class II association with insulin-dependent diabetes mellitus (IDDM) is well established but is still difficult to map to a particular locus. Polymorphism of the genes coding for transporter associated with antigen processing (TAP1 and TAP2), and located in the HLA class II region, was studied in 167 IDDM patients...

journal_title：European journal of immunology

authors： Caillat-Zucman S,Bertin E,Timsit J,Boitard C,Assan R,Bach JF

更新日期：1993-08-01 00:00:00

abstract：:Dendritic cells isolated from sheep afferent lymph were examined for their ability to bind soluble protein and peptide antigens labeled with fluorescein both in in vitro assays and following intradermal injection of antigen in vivo. Analysis of dendritic cells by flow cytometry revealed weak direct binding of proteins...

journal_title：European journal of immunology

authors： Harkiss GD,Hopkins J,McConnell I

更新日期：1990-11-01 00:00:00

abstract：:CD40-CD40 ligand (CD40L) signaling plays multiple indispensable roles in cellular and humoral immunity. Impaired memory T-cell responses in the absence of CD40L have been well documented, but the requirement of this interaction for efficient priming of CD8+ T cells especially under inflammatory conditions has been und...

journal_title：European journal of immunology

authors： Durlanik S,Loyal L,Stark R,Sercan Alp Ö,Hartung A,Radbruch A,von Herrath M,Matzmohr N,Frentsch M,Thiel A

更新日期：2016-11-01 00:00:00

abstract：:Inhibitory anti-antibodies induced in patients by xenogeneic or even by humanized anti-T cell antibodies remain an unresolved problem. Mice also produce anti-antibodies following injection of xeno- or allogeneic anti-T cell antibodies. Here we report a principle based on sequentially applied anti-T cell antibodies gen...

journal_title：European journal of immunology

authors： Mysliwietz J,Thierfelder S,Mocikat R,Kremmer E

更新日期：1994-10-01 00:00:00

abstract：:The pro-inflammatory cytokines tumor necrosis factor (TNF) and interleukin-1 (IL-1) have been shown to be primary mediators in the pathogenesis of chronic inflammatory joint diseases. However, the relative contributions of these molecules to the development and progression of disease is not known. In the present study...

journal_title：European journal of immunology

authors： Probert L,Plows D,Kontogeorgos G,Kollias G

更新日期：1995-06-01 00:00:00

abstract：:Th17 cells are defined by their capacity to produce IL-17, and are important mediators of inflammation and autoimmunity. Human Th17 cells express high levels of the retinoic acid-related orphan receptor variant 2 (RORC2), but it is currently unclear whether expression of this transcription factor alone is sufficient t...

journal_title：European journal of immunology

authors： Crome SQ,Wang AY,Kang CY,Levings MK

更新日期：2009-06-01 00:00:00

abstract：:The inflammatory process that underlies allergic diseases such as asthma is characterized by tissue infiltration of eosinophils and T cells. We have used the Stamper-Woodruff frozen-section assay to characterize the receptors involved in adhesion of human peripheral blood T cells to nasal polyp endothelium (NPE) as a ...

journal_title：European journal of immunology

authors： Symon FA,McNulty CA,Wardlaw AJ

更新日期：1999-04-01 00:00:00

abstract：:We recently reported that differentiation of CD8(+) T cells from the naïve to the effector state involves the upregulation of glucose-dependent metabolism. Glucose deprivation or inhibition of glycolysis by 2-deoxy-D-glucose (2-DG) selectively inhibited production of IFN-gamma but not of IL-2. To determine a more glob...

journal_title：European journal of immunology

authors： Cham CM,Driessens G,O'Keefe JP,Gajewski TF

更新日期：2008-09-01 00:00:00

abstract：:Activated leukocyte cell adhesion molecule (ALCAM; CD166) is a member of the immunoglobulin gene superfamily (IgSF) which is expressed by activated leukocytes and thymic epithelial cells and is a ligand for the lymphocyte antigen CD6. Herein, we report on the isolation and characterization of cDNA clones encoding mous...

journal_title：European journal of immunology

authors： Bowen MA,Bajorath J,D'Egidio M,Whitney GS,Palmer D,Kobarg J,Starling GC,Siadak AW,Aruffo A

更新日期：1997-06-01 00:00:00

abstract：:MyD88 is a key adaptor molecule in innate resistance, engaged in most Toll-like receptor, as well as IL-1 and IL-18, signalling. Here, we analyzed the role of MyD88 in innate resistance during infection with vesicular stomatitis virus (VSV) using myd88(-/-) mice. We found an increased susceptibility to VSV in myd88(-/...

journal_title：European journal of immunology

authors： Lang KS,Navarini AA,Recher M,Lang PA,Heikenwalder M,Stecher B,Bergthaler A,Odermatt B,Akira S,Honda K,Hengartner H,Zinkernagel RM

