Anti-idiotypes against anti-H-2 antibodies VI. Detection of shared idiotypes among monoclonal anti-H-2 antibodies.

abstract：:To investigate negative selection events during intrathymic ontogeny, we established T cell receptor (TCR)-transgenic mice [N15tg/RAG-2-/- (H-2b)] expressing a single TCR specific for vesicular stomatitis virus nuclear octapeptide N52-59 (VSV8) in the context of the major histocompatibility complex (MHC) class I molec...

journal_title：European journal of immunology

authors： Ghendler Y,Hussey RE,Witte T,Mizoguchi E,Clayton LK,Bhan AK,Koyasu S,Chang HC,Reinherz EL

更新日期：1997-09-01 00:00:00

abstract：:Normal BALB/c spleen cells incubated for 2 days with Streptococcus pneumoniae R 36 a (Pn) vaccine in vitro acquired the specific ability to inhibit the T-independent anti-Pn response of fresh lymphocytes. The activated suppressor cells were susceptible to cytotoxic treatment with mouse anti-theta serum plus complement...

journal_title：European journal of immunology

authors： Cerny J,Caulfield MJ,Siat M

更新日期：1980-09-01 00:00:00

abstract：:Self-glycosphingolipids bind to surface CD1 molecules and are readily displaced by other CD1 ligands. This capacity to exchange antigens at the cell surface is not common to other antigen-presenting molecules and its physiological importance is unclear. Here we show that a large pool of cell-surface CD1a, but not CD1b...

journal_title：European journal of immunology

authors： Manolova V,Kistowska M,Paoletti S,Baltariu GM,Bausinger H,Hanau D,Mori L,De Libero G

更新日期：2006-05-01 00:00:00

abstract：:Lipopolysaccharide (LPS) is a potent inducer of interleukin 1 (IL 1) synthesis and release, and of tumor necrosis factor (TNF) secretion. Many signals can enhance the LPS-induced production of these cytokines. We have previously observed that addition of low amounts of normal human serum to the culture medium enhances...

journal_title：European journal of immunology

authors： Cavaillon JM,Fitting C,Haeffner-Cavaillon N

更新日期：1990-02-01 00:00:00

abstract：:In the fetus the peripheral T cell pool expands as the fetus grows, but the mechanisms that regulate T cell homeostasis during fetal life are unknown. Here, we show that the peripheral T cell pool in the sheep fetus is established by the export from the fetal thymus of twice as many CD8+ as CD4+ thymic emigrants every...

journal_title：European journal of immunology

authors： Holder JE,Washington EA,Cunningham CP,Cahill RN,Kimpton WG

更新日期：2006-10-01 00:00:00

abstract：:Mitogens such as pokeweed mitogen, Staphylococcus aureus Cowan I, concanavalin A and phytohemagglutinin and monoclonal anti-CD antibodies were examined for their capacity to induce IgE synthesis by peripheral blood leukocytes obtained from both atopic and nonatopic individuals. While lectins failed to induce IgE synth...

journal_title：European journal of immunology

authors： Yang XD,De Weck AL,Stadler BM

更新日期：1988-03-01 00:00:00

abstract：:Newborn mouse spleen, whose cells strongly suppress the in vitro humoral response of adult spleen cells, is essentially a hematopoietic organ. It contains a large percentage of proliferating cells, among which about 50% are erythroblasts (identified by their spectrin content) and about 15% are cells of the myelocytic ...

journal_title：European journal of immunology

authors： Piguet PF,Irle C,Vassalli P

更新日期：1981-01-01 00:00:00

abstract：:Hematopoietic development is a delicate balance of cell fate decisions in multipotent cells between self-renewal and differentiation. In multiple developmental systems, the Notch receptors are important factors regulating these processes. Hematopoietic progenitor cells have been shown to express Notch1, and studies wi...

journal_title：European journal of immunology

authors： Jönsson JI,Xiang Z,Pettersson M,Lardelli M,Nilsson G

更新日期：2001-11-01 00:00:00

abstract：:Upon receptor activation, the myeloid C-type lectin receptor Mincle signals via the Syk-CARD9-Bcl10-MALT1 pathway. It does so by recruiting the ITAM-bearing FcεRI-γ. The related receptor macrophage C-type Lectin (MCL) has also been shown to be associated with Syk and to be dependent upon this signaling axis. We have p...

journal_title：European journal of immunology

authors： Lobato-Pascual A,Saether PC,Fossum S,Dissen E,Daws MR

更新日期：2013-12-01 00:00:00

abstract：:Soluble TRAIL (sTRAIL) can be produced by myeloid-derived cells to kill cancer cells. Whether this mechanism is used by T cells, and if so, how sTRAIL production is regulated, remains unclear. Our previous studies showed that ex vivo expanded human γδ T cells express TRAIL and NK receptor group 2 (R2), member D (NKG2D...

