Abstract:
:MyD88 is a key adaptor molecule in innate resistance, engaged in most Toll-like receptor, as well as IL-1 and IL-18, signalling. Here, we analyzed the role of MyD88 in innate resistance during infection with vesicular stomatitis virus (VSV) using myd88(-/-) mice. We found an increased susceptibility to VSV in myd88(-/-) mice, which was not explained by reduced type I IFN or neutralizing antibody responses. Susceptibility of myd88(-/-) mice correlated with impaired recruitment of immune cells to the site of infection. In the absence of MyD88 signalling, VSV rapidly spread to the spinal cord and brain causing lethal encephalitis.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Lang KS,Navarini AA,Recher M,Lang PA,Heikenwalder M,Stecher B,Bergthaler A,Odermatt B,Akira S,Honda K,Hengartner H,Zinkernagel RMdoi
10.1002/eji.200737310subject
Has Abstractpub_date
2007-09-01 00:00:00pages
2434-40issue
9eissn
0014-2980issn
1521-4141journal_volume
37pub_type
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