更新日期：2007-09-01 00:00:00

abstract：:The monoclonal antibody W6/32.1 recognizes a public determinant on the HLA-A, B and C antigens of all tested human haplotypes. Though the antibody does not bind to normal mouse cells of any H-2 haplotype, it does show an unexpected specificity for the T cell leukemia line MBL-2 from a C57BL/6 mouse. It is shown that t...

journal_title：European journal of immunology

authors： Evan GI,Lennox ES,Alderson T,Croft L

更新日期：1983-02-01 00:00:00

abstract：:CD4+ CD25+ Foxp3+ regulatory T cells (Treg) are natural suppressors of autoimmunity but they can also dampen the effective clearance of infectious organisms. These cells have the potential to be exploited to prevent transplant rejection and to treat autoimmune disease. A paper in this issue of the European Journal of ...

journal_title：European journal of immunology

authors： Graça L,Silva-Santos B,Coutinho A

更新日期：2006-04-01 00:00:00

abstract：:Reciprocal induction of the Th1 and Th17 immune responses is essential for optimal protection against Mycobacterium tuberculosis (Mtb); however, only a few Mtb antigens are known to fulfill this task. A functional role for resuscitation-promoting factor (Rpf) E, a latency-associated member of the Rpf family, in promot...

journal_title：European journal of immunology

authors： Choi HG,Kim WS,Back YW,Kim H,Kwon KW,Kim JS,Shin SJ,Kim HJ

更新日期：2015-07-01 00:00:00

abstract：:B cell abnormalities are a prominent feature of the immunologic derangement in NZB and NZB / W mice. We recently demonstrated that these mice have an increased proportion of splenic B cells expressing B7.1 and elevated levels of B7.2 and ICAM-1 that possess the characteristics of marginal zone B cells (CD23(low / -) C...

journal_title：European journal of immunology

authors： Wither JE,Paterson AD,Vukusic B

更新日期：2000-02-01 00:00:00

abstract：:In the fetus the peripheral T cell pool expands as the fetus grows, but the mechanisms that regulate T cell homeostasis during fetal life are unknown. Here, we show that the peripheral T cell pool in the sheep fetus is established by the export from the fetal thymus of twice as many CD8+ as CD4+ thymic emigrants every...

journal_title：European journal of immunology

authors： Holder JE,Washington EA,Cunningham CP,Cahill RN,Kimpton WG

更新日期：2006-10-01 00:00:00

abstract：:Twelve continuous rat tissue cultured mast cell (MC) lines were established by prolonged culture of rat peritoneal MC in the absence of added factors or feeder layers. Two of these lines, RCMC1 and RCMC2, have been briefly described previously, seven others are now also described. Both RCMC1 and RCMC2 lack a marker ch...

journal_title：European journal of immunology

authors： Chan BM,Ra CS,Hu WN,McNeill K,Miller HR,Befus D,Kinet JP,Froese A

更新日期：1990-01-01 00:00:00

abstract：:Activation-induced deaminase (AID) is the master regulator of class switch recombination (CSR) and somatic hypermutation (SHM), but the mechanisms regulating AID function are obscure. The differential pattern of switch plasmid activity in three IgM(+)/AID(+) and two IgG(+)/AID(+) B cell lines prompted an analysis of g...

journal_title：European journal of immunology

authors： Bhattacharya P,Grigera F,Rogozin IB,McCarty T,Morse HC 3rd,Kenter AL

更新日期：2008-01-01 00:00:00

abstract：:Bacterial antigens recognized by CD8(+) T cells in the context of MHC class I are thought to play a crucial role in protection against pathogenic intracellular bacteria. Here, we demonstrate the induction of HLA-A*0201-restricted CD8(+) T cell responses against six new high-affinity HLA-A*0201-binding CTL epitopes, en...

journal_title：European journal of immunology

authors： Charo J,Geluk A,Sundbäck M,Mirzai B,Diehl AD,Malmberg KJ,Achour A,Huriguchi S,van Meijgaarden KE,Drijfhout JW,Beekman N,van Veelen P,Ossendorp F,Ottenhoff TH,Kiessling R

更新日期：2001-12-01 00:00:00

abstract：:In the present study, we sought evidence for a surface nucleosome receptor in the fibroblastic cell line CV-1, and questioned whether anti-double-stranded (ds) DNA and/or anti-histone autoantibodies could recognize and influence the fate of cell surface-bound nucleosomes. 125I-labeled mononucleosomes were shown to bin...

journal_title：European journal of immunology

authors： Koutouzov S,Cabrespines A,Amoura Z,Chabre H,Lotton C,Bach JF

更新日期：1996-02-01 00:00:00

abstract：:There is a current need for safe, cheap, and effective vaccine adjuvants, to combine with sub-unit antigens to enhance their immunogenicity. In this study we have used probiotic Bacillus subtilis spores, known to be safe and fully tolerated by ingestion in man, and explored their ability to influence the magnitude and...

journal_title：European journal of immunology

authors： Barnes AG,Cerovic V,Hobson PS,Klavinskis LS

更新日期：2007-06-01 00:00:00