journal_title：European journal of immunology

authors： Dokouhaki P,Schuh NW,Joe B,Allen CA,Der SD,Tsao MS,Zhang L

更新日期：2013-12-01 00:00:00

abstract：:Syntaxin 11 (STX11) controls vesicular trafficking and is a key player in exocytosis. Since Stx11 mutations are causally associated with a familial hemophagocytic lymphohistio-cytosis, we wanted to clarify whether STX11 is functionally important for key immune cell populations. This was studied in primary cells obtain...

journal_title：European journal of immunology

authors： D'Orlando O,Zhao F,Kasper B,Orinska Z,Müller J,Hermans-Borgmeyer I,Griffiths GM,Zur Stadt U,Bulfone-Paus S

更新日期：2013-01-01 00:00:00

abstract：:CD16-positive (CD14(++) CD16(+) and CD14(+) CD16(++) ) monocytes have unique features with respect to phenotype and function. We have used transcriptional profiling for comparison of CD16-positive monocytes and classical monocytes. We show herein that 187 genes are greater than fivefold differentially expressed, incl...

journal_title：European journal of immunology

authors： Frankenberger M,Hofer TP,Marei A,Dayyani F,Schewe S,Strasser C,Aldraihim A,Stanzel F,Lang R,Hoffmann R,Prazeres da Costa O,Buch T,Ziegler-Heitbrock L

更新日期：2012-04-01 00:00:00

abstract：:A panel of HLA-DRB1*0401-restricted CD4+ mouse T cell hybridomas specific for bovine type II collagen were generated from transgenic mice expressing the human HLA-DRA1*0101/-DRB1*0401 and CD4 molecules. The vast majority recognized a single peptide determinant corresponding to residues 261-273 (CII 261-273). This dete...

journal_title：European journal of immunology

authors： Fugger L,Rothbard JB,Sonderstrup-McDevitt G

更新日期：1996-04-01 00:00:00

abstract：:A T cell activation antigen, Ly6C, is considered to be involved in the autoimmunity of some autoimmune-prone mice; however, the function of Ly6C remains largely unknown. We prepared a rat anti-mouse Ly6C monoclonal antibody (mAb) (S14) that inhibits the proliferation of peripheral T cells stimulated with anti-CD3 mAb ...

journal_title：European journal of immunology

authors： Yamanouchi S,Kuwahara K,Sakata A,Ezaki T,Matsuoka S,Miyazaki J,Hirose S,Tamura T,Nariuchi H,Sakaguchi N

更新日期：1998-02-01 00:00:00

abstract：:The lectin leucoagglutinin has been used to induce reactivity to interleukin 2 (IL2) in unseparated spleen cells and in highly purified Lyt-2+ lymph node T cells. Recombinant human IL2 and various other IL2-containing preparations, including concanavalin A-induced spleen cell supernatant, were compared for their capac...

journal_title：European journal of immunology

authors： Vohr HW,Hünig T

更新日期：1985-04-01 00:00:00

abstract：:The relationship between immunogenicity of Shigella paradysenteriae, the branched synthetic polypeptide poly-L (Tyr, Glu)-polylpro-polyllys [(T, G)-Pro--L] and human albumin (HSA) interacting with macrophages and kinetics of antigen degradation and degree of binding to the cell surface was studied. Following thioglyco...

journal_title：European journal of immunology

authors： Gallily R,Bar-Eli M

更新日期：1976-11-01 00:00:00

abstract：:Developing T cells undergo distinct selection processes that determine the T cell receptor (TcR) repertoire. One of these processes is positive selection. Positive selection involves the differentiation to mature T cells of thymocytes bearing TcR capable of recognizing antigens in the context of self-major histocompat...

journal_title：European journal of immunology

authors： Carrera AC,Baker C,Roberts TM,Pardoll DM

更新日期：1992-09-01 00:00:00

abstract：:Immunity to tumor differentiation antigens, such as melanoma antigen recognized by T cells 1 (MART-1), has been comprehensively studied. Intriguingly, CD8(+) T cells specific for the MART-1(26(27)-35) epitope in the context of HLA-A0201 are about 100 times more abundant compared with T cells specific for other tumor-a...

journal_title：European journal of immunology

authors： Pinto S,Sommermeyer D,Michel C,Wilde S,Schendel D,Uckert W,Blankenstein T,Kyewski B

更新日期：2014-09-01 00:00:00

abstract：:In this study we examined the effect of interleukin 4 (IL 4) on T cell activation and proliferation via the alternative CD2 pathway. To this end highly purified human resting T cells were cultured with a stimulating pair of anti-CD2 monoclonal antibodies in the absence of accessory signals from monocytes. Addition of ...

journal_title：European journal of immunology

authors： Lorré K,Van Damme J,Ceuppens JL

更新日期：1990-07-01 00:00:00

abstract：:Regulatory T cells (Treg) provide protection from autoimmune disease, graft-versus-host disease, transplant rejection and overwhelming tissue destruction during infections. Conversely, high Treg numbers enable cancer cells to evade the host immune response. Thus, Treg are seen as an important tool to manipulate the im...

journal_title：European journal of immunology

authors： Banham AH,Powrie FM,Suri-Payer E

更新日期：2006-11-01 00:00:00

abstract：:Hybrid virus-like particles (VLP) were prepared by self-assembly of the modified porcine parvovirus (PPV) VP2 capsid protein carrying a CD8+ or CD4+ T cell epitope. Immunization of mice with a single dose of these hybrid pseudo-particles, without adjuvant, induced strong cytotoxic T lymphocyte and T helper (Th) respon...

journal_title：European journal of immunology

authors： Lo-Man R,Rueda P,Sedlik C,Deriaud E,Casal I,Leclerc C

更新日期：1998-04-01 00:00:00

abstract：:B cells and regulatory T (Treg) cells can both facilitate remission from experimental auto immune encephalomyelitis (EAE), a disease of the central nervous system (CNS) used as a model for multiple sclerosis (MS). Considering that B-cell-depletion therapy (BCDT) is used to treat MS patients, we asked whether Treg-cell...

journal_title：European journal of immunology

authors： Hoehlig K,Shen P,Lampropoulou V,Roch T,Malissen B,O'Connor R,Ries S,Hilgenberg E,Anderton SM,Fillatreau S

更新日期：2012-05-01 00:00:00

abstract：:Spleen cells from chickens injected with sheep erythrocytes (SE) intravenously 2 to 14 days prior to culture were found to give faster and higher plaque-forming cell responses upon addition of antigen on day 2 rather than on day 0 of culture. Cell mixture experiments showed that this was due to the induction of suppre...

journal_title：European journal of immunology

authors： Chi DS,Grebenau MD,Thorbecke GJ

更新日期：1980-03-01 00:00:00

abstract：:The transforming protein of mouse polyomavirus, the mouse middle T antigen (MomT), and its counterpart in the hamster polyomavirus, the hamster middle T antigen (HamT), interact with a number of cellular proteins. Among these are members of the Src family of tyrosine kinases, the phosphatidylinositol 3-kinase, the ser...

journal_title：European journal of immunology

authors： Brizuela L,Ulug ET,Jones MA,Courtneidge SA

更新日期：1995-02-01 00:00:00

abstract：:Hypersensitivity to nickel (Ni) represents the most common manifestation of contact allergy in humans. The role of metal-specific T cells in this disease is well established, but the molecular interactions involved in their activation are poorly understood. We examined the T cell receptor (TCR) repertoire in T cells a...

journal_title：European journal of immunology

authors： Vollmer J,Fritz M,Dormoy A,Weltzien HU,Moulon C

更新日期：1997-08-01 00:00:00

abstract：:The squirrel monkey Saimiri sciureus is one of the World Health Organization recommended experimental models of Plasmodium falciparum blood stage infection. Anti-malaria antibodies developed by this host after a drug-controlled infection play an important part in the acquired protection against the P. falciparum blood...

journal_title：European journal of immunology

authors： Groux H,Perraut R,Garraud O,Poingt JP,Gysin J

更新日期：1990-10-01 00:00:00

abstract：:Interferon-gamma inducing factor (IGIF) is a recently identified cytokine which stimulates the production of interferon-gamma (IFN-gamma) by T cells and enhances natural killer (NK) cell cytolytic activity. Protein fold recognition, structure prediction and comparative modeling have revealed that IGIF is a member of t...

journal_title：European journal of immunology

authors： Hunter CA,Timans J,Pisacane P,Menon S,Cai G,Walker W,Aste-Amezaga M,Chizzonite R,Bazan JF,Kastelein RA

更新日期：1997-11-01 00:00:00

abstract：:T cell clones of C57BL/6 origin which recognize porcine lactate dehydrogenase B (LDH-BP) together with the Ab molecule were characterized in terms of fine specificity for both LDH-B and self-major histocompatibility complex determinants. Using antigen-presenting cells from the Ab-mutant strain B6.C-H-2bm12 (bm12), thr...

journal_title：European journal of immunology

authors： Nagy ZA,Servis C,Walden P,Klein J,Goldberg E

更新日期：1985-08-01 00:00:00

abstract：:A large panel of T cell clones (TCC) specific for the recombinant form of Poa pratensis allergen (rKBG7.2 or Poa p9) were established from the peripheral blood of grass pollen-sensitive donor in the absence or presence of recombinant interferon-alpha (IFN-alpha) in bulk culture and their pattern of cytokine secretion,...

journal_title：European journal of immunology

authors： Parronchi P,Mohapatra S,Sampognaro S,Giannarini L,Wahn U,Chong P,Mohapatra S,Maggi E,Renz H,Romagnani S

更新日期：1996-03-01 00:00:00

abstract：:Vaccinia virus (VV) has been most commonly used as the vaccine to protect individuals against the causative agent of smallpox (variola virus), but it also uses a number of strategies meant to evade or blunt the host's antiviral immune response. Natural killer T (NKT) cells are a subset of immunoregulatory CD1d-restric...

journal_title：European journal of immunology

authors： Webb TJ,Litavecz RA,Khan MA,Du W,Gervay-Hague J,Renukaradhya GJ,Brutkiewicz RR

更新日期：2006-10-01 00:00